Mechanisms of behavioral, atopic, and other reactions to artificial food colors in children

Nutrition Reviews

Volumn 71, Issue 5, 2013, Pages 268-281

  Stevens, Laura J ^a   Kuczek, Thomas ^b   Burgess, John R ^a   Stochelski, Mateusz A ^a   Arnold, L Eugene ^c   Galland, Leo ^d  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d Foundation for Integrated Medicine   (United States)

Author keywords

Artificial food colors; Attention deficit hyperactivity disorder (ADHD); Behavior; Children; Tartrazine

Indexed keywords

AZO DYE; COPPER ZINC SUPEROXIDE DISMUTASE; FOOD DYE; LIPID PEROXIDE; SUPEROXIDE DISMUTASE;

ABSORPTION; ARTICLE; ARTIFICIAL FOOD COLOR; ATOPY; ATTENTION DEFICIT DISORDER; BEHAVIOR CHANGE; FOOD COLOR; HIGH RISK PATIENT; HUMAN; HYPERACTIVITY; HYPERSENSITIVITY; IMMUNE SYSTEM; IMPULSIVENESS; INTESTINE MUCOSA; NONHUMAN; NUTRITION; TOXICOLOGY;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CHILD BEHAVIOR; FOOD COLORING AGENTS; FOOD HYPERSENSITIVITY; HUMANS; INTESTINAL ABSORPTION;

ANIMALIA;

EID: 84876436230     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/nure.12023     Document Type: Article

References (136)

