Exposure of human lung cancer cells to 8-chloro-adenosine induces G 2/M arrest and mitotic catastrophe

Neoplasia

Volumn 6, Issue 6, 2004, Pages 802-812

  Zhang, Hong Yu ^a   Gu, Yan Yan ^a   Li, Zeng Gang ^a   Jia, Yu Hong ^a   Yuan, Lan ^a   Li, Shu Yan ^a   An, Guo Shun ^a   Ni, Ju Hua ^a   Jia, Hong Ti ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

8 chloro adenosine; Apoptosis; Cytotoxicity; G2 M arrest; Mitotic catastrophe

Indexed keywords

8 CHLOROADENOSINE; ADENOSINE DERIVATIVE; ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN; PROTEIN CDC25C; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CONTROLLED STUDY; CYTOKINESIS; DRUG CYTOTOXICITY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LUNG CANCER; MICROFILAMENT; MICROTUBULE; MITOSIS INHIBITION; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

EID: 11144332511     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1593/neo.04247     Document Type: Article

References (40)

1. Hartwell LH and Kastan MB (1994). Cell cycle control and cancer. Science 266, 1821-1828.
2. Shapiro GI and Harper JW (1999). Anticancer drug targets: cell cycle and checkpoint control. J Clin Invest 104, 1645-1653.
3. Roninson IB, Broude EV, and Chang BD (2001). If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat 4, 303-313.
4. Raff JW (2003). Cell division: genome maintenance. Nature 423, 493-495.
5. Sibon OC, Kelker A, Lemstra W, and Theurkauf WE (2000). DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos. Nat Cell Biol 2, 90-95.
6. Takada S, Kelkar A, and Theurkauf WE (2003). Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity. Cell 13, 87-99.
7. Scholey JM, Brust-Mascher I, and Mogilner A (2003). Cell division. Nature 422, 746-752.
8. Tortora G, Ciardiello F, Pepe S, Tagliaferri P, Ruggiero A, Bianco C, Guarrasi R, Miki K, and Bianco AR (1995). Phase I clinical study with 8-chloro-cAMP and evaluation of immunological effects in cancer patients. Clin Cancer Res 1, 377-384.
9. Halgren RG, Traynor AE, Pillay S, Zell JL, Heller KF, Krett NL, and Rosen ST (1998). 8Cl-cAMP cytotoxicity in both steroid sensitive and insensitive multiple myeloma cell lines is mediated by 8Cl-adenosine. Blood 92, 2893-2898.
10. Langeveld CH, Jongenelen CAM, Heimans JJ, and Stoof JV (1991). Growth inhibition of human glioma cells induced by 8-chloroadenosine, an active metabolite of 8-chlorocyclic adenosine 3′,5′-monophosphate. Cancer Res 51, 6207-6208.
11. Ally S, Clair T, Katsaros D, Tortora G, Yokozaki H, Finch RA, Avery TL, and Cho-Chung YS (1989). Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate. Cancer Res 49, 5650-5655.
12. Kim SN, Ahn YH, Kim SG, Park SD, Cho-Chung YS, and Hong SH (2001). 8-Cl-cAMP induces cell cycle-specific apoptosis in human cancer cells. Int J Cancer 93, 33-41.
13. Grbovic O, Jovic V, Ruzdijic S, Pejanovic V, Rakic L, and Kanazir S (2002). 8-Cl-cAMP affects glioma cell-cycle kinetics and selectively induces apoptosis. Cancer Invest 20, 972-982.
14. Taylor CW and Yeoman LC (1992). Inhibition of colon tumor cell growth by 8-chloro-cAMP is dependent upon its conversion to 8-chloro-adenosine. Anticancer Drugs 3, 485-491.
15. Carlson CC, Chinery R, Burnham LL, and Dransfield DT (2000). 8-Cl-Adenosine-induced inhibition of colorectal cancer growth in vitro and in vivo. Neoplasia 2, 441-448.
16. Gandhi V, Ayres M, Halgren RG, Krett NL, Newman RA, and Rosen ST (2001). 8-Chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cells. Cancer Res 61, 5474-5479.
17. Stellrecht CM, Rodriguez C Jr, Ayres M, and Gandhi V (2003). RNA-directed actions of 8-chloro-adenosine in multiple myeloma cells. Cancer Res 63, 7968-7974.
