-
1
-
-
0031587289
-
Characterization of nucleosome core particles containing histone proteins made in bacteria
-
Luger, K., Rechsteiner, T.J., Flaus, A.J., Waye, M.M. and Richmond, T.J. (1997) Characterization of nucleosome core particles containing histone proteins made in bacteria. J. Mol. Biol., 272, 301-311.
-
(1997)
J. Mol. Biol.
, vol.272
, pp. 301-311
-
-
Luger, K.1
Rechsteiner, T.J.2
Flaus, A.J.3
Waye, M.M.4
Richmond, T.J.5
-
2
-
-
3242880238
-
H2AX: The histone guardian of the genome
-
Fernandez-Capetillo, O., Lee, A., Nussenzweig, M. and Nussenzweig, A. (2004) H2AX: the histone guardian of the genome. DNA Repair (Amst), 3, 959-967.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 959-967
-
-
Fernandez-Capetillo, O.1
Lee, A.2
Nussenzweig, M.3
Nussenzweig, A.4
-
3
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou, E.P., Pilch, D.R., Orr, A.H., Ivanova, V.S. and Bonner, W.M. (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem., 273, 5858-5868.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
4
-
-
78649450619
-
Assembly and function of DNA double-strand break repair foci in mammalian cells
-
Bekker-Jensen, S. and Mailand, N. (2010) Assembly and function of DNA double-strand break repair foci in mammalian cells. DNA Repair (Amst), 9, 1219-1228.
-
(2010)
DNA Repair (Amst)
, vol.9
, pp. 1219-1228
-
-
Bekker-Jensen, S.1
Mailand, N.2
-
5
-
-
22944462083
-
Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
-
Bekker-Jensen, S., Lukas, C., Melander, F., Bartek, J. and Lukas, J. (2005) Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J. Cell Biol., 170, 201-211.
-
(2005)
J. Cell Biol.
, vol.170
, pp. 201-211
-
-
Bekker-Jensen, S.1
Lukas, C.2
Melander, F.3
Bartek, J.4
Lukas, J.5
-
6
-
-
55249116558
-
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
-
Kinner, A., Wu, W., Staudt, C. and Iliakis, G. (2008) Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res., 36, 5678-5694.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 5678-5694
-
-
Kinner, A.1
Wu, W.2
Staudt, C.3
Iliakis, G.4
-
7
-
-
33646446295
-
Imaging features that discriminate between foci induced by high-and low-LET radiation in human fibroblasts
-
Costes, S.V., Boissiere, A., Ravani, S., Romano, R., Parvin, B. and Barcellos-Hoff, M.H. (2006) Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts. Radiat. Res., 165, 505-515.
-
(2006)
Radiat. Res.
, vol.165
, pp. 505-515
-
-
Costes, S.V.1
Boissiere, A.2
Ravani, S.3
Romano, R.4
Parvin, B.5
Barcellos-Hoff, M.H.6
-
8
-
-
39149122177
-
Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling
-
Yamauchi, M., Oka, Y., Yamamoto, M., Niimura, K., Uchida, M., Kodama, S., Watanabe, M., Sekine, I., Yamashita, S. and Suzuki, K. (2008) Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling. DNA Repair, 7, 405-417.
-
(2008)
DNA Repair
, vol.7
, pp. 405-417
-
-
Yamauchi, M.1
Oka, Y.2
Yamamoto, M.3
Niimura, K.4
Uchida, M.5
Kodama, S.6
Watanabe, M.7
Sekine, I.8
Yamashita, S.9
Suzuki, K.10
-
9
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
d'Adda di Fagagna, F., Reaper, P.M., Clay-Farrace, L., Fiegler, H., Carr, P., Von Zglinicki, T., Saretzki, G., Carter, N.P. and Jackson, S.P. (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature, 426, 194-198.
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
D'Adda Di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
Von Zglinicki, T.6
Saretzki, G.7
Carter, N.P.8
Jackson, S.P.9
-
10
-
-
33846090789
-
Accumulation of senescent cells in mitotic tissue of aging primates
-
Jeyapalan, J.C., Ferreira, M., Sedivy, J.M. and Herbig, U. (2007) Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev., 128, 36-44.
-
(2007)
Mech. Ageing Dev.