1. Feingold BF. Hyperkinesis and learning disabilities linked to artificial food flavors and colors. Am J Nurs. 1975;75:797-803.
2. Feingold BF. Hyperkinesis and learning disabilities linked to the ingestion of artificial food colors and flavors. J Learn Disabil. 1976;9:551-559.
3. Feingold BF. Behavioral disturbances linked to the ingestion of food additives. Del Med J. 1977;49:89-94.
4. Feingold BF. The role of diet in behaviour. Ecol Dis. 1982;1:153-165.
5. Conners CK, Goyette CH, Southwick DA. Food additives and hyperkinesis: preliminary report of a double-blind crossover experiment. Psychopharmacol Bull. 1976;12:10-11.
6. Harley JP, Matthews CG, Eichman P. Synthetic food colors and hyperactivity in children: a double-blind challenge experiment. Pediatrics. 1978;62:975-983.
7. Goyette GH, Connors CK, Petti TA, etal. Effects of artificial colors on hyperkinetic children: a double-blind challenge study [proceedings]. Psychopharmacol Bull. 1978;14:39-40.
8. Williams JI, Cram DM. Diet in the management of hyperkinesis: a review of the tests of Feingold's hypotheses. Can Psychiatr Assoc J. 1978;23:241-248.
9. Harley JP, Ray RS, Tomasi L, etal. Hyperkinesis and food additives: testing the Feingold hypothesis. Pediatrics. 1978;61:818-828.
10. Weiss B, Williams JH, Margen S, etal. Behavioral responses to artificial food colors. Science. 1980;207:1487-1489.
11. Swanson JM, Kinsbourne M. Food dyes impair performance of hyperactive children on a laboratory learning test. Science. 1980;207:1485-1487.
12. Pollock I, Warner JO. Effect of artificial food colours on childhood behaviour. Arch Dis Child. 1990;65:74-77.
13. Rowe KS, Rowe KJ. Synthetic food coloring and behavior: a dose response effect in a double-blind, placebo-controlled, repeated-measures study. J Pediatr. 1994;125(5 Pt 1):691-698.
14. Williams JI, Cram DM, Tausig FT, etal. Relative effects of drugs and diet on hyperactive behaviors: an experimental study. Pediatrics. 1978;61:811-817.
15. Swanson JM, Tryphonas H, Kinsbourne JM. Diet treatment for hyperactive children with food allergies. In: Bakker D, Knights R, eds. Treatment of Hyperactive and Learning Disordered Children. Baltimore: University Park Press; 1980.
16. Rowe KS. Synthetic food colourings and "hyperactivity": a double-blind crossover study. Aust Paediatr J. 1988;24:143-147.
17. Stevens LJ, Kuczek T, Burgess JR, etal. Dietary sensitivities and ADHD symptoms: thirty-five years of research. Clin Pediatr (Phila). 2011;50:279-293.
18. Arnold LE, Lofthouse N, Hurt E. Artificial food colors and attention-deficit/hyperactivity symptoms: conclusions to dye for. Neurotherapeutics. 2012;9:599-609.
19. Kanarek RB. Artificial food dyes and attention deficit hyperactivity disorder. Nutr Rev. 2011;69:385-391.
20. Weiss B. Synthetic food colors and neurobehavioral hazards: the view from environmental health research. Environ Health Perspect. 2011;120:1-5.
21. Millichap JG, Yee MM. The diet factor in attention-deficit/hyperactivity disorder. Pediatrics. 2012;129:330-337.
22. Hughes EC, Weinstein RC, Gott PS, etal. Food sensitivity in attention deficit disorder with hyperactivity (ADD/HA): a procedure for differential diagnosis. Ann Allergy. 1982;49:276-280.
23. Egger J, Carter CM, Graham PJ, etal. Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome. Lancet. 1985;1:540-545.
24. Carter CM, Urbanowicz M, Hemsley R, etal. Effects of a few food diet in attention deficit disorder. Arch Dis Child. 1993;69:564-568.
25. Schmidt MH, Möcks P, Lay B, etal. Does oligoantigenic diet influence hyperactive/conduct-disordered children - a controlled trial. Eur Child Adolesc Psychiatry. 1997;6:88-95.
26. Kaplan BJ, McNicol J, Conte RA, etal. Dietary replacement in preschool-aged hyperactive boys. Pediatrics. 1989;83:7-17.
27. Boris M, Mandel FS. Foods and additives are common causes of the attention deficit hyperactive disorder in children. Ann Allergy. 1994;72:462-468.
28. Pelsser LM, Frankena K, Toorman J, etal. A randomised controlled trial into the effects of food on ADHD. Eur Child Adolesc Psychiatry. 2009;18:12-19.