18. Chen LS and Sheppard TL (2002). Synthesis and hybridization properties of RNA containing 8-chloroadenosine. Nucleosides Nucleotides Nucleic Acids 21, 599-617.
19. Rohlff C, Clair T, and Cho-Chung YS (1993). 8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J Biol Chem 268, 5774-5782.
20. Lange-Carter CA, Vuillequez JJ, and Malkinson AM (1993). 8-Chloroadenosine mediates 8-chloro-cyclic AMP-induced down-regulation of cyclic AMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cyclic AMP-independent mechanism. Cancer Res 53, 393-400.
21. 2+-dependent protease activities in kainite-induced apoptotic cell death in cultured rat hippocampal neurons. Neurosci Lett 352, 105-108.
22. Yamazaki Y, Tsuruga M, Zhou D, Fujita Y, Shang X, Dang Y, Kawasaki K, and Oka S (2000). Cytoskeletal disruption accelerates Caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis. Exp Cell Res 259, 64-78.
23. Canman JC, Cameron LA, Maddox PS, Straight A, Tirnauer JS, Mitchison TJ, Fang G, Kapoor TM, and Salmon ED (2003). Determining the position of the cell division plane. Nature 424, 1074-1078.
24. Zhu WG, Lakshmanan R, Beal MD, and Otterson GA (2001). DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. Cancer Res 61, 1327-1333.
25. Gong M, Ni J-H, and Jia H-T (2002). Increased exchange rate of histone H1 on chromotin by exogenous myogenin expression. Cell Res 12, 395-400.
26. Hendzel MJ, Wei Y, Mancini MA, Van Hooser A, Ranalli T, Brinkley BR, Bazett-Jones DP, and Allis CD (1997). Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincide with mitotic chromosome condensation. Chromosome 106, 348-360.
27. Nilsson I and Hoffmann I (2000). Cell cycle regulation by the Cdc25 phosphatase family. Prog Cell Cycle Res 4, 107-114.
28. Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, and Fornace AJ Jr (2001). Initiation of G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 411, 102-107.
29. Pines J (1999). Four-dimensional control of the cell cycle. Nat Cell Biol 1, E73-E79.
30. Howard J and Hyman AA (2003). Dynamics and mechanics of the microtubule plus end. Nature 422, 753-758.
31. Harvey S, Decker R, Dai Y, Schaefer G, Tang L, Kramer L, Dent P, and Grant S (2001). Interactions between 2-fluoroadenine 9-β-D- arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells. Clin Cancer Res 7, 320-330.
32. Iliakis G, Wang YA, Guan J, and Wang H (2003). DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 22, 5834-5847.
33. Jordan MA and Wilson L (1999). The use and action of drugs in analyzing mitosis. Methods Cell Biol 61, 267-295.
34. Sato N, Mizumoto K, Nakamura M, and Tanaka M (2000). Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells. Exp Cell Res 255, 321-326.
35. Scolnick DM and Halazonetis TD (2000). Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature 406, 430-435.
36. Tokuyama Y, Henning HF, Kawamura K, Tarapore P, and Fukasawa K (2001). Specific phosphorylation of nucleophosmin on Thr199 by CDK2/cyclin E and its role in centrosome duplication. J Biol Chem 276, 21529-21537.
37. Nabha SM, Mohammad RM, Dandashi MH, Coupaye-Gerard B, Aboukameel A, Pettit GR, and Al-Katib AM (2002). Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly (ADP-ribose) polymerase cleavage. Clin Cancer Res 8, 2735-2741.
38. Hyman AA, Chretien D, Arnal I, and Wade RH (1995). Structural changes accompanying GTP hydrolysis in microtubules: information from a slowly hydrolyzable analogue guanylyl-(alpha,beta)-methylene-diphosphonate. J Cell Biol 128, 117-125.
39. Walczak CE, Vernos I, Mitchison TJ, Karsenti E, and Heald R (1998). A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity. Curr Biol 8, 903-913.
40. Kim AJ and Endow SA (2000). A kinesin family tree. J Cell Sci 113, 3681-3682.