, vol.128
, pp. 36-44
-
-
Jeyapalan, J.C.1
Ferreira, M.2
Sedivy, J.M.3
Herbig, U.4
-
11
-
-
14044255880
-
Activation of the DNA damage response by telomere attrition: A passage to cellular senescence
-
Reaper, P.M., di Fagagna, F. and Jackson, S.P. (2004) Activation of the DNA damage response by telomere attrition: a passage to cellular senescence. Cell Cycle, 3, 543-546.
-
(2004)
Cell Cycle
, vol.3
, pp. 543-546
-
-
Reaper, P.M.1
Di Fagagna, F.2
Jackson, S.P.3
-
12
-
-
68249096784
-
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
-
Rodier, F., Coppe, J.P., Patil, C.K., Hoeijmakers, W.A., Munoz, D.P., Raza, S.R., Freund, A., Campeau, E., Davalos, A.R. and Campisi, J. (2009) Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol., 11, 973-979.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 973-979
-
-
Rodier, F.1
Coppe, J.P.2
Patil, C.K.3
Hoeijmakers, W.A.4
Munoz, D.P.5
Raza, S.R.6
Freund, A.7
Campeau, E.8
Davalos, A.R.9
Campisi, J.10
-
13
-
-
0036903037
-
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
-
Fernandez-Capetillo, O., Chen, H.T., Celeste, A., Ward, I., Romanienko, P.J., Morales, J.C., Naka, K., Xia, Z., Camerini-Otero, R.D., Motoyama, N. et al. (2002) DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat. Cell Biol., 4, 993-997.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 993-997
-
-
Fernandez-Capetillo, O.1
Chen, H.T.2
Celeste, A.3
Ward, I.4
Romanienko, P.J.5
Morales, J.C.6
Naka, K.7
Xia, Z.8
Camerini-Otero, R.D.9
Motoyama, N.10
-
14
-
-
3543056880
-
Functional links between telomeres and proteins of the DNA-damage response
-
d'Adda di Fagagna, F., Teo, S.H. and Jackson, S.P. (2004) Functional links between telomeres and proteins of the DNA-damage response. Genes Dev., 18, 1781-1799.
-
(2004)
Genes Dev.
, vol.18
, pp. 1781-1799
-
-
D'Adda Di Fagagna, F.1
Teo, S.H.2
Jackson, S.P.3
-
15
-
-
74949108644
-
The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks
-
Nakamura, A.J., Rao, V.A., Pommier, Y. and Bonner, W.M. (2010) The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks. Cell Cycle, 9, 389-397.
-
(2010)
Cell Cycle
, vol.9
, pp. 389-397
-
-
Nakamura, A.J.1
Rao, V.A.2
Pommier, Y.3
Bonner, W.M.4
-
16
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh, Y. (2003) ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer, 3, 155-168.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
17
-
-
0035834693
-
ATM phosphorylates histone H2AX in response to DNA double-strand breaks
-
Burma, S., Chen, B.P., Murphy, M., Kurimasa, A. and Chen, D.J. (2001) ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem., 276, 42462-42467.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42462-42467
-
-
Burma, S.1
Chen, B.P.2
Murphy, M.3
Kurimasa, A.4
Chen, D.J.5
-
18
-
-
1942538492
-
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
-
Stiff, T., O'Driscoll, M., Rief, N., Iwabuchi, K., Lobrich, M. and Jeggo, P.A. (2004) ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res., 64, 2390-2396.
-
(2004)
Cancer Res.
, vol.64
, pp. 2390-2396
-
-
Stiff, T.1
O'Driscoll, M.2
Rief, N.3
Iwabuchi, K.4
Lobrich, M.5
Jeggo, P.A.6
-
19
-
-
0035930537
-
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
-
Ward, I.M. and Chen, J. (2001) Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem., 276, 47759-47762.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47759-47762
-
-
Ward, I.M.1
Chen, J.2
-
21
-
-
0142154314
-
ATM, ATR and DNA-PK: Initiators of the cellular genotoxic stress responses
-
Yang, J., Yu, Y., Hamrick, H.E. and Duerksen-Hughes, P.J. (2003) ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses. Carcinogenesis, 24, 1571-1580.
