A review of the cardiovascular benefits and antioxidant properties of allicin

Phytotherapy Research

Volumn 27, Issue 5, 2013, Pages 637-646

  Chan, Jackie Yan Yan ^a   Yuen, Ailsa Chui Ying ^b   Chan, Robbie Yat Kan ^c   Chan, Shun Wan ^a,b  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b State Key Laboratory of Chinese Medicine and Molecular Pharmacology   (China)

^c BNU HKBU UNITED INTERNATIONAL COLLEGE   (China)

Author keywords

allicin; antioxidant; cardiovascular disease; garlic; health products; pharmacology

Indexed keywords

ALLICIN; GLUTATHIONE; REACTIVE OXYGEN METABOLITE;

ANGIOGENESIS; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; CARDIOVASCULAR DISEASE; CELL MEMBRANE; DIABETES MELLITUS; DRUG ABSORPTION; DRUG METABOLISM; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERGLYCEMIA; HYPERLIPIDEMIA; NONHUMAN; PHOSPHOLIPID BILAYER; REVIEW; THROMBOCYTE AGGREGATION; VASODILATATION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTIOXIDANTS; CARDIOTONIC AGENTS; CARDIOVASCULAR DISEASES; FREE RADICAL SCAVENGERS; GARLIC; HUMANS; HYPERGLYCEMIA; HYPERLIPIDEMIAS; PLATELET AGGREGATION INHIBITORS; SULFINIC ACIDS; VASODILATOR AGENTS;

ALLIUM SATIVUM;

EID: 84876486426     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4796     Document Type: Review

References (60)

