Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice

Gut

Volumn 62, Issue 6, 2013, Pages 899-910

  Uriarte, Iker ^a   Fernandez Barrena, Maite G ^a   Monte, Maria J ^b   Latasa, Maria U ^a   Chang, Haisul C Y ^a   Carotti, Simone ^c   Vespasiani Gentilucci, Umberto ^c   Morini, Sergio ^c   Vicente, Eva ^a   Concepcion, Axel R ^a   Medina, Juan F ^a   Marin, José Juan G ^b   Berasain, Carmen ^a   Prieto, Jesus ^a   Avila, Matías A ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

^c UNIVERSITY CAMPUS BIO MEDICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; COLESTYRAMINE; CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; MACROPHAGE INFLAMMATORY PROTEIN 2; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE ACID METABOLISM; BILIRUBIN BLOOD LEVEL; CDC25B GENE; CELL CYCLE REGULATION; CELL PROLIFERATION; CHOLESTASIS; CONTROLLED STUDY; FOXM1B GENE; GENE; GENETIC TRAIT; HOMEOSTASIS; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER FAILURE; LIVER REGENERATION; LIVER RESECTION; MALE; MITOGENICITY; MORBIDITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; BILE ACIDS AND SALTS; FIBROBLAST GROWTH FACTORS; HEPATECTOMY; HOMEOSTASIS; LIVER FAILURE; LIVER REGENERATION; MICE; MICE, INBRED C57BL; POSTOPERATIVE COMPLICATIONS;

EID: 84876934226     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-302945     Document Type: Article

References (55)