29. Schab DW, Trinh NH. Do artificial food colors promote hyperactivity in children with hyperactive syndromes? A meta-analysis of double-blind placebo-controlled trials. J Dev Behav Pediatr. 2004;25:423-434.
30. Nigg JT, Lewis K, Edinger T, etal. Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. J Am Acad Child Adolesc Psychiatry. 2012;51:86-97.
31. Bateman B, Warner JO, Hutchinson E, etal. The effects of a double blind, placebo controlled, artificial food colourings and benzoate preservative challenge on hyperactivity in a general population sample of preschool children. Arch Dis Child. 2004;89:506-511.
32. McCann D, Barrett A, Cooper A, etal. Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial. Lancet. 2007;370:1560-1567.
33. Stevenson J, Sonuga-Barke E, McCann D, etal. The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms. Am J Psychiatry. 2010;167:1108-1115.
34. Collins-Williams C. Clinical spectrum of adverse reactions to tartrazine. J Asthma. 1985;22:139-143.
35. Hodge L, Yan KY, Loblay RL. Assessment of food chemical intolerance in adult asthmatic subjects. Thorax. 1996;51:805-809.
36. Weber RW. Food additives and allergy. Ann Allergy. 1993;70:183-190.
37. Van Bever HP, Docx M, Stevens WJ. Food and food additives in severe atopic dermatitis. Allergy. 1989;44:588-594.
38. Allen DH, Van Nunen S, Loblay R, etal. Adverse reactions to foods. Med J Aust. 1984;141(Suppl 5):S37-S42.
39. Murdoch RD, Lessof MH, Pollock I, etal. Effects of food additives on leukocyte histamine release in normal and urticaria subjects. J R Coll Physicians Lond. 1987;21:251-256.
40. Egger J, Carter CM, Wilson J, etal. Is migraine food allergy? A double-blind controlled trial of oligoantigenic diet treatment. Lancet. 1983;322:865-869.
41. Egger J, Carter CM, Soothill JF, etal. Oligoantigenic diet treatment of children with epilepsy and migraine. J Pediatr. 1989;114:51-58.
42. Millichap JG, Yee MM. The diet factor in pediatric and adolescent migraine. Pediatr Neurol. 2003;28:9-15.
43. Parkinson TM, Brown JP. Metabolic fate of food colorants. Annu Rev Nutr. 1981;1:175-205.
44. US Food and Drug Adminstration. Termination of provisional listings of FD&C Red No. 3 for use in cosmetics and externally applied drugs and lakes of FD&C Red No. 3 for all uses. Fed Regist. 1990;55:3516-3519.
45. Food Standards Australia New Zealand (FSANZ). Survey of Added Colours in Foods Available in Australia. 2008; Available at: http://www.foodstandards.gov.au/scienceandeducation/monitoringandsurveillance/foodsurveillance/surveyofaddedcolours5519.cfm. Accessed Feb 13 2013.
46. Connolly A, Hearty A, Nugent A, etal. Pattern of intake of food additives associated with hyperactivity in Irish children and teenagers. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010;27:447-456.
47. Marmion DM. Handbook of U.S. Colorants: Foods, Drugs, Cosmetics, and Medical Devices, 3rd ed. New York: Wiley-Interscience; 1991:94.
48. Moreno LA, Rodriguez G, Fleta J, etal. Trends of dietary habits in adolescents. Crit Rev Food Sci Nutr. 2010;50:106-112.
49. Libuda L, Kersting M. Soft drinks and body weight development in childhood: is there a relationship? Curr Opin Clin Nutr Metab Care. 2009;12:596-600.
50. Nseir W, Nassar F, Assy N. Soft drinks consumption and nonalcoholic fatty liver disease. World J Gastroenterol. 2010;16:2579-2588.
51. Koschinsky T, He CJ, Mitsuhashi T, etal. Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy. Proc Natl Acad Sci U S A. 1997;94:6474-6479.
52. O'Brien J, Morrissey PA. Nutritional and toxicological aspects of the Maillard browning reaction in foods. Crit Rev Food Sci Nutr. 1989;28:211-248.
53. Lockey SD. Drug reactions and sublingual testing with certified food colors. Ann Allergy. 1973;31:423-429.
54. Green M. Sublingual provocative testing for foods and FD and C dyes. Ann Allergy. 1974;33:274-281.
55. Collier SW, Storm JE, Bronaugh RL. Reduction of azo dyes during in vitro percutaneous absorption. Toxicol Appl Pharmacol. 1993;118:73-79.
56. Ryan AJ, Welling PG, Wright SE. Further studies on the metabolism of tartrazine and related compounds in the intact rat. Food Cosmet Toxicol. 1969;7:287-295.
