Allicin protects against cardiac hypertrophy and fibrosis via attenuating reactive oxygen species-dependent signaling pathways

Journal of Nutritional Biochemistry

Volumn 21, Issue 12, 2010, Pages 1238-1250

  Liu, Chen ^a   Cao, Feng ^b,c   Tang, Qi Zhu ^b,c   Yan, Ling ^b,c   Dong, Yu Gang ^a   Zhu, Li Hua ^b,c   Wang, Lang ^b,c   Bian, Zhou Yan ^b,c   Li, Hongliang ^c  

^a SUN YAT SEN UNIVERSITY   (China)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c WUHAN UNIVERSITY   (China)

Author keywords

Allicin; Cardiac hypertrophy; MAPK; Reactive oxygen species

Indexed keywords

ALLICIN; ANGIOTENSIN II; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMAD2 PROTEIN; SMAD3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART STIMULATION; HEART VENTRICLE HYPERTROPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; CARDIOMEGALY; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FIBROBLASTS; FIBROSIS; MALE; MICE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; NF-KAPPA B; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SULFINIC ACIDS;

ANIMALIA;

EID: 78249281033     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.11.001     Document Type: Article

References (43)

1. Chien K.R Stress pathways and heart failure. Cell 1999, 98:555-558.
2. Hennersdorf M.G., Strauer B.E. Arterial hypertension and cardiac arrhythmias. J Hypertens 2001, 19:167-177.
3. Vakili B.A., Okin P.M., Devereux R.B. Prognostic implications of left ventricular hypertrophy. Am Heart J 2001, 141:334-341.
4. Cheng L., Ding G., Qin Q., Huang Y., Lewis W., He N., Evans R.M., Schneider M.D., Brako F.A., Xiao Y., Chen Y.E., Yang Q. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med 2004, 10:1245-1250.
5. Cameron V.A., Mocatta T.J., Pilbrow A.P., Frampton C.M., Troughton R.W., Richards A.M., Winterbourn C.C. Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure. Hypertension 2006, 47:1155-1161.
6. Kumar V., Kitaeff N., Hampton M.B., Cannell M.B., Winterbourn C.C. Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion. FEBS Lett 2009, 583:997-1000.
7. Nadtochiy S.M., Burwell L.S., Brookes P.S. Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury. J Mol Cell Cardiol 2007, 42:812-825.
8. Burwell L.S., Brookes P.S Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury. Antioxid Redox Signal 2008, 10:579-599.
9. Kwon S.H., Pimentel D.R, Remondino A, Sawyer D.B, Colucci W.S. H2O2 regulates cardiac myocyte phenotype via concentration -dependent activation of distinct kinase pathways. J Mol Cell Cardiol 2003, 35:615-621.
10. Li J.M., Gall N.P, Grieve D.J, Chen M, Shah A.M Activation of NADPH oxidase during progression of cardiac hypertrophy to failure. Hypertension 2002, 40:477-484.
11. Date M.O., Morita T, Yamashita N, Nishida K, Yamaguchi O, Higuchi Y, Hirotani S, Matsumura Y, Hori M, Tada M, Otsu K. The antioxidant N-2-mercaptopropionyl glycine attenuates left ventricular hypertrophy in vivo murine pressure-overload model. J Am Coll Cardiol 2002, 39:907-912.
12. Higuchi Y., Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, Matsumura Y, Ueno H, Tada M, Hori M. Involvement of reactive oxygen species-mediated NF-kappa B activation in TNF-alpha-induced cardiomyocyte hypertrophy. J Mol Cell Cardiol 2002, 34:233-240.
13. Pimentel D.R., Amin J.K, Xiao L, Miller T, Viereck J, Oliver-Krasinski J, Baliga R, Wang J, Siwik D.A, Singh K, Pagano P, Colucci W.S, Sawyer D.B. Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circ Res 2001, 89:453-460.
14. Das D.K., Maulik N., Engelman R.M. Redox regulation of angiotensin II signaling in the heart. J Cell Mol Med 2004, 8:144-152.
15. Chung L.Y The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide. J Med Food 2006, 9:205-213.
16. Hasan N., Yusuf N., Toossi Z., Islam N. Suppression of Mycobacterium tuberculosis induced reactive oxygen species (ROS) and TNF-alpha mRNA expression in human monocytes by allicin. FEBS Lett 2006, 580:2517-2522.
17. Rabinkov A., Miron T., Konstantinovski L., Wilchek M., Mirelman D., Weiner L The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. Biochim Biophys Acta 1998, 1379:233-244.
18. Borek C. Antioxidant health effects of aged garlic extract. J Nutr 2001, 131:1010S-1015S.
19. Adetumbi M.A., Lau B.H. Allium sativum (garlic) - a natural antibiotic. Med. Hypotheses 1983, 12:227-237.
20. Mirelman D., Monheit D., Varon S. Inhibition of growth of Entamoeba histolytica by allicin, the active principle of garlic extract (Allium sativum). J Infect Dis 1987, 156:243-244.
21. Prasad K., Laxdal V.A., Yu M., Raney B.L. Antioxidant activity of allicin, an active principle in garlic. Mol Cell Biochem 1995, 148:183-189.
