Allicin up-regulates cellular glutathione level in vascular endothelial cells

European Journal of Nutrition

Volumn 48, Issue 2, 2009, Pages 67-74

  Horev Azaria, Limor ^a   Eliav, Shlomit ^a   Izigov, Nira ^a   Pri Chen, Sarah ^a   Mirelman, David ^b   Miron, Talia ^b   Rabinkov, Aharon ^b   Wilchek, Meir ^b   Jacob Hirsch, Jasmine ^c   Amariglio, Ninette ^c   Savion, Naphtali ^a,c  

^a TEL AVIV UNIVERSITY   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c SHEBA MEDICAL CENTER   (Israel)

Author keywords

Antioxidant capacity; Endothelial cells; Glutathione; Oxidative stress; Thiols

Indexed keywords

ALLICIN; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; MESSENGER RNA; THIOREDOXIN REDUCTASE 1; THIOREDOXIN REDUCTASE 2;

ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; GARLIC; GENE EXPRESSION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; ANTIOXIDANTS; AORTA; CATTLE; CELLS, CULTURED; CYSTEINE; ENDOTHELIAL CELLS; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE-1; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SULFINIC ACIDS; THIOREDOXIN-DISULFIDE REDUCTASE; UMBILICAL VEINS; UP-REGULATION;

ALLIUM SATIVUM;

EID: 61449197654     PISSN: 14366207     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00394-008-0762-3     Document Type: Article

References (36)