57. Honohan T, Enderlin FE, Ryerson BA, etal. Intestinal absorption of polymeric derivatives of the food dyes sunset yellow and tartrazine in rats. Xenobiotica. 1977;7:765-774.
58. Hess SM, Fitzhugh OG. Absorption and excretion of certain triphenylmethane colors in rats and dogs. J Pharmacol Exp Ther. 1955;114:38-42.
59. Webb JM, Fonda M, Brouwer EA. Metabolism and excretion patterns of fluorescein and certain halogenated fluorescein dyes in rats. J Pharmacol Exp Ther. 1962;137:141-147.
60. van Ampting MT, Schonewille AJ, Vink C, etal. Damage to the intestinal epithelial barrier by antibiotic pretreatment of Salmonella-infected rats is lessened by dietary calcium or tannic acid. J Nutr. 2010;140:2167-2172.
61. Bjarnason I, MacPherson A, Hollander D. Intestinal permeability: an overview. Gastroenterology. 1995;108:1566-1581.
62. Spruss A, Bergheim I. Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease. J Nutr Biochem. 2009;20:657-662.
63. Kiefer D, Ali-Akbarian L. A brief evidence-based review of two gastrointestinal illnesses: irritable bowel and leaky gut syndromes. Altern Ther Health Med. 2004;10:22-30; quiz 31, 92.
64. Stevens LJ, Zentall SS, Deck JL, etal. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr. 1995;62:761-768.
65. Zelnik N, Pacht A, Obeid R, etal. Range of neurologic disorders in patients with celiac disease. Pediatrics. 2004;113:1672-1676.
66. Pynnonen PA, Isometsa ET, Verkasalo MA, etal. Untreated celiac disease and development of mental disorders in children and adolescents. Psychosomatics. 2002;43:331-334.
67. Lahat E, Broide E, Leshem M, etal. Prevalence of celiac antibodies in children with neurologic disorders. Pediatr Neurol. 2000;22:393-396.
68. Niederhofer H, Pittschieler K. A preliminary investigation of ADHD symptoms in persons with celiac disease. J Atten Disord. 2006;10:200-204.
69. Tappy L, Le KA. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev. 2010;90:23-46.
70. Kneepkens CM, Vonk RJ, Fernandes J. Incomplete intestinal absorption of fructose. Arch Dis Child. 1984;59:735-738.
71. Thuy S, Ladurner R, Volynets V, etal. Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. J Nutr. 2008;138:1452-1455.
72. Andre F, Andre C, Feknous M, etal. Digestive permeability to different-sized molecules and to sodium cromoglycate in food allergy. Allergy Proc. 1991;12:293-298.
73. Benard A, Desreumeaux P, Huglo D, etal. Increased intestinal permeability in bronchial asthma. J Allergy Clin Immunol. 1996;97:1173-1178.
74. Hijazi Z, Molla AM, Al-Habashi H, etal. Intestinal permeability is increased in bronchial asthma. Arch Dis Child. 2004;89:227-229.
75. Du Mont GC, Beach RC, Menzies IS. Gastrointestinal permeability in food-allergic eczematous children. Clin Allergy. 1984;14:55-59.
76. Caffarelli C, Cavagni G, Menzies IS, etal. Elimination diet and intestinal permeability in atopic eczema: a preliminary study. Clin Exp Allergy. 1993;23:28-31.
77. Pike MG, Heddle RJ, Boulton P, etal. Increased intestinal permeability in atopic eczema. J Invest Dermatol. 1986;86:101-104.
78. Dupont C, Barau E, Molkhou P, etal. Food-induced alterations of intestinal permeability in children with cow's milk-sensitive enteropathy and atopic dermatitis. J Pediatr Gastroenterol Nutr. 1989;8:459-465.
79. Buhner S, Reese I, Kuehl F, etal. Pseudoallergic reactions in chronic urticaria are associated with altered gastroduodenal permeability. Allergy. 2004;59:1118-1123.
80. Chung KT, Fulk GE, Egan M. Reduction of azo dyes by intestinal anaerobes. Appl Environ Microbiol. 1978;35:558-562.
81. Chung KT, Stevens SE Jr., Cerniglia CE. The reduction of azo dyes by the intestinal microflora. Crit Rev Microbiol. 1992;18:175-190.
82. Walker R. The metabolism of azo compounds: a review of the literature. Food Cosmet Toxicol. 1970;8:659-676.
83. Levine WG. Metabolism of azo dyes: implication for detoxication and activation. Drug Metab Rev. 1991;23:253-309.
84. Daniel JW. The excretion and metabolism of edible food colors. Toxicol Appl Pharmacol. 1962;4:572-594.
85. Brown JP, Dorsky A, Enderlin FE, etal. Synthesis of 14C-labelled FD & C Blue No. 1 (Brilliant Blue FCF) and its intestinal absorption and metabolic fate in rats. Food Cosmet Toxicol. 1980;18:1-5.