22. Horev-Azaria L., Eliav S., Izigov N., Pri-Chen S., Mirelman D., Miron T., Rabinkov A., Wilchek M., Jacob-Hirsch J., Amariglio N., Savion N. Allicin up-regulates cellular glutathione level in vascular endothelial cells. Eur J Nutr 2009, 48:67-74.
23. Schwartz I.F., Hershkovitz R., Iaina A., Gnessin E., Wollman Y., Chernichowski T., Blum M., Levo Y., Schwartz D. Garlic attenuates nitric oxide production in rat cardiac myocytes through inhibition of inducible nitric oxide synthase and the arginine transporter CAT-2 (cationic amino acid transporter-2). Clin Sci (Lond) 2002, 102:487-493.
24. Sun X., Ku D.D. Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats. Am J Physiol Heart Circ Physiol 2006, 291:H2431-2438.
25. Wang Z., Wang D.Z., Hockemeyer D., McAnally J., Nordheim A., Olson E.N. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 2004, 428:185-189.
26. Tang Q., Cai J., Shen D., Bian Z., Yan L., Wang Y.X., Lan J., Zhuang G.Q., Ma W.Z., Wang W. Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling. J Mol Med 2009, 87:249-260.
27. Li H.L., She Z.G., Li T.B., Wang A.B., Yang Q., Wei Y.S., Wang Y.G., Liu D.P Overexpression of myofibrillogenesis regulator-1 aggravates cardiac hypertrophy induced by angiotensin II in mice. Hypertension 2007, 49:1399-1408.
28. Li H.L., Huang Y., Zhang C.N., Liu G., Wei Y.S., Wang A.B., Liu Y.Q., Hui R.T., Wei C., Williams G.M., Liu D.P., Liang C.C. Epigallocathechin-3 gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways. Free Radic Biol Med 2006, 40:1756-1775.
29. Cole M.P., Chaiswing L., Oberley T.D., Edelmann S.E., Piascik M.T., Lin S.M., Kiningham K.K., St Clair D.K. The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. Cardiovasc Res 2006, 69:186-197.
30. Zhao Y., Wang L.M., Chaiswing L., Yen H.C., Oberley T.D., Lien Y.C., Lin S.M., Mattson M.P., St Clair D.K Tamoxifen protects against acute tumor necrosis factor alpha-induced cardiac injury via improving mitochondrial functions. Free Radic Biol Med 2006, 40:1234-1241.
31. Baker J.E., Su J., Fu X., Hsu A., Gross G.J., Tweddell J.S., Hogg N Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. J Mol Cell Cardiol 2007, 43:437-444.
32. van Empel V.P., Bertrand A.T., van Oort R.J., van der Nagel R., Engelen M., van Rijen H.V., Doevendans P.A., Crijns H.J., Ackerman S.L., Sluiter W., De Windt L.J. EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol 2006, 48:824-832.
33. Tsujimoto I., Hikoso S., Yamaguchi O., Kashiwase K., Nakai A., Takeda T., Watanabe T., Taniike M., Matsumura Y., Nishida K., Hori M., Kogo M., Otsu K. The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy. Hypertension 2005, 45:921-926.
34. Nakagami H., Takemoto M., Liao J.K NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy. J Mol Cell Cardiol 2003, 35:851-859.
35. Nakamura K., Fushimi K., Kouchi H., Mihara K., Miyazaki M., Ohe T., Namba M Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II. Circulation 1998, 98:794-799.
36. Tanaka K., Honda M., Takabatake T. Redox regulation of MAPK pathways and cardiac hypertrophy in adult rat cardiac myocyte. J Am Coll Cardiol 2001, 37:676-685.
37. Kubota T., McTiernan C.F., Frye C.S., Slawson S.E., Lemster B.H., Koretsky A.P., Demetris A.J., Feldman A.M. Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha. Circ Res 1997, 81:627-635.
38. Kadokami T., Frye C., Lemster B., Wagner C.L., Feldman A.M., McTiernan C.F Anti-tumor necrosis factor-κ antibody limits heart failure in a transgenic model. Circulation 2001, 104:1094-1097.
39. Nishikawa K., Yoshida M., Kusuhara M., Ishigami N., Isoda K., Miyazaki K., Ohsuzu F. Left ventricular hypertrophy in mice with a cardiac-specific overexpression of interleukin-1. Am J Physiol Heart Circ Physiol 2006, 291:H176-H183.
40. Lang A., Lahav M., Sakhnini E., Barshack I., Fidder H.H., Avidan B., Bardan E., Hershkoviz R., Bar-Meir S., Chowers Y. Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Clin Nutr 2004, 23:1199-1208.
41. Mo S.J., Son E.W., Rhee D.K., Pyo S. Modulation of TNF-alpha-induced ICAM-1 expression, NO and H2O2 production by alginate, allicin and ascorbic acid in human endothelial cells. Arch Pharm Res 2003, 26:244-251.
42. Smeets P.J., Teunissen B.E., Planavila A., de Vogel-van den Bosch H., Willemsen P.H., van der Vusse G.J., van Bilsen M. Inflammatory pathways are activated during cardiomyocyte hypertrophy and attenuated by peroxisome proliferator-activated receptors PPARα and PPARδ. J Biol Chem 2008, 283:29109-29118.
43. Rossi M.A. Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. J Hypertens 1998, 16:1031-1041.