-
(2003)
Carcinogenesis
, vol.24
, pp. 1571-1580
-
-
Yang, J.1
Yu, Y.2
Hamrick, H.E.3
Duerksen-Hughes, P.J.4
-
22
-
-
77955847245
-
Multiple roles of ATM in monitoring and maintaining DNA integrity
-
Derheimer, F.A. and Kastan, M.B. (2010) Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett., 584, 3675-3681.
-
(2010)
FEBS Lett.
, vol.584
, pp. 3675-3681
-
-
Derheimer, F.A.1
Kastan, M.B.2
-
23
-
-
23244468167
-
How important is ATM?
-
Lavin, M.F. (2005) How important is ATM? Radiat. Res., 163, 704.
-
(2005)
Radiat. Res.
, vol.163
, pp. 704
-
-
Lavin, M.F.1
-
24
-
-
79957547966
-
Beyond ATM: The protein kinase landscape of the DNA damage response
-
Bensimon, A., Aebersold, R. and Shiloh, Y. (2011) Beyond ATM: the protein kinase landscape of the DNA damage response. FEBS Lett., 585, 1625-1639.
-
(2011)
FEBS Lett.
, vol.585
, pp. 1625-1639
-
-
Bensimon, A.1
Aebersold, R.2
Shiloh, Y.3
-
25
-
-
0032052815
-
Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids
-
Dynan, W.S. and Yoo, S. (1998) Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. Nucleic Acids Res., 26, 1551-1559.
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 1551-1559
-
-
Dynan, W.S.1
Yoo, S.2
-
26
-
-
3242881500
-
The cellular response to general and programmed DNA double strand breaks
-
Bassing, C.H. and Alt, F.W. (2004) The cellular response to general and programmed DNA double strand breaks. DNA Repair, 3, 781-796.
-
(2004)
DNA Repair
, vol.3
, pp. 781-796
-
-
Bassing, C.H.1
Alt, F.W.2
-
27
-
-
78649446475
-
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
-
Dobbs, T.A., Tainer, J.A. and Lees-Miller, S.P. (2010) A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair, 9, 1307-1314.
-
(2010)
DNA Repair
, vol.9
, pp. 1307-1314
-
-
Dobbs, T.A.1
Tainer, J.A.2
Lees-Miller, S.P.3
-
28
-
-
0035851181
-
Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase
-
Yannone, S.M., Roy, S., Chan, D.W., Murphy, M.B., Huang, S., Campisi, J. and Chen, D.J. (2001) Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. J. Biol. Chem., 276, 38242-38248.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38242-38248
-
-
Yannone, S.M.1
Roy, S.2
Chan, D.W.3
Murphy, M.B.4
Huang, S.5
Campisi, J.6
Chen, D.J.7
-
29
-
-
33947541157
-
Processing of 3'-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease
-
Povirk, L.F., Zhou, T., Zhou, R., Cowan, M.J. and Yannone, S.M. (2007) Processing of 3'-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease. J. Biol. Chem., 282, 3547-3558.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 3547-3558
-
-
Povirk, L.F.1
Zhou, T.2
Zhou, R.3
Cowan, M.J.4
Yannone, S.M.5
-
30
-
-
33845666681
-
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair
-
Botuyan, M.V., Lee, J., Ward, I.M., Kim, J.E., Thompson, J.R., Chen, J. and Mer, G. (2006) Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell, 127, 1361-1373.
-
(2006)
Cell
, vol.127
, pp. 1361-1373
-
-
Botuyan, M.V.1
Lee, J.2
Ward, I.M.3
Kim, J.E.4
Thompson, J.R.5
Chen, J.6
Mer, G.7
-
31
-
-
3142642685
-
Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1
-
Huyen, Y., Jeffrey, P.D., Derry, W.B., Rothman, J.H., Pavletich, N.P., Stavridi, E.S. and Halazonetis, T.D. (2004) Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1. Structure, 12, 1237-1243.
-
(2004)
Structure
, vol.12
, pp. 1237-1243
-
-
Huyen, Y.1
Jeffrey, P.D.2
Derry, W.B.3
Rothman, J.H.4
Pavletich, N.P.5
Stavridi, E.S.6
Halazonetis, T.D.7
-
32
-
-
0037468192
-
MDC1 is a mediator of the mammalian DNA damage checkpoint
-
Stewart, G.S., Wang, B., Bignell, C.R., Taylor, A.M. and Elledge, S.J. (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature, 421, 961-966.
