Effect of Food Azo Dye Tartrazine on Learning and Memory Functions in Mice and Rats, and the Possible Mechanisms Involved

Journal of Food Science

Volumn 76, Issue 6, 2011, Pages

  Gao, Yonglin ^a   Li, Chunmei ^a   shen, Jingyu ^a   Yin, Huaxian ^a   An, Xiulin ^a   Jin, Haizhu ^a  

^a YANTAI UNIVERSITY   (China)

Author keywords

Learning and memory; Oxidative stress; Pathological lesion; Tartrazine

Indexed keywords

BIOLOGICAL MARKER; FOOD DYE; MALONALDEHYDE; OXIDOREDUCTASE; TARTRAZINE;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; BRAIN; DOSE RESPONSE; DRUG EFFECT; ESCAPE BEHAVIOR; EXPLORATORY BEHAVIOR; FEMALE; LEARNING; MALE; MEMORY; METABOLISM; MOUSE; MOUSE STRAIN; NERVE CELL; OXIDATIVE STRESS; PATHOLOGY; RANDOMIZATION; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BEHAVIOR, ANIMAL; BIOLOGICAL MARKERS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCAPE REACTION; EXPLORATORY BEHAVIOR; FEMALE; FOOD COLORING AGENTS; LEARNING; MALE; MALONDIALDEHYDE; MEMORY; MICE; MICE, INBRED STRAINS; NEURONS; OXIDATIVE STRESS; OXIDOREDUCTASES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TARTRAZINE;

ANIMALIA; MUS; RATTUS;

EID: 79961107462     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2011.02267.x     Document Type: Article

References (33)

