Similarity in the linear and non-linear oral absorption of drugs between human and rat

International Journal of Clinical Pharmacology and Therapeutics

Volumn 38, Issue 11, 2000, Pages 532-539

  Chiou, W L ^a   Ma, C ^a   Chung, S M ^a   Wu, T C ^a   Jeong, H Y ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Human and rat; Interspecies scaling; Non linear absorption; Oral absorption; Pharmacokinetics

Indexed keywords

ACICLOVIR; CHLOROTHIAZIDE; MIGLITOL; PAFENOLOL;

ARTICLE; BODY WEIGHT; DOSE CALCULATION; DOSE RESPONSE; DRUG ABSORPTION; DRUG SOLUBILITY; GASTROINTESTINAL ABSORPTION; HUMAN; NONHUMAN; RAT; SPECIES DIFFERENCE;

EID: 0033766011     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP38532     Document Type: Article

References (29)

1. The effect of different concentrations of mannitol in solution on small intestinal transit: Implications for drug absorption
2. Pharmacokinetics of miglitol: Absorption, distribution, metabolism, and excretion following administration to rats, dogs, and man
3. Prediction of oral absorption rate constant in human from in vivo rat data-applications to interspecies scaling and first-dose in man study optimization
4. New compartment- and model-independent method for rapid calculation of drug absorption rates
5. Determination of drug permeability in a flat or distended stirred intestine - Prediction of fraction dose absorbed in humans after oral administration
6. Effect of unstirred water layer in the intestine on the rate and extent of absorption after oral administration
7. The validation of the intestinal permeability approach to predict oral fraction of dose absorbed in humans and rats
8. New perspectives on the theory of permeability and resistance in the study of drug absorption and transport
9. Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats
10. Alternative derivation for the gastrointestinal absorption residence time
11. Correlation of unbound plasma clearances of fifteen extensively metabolized drugs between humans and rats
12. Evaluation of using dog as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans
13. Correlation of plasma clearance of 54 extensively metabolized drugs between humans and rats: Mean allometric coefficient of 0.66
14. Comparison of in vivo and post-mortem intestinal lengths of rats: Implications in absorption prediction
15. First-pass accumulation of salicylic acid in gut tissue after absorption in anesthetized rats
16. Transit of pharmaceutical dosage forms through the small intestine
17. The disposition of acyclovir in different species
18. Comparison of canine and human gastrointestinal physiology
19. Comparison between permeability coefficients in rat and human jejunum
20. Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly- (ethylene glycol) and D-peptides
21. The phenomenon and cause of dose-dependent oral absorption of chlorothiazide in rats: Extrapolation to human data based on the body surface area concept
22. Pharmacokinetics of pafenolol in the rat: A suitable model for studying absorption mechanisms of a drug exhibiting unusual absorption properties in man
23. Presystemic elimination of the β-blocker pafenolol in the rat after oral and intraperitoneal administration and identification of a main metabolite in both rats and humans
24. Pharmacokinetics of pafenolol after i.v. and oral administration of three separate doses of different strength to man
25. Prediction of the plasma concentration profiles of orally administered drugs in rats on the bases of gastrointestinal transit kinetics and absorbability
26. +-dependent nucleoside transporters
27. An integrated model for determining causes of poor oral drug absorption