-
(2003)
Nature
, vol.421
, pp. 961-966
-
-
Stewart, G.S.1
Wang, B.2
Bignell, C.R.3
Taylor, A.M.4
Elledge, S.J.5
-
33
-
-
0034677786
-
Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/ threonine protein kinase
-
Chan, D.W., Son, S.C., Block, W., Ye, R., Khanna, K.K., Wold, M.S., Douglas, P., Goodarzi, A.A., Pelley, J., Taya, Y. et al. (2000) Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/ threonine protein kinase. J. Biol. Chem., 275, 7803-7810.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 7803-7810
-
-
Chan, D.W.1
Son, S.C.2
Block, W.3
Ye, R.4
Khanna, K.K.5
Wold, M.S.6
Douglas, P.7
Goodarzi, A.A.8
Pelley, J.9
Taya, Y.10
-
34
-
-
0024357643
-
The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues
-
Lees-Miller, S.P. and Anderson, C.W. (1989) The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues. J. Biol. Chem., 264, 17275-17280.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 17275-17280
-
-
Lees-Miller, S.P.1
Anderson, C.W.2
-
35
-
-
0025037502
-
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase
-
Jackson, S.P., MacDonald, J.J., Lees-Miller, S. and Tjian, R. (1990) GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell, 63, 155-165.
-
(1990)
Cell
, vol.63
, pp. 155-165
-
-
Jackson, S.P.1
MacDonald, J.J.2
Lees-Miller, S.3
Tjian, R.4
-
36
-
-
0027048773
-
Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II
-
Dvir, A., Peterson, S.R., Knuth, M.W., Lu, H. and Dynan, W.S. (1992) Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II. Proc. Natl. Acad. Sci. USA, 89, 11920-11924.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 11920-11924
-
-
Dvir, A.1
Peterson, S.R.2
Knuth, M.W.3
Lu, H.4
Dynan, W.S.5
-
37
-
-
54949109808
-
PI3K/Akt: Getting it right matters
-
Franke, T.F. (2008) PI3K/Akt: getting it right matters. Oncogene, 27, 6473-6488.
-
(2008)
Oncogene
, vol.27
, pp. 6473-6488
-
-
Franke, T.F.1
-
38
-
-
42949165854
-
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
-
Bozulic, L., Surucu, B., Hynx, D. and Hemmings, B.A. (2008) PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol. Cell, 30, 203-213.
-
(2008)
Mol. Cell
, vol.30
, pp. 203-213
-
-
Bozulic, L.1
Surucu, B.2
Hynx, D.3
Hemmings, B.A.4
-
39
-
-
63749118028
-
DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif
-
Park, J., Feng, J., Li, Y., Hammarsten, O., Brazil, D.P. and Hemmings, B.A. (2009) DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif. J. Biol. Chem., 284, 6169-6174.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 6169-6174
-
-
Park, J.1
Feng, J.2
Li, Y.3
Hammarsten, O.4
Brazil, D.P.5
Hemmings, B.A.6
-
40
-
-
57649219414
-
In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis
-
Surucu, B., Bozulic, L., Hynx, D., Parcellier, A. and Hemmings, B.A. (2008) In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis. J. Biol. Chem., 283, 30025-30033.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 30025-30033
-
-
Surucu, B.1
Bozulic, L.2
Hynx, D.3
Parcellier, A.4
Hemmings, B.A.5
-
41
-
-
67349288164
-
Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells
-
Tomimatsu, N., Mukherjee, B. and Burma, S. (2009) Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. EMBO Reports, 10, 629-635.
-
(2009)
EMBO Reports
, vol.10
, pp. 629-635
-
-
Tomimatsu, N.1
Mukherjee, B.2
Burma, S.3
-
42
-
-
66149143110
-
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase
-
Schwartz, R.A., Carson, C.T., Schuberth, C. and Weitzman, M.D. (2009) Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase. J. Virol., 83, 6269-6278.
-
(2009)
J. Virol.
, vol.83
, pp. 6269-6278
-
-
Schwartz, R.A.1
Carson, C.T.2
Schuberth, C.3
Weitzman, M.D.4
-
43
-
-
0032189483
-
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
-
Sarkaria, J.N., Tibbetts, R.S., Busby, E.C., Kennedy, A.P., Hill, D.E. and Abraham, R.T. (1998) Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res., 58, 4375-4382.
