Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulated Fas/death receptor signaling

Toxicology and Applied Pharmacology

Volumn 269, Issue 2, 2013, Pages 150-162

  Chiang, Jo Hua ^a   Yang, Jai Sing ^b   Lu, Chi Cheng ^a   Hour, Mann Jen ^b   Chang, Shu Jen ^b   Lee, Tsung Han ^a,b   Chung, Jing Gung ^b,c  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

Author keywords

Angiogenesis; Apoptosis; Fas death receptor; HMJ 38; Human umbilical vein endothelial cells; P53

Indexed keywords

2 (3' METHOXYPHENYL) 6 PYRROLIDINYL 4 QUINAZOLINONE; ANGIOGENESIS INHIBITOR; DEATH RECEPTOR; DOCETAXEL; FAS ANTIGEN; HMJ 38; PROTEIN P53; QUINAZOLINONE DERIVATIVE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; BLOOD VESSEL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG SYNTHESIS; EX VIVO STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROVASCULATURE; MOUSE; NONHUMAN; OXIDATIVE STRESS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD95; AORTA; APOPTOSIS; CASPASES; COLLAGEN; DRUG COMBINATIONS; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; LAMININ; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEOGLYCANS; PYRROLIDINES; QUINAZOLINONES; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

RATTUS;

EID: 84876698353     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.03.007     Document Type: Article

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