86. Lethco EJ, Webb JM. The fate of FD&C blue no. 2 in rats. J Pharmacol Exp Ther. 1966;154:384-389.
87. Jones R, Ryan AJ, Wright SE. The metabolism and excretion of tartrazine in the rat, rabbit and man. Food Cosmet Toxicol. 1964;2:447-452.
88. Peng W, Cotrina ML, Han X, etal. Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury. Proc Natl Acad Sci U S A. 2009;106:12489-12493.
89. Takenouchi T, Sekiyama K, Sekigawa A, etal. P2X7 receptor signaling pathway as a therapeutic target for neurodegenerative diseases. Arch Immunol Ther Exp (Warsz). 2010;58:91-96.
90. Levitan H, Ziylan Z, Smith QR, etal. Brain uptake of a food dye, erythrosin B, prevented by plasma protein binding. Brain Res. 1984;322:131-134.
91. Goldenring JR, Batter DK, Shaywitz BA. Sulfanilic acid: behavioral change related to azo food dyes in developing rats. Neurobehav Toxicol Teratol. 1982;4:43-49.
92. Shaywitz BA, Goldenring JR, Wool RS. Effects of chronic administration of food colorings on activity levels and cognitive performance in developing rat pups treated with 6- hydroxydopamine. Neurobehav Toxicol. 1979;1:41-47.
93. Aboel-Zahab H, el-Khyat Z, Sidhom G, etal. Physiological effects of some synthetic food colouring additives on rats. Boll Chim Farm. 1997;136:615-627.
94. Abd El-Wahab HM, El-Deen Moram GS. Toxic effects of some synthetic food colorants and/or flavor additives on male rats. Toxicol Ind Health. 2013;doi: 10.1177/0748233711433935.
95. Amin KA, Abdel Hameid H, 2nd, Abd Elsttar AH. Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats. Food Chem Toxicol. 2010;48:2994-2999.
96. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J. 2008;22:659-661.
97. Chiou WL, Ma C, Chung SM, etal. Similarity in the linear and non-linear oral absorption of drugs between human and rat. Int J Clin Pharmacol Ther. 2000;38:532-539.
98. Weiss B. Behavioral toxicology and environmental health science. Opportunity and challenge for psychology. Am Psychol. 1983;38:1174-1187.
99. Kamel MM, El-lethey HS. The potential health hazard of tartrazine and levels of hyperactivity, anxiety-like symptoms, depression and anti-social behaviour in rats. J Am Sci. 2011;7:1211-1218.
100. Tanaka T, Takahashi O, Oishi S, etal. Effects of tartrazine on exploratory behavior in a three-generation toxicity study in mice. Reprod Toxicol. 2008;26:156-163.
101. Lau K, McLean WG, Williams DP, etal. Synergistic interactions between commonly used food additives in a developmental neurotoxicity test. Toxicol Sci. 2006;90:178-187.
102. Dalal A, Poddar MK. Short-term erythrosine B-induced inhibition of the brain regional serotonergic activity suppresses motor activity (exploratory behavior) of young adult mammals. Pharmacol Biochem Behav. 2009;92:574-582.
103. Gao Y, Li C, Shen J, etal. Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved. J Food Sci. 2011;76:T125-T129.
104. Peiperl MD, Prival MJ, Bell SJ. Determination of combined benzidine in FD&C yellow no. 6 (sunset yellow FCF). Food Chem Toxicol. 1995;33:829-839.
105. Davis VM, Bailey JE Jr. Chemical reduction of FD&C yellow no. 5 to determine combined benzidine. J Chromatogr. 1993;635:160-164.
106. Prival MJ, Peiperl MD, Bell SJ. Determination of combined benzidine in FD & C yellow no. 5 (tartrazine), using a highly sensitive analytical method. Food Chem Toxicol. 1993;31:751-758.
107. Lancaster FE, Lawrence JF. Determination of total non-sulphonated aromatic amines in soft drinks and hard candies by reduction and derivatization followed by high-performance liquid chromatography. Food Addit Contam. 1992;9:171-182.
108. Lancaster FE, Lawrence JF. Determination of benzidine in the food colours tartrazine and sunset yellow FCF, by reduction and derivatization followed by high-performance liquid chromatography. Food Addit Contam. 1999;16:381-390.
109. Cooke K, Gould MH. The health effects of aluminium - a review. J R Soc Health. 1991;111:163-168.
110. Kumar V, Gill KD. Aluminium neurotoxicity: neurobehavioural and oxidative aspects. Arch Toxicol. 2009;83:965-978.
111. Soni MG, White SM, Flamm WG, etal. Safety evaluation of dietary aluminum. Regul Toxicol Pharmacol. 2001;33:66-79.