-
(1998)
Cancer Res.
, vol.58
, pp. 4375-4382
-
-
Sarkaria, J.N.1
Tibbetts, R.S.2
Busby, E.C.3
Kennedy, A.P.4
Hill, D.E.5
Abraham, R.T.6
-
44
-
-
35248898241
-
ATF2 on the double - Activating transcription factor and DNA damage response protein
-
Bhoumik, A., Lopez-Bergami, P. and Ronai, Z. (2007) ATF2 on the double - activating transcription factor and DNA damage response protein. Pigment Cell Res., 20, 498-506.
-
(2007)
Pigment Cell Res.
, vol.20
, pp. 498-506
-
-
Bhoumik, A.1
Lopez-Bergami, P.2
Ronai, Z.3
-
45
-
-
19444363740
-
ATM-dependent phosphorylation of ATF2 is required for the DNA damage response
-
Bhoumik, A., Takahashi, S., Breitweiser, W., Shiloh, Y., Jones, N. and Ronai, Z. (2005) ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol. Cell, 18, 577-587.
-
(2005)
Mol. Cell
, vol.18
, pp. 577-587
-
-
Bhoumik, A.1
Takahashi, S.2
Breitweiser, W.3
Shiloh, Y.4
Jones, N.5
Ronai, Z.6
-
46
-
-
78650683727
-
Radiation sensitivity and tumor susceptibility in ATM phospho-mutant ATF2 Mice
-
Li, S., Ezhevsky, S., Dewing, A., Cato, M.H., Scortegagna, M., Bhoumik, A., Breitwieser, W., Braddock, D., Eroshkin, A., Qi, J. et al. (2010) Radiation sensitivity and tumor susceptibility in ATM phospho-mutant ATF2 Mice. Genes Cancer, 1, 316-330.
-
(2010)
Genes Cancer
, vol.1
, pp. 316-330
-
-
Li, S.1
Ezhevsky, S.2
Dewing, A.3
Cato, M.H.4
Scortegagna, M.5
Bhoumik, A.6
Breitwieser, W.7
Braddock, D.8
Eroshkin, A.9
Qi, J.10
-
47
-
-
0032576820
-
ATF2 confers radiation resistance to human melanoma cells
-
Ronai, Z., Yang, Y.M., Fuchs, S.Y., Adler, V., Sardana, M. and Herlyn, M. (1998) ATF2 confers radiation resistance to human melanoma cells. Oncogene, 16, 523-531.
-
(1998)
Oncogene
, vol.16
, pp. 523-531
-
-
Ronai, Z.1
Yang, Y.M.2
Fuchs, S.Y.3
Adler, V.4
Sardana, M.5
Herlyn, M.6
-
48
-
-
0036500555
-
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
-
Kim, S.T., Xu, B. and Kastan, M.B. (2002) Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev., 16, 560-570.
-
(2002)
Genes Dev.
, vol.16
, pp. 560-570
-
-
Kim, S.T.1
Xu, B.2
Kastan, M.B.3
-
49
-
-
2942687831
-
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
-
Kitagawa, R., Bakkenist, C.J., McKinnon, P.J. and Kastan, M.B. (2004) Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev., 18, 1423-1438.
-
(2004)
Genes Dev.
, vol.18
, pp. 1423-1438
-
-
Kitagawa, R.1
Bakkenist, C.J.2
McKinnon, P.J.3
Kastan, M.B.4
-
50
-
-
62149091065
-
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes
-
Nahas, S.A., Butch, A.W., Du, L. and Gatti, R.A. (2009) Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes. Clin. Chem., 55, 463-472.
-
(2009)
Clin. Chem.
, vol.55
, pp. 463-472
-
-
Nahas, S.A.1
Butch, A.W.2
Du, L.3
Gatti, R.A.4
-
51
-
-
9244237084
-
Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates
-
Butch, A.W., Chun, H.H., Nahas, S.A. and Gatti, R.A. (2004) Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates. Clin. Chem., 50, 2302-2308.
-
(2004)
Clin. Chem.