1. Amin KA, Abdel Hameid II H, Abd Elsttar AH. 2010. Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats. Food ChemToxicol 48:2994-9.
2. Borzelleca JF, Hallagan JB. 1988a. Chronic toxicity/carcinogenicity studies of FD&C Yellow No. 5 (tartrazine) in rats. Food Chem Toxicol 26:179-87.
3. Borzelleca JF, Hallagan JB. 1988b. A chronic toxicity/carcinogenicity study of FD&C Yellow No. 5 (tartrazine) in mice. Food Chem Toxicol 26:189-94.
4. Chen D, Wu CF, Shi B, Xu YM. 2002. Tamoxifen and toremifene impair retrieval, but not acquisition, of spatial information processing in mice. Pharmacol Biochem Behav 72:417-21.
5. Chen XN, Meng QY, Bao AM, Swaab DF, Wang GH, Zhou JN. 2009. The involvement of retinoic acid receptor-alpha in corticotropin-releasing hormone gene expression and affective disorders. Biol Psychiatry 66:832-9.
6. Davis KJ, Fitzhugh OG, Nelson AA. 1964. Chronic rat and dog toxicity studies on tartrazine. Toxicol Appl Pharmacol 6:621-6.
7. Doverhag C, Keller M, Karlsson A, Hedtjarn M, Nilsson U, Kapeller E, Sarkozy G, Klimaschewski L, Humpel C, Hagberg H, Simbruner G, Gressens P, Savman K. 2008. Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice. Neurobiol Dis 31:133-44.
8. Gargiulo PA, Viana MB, Graeff FG, Silva MA, Tomaz C. 1996. Effects of anxiety and memory of systemic and intra-amygdala injection of 5-HT3 receptor antagonist BRL 46470A. Neuropsychobiology 33:189-95.
9. Hamid R, Jaouad E, Zafar HI, Badiaa L. 2008. Acute and sub-chronic toxicity of an aqueous extract of the leaves of Herniaria glabra in rodents. J Ethnopharmacol 118:378-86.
10. Harro J, Haidkind R, Harro M, Modiri AR, Gillberg PG, Pähkla R, Matto V, Oreland L. 1999. Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment. Eur Neuropsychopharmacol 10:5-16.
11. Huang LT, Yang SN, Liu CW, Hung PL, Lai MC, Wang CL, Wang TJ. 2002. Pentylenetetrazol-induced recurrent seizures in rat pups: time course on spatial learning and long-term effects. Epilepsia 43:567-73.
12. Introini-Collison IB, Castellani C, McGaugh JL. 1994. Interaction of GABAergic and beta-noradrenergic drugs in regulation of memory storage. Behav Neural Biol 61:150-5.
13. Joint FAO/WHO Expert Committee on Food Additives. 1996. Summary of evaluations performed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) 19561995 (first through forty-fourth meetings). Washington, DC Intl. Life Sciences Inst. (ILSI) Press.
14. Li GS, Gao YL, li SJ, Li CM, Zhu XY, Li M, Liu ZF. 2009. Study on toxicity of danshensu in beagle dogs after 3-month continuous intravenous infusion. Toxicol Mech Methods 19:441-6.
15. Maekawa A, Matsuoka C, Onodera H, Tanigawa H, Furuta K, Kanno J, Jang JJ, Hayashi Y. 1987. Lack of carcinogenicity of tartrazine (FD&C Yellow No. 5) in the F344 rat. Food Chem Toxicol 25:891-6.
16. Mechan A, Moran P, Elliot J, Young A, Joseph M, Green A. 2002. A study of the effect of a single neurotoxic dose of 3, 4-methylenedioxymethamphetamine (MDMA; "ecstasy") on the subsequent long-term behaviour of rats in the plus maze and open field. Psychopharmacology 159:167-75.
17. Mekkawy HA, Ali MO, El-Zawahry AM. 1998. Toxic effect of synthetic and natural food dyes on renal and hepatic functions in rats. Toxicol Lett 95:155.
18. Mittal A, Kurup L, Mittal J. 2007. Freundlich and Langmuir adsorption isotherms and kinetics for the removal of tartrazine from aqueous solutions using hen feathers. J Hazard Mater 146:243-8.
19. Morris R.1984. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11:47-60.
20. Moutinho II D, Bertges LC, Assis RVC. 2007. Prolonged use of the food dye tartrazine (FD&C Yellow n degrees 5) and its effects on the gastric mucosa of Wistar rats. Braz J Biol 67: 141-5.
21. Panda VS, Suresh R, Naik SR. 2008. Cardioprotective activity of Ginkgo biloba phytosomes in isoproterenol-induced myocardial necrosis in rats: a biochemical and histoarchitectural evaluation. Exp Toxicol Pathol 60:397-404.
22. Park M, Park HR, Kim SJ, Kim MS, Kong KH, Kim HS, Gong EJ, Kim ME, Kim HS, Lee BM, Lee J. 2009. Risk assessment for the combinational effects of food color additives: neural progenitor cells and hippocampal neurogenesis. J Toxicol Environ Health A 72:1412-23.
23. Phillips K. 1982. Effects of time and administration of ethanol on open field behavior in hamsters. Physiol Behav 29:785-7.
24. Qin F Liu YX, Zhao HW, Huang X, Ren P, Zhu ZY. 2009. Chinese medicinal formula Guan-Xin-Er-Hao protects the heart against oxidative stress induced by acute ischemic myocardial injury in rats. Phytomedicine 16:215-21.
25. Ramos A, Mormede P. 1998. Stress and emotionality: a multidimensional and genetic approach. Neurosci Biobehav Rev 22:33-57.
26. Rowe KS, Rowe KJ. 1994. Synthetic food coloring and behavior: a dose response effect in a double-blind, placebo-controlled, repeated-measures study. J Pediatr 125:691-8.
27. Stafstrom CE, Chronopoulos A, Thurber S, Thompson JL, Holmes GL. 1993. Age-dependent cognitive and behavioral deficits after kainic acid seizures. Epilepsia 34:420-32.
28. Tanaka T. 2006. Reproductive and neurobehavioural toxicity study of tartrazine administered to mice in the diet. Food Chem Toxicol 44:179-87
29. Tanaka T, Takahashi O, Oishi S, Ogata A. 2008. Effects of tartrazine on exploratory behavior in a three-generation toxicity study in mice. Reprod Toxicol 26:156-63.
30. Volke V, Soosaar A, Koks S, Bourin M, Mannisto P, Vasar E. 1997. 7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety. Psychopharmacology 131:399-405.
31. Wan Ngah WS, Md Ariff NF, Hanafiah MAKM. 2010. Preparation, characterization, and environmental application of crosslinked chitosan-coated bentonite for tartrazine adsorption from aqueous solutions. Water Air Soil Pollut 206:225-36.
32. Ward NI. 1997. Assessment of chemical factors in relation to child hyperactivity. J Nutr Environ Med 7:333-42.
33. Zhang R, Lu HZ, Tian S, Yin J, Chen Q, Ma L, Cui SJ, Niu YJ. 2010. Protective effects of pre-germinated brown rice diet on low levels of Pb-induced learning and memory deficits in developing rat. Chem Biol Interact 184:484-91.