112. Joint FAO/WHO Expert Committee on Food Additives. Evaluation of certain food additives and contaminants. 67th Report of the WHO Technical Report Series Joint FAO/WHO Expert Committee on Food Additives. Vol 67. Geneva: World Health Organization; 2007.
113. Marshall P. Attention deficit disorder and allergy: a neurochemical model of the relation between the illnesses. Psychol Bull. 1989;106:434-446.
114. Johansson SG, Bieber T, Dahl R, etal. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004;113:832-836.
115. Kucharska E, Bober J, Jedrychowski L. Involvement of haptens in allergic and non-allergic hypersensitivity. Pol J Environ Stud. 2009;18:325-330.
116. Moutinho IL, Bertges LC, Assis RV. Prolonged use of the food dye tartrazine (FD&C yellow no 5) and its effects on the gastric mucosa of Wistar rats. Braz J Biol. 2007;67:141-145.
117. Schaubschlager WW, Zabel P, Schlaak M. Tartrazine-induced histamine release from gastric mucosa. Lancet. 1987;330:800-801.
118. Pelsser LM, Buitelaar JK, Savelkoul HF. ADHD as a (non) allergic hypersensitivity disorder: a hypothesis. Pediatr Allergy Immunol. 2009;20:107-112.
119. Murdoch RD, Pollock I, Naeem S. Tartrazine induced histamine release in vivo in normal subjects. J R Coll Physicians Lond. 1987;21:257-261.
120. Di Lorenzo G, Pacor ML, Vignola AM, etal. Urinary metabolites of histamine and leukotrienes before and after placebo-controlled challenge with ASA and food additives in chronic urticaria patients. Allergy. 2002;57:1180-1186.
121. Arnold LE, Disilvestro RA, Bozzolo D, etal. Zinc for attention-deficit/hyperactivity disorder: placebo-controlled double-blind pilot trial alone and combined with amphetamine. J Child Adolesc Psychopharmacol. 2010;21:1-19.
122. Halas ES, Sandstead HH. Some effects of prenatal zinc deficiency on behavior of the adult rat. Pediatr Res. 1975;9:94-97.
123. Sandstead HH, Fosmire GJ, Halas ES, etal. Zinc deficiency: effects on brain and behavior of rats and rhesus monkeys. Teratology. 1977;16:229-234.
124. Golub MS, Takeuchi PT, Keen CL, etal. Activity and attention in zinc-deprived adolescent monkeys. Am J Clin Nutr. 1996;64:908-915.
125. Arnold LE, DiSilvestro RA. Zinc in attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2005;15:619-627.
126. Toren P, Eldar S, Sela BA, etal. Zinc deficiency in attention-deficit hyperactivity disorder. Biol Psychiatry. 1996;40:1308-1310.
127. Bekaroglu M, Aslan Y, Gedik Y, etal. Relationships between serum free fatty acids and zinc, and attention deficit hyperactivity disorder: a research note. J Child Psychol Psychiatry. 1996;37:225-227.
128. Ward N, Soulsbury K, Zettel V, etal. The influence of the chemical additive tartrazine on the zinc status of hyperactive children - a double-blind placebo-controlled study. J Nutr Med. 1990;1:51-57.
129. Ward NI. Assessment of chemical factors in relation to child hyperactivity. J Nutr Environ Med. 1997;7:333-342.
130. Bencini A, Failli P, Valtancoli B, etal. Low molecular weight compounds with transition metals as free radical scavengers and novel therapeutic agents. Cardiovasc Hematol Agents Med Chem. 2010;8:128-146.
131. Dimitrova AA, Strashimirov D, Betova T, etal. Zinc content in the diet affects the activity of Cu/ZnSOD, lipid peroxidation and lipid profile of spontaneously hypertensive rats. Acta Biol Hung. 2008;59:305-314.
132. Oner O, Oner P, Bozkurt OH, etal. Effects of zinc and ferritin levels on parent and teacher reported symptom scores in attention deficit hyperactivity disorder. Child Psychiatry Hum Dev. 2010;41:441-447.
133. Konofal E, Lecendreux M, Arnulf I, etal. Iron deficiency in children with attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med. 2004;158:1113-1115.
134. Sagvolden T. Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD). Neurosci Biobehav Rev. 2000;24:31-39.
135. Oades RD, Sadile AG, Sagvolden T, etal. The control of responsiveness in ADHD by catecholamines: evidence for dopaminergic, noradrenergic and interactive roles. Dev Sci. 2005;8:122-131.
136. Bales CW, DiSilvestro RA, Currie KL, etal. Marginal zinc deficiency in older adults: responsiveness of zinc status indicators. J Am Coll Nutr. 1994;13:455-462.