, vol.50
, pp. 2302-2308
-
-
Butch, A.W.1
Chun, H.H.2
Nahas, S.A.3
Gatti, R.A.4
-
52
-
-
79953288925
-
Functional interaction of BRCA1/ ATM-associated BAAT1 with the DNA-PK catalytic subunit
-
So, E.Y. and Ouchi, T. (2011) Functional interaction of BRCA1/ ATM-associated BAAT1 with the DNA-PK catalytic subunit. Exp. Ther. Med., 2, 443-447.
-
(2011)
Exp. Ther. Med.
, vol.2
, pp. 443-447
-
-
So, E.Y.1
Ouchi, T.2
-
53
-
-
79960050609
-
Regulation of ATM/DNA-PKcs phosphorylation by BRCA1-associated BAAT1
-
Ouchi, M. and Ouchi, T. (2010) Regulation of ATM/DNA-PKcs phosphorylation by BRCA1-associated BAAT1. Genes Cancer, 1, 1211-1214.
-
(2010)
Genes Cancer
, vol.1
, pp. 1211-1214
-
-
Ouchi, M.1
Ouchi, T.2
-
54
-
-
84862899536
-
The Smc complexes in DNA damage response
-
Wu, N. and Yu, H. (2012) The Smc complexes in DNA damage response. Cell Biosci., 2, 5.
-
(2012)
Cell Biosci.
, vol.2
, pp. 5
-
-
Wu, N.1
Yu, H.2
-
55
-
-
77952095382
-
Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization
-
Costes, S.V., Chiolo, I., Pluth, J.M., Barcellos-Hoff, M.H. and Jakob, B. (2010) Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization. Mutat. Res., 704, 78-87.
-
(2010)
Mutat. Res.
, vol.704
, pp. 78-87
-
-
Costes, S.V.1
Chiolo, I.2
Pluth, J.M.3
Barcellos-Hoff, M.H.4
Jakob, B.5
-
56
-
-
78649797887
-
Sequence-dependent histone variant positioning signatures
-
Le, N.T., Ho, T.B. and Ho, B.H. (2010) Sequence-dependent histone variant positioning signatures. BMC Genomics, 11(Suppl. 4), S3.
-
(2010)
BMC Genomics
, vol.11
, Issue.SUPPL. 4
-
-
Le, N.T.1
Ho, T.B.2
Ho, B.H.3
-
57
-
-
26444553297
-
Does gammaH2AX foci formation depend on the presence of DNA double strand breaks?
-
Takahashi, A. and Ohnishi, T. (2005) Does gammaH2AX foci formation depend on the presence of DNA double strand breaks? Cancer Lett. 229, 171-179.
-
(2005)
Cancer Lett.
, vol.229
, pp. 171-179
-
-
Takahashi, A.1
Ohnishi, T.2
-
58
-
-
78649449767
-
The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax
-
Goodarzi, A.A., Jeggo, P. and Lobrich, M. (2010) The influence of heterochromatin on DNA double strand break repair: getting the strong, silent type to relax. DNA Repair, 9, 1273-1282.
-
(2010)
DNA Repair
, vol.9
, pp. 1273-1282
-
-
Goodarzi, A.A.1
Jeggo, P.2
Lobrich, M.3
-
59
-
-
38949124412
-
ATR signaling can drive cells into senescence in the absence of DNA breaks
-
Toledo, L.I., Murga, M., Gutierrez-Martinez, P., Soria, R. and Fernandez-Capetillo, O. (2008) ATR signaling can drive cells into senescence in the absence of DNA breaks. Genes Dev., 22, 297-302.
-
(2008)
Genes Dev.
, vol.22
, pp. 297-302
-
-
Toledo, L.I.1
Murga, M.2
Gutierrez-Martinez, P.3
Soria, R.4
Fernandez-Capetillo, O.5
-
60
-
-
33646714595
-
Three-dimensional structure of the human DNA-PKcs/Ku70/ Ku80 complex assembled on DNA and its implications for DNA DSB repair
-
Spagnolo, L., Rivera-Calzada, A., Pearl, L.H. and Llorca, O. (2006) Three-dimensional structure of the human DNA-PKcs/Ku70/ Ku80 complex assembled on DNA and its implications for DNA DSB repair. Mol. Cell, 22, 511-519.