1. Abramovitz D, Gavri S, Harats D, et al,. 1999. Allicin-induced decrease in formation of fatty streaks (atherosclerosis) in mice fed a cholesterol-rich diet. Coron Artery Dis 10: 515-519.
2. Ali M, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T,. 2000. Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet. Prostaglandins Leukot Essent Fatty Acids 62: 253-259.
3. Ankri S, Miron T, Rabinkov A, Wilchek M, Mirelman D,. 1997. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrob Agents Chemother 41: 2286-2288.
4. Arzanlou M, Bohlooli S, Jannati E, Mirzanejad-Asl H,. 2011. Allicin from garlic neutralizes the hemolytic activity of intra- and extra-cellular pneumolysin O in vitro. Toxicon 57: 540-545.
5. Asano G, Takashi E, Ishiwata T, et al,. 2003. Pathogenesis and protection of ischemia and reperfusion injury in myocardium. J Nihon Med Sch 70: 384-392.
6. Ashraf R, Aamir K, Shaikh AR, Ahmed T,. 2005. Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus. J Ayub Med Coll Abbottabad 17: 60-64.
7. Baluchnejadmojarad T, Roghani M,. 2003a. Garlic extract attenuates time-dependent changes in the reactivity of isolated aorta in streptozotocin-diabetic rats. Life Sci 73: 2281-2289.
8. Baluchnejadmojarad T, Roghani M,. 2003b. Endothelium-dependent and -independent effectof aqueous extract of garlic on vascular reactivity on diabetic rats. Fitoterapia 74: 630-637.
9. Bat-Chen W, Golan T, Peri I, Ludmer Z, Schwartz B,. 2010. Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2. Nutr Cancer 62: 947-957.
10. Burwell LS, Brookes PS,. 2008. Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury. Antioxid Redox Signal 10: 579-599.
11. Cameron VA, Mocatta TJ, Pilbrow AP, et al,. 2006. Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure. Hypertension 47: 1155-1161.
12. Chan E, Liu XX, Guo DJ, et al,. 2011. Extract of Scutellaria baicalensis Georgi root exerts protection against myocardial ischemia-reperfusion injury in rats. Am J Chin Med 39: 693-704.
13. Chung LY,. 2006. The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide. J Med Food 9: 205-213.
14. Comporti M,. 1989. Three models of free radical-induced cell injury. Chem Biol Interact 72: 1-56.
15. Eilat S, Oestraicher Y, Rabinkov A, et al,. 1995. Alteration of lipid profile in hyperlipidemic rabbits by allicin, an active constituent of garlic. Coron Artery Dis 6: 985-990.
16. Elkayam A, Mirelman D, Peleg E, et al,. 2001. The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats. Am J Hypertens 14: 377-381.
17. Focke M, Feld A, Lichtenthaler K,. 1990. Allicin, a naturally occurring antibiotic from garlic, specifically inhibits acetyl-CoA synthetase. FEBS Lett 261: 106-108.
18. Fujisawa H, Suma K, Origuchi K, Kumagai H, Seki T, Ariga T,. 2008a. Biological and chemical stability of garlic-derived allicin. J Agric Food Chem 56: 4229-4235.
19. Fujisawa H, Suma K, Origuchi K, Seki T, Ariga T,. 2008b. Thermostability of allicin determined by chemical and biological assays. Biosci Biotechnol Biochem 72: 2877-2883.
20. Gebhardt R, Beck H, Wagner KG,. 1994. Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells. Biochim Biophys Acta 1213: 57-62.
21. Gebhardt R, Beck H,. 1996. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. Lipids 31: 1269-1276.
22. Ghorai M, Mandal SC, Pal M, Pal SP, Saha BP,. 2000. A comparative study on hypocholesterolaemic effect of allicin, whole germinated seeds of bengal gram and guggulipid of gum gugglu. Phytother Res 14: 200-202.
23. Gonen A, Harats D, Rabinkov A, et al,. 2005. The antiatherogenic effect of allicin: possible mode of action. Pathobiology 72: 325-334.
24. Horev-Azaria L, Eliav S, Izigov N, et al,. 2009. Allicin up-regulates cellular glutathione level in vascular endothelial cells. Eur J Nutr 48: 67-74.
25. Izigov N, Farzam N, Savion N,. 2011. S-allylmercapto-N-acetylcysteine up-regulates cellular glutathione and protects vascular endothelial cells from oxidative stress. Free Radic Biol Med 50: 1131-1139.
26. Kameda K, Matsunaga T, Abe N, et al,. 2003. Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease. Possible role for left ventricular remodelling. Eur Heart J 24: 2180-2185.
27. Kaushik G, Satya S, Khandelwal RK, Naik SN,. 2010. Commonly consumed Indian plant food materials in the management of diabetes mellitus. Diab Metab Synd: Clin Res Rev 4: 21-40.
28. Kaye AD, De Witt BJ, Anwar M, et al,. 2000. Analysis of responses of garlic derivatives in the pulmonary vascular bed of the rat. J Appl Physiol 89: 353-358.
29. Kelsey NA, Wilkins HM, Linseman DA,. 2010. Nutraceutical Antioxidants as Novel Neuroprotective Agents. Molecules 15: 7792-7814.
30. Ku DD, Abdel-Razek TT, Dai J, Kim-Park S, Fallon MB, Abrams GA,. 2002. Garlic and its active metabolite allicin produce endothelium- and nitric oxide-dependent relaxation in rat pulmonary arteries. Clin Exp Pharmacol Physiol 29: 84-91.
