Hepatic steatosis is associated with intrahepatic cholestasis and transient hyperbilirubinemia during regeneration after living donor liver transplantation

Transplant International

Volumn 19, Issue 10, 2006, Pages 807-813

  Cho, Jai Young ^a   Suh, Kyung Suk ^a,b   Lee, Hae Won ^a   Cho, Eung Ho ^a   Yang, Sung Hoon ^a   Cho, Yong Beom ^a   Yi, Nam Joon ^a   Kim, Min A ^a   Jang, Ja June ^a   Lee, Kuhn U K ^a  

^a Seoul National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

Hepatic steatosis; Liver; Outcomes; Regeneration; Structure; Transplantation

Indexed keywords

BILIRUBIN; CYCLINE; KI 67 ANTIGEN;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FATTY LIVER; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERBILIRUBINEMIA; IMMUNOHISTOCHEMISTRY; INTRAHEPATIC CHOLESTASIS; LIVER BIOPSY; LIVER CELL; LIVER GRAFT; LIVING DONOR; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL;

ADULT; BIOPSY; CHOLESTASIS, INTRAHEPATIC; FEMALE; HUMANS; HYPERBILIRUBINEMIA; IMMUNOSUPPRESSIVE AGENTS; KI-67 ANTIGEN; LIVER; LIVER REGENERATION; LIVER TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; PROLIFERATING CELL NUCLEAR ANTIGEN;

EID: 33748506084     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2006.00355.x     Document Type: Article

References (35)

1. Selzner M, Clavien PA. Fatty liver in liver transplantation and surgery. Semin Liver Dis 2001; 21: 105.
2. Imber CJ, St Peter SD, Handa A, Friend PJ. Hepatic steatosis and its relationship to transplantation. Liver Transpl 2002; 8: 415.
3. Selzner N, Selzner M, Jochum W, Clavien PA. Ischemic preconditioning protects the steatotic mouse liver against reperfusion injury: an ATP dependent mechanism. J Hepatol 2003; 39: 55.
4. Yoo HY, Molmenti E, Thuluvath PJ. The effect of donor body mass index on primary graft nonfunction, retransplantation rate, and early graft and patient survival after liver transplantation. Liver Transpl 2003; 9: 72.
5. Adam R, Bismuth H, Diamond T, et al. Effect of extended cold ischaemia with UW solution on graft function after liver transplantation. Lancet 1992; 340: 1373.
6. Strasberg SM, Howard TK, Molmenti EP, Hertl M. Selecting the donor liver: risk factors for poor function after orthotopic liver transplantation. Hepatology 1994; 20: 829.
7. Cho JY, Suh KS, Kwon CH, et al. The hepatic regeneration power of mild steatotic grafts is not impaired in living-donor liver transplantation. Liver Transpl 2005; 11: 210.
8. Behrns KE, Tsiotos GG, DeSouza NF, Krishna MK, Ludwig J, Nagorney DM. Hepatic steatosis as a potential risk factor for major hepatic resection. J Gastrointest Surg 1998; 2: 292.
9. Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O. Seven hundred forty-seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. J Am Coll Surg 2000; 191: 38.
10. Kooby DA, Fong Y, Suriawinata A, et al. Impact of steatosis on perioperative outcome following hepatic resection. J Gastrointest Surg 2003; 7: 1034.
11. Ross MA, Sander CM, Kleeb TB, Watkins SC, Stolz DB. Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver. Hepatology 2001; 34: 1135.
12. Stamatoglou SC, Enrich C, Manson MM, Hughes RC. Temporal changes in the expression and distribution of adhesion molecules during liver development and regeneration. J Cell Biol 1992; 116: 1507.
13. Huang R, Schiano TD, Amolat MJ, Miller CM, Thung SN, Saxena R. Hepatocellular proliferation and changes in microarchitecture of right lobe allografts in adult transplant recipients. Liver Transpl 2004; 10: 1461.
14. Xu HS, Rosenlof LK, Jones RS. Bile secretion and liver regeneration in partially hepatectomized rats. Ann Surg 1993; 218: 176.
15. Ben-Ari Z, Pappo O, Mor E. Intrahepatic cholestasis after liver transplantation. Liver Transpl 2003; 9: 1005.
16. Sherlock S. Acute fatty liver of pregnancy and the microvesicular fat diseases. Gut 1983; 24: 265.
17. Crawford AR, Lin XZ, Crawford JM. The normal adult human liver biopsy: a quantitative reference standard. Hepatology 1998; 28: 323.
18. Day CP, James OF. Hepatic steatosis: innocent bystander or guilty party? Hepatology 1998; 27: 1463.
19. Powell EE, Jonsson JR, Clouston AD. Steatosis: co-factor in other liver diseases. Hepatology 2005; 42: 5.
20. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997; 276: 60.
21. Clouston AD, Powell EE, Walsh MJ, Richardson MM, Demetris AJ, Jonsson JR. Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis. Hepatology 2005; 41: 809.
22. Yang S, Koteish A, Lin H, et al. Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. Hepatology 2004; 39: 403.
23. Cho JY, Suh KS, Kwon CH, Yi NJ, Lee KU. Mild hepatic steatosis is not a major risk factor for hepatectomy and regenerative power is not impaired. Surgery 2006; 139: 508.
24. Pizarro M, Balasubramaniyan N, Solis N, et al. Bile secretory function in the obese Zucker rat: evidence of cholestasis and altered canalicular transport function. Gut 2004; 53: 1837.
25. Saab S, Wang V, Ibrahim AB, et al. MELD score predicts 1-year patient survival post-orthotopic liver transplantation. Liver Transpl 2003; 9: 473.
26. Ozawa K. Hepatic function and liver resection. J Gastroenterol Hepatol 1990; 5: 296.
27. Nagasue N, Yukaya H, Ogawa Y, Kohno H, Nakamura T. Human liver regeneration after major hepatic resection. A study of normal liver and livers with chronic hepatitis and cirrhosis. Ann Surg 1987; 206: 30.
28. Hui AM, Kawasaki S, Makuuchi M, Nakayama J, Ikegami T, Miyagawa S. Liver injury following normothermic ischemia in steatotic rat liver. Hepatology 1994; 20: 1287.
29. Hakamada K, Sasaki M, Takahashi K, Umehara Y, Konn M. Sinusoidal flow block after warm ischemia in rats with diet-induced fatty liver. J Surg Res 1997; 70: 12.
30. Muller M, Jansen PL. Molecular aspects of hepatobiliary transport. Am J Physiol 1997; 272: G1285.
31. Muller M, Jansen PL. The secretory function of the liver: new aspects of hepatobiliary transport. J Hepatol 1998; 28: 344.
32. Gerloff T, Geier A, Stieger B, et al. Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver. Gastroenterology 1999; 117: 1408.
33. Vos TA, Ros JE, Havinga R, et al. Regulation of hepatic transport systems involved in bile secretion during liver regeneration in rats. Hepatology 1999; 29: 1833.
34. Ninomiya M, Shimada M, Terashi T, et al. Sustained spatial disturbance of bile canalicular networks during regeneration of the steatotic rat liver. Transplantation 2004; 77: 373.
35. Li MK, Crawford JM. The pathology of cholestasis. Semin Liver Dis 2004; 24: 21.