Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling

Toxicology and Applied Pharmacology

Volumn 218, Issue 2, 2007, Pages 107-118

  Weng, Meng Shih ^a   Ho, Chi Tang ^b   Ho, Yuan Soon ^c   Lin, Jen Kun ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b RUTGERS UNIVERSITY   (United States)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

EGFR; ErbB 2; Fatty acid synthase; SREBP 1; Theanaphthoquinone

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 MORPHOLINO 8 PHENYLCHROMONE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; THEAFLAVIN; THEANAPHTHOQUINONE; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; AUTOPHOSPHORYLATION; BREAST CANCER; CANCER CELL CULTURE; CELL DEATH; CELL NUCLEUS; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; DIMERIZATION; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD95; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; DOWN-REGULATION; EPIDERMAL GROWTH FACTOR; FATTY ACID SYNTHETASE COMPLEX; FEMALE; FLOW CYTOMETRY; GENES, ERBB-2; HUMANS; IMMUNOPRECIPITATION; NAPHTHOQUINONES; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STIMULATION, CHEMICAL; TRANSLOCATION, GENETIC; TYROSINE;

EID: 33846632826     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2006.10.021     Document Type: Article

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