-
(2006)
Mol. Cell
, vol.22
, pp. 511-519
-
-
Spagnolo, L.1
Rivera-Calzada, A.2
Pearl, L.H.3
Llorca, O.4
-
61
-
-
77953229115
-
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
-
Lieber, M.R. (2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu. Rev. Biochem., 79, 181-211.
-
(2010)
Annu. Rev. Biochem.
, vol.79
, pp. 181-211
-
-
Lieber, M.R.1
-
62
-
-
0041732381
-
Characteristics of gamma-H2AX foci at DNA double-strand breaks sites
-
Pilch, D.R., Sedelnikova, O.A., Redon, C., Celeste, A., Nussenzweig, A. and Bonner, W.M. (2003) Characteristics of gamma-H2AX foci at DNA double-strand breaks sites. Biochem. Cell Biol., 81, 123-129.
-
(2003)
Biochem. Cell Biol.
, vol.81
, pp. 123-129
-
-
Pilch, D.R.1
Sedelnikova, O.A.2
Redon, C.3
Celeste, A.4
Nussenzweig, A.5
Bonner, W.M.6
-
63
-
-
0037012845
-
Genomic instability in mice lacking histone H2AX
-
Celeste, A., Petersen, S., Romanienko, P.J., Fernandez-Capetillo, O., Chen, H.T., Sedelnikova, O.A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M.J. et al. (2002) Genomic instability in mice lacking histone H2AX. Science, 296, 922-927.
-
(2002)
Science
, vol.296
, pp. 922-927
-
-
Celeste, A.1
Petersen, S.2
Romanienko, P.J.3
Fernandez-Capetillo, O.4
Chen, H.T.5
Sedelnikova, O.A.6
Reina-San-Martin, B.7
Coppola, V.8
Meffre, E.9
Difilippantonio, M.J.10
-
64
-
-
41149127607
-
The R215W mutation in NBS1 impairs gamma-H2AX binding and affects DNA repair: Molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients
-
di Masi, A., Viganotti, M., Polticelli, F., Ascenzi, P., Tanzarella, C. and Antoccia, A. (2008) The R215W mutation in NBS1 impairs gamma-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients. Biochem. Biophys. Res. Commun., 369, 835-840.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.369
, pp. 835-840
-
-
Di Masi, A.1
Viganotti, M.2
Polticelli, F.3
Ascenzi, P.4
Tanzarella, C.5
Antoccia, A.6
-
65
-
-
70449940264
-
High resolution imaging of changes in the structure and spatial organization of chromatin, gamma-H2A.X and the MRN complex within etoposide-induced DNA repair foci
-
Dellaire, G., Kepkay, R. and Bazett-Jones, D.P. (2009) High resolution imaging of changes in the structure and spatial organization of chromatin, gamma-H2A.X and the MRN complex within etoposide-induced DNA repair foci. Cell Cycle, 8, 3750-3769.
-
(2009)
Cell Cycle
, vol.8
, pp. 3750-3769
-
-
Dellaire, G.1
Kepkay, R.2
Bazett-Jones, D.P.3
-
66
-
-
27844607415
-
Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae
-
Tsukuda, T., Fleming, A.B., Nickoloff, J.A. and Osley, M.A. (2005) Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae. Nature, 438, 379-383.
-
(2005)
Nature
, vol.438
, pp. 379-383
-
-
Tsukuda, T.1
Fleming, A.B.2
Nickoloff, J.A.3
Osley, M.A.4
-
67
-
-
70349873824
-
Comprehensive mapping of long-range interactions reveals folding principles of the human genome
-
Lieberman-Aiden, E., van Berkum, N.L., Williams, L., Imakaev, M., Ragoczy, T., Telling, A., Amit, I., Lajoie, B.R., Sabo, P.J., Dorschner, M.O. et al. (2009) Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science, 326, 289-293.
-
(2009)
Science
, vol.326
, pp. 289-293
-
-
Lieberman-Aiden, E.1
Van Berkum, N.L.2
Williams, L.3
Imakaev, M.4
Ragoczy, T.5
Telling, A.6
Amit, I.7
Lajoie, B.R.8
Sabo, P.J.9
Dorschner, M.O.10
-
68
-
-
33750465872
-
SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes
-
Cai, S., Lee, C.C. and Kohwi-Shigematsu, T. (2006) SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat. Genet., 38, 1278-1288.
-
(2006)
Nat. Genet.