1. ME Anderson 1985 Determination of glutathione and glutathione disulfide in biological samples Methods Enzymol 113 548 555
2. ME Anderson 1998 Glutathione: an overview of biosynthesis and modulation Chem Biol Interact 112 1 14
3. J Balla GM Vercellotti V Jeney A Yachie Z Varga JW Eaton G Balla 2005 Heme, heme oxygenase and ferritin in vascular endothelial cell injury Mol Nutr Food Res 49 1030 1043
4. CM Bergamini S Gambetti A Dondi C Cervellati 2004 Oxygen, reactive oxygen species and tissue damage Curr Pharm Des 10 1611 1626
5. XL Chen SE Varner AS Rao JY Grey S Thomas CK Cook MA Wasserman RM Medford AK Jaiswal C Kunsch 2003 Laminar flow induction of antioxidant response element-mediated genes in endothelial cells J Biol Chem 278 703 711
6. C Chen D Pung V Leong V Hebbar G Shen S Nair W Li AN Kong 2004 Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals Free Radic Biol Med 37 1578 1590
7. R Dardik N Savion N Gal D Varon 2002 Flow conditions modulate homocysteine induced changes in the expression of endothelial cell genes associated with cell-cell interaction and cytoskeletal rearrangement Thromb Haemost 88 1047 1053
8. DA Dickinson HJ Forman 2002 Glutathione in defense and signaling-lessons from a small thiol Ann NY Acad Sci 973 488 504
9. I Durak HS Ozturk E Olcay B Can M Kavutcu 2002 Effects of garlic extract on oxidant/antioxidant status and atherosclerotic plaque formation in rabbit aorta Nutr Metab Cardiovasc Dis 12 141 147
10. CD Fisher LM Augustine JM Maher DM Nelson AL Slitt CD Klaassen LD Lehman-McKeeman NJ Cherrington 2007 Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2 Drug Metab Dispos 35 995 1000
11. A Gonen D Harats A Rabinkov T Miron D Mirelman M Wilchek L Weiner E Ulman H Levkovitz D Ben-Shushan A Shaish 2005 The antiatherogenic effect of allicin: possible mode of action Pathobiology 72 325 334
12. D Gospodarowicz J Moran D Braun C Birdwell 1976 Clonal growth of bovine vascular endothelial cells: fibroblast growth factor as a survival agent Proc Natl Acad Sci USA 73 4120 4124
13. J Hayes LI Mclellan 1999 Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defense against oxidative stress Free Radic Res 31 273 300
14. SE Ho N Ide BH Lau 2001 S-allyl cysteine reduces oxidant load in cells involved in the atherogenic process Phytomedicine 8 39 46
15. KA Hoekstra DV Godin J Kurtu KM Cheng 2003 Effects of oxidant-induced injury on heme oxygenase and glutathione in cultured aortic endothelial cells from atherosclerosis-susceptible and -resistant Japanese quail Mol Cell Biochem 254 61 71
16. N Ide BH Lau 2001 Garlic compounds minimize intracellular oxidative stress and inhibit nuclear factor-kappa b activation J Nutr 131 1020S 1026S
17. S Ishida H Jinno T Tanaka-Kagawa M Ando Y Ohno S Ozawa J Sawada 2002 Characterization of human CYP1A1/1A2 induction by DNA microarray and alpha-naphthoflavone Biochem Biophys Res Commun 296 172 177
18. EA Jaffe RL Nachman CG Becker CR Minick 1973 Culture of human endothelial cells derived from umbilical veins: identification by morphologic and immunologic criteria J Clin Invest 52 2745 2756
19. CG Kevil H Pruitt TJ Kavanagh J Wilkerson F Farin D Moellering VM Darley-Usmar DC Bullard RP Patel 2004 Regulation of endothelial glutathione by ICAM-1: implications for inflammation FASEB J 18 1321 1323
20. LD Lawson 1998
21. C Liu Y Shi Z Han Y Pan N Liu S Han Y Chen M Lan T Qiao D Fan 2003 Suppression of the dual-specificity phosphatase MKP-1 enhances HIF-1 trans-activation and increases expression of EPO Biochem Biophys Res Commun 312 780 786
22. H Liu H Wang S Shenvi TM Hagen RM Liu 2004 Glutathione metabolism during aging and in Alzheimer disease Ann NY Acad Sci 1019 346 349
23. OH Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the folin phenol reagent J Biol Chem 193 265 275
24. R Masella BR Di R Vari C Filesi C Giovannini 2005 Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes J Nutr Biochem 16 577 586
25. T Miron A Rabinkov D Mirelman M Wilchek L Weiner 2000 The mode of action of allicin: its ready permeability through phospholipid membranes may contribute to its biological activity Biochim Biophys Acta 1463 20 30
26. T Miron H SivaRaman A Rabinkov D Mirelman M Wilchek 2006 A method for continuous production of allicin using immobilized alliinase Anal Biochem 351 152 154
27. A Rabinkov T Miron L Konstantinovski M Wilchek D Mirelman L Weiner 1998 The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins Biochim Biophys Acta 1379 233 244
28. A Rabinkov T Miron D Mirelman M Wilchek S Glozman E Yavin L Weiner 2000 S-Allylmercaptoglutathione: the reaction product of allicin with glutathione possesses SH-modifying and antioxidant properties Biochim Biophys Acta 1499 144 153
29. H Sasaki H Sato K Kuriyama-Matsumura K Sato K Maebara H Wang M Tamba K Itoh M Yamamoto S Bannai 2002 Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression J Biol Chem 277 44765 44771
30. H Shirin JT Pinto Y Kawabata JW Soh T Delohery SF Moss V Murty RS Rivlin PR Holt IB Weinstein 2001 Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide Cancer Res 61 725 731
31. E Warabi Y Wada H Kajiwara M Kobayashi N Koshiba T Hisada M Shibata J Ando M Tsuchiya T Kodama N Noguchi 2004 Effect on endothelial cell gene expression of shear stress, oxygen concentration, and low-density lipoprotein as studied by a novel flow cell culture system Free Radic Biol Med 37 682 694
32. S Wassmann K Wassmann G Nickenig 2004 Modulation of oxidant and antioxidant enzyme expression and function in vascular cells Hypertension 44 381 386
33. H Yamawaki BC Berk 2005 Thioredoxin: a multifunctional antioxidant enzyme in kidney, heart and vessels Curr Opin Nephrol Hypertens 14 149 153
34. Y Yang Y Chen E Johansson SN Schneider HG Shertzer DW Nebert TP Dalton 2007 Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase Biochem Pharmacol 74 372 381
35. http://www.affymetrix.com/support/technical/datasheets/human-datasheet. pdf
36. http://www.affymetrix.com/support/technical/manual/expression-manual.affx