31. Kumar V, Kitaeff N, Hampton MB, Cannell MB, Winterbourn CC,. 2009. Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion. FEBS Lett 583: 997-1000.
32. Lachmann G, Lorenz D, Radeck W, Steiper M,. 1994. Untersuchungen zur Pharmakokinetik der mit 35S markierten Knoblauchinhaltsstoffe Alliin, Allicin, und Vinyldithiine. Arzneimittelforschung 44: 734-743.
33. Lawson LD, Wang ZJ,. 2005. Allicin and allicin-derived garlic compounds increase breath acetone through allyl methyl sulfide: use in measuring allicin bioavailability. J Agric Food Chem 53: 1974-1983.
34. Leng BF, Qiu JZ, Dai XH, et al,. 2011. Allicin reduces the production of α-toxin by Staphylococcus aureus. Molecules 16: 7958-7968.
35. Lin L, Nasjletti A,. 1991. Role of endothelium-derived prostanoid in angiotensin-induced vasoconstriction. Hypertension 18: 158-164.
36. Liu C, Cao F, Tang QZ, et al,. 2010. Allicin protects against cardiac hypertrophy and fibrosis via attenuating reactive oxygen species-dependent signaling pathways. J Nutr Biochem 21: 1238-1250.
37. Liu Y, Qi H, Wang Y, et al,. 2012. Allicin protects against myocardial apoptosis and fibrosis in streptozotocin-induced diabetic rats. Phytomedicine 19: 693-698.
38. Mayeux PR, Agrawai KC, Tou JS, et al,. 1988. The pharmacological effects of allicin, a constituent of garlic oil. Agents Actions 25: 182-190.
39. Miron T, Rabinkov A, Mirelman D, Wilchek M, Weiner L,. 2000. The mode of action of allicin: its ready permeability through phospholipid membranes may contribute to its biological activity. Biochim Biophys Acta 1463: 20-30.
40. Nadtochiy SM, Burwell LS, Brookes PS,. 2007. Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury. J Mol Cell Cardiol 42: 812-825.
41. Neil HA, Silagy CA, Lancaster T, et al,. 1996. Garlic powder in the treatment of moderate hyperlipidaemia: a controlled trial and meta-analysis. J R Coll Physicians Lond 30: 329-334.
42. Okada Y, Tanaka K, Fujita I, Sato E, Okajima H,. 2005. Antioxidant activity of thiosulfinates derived from garlic. Redox Rep 10: 96-102.
43. Orekhov AN, Tertov VV,. 1997. In vitro effect of garlic powder extract on lipid content in normal and atherosclerotic human aortic cells. Lipids 32: 1055-1060.
44. Padilla-Camberos E, Zaitseva G, Padilla C, Puebla AM,. 2010. Antitumoral activity of allicin in murine lymphoma L5178Y. Asian Pac J Cancer Prev 11: 1241-1244.
45. Rabinkov A, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L,. 1998. The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. Biochim Biophys Acta 1379: 233-244.
46. Rabinkov A, Miron T, Mirelman D, et al,. 2000. S- Allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties. Biochim Biophys Acta 1499: 144-153.
47. Ried K, Frank OR, Stocks NP, Fakler P, Sullivan T,. 2008. Effect of garlic on blood pressure: a systematic review and meta-analysis. BMC Cardiovasc Disord 8: 13.
48. Sela U, Brill A, Kalchenko V, Dashevsky O, Hershkoviz R,. 2008. Allicin inhibits blood vessel growth and downregulates Akt phosphorylation and actin polymerization. Nutr Cancer 60: 412-420.
49. Sessa WC, Lin L, Nasjletti A,. 1990. Reciprocal effects of dexamethasone on vasodilatory responses to arachidonic acid and prostanoids in the isolated perfused rabbit kidney. Hypertension 15: I93-I196.
50. Spinale FG,. 2002. Matrix metalloproteinases: regulation and dysregulation in the failing heart. Circ Res 90: 520-530.
51. Sun X, Ku DD,. 2006. Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats. Am J Physiol Heart Circ Physiol 291: H2431-H2438.
52. Thannickal VJ, Fanburg BL,. 2000. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 279: L1005-L1028.
53. Turrens JF,. 2003. Mitochondrial formation of reactive oxygen species. J Physiol 552: 335-344.
54. Vazquez-Prieto MA, Miatello RM,. 2010. Organosulfur compounds and cardiovascular disease. Mol Aspects Med 31: 540-545.
55. Wang Z, Liu Z, Cao Z, Li L,. 2011. Allicin induces apoptosis in EL-4 cells in vitro by activation of expression of caspase-3 and -12 and up-regulation of the ratio of Bax/Bcl-2. Nat Prod Res 26: 1033-1037.
56. Williams MJ, Sutherland WH, McCormick MP, Yeoman DJ, de Jong SA,. 2005. Aged garlic extract improves endothelial function in men with coronary artery disease. Phyother Res 19: 314-319.
57. World Health Organization. 2011a. Global status report on noncommunicable diseases 2010.1.
58. World Health Organization. 2011b. Global atlas on cardiovascular disease prevention and control.
59. Xiao H, Parkin KL,. 2002. Antioxidant functions of selected allium thiosulfinates and S-alk(en)yl-L-cysteine sulfoxides. J Agric Food Chem 50: 2488-2493.
60. Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y,. 2010. Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways. Oncol Rep 24: 1585-1592.