, vol.38
, pp. 1278-1288
-
-
Cai, S.1
Lee, C.C.2
Kohwi-Shigematsu, T.3
-
69
-
-
33644905252
-
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks
-
Kruhlak, M.J., Celeste, A., Dellaire, G., Fernandez-Capetillo, O., Muller, W.G., McNally, J.G., Bazett-Jones, D.P. and Nussenzweig, A. (2006) Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J. Cell Biol., 172, 823-834.
-
(2006)
J. Cell Biol.
, vol.172
, pp. 823-834
-
-
Kruhlak, M.J.1
Celeste, A.2
Dellaire, G.3
Fernandez-Capetillo, O.4
Muller, W.G.5
McNally, J.G.6
Bazett-Jones, D.P.7
Nussenzweig, A.8
-
70
-
-
0032861343
-
Megabase chromatin domains involved in DNA double-strand breaks in vivo
-
Rogakou, E.P., Boon, C., Redon, C. and Bonner, W.M. (1999) Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol., 146, 905-916.
-
(1999)
J. Cell Biol.
, vol.146
, pp. 905-916
-
-
Rogakou, E.P.1
Boon, C.2
Redon, C.3
Bonner, W.M.4
-
71
-
-
77951498531
-
High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome
-
Iacovoni, J.S., Caron, P., Lassadi, I., Nicolas, E., Massip, L., Trouche, D. and Legube, G. (2010) High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome. EMBO J., 29, 1446-1457.
-
(2010)
EMBO J.
, vol.29
, pp. 1446-1457
-
-
Iacovoni, J.S.1
Caron, P.2
Lassadi, I.3
Nicolas, E.4
Massip, L.5
Trouche, D.6
Legube, G.7
-
72
-
-
29244434544
-
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
-
Stucki, M., Clapperton, J.A., Mohammad, D., Yaffe, M.B., Smerdon, S.J. and Jackson, S.P. (2005) MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell, 123, 1213-1226.
-
(2005)
Cell
, vol.123
, pp. 1213-1226
-
-
Stucki, M.1
Clapperton, J.A.2
Mohammad, D.3
Yaffe, M.B.4
Smerdon, S.J.5
Jackson, S.P.6
-
73
-
-
45849117573
-
Activation of the cellular DNA damage response in the absence of DNA lesions
-
Soutoglou, E. and Misteli, T. (2008) Activation of the cellular DNA damage response in the absence of DNA lesions. Science, 320, 1507-1510.
-
(2008)
Science
, vol.320
, pp. 1507-1510
-
-
Soutoglou, E.1
Misteli, T.2
-
74
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist, C.J. and Kastan, M.B. (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature, 421, 499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
75
-
-
4544295689
-
Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends
-
Reddy, Y.V., Ding, Q., Lees-Miller, S.P., Meek, K. and Ramsden, D.A. (2004) Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends. J. Biol. Chem., 279, 39408-39413.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 39408-39413
-
-
Reddy, Y.V.1
Ding, Q.2
Lees-Miller, S.P.3
Meek, K.4
Ramsden, D.A.5
-
76
-
-
33748089029
-
DNA-PK autophosphorylation facilitates Artemis endonuclease activity
-
Goodarzi, A.A., Yu, Y., Riballo, E., Douglas, P., Walker, S.A., Ye, R., Härer, C., Marchetti, C., Morrice, N., Jeggo, P.A. et al. (2006) DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J., 25, 3880-3889.
-
(2006)
EMBO J.
, vol.25
, pp. 3880-3889
-
-
Goodarzi, A.A.1
Yu, Y.2
Riballo, E.3
Douglas, P.4
Walker, S.A.5
Ye, R.6
Härer, C.7
Marchetti, C.8
Morrice, N.9
Jeggo, P.A.10
-
77
-
-
47349107760
-
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
-
Goodarzi, A.A., Noon, A.T., Deckbar, D., Ziv, Y., Shiloh, Y., Lobrich, M. and Jeggo, P.A. (2008) ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol. Cell, 31, 167-177.
-
(2008)
Mol. Cell
, vol.31
, pp. 167-177
-
-
Goodarzi, A.A.1
Noon, A.T.2
Deckbar, D.3
Ziv, Y.4
Shiloh, Y.5
Lobrich, M.6
Jeggo, P.A.7
|