Pepsin Digest of Wheat Gliadin Fraction Increases Production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-κB Signaling Pathway and an NLRP3 Inflammasome Activation

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Palová Jelínková, Lenka ^a   Dáňová, Klára ^a   Drašarová, Hana ^a   Dvořák, Miloš ^b   Funda, David P ^a   Fundová, Petra ^a   Kotrbová Kozak, Anna ^b   Černá, Marie ^b   Kamanová, Jana ^a   Martin, Stefan F ^c   Freudenberg, Marina ^d   Tučková, Ludmila ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c UNIVERSITY OF FREIBURG   (Germany)

^d MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS SPECK LIKE PROTEIN; CRYOPYRIN; GLIADIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PEPSIN A; PEPSIN DIGEST OF WHEAT GLIADIN FRACTION; PURINERGIC P2X7 RECEPTOR; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELIAC DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME ACTIVITY; ENZYME SYNTHESIS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; MONOCYTE; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; POTASSIUM TRANSPORT; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SUPERNATANT; UPREGULATION; WESTERN BLOTTING;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADULT; ANIMALS; CARRIER PROTEINS; CELIAC DISEASE; FEMALE; GENE EXPRESSION REGULATION; GLIADIN; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; MYELOID DIFFERENTIATION FACTOR 88; PEPSIN A; PEPTIDE FRAGMENTS; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

MUS; TRITICUM AESTIVUM;

EID: 84876935554     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062426     Document Type: Article

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