1. Dahm F, Georgiev P, Clavien P-A. Small-for-size syndrome after partial liver transplantation: definition, mechanisms of disease and clinical implications. Am J Transplant 2005;5:2605-10.
2. Van den Broek MAJ, Olde Damink SWM, Dejong CHC, et al. Liver failure after partial hepatic resection: definition, pathophysiology, risk factors and treatment. Liv Int 2008;28:767-80. (Pubitemid 351818638)
3. Karp SJ. Clinical implications of advances in the basic science of liver repair and regeneration. Am J Transplant 2009;9:1973-80.
4. Hammond JS, Guha IN, Beckingham IJ, et al. Prediction, prevention and management of postresection liver failure. Brit J Surg 2011;98:1188-200.
5. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997;276:60-6.
6. Rihele KJ, Dan YY, Campbell JS, et al. New concepts in liver regeneration. J Gastroenterol Hepatol 2011;26:203-12.
7. Gilgenkrantz H, de l'Hortet AC. New insights into liver regeneration. Clinics and Res in Hepatol Gastroenterol 2011;35:623-9.
8. Mortensen KE, Revhaug A. Liver regeneration in surgical animal models - a historical perspective and clinical implications. Eur Surg Res 2010;46:1-18.
9. Michalopoulos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol 2010;176:2-13.
10. Huang W, Ma K, Qatanani M, et al. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 2006;312:233-6.
11. Csanaky IL, Aleskunes LM, Tanaka AY, et al. Role of hepatic transporters I prevention of bile acid toxicity after partial hepatectomy in mice. Am J Physiol Gastrointest Liver Physiol 2009;297:G419-33.
12. Doignon I, Julien B, Serrière-Lanneau V, et al. Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis. J Hepatol 2011;54:481-8.
13. Fernández-Barrena MG, Monte MJ, Latasa MU, et al. Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice. J Hepatol 2012;56:367-73.
14. Hayashi H, Beppu T, Sugita H, et al. Increase in the serum bile acid level predicts the effective hypertrophy of the nonembolized hepatic lobe after right portal vein embolization. World J Surg 2009;33:1933-40.
15. Zhang L, Huang X, Meng Z, et al. Significance and mechanisms of Cyp7a1 gene regulation during the acute phase of liver regeneration. Mol Endocrinol 2009;23:137-45.
16. Chiang JYL. Bile acids: regulation of synthesis. J Lipid Res 2009;50:1955-66.
17. Monte MJ, Marin JGG, Antelo A, et al. Bile acids: chemistry, physiology, and pathophysiology. World J Gastroenterol 2009;15:804-16.
18. Hofmann AF. The enterohepatic circulation of bile acids in mammals: form and functions. Front Biosci 2009;14:2584-98.
19. Suzuki H, Iyomasa S, Nimura Y, et al. Internal biliary drainage, unlike external drainage, does not suppress the regeneration of cholestatic rat liver after partial hepatectomy. Hepatology 1994;20:1319-22.
20. Holt JA, Luo G, Billin AN, et al. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev 2003;17:1581-91. (Pubitemid 36828786)
21. Inagaki T, Choi M, Moschetta A, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005;2:217-25.
22. Kir S, Beddow SA, Samuel VT, et al. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science 2011;331:1621-24.
23. Kir S, Kliewer SA, Mangelsdorf DJ. Roles of FGF19 in liver metabolism. Cold Spring Harbor Symp Quant Biol 2011;76:1-6.
24. Ben-Ari Z, Pappo O, Mor E. Intrahepatic cholestasis after liver transplantation. Liver Transplant 2003;9:1005-18. (Pubitemid 37304454)
25. Yokoyama Y, Nagino M, Nimura Y. Mechanism of impaired hepatic regeneration in cholestatic liver. J Hepatobiliary Pancreat Surg 2007;14:159-66. (Pubitemid 46502143)
26. Cho JY, Suh KS, Lee HW, et al. Hepatic steatosis is associated with intrahepatic cholestasis and transient hyperbilirubinemia during regeneration after living donor liver transplantation. Transpl Int 2006;19:807-13. (Pubitemid 44358847)
27. Wright TJ, Ladher R, McWhirter J, et al. Mouse FGF15 is the ortholog of human and chick FGF19, but is not required for otic induction. Dev Biol 2004;269:264-75. (Pubitemid 38471838)
28. Berasain C, Garcia-Trevijano ER, Castillo E, et al. Amphiregulin: an early trigger of liver regeneration in mice. Gastroenterology 2005;128:424-32. (Pubitemid 40431094)
29. -/- mice. PLoS One 2010;5:e15690.
30. Wang X, Kiyokawa H, Dennewitz MB, et al. The forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc Natl Acad Sci U S A 2002;99:16881-6. (Pubitemid 36034067)
31. Ochoa B, Syn WK, Delgado I, et al. Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice. Hepatology 2010;51:1712-23.
32. Bénazéraf B, Chen Q, Peco E, et al. Identification of an unexpected link between the Shh pathway and a G2/M regulator, the phosphatase CDC25B. Dev Biol 2006;294:133-47. (Pubitemid 44275140)
33. Hsieh WL, Lin YK, Tsai CN, et al. Indirubin, an actin component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal keratinocytes. J Dermatol Sci 2012;67:140-6.
34. Chen WD, Wang YD, Zhang L, et al. Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology 2010;51:953-62.
35. Allen K, Jaeschke H, Copple BL. Bile acids induce inflammatory genes in hepatocytes. A novel mechanism of inflammation during obstructive cholestasis. Am J Pathol 2011;178:175-86.
36. Zhang Y, Hong JY, Rockwell CE, et al. Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver Int 2012;32:58-69.
37. Kaita KDE, Pettigrew N, Minuk GY. Hepatic regeneration in humans with various liver diseases as assessed by Ki-67 staining of formalin-fixed paraffin-embedded liver tissue. Liver 1997;17:13-16. (Pubitemid 27092776)
38. Hylemon PB, Zhou H, Pandak WM, et al. Bile acids as regulatory molecules. J Lipid Res 2009;50:1509-20.
39. -/- mice. J Hepatol 2011;55:885-95.
40. Modica S, Petruzelli M, Bellafante E, et al. Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. Gastroenterology 2012;142:355-65.
41. Garcea G, Maddern GJ. Liver failure after major hepatic resection. J Hepatobiliary Pancreat Surg 2009;16:145-55.
42. Schaap FG, van der Gaag NA, Gouma DJ, et al. High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis. Hepatology 2009;49:1228-35.
43. Song KH, Li T, Owsley E, et al. Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7a-hydroxylase gene expression. Hepatology 2009;49:297-305.
44. Sakai N, Van Sweringen HL, Belizaire RM, et al. Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells. J Gastroenterol Hepatol 2012;27:1609-16.
45. Ishizaki K, Iwaki T, Kinoshita S, et al. Ursodeoxycholic acid protects concanavalin A-induced mouse liver injury through inhibition of intrahepatic tumor necrosis factor-alpha and macrophage inflammatory protein-2 production. Eur J Pharmacol 2008;578:57-64. (Pubitemid 350179748)
46. Wu AL, Coulter S, Liddle C, et al. FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways. PLoS One 2011;6:e17868.
47. Drafahl KA, McAndrew CW, Meyer AN, et al. The receptor tyrosine kinase FGFR4 negatively regulates NF-kappaB signalling. PLoS One 2010;5:e14412.
48. Tucker ON, Heaton N. The "small for size" syndrome. Curr Opin Crit Care 2005;11:150-5.
49. Nicholes K, Guillet S, Tomlison E, et al. A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. Am J Pathol 2002;160:2295-307. (Pubitemid 34663420)
50. -/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation. Gut 2010;59:521-30.
51. Alpini G, Glasser SS, Ueno Y, et al. Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile-acid regulated ductal secretion. Gastroenterology 1999;116:179-86. (Pubitemid 29013507)
52. Alpini G, Glasser S, Robertson W, et al. Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes. Am J Physiol 1997;273:G518-29.
53. Fisette A, Hassanain M, Metrakos P, et al. High-dose insulin therapy reduces postoperative liver dysfunction and complications in liver resection patients through reduced apoptosis and altered in flammation. J Clin Endocrinol Metab 2012;97:217-26.
54. - output. Hepatology 2011;54:1303-12.
55. Meng Z, Wang Y, Wang L, et al. FXR regulates liver repair after CCl4-induced toxic injury. Mol Enodocrinol 2010;24:886-97.