메뉴 건너뛰기




Volumn 43, Issue 7, 2008, Pages 509-518

Liver diseases and metabolic syndrome

Author keywords

Chronic hepatitis C; Metabolic syndrome; Nonalcoholic fatty liver diseases; Nonalcoholic steatohepatitis; Pegylated interferon; Ribavirin; Sustained viral response

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ALPHA2B INTERFERON; ANTIVIRUS AGENT; CYTOKINE; ETANERCEPT; FATTY ACID; INTERFERON; LEPTIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PEGINTERFERON; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PIOGLITAZONE; PLACEBO; PROTEIN KINASE B; RIBAVIRIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 48449100526     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-008-2193-6     Document Type: Review
Times cited : (147)

References (110)
  • 1
    • 0035897696 scopus 로고    scopus 로고
    • Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)
    • Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001;285:2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 3
    • 34247557647 scopus 로고    scopus 로고
    • Metabolic syndrome and gastrointestinal diseases
    • Watanabe S, Hojo M, Nagahara A. Metabolic syndrome and gastrointestinal diseases. J Gastroenterol 2007;42:267-274.
    • (2007) J Gastroenterol , vol.42 , pp. 267-274
    • Watanabe, S.1    Hojo, M.2    Nagahara, A.3
  • 4
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346:1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 6
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease
    • Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980;55:434-438.
    • (1980) Mayo Clin Proc , vol.55 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3    Oh, B.J.4
  • 10
    • 18244385511 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association
    • Pagano G, Pacini G, Musso G, Gambino R, Mecca F, Depetris N, et al. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: Further evidence for an etiologic association. Hepatology 2002;35:367-372.
    • (2002) Hepatology , vol.35 , pp. 367-372
    • Pagano, G.1    Pacini, G.2    Musso, G.3    Gambino, R.4    Mecca, F.5    Depetris, N.6
  • 12
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day CP, James OF. Steatohepatitis: A tale of two "hits"? Gastroenterology 1998;114:842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 15
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
    • Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003;37:1202-1219.
    • (2003) Hepatology , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 16
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 17
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology 2004;40:1387-1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3    Nuremberg, P.4    Horton, J.D.5    Cohen, J.C.6
  • 19
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years. Hepatology 1990;11:74-80.
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 21
    • 0028875908 scopus 로고
    • The natural history of nonalcoholic fatty liver: A follow-up study
    • Teli MR, James OF, Burt AD, Bennett MK, Day CP. The natural history of nonalcoholic fatty liver: A follow-up study. Hepatology 1995;22:1714-1719.
    • (1995) Hepatology , vol.22 , pp. 1714-1719
    • Teli, M.R.1    James, O.F.2    Burt, A.D.3    Bennett, M.K.4    Day, C.P.5
  • 22
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: From steatosis to cirrhosis. Hepatology 2006;43:S99-S112.
    • (2006) Hepatology , vol.43
    • Farrell, G.C.1    Larter, C.Z.2
  • 24
    • 0038606277 scopus 로고    scopus 로고
    • High dietary fat promotes syndrome X in nonobese rats
    • Axen KV, Dikeakos A, Sclafani A. High dietary fat promotes syndrome X in nonobese rats. J Nutr 2003;133:2244-2249.
    • (2003) J Nutr , vol.133 , pp. 2244-2249
    • Axen, K.V.1    Dikeakos, A.2    Sclafani, A.3
  • 25
    • 0026534940 scopus 로고
    • Development of dietary obesity in rats: Influence of amount and composition of dietary fat
    • Hill JO, Lin D, Yakubu F, Peters JC. Development of dietary obesity in rats: Influence of amount and composition of dietary fat. Int J Obes Relat Metab Disord 1992;16:321-333.
    • (1992) Int J Obes Relat Metab Disord , vol.16 , pp. 321-333
    • Hill, J.O.1    Lin, D.2    Yakubu, F.3    Peters, J.C.4
  • 26
    • 11244348954 scopus 로고    scopus 로고
    • A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats
    • Carmiel-Haggai M, Cederbaum AI, Nieto N. A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats. FASEB J 2005;19:136-138.
    • (2005) FASEB J , vol.19 , pp. 136-138
    • Carmiel-Haggai, M.1    Cederbaum, A.I.2    Nieto, N.3
  • 29
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
    • Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996;84:491-495.
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1    Charlat, O.2    Tartaglia, L.A.3    Woolf, E.A.4    Weng, X.5    Ellis, S.J.6
  • 30
    • 0030570741 scopus 로고    scopus 로고
    • Molecular cloning of rat leptin receptor isoform complementary DNAs: Identification of a missense mutation in Zucker fatty (fa/fa) rats
    • Takaya K, Ogawa Y, Isse N, Okazaki T, Satoh N, Masuzaki H, et al. Molecular cloning of rat leptin receptor isoform complementary DNAs: identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochem Biophys Res Commun 1996;225:75-83.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 75-83
    • Takaya, K.1    Ogawa, Y.2    Isse, N.3    Okazaki, T.4    Satoh, N.5    Masuzaki, H.6
  • 31
    • 18244364864 scopus 로고    scopus 로고
    • NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome
    • Chitturi S, Abeygunasekera S, Farrell GC, Holmes-Walker J, Hui JM, Fung C, et al. NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002;35:373-379.
    • (2002) Hepatology , vol.35 , pp. 373-379
    • Chitturi, S.1    Abeygunasekera, S.2    Farrell, G.C.3    Holmes-Walker, J.4    Hui, J.M.5    Fung, C.6
  • 32
    • 0033562693 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: Another disease of affluence
    • James O, Day C. Non-alcoholic steatohepatitis: Another disease of affluence. Lancet 1999;353:1634-1636.
    • (1999) Lancet , vol.353 , pp. 1634-1636
    • James, O.1    Day, C.2
  • 34
    • 33748111665 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance
    • Tilg H, Hotamisligil GS. Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 2006;131:934-945.
    • (2006) Gastroenterology , vol.131 , pp. 934-945
    • Tilg, H.1    Hotamisligil, G.S.2
  • 35
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 1993;259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 36
    • 0035183475 scopus 로고    scopus 로고
    • Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
    • Crespo J, Cayon A, Fernandez-Gil P, Hernandez-Guerra M, Mayorga M, Dominguez-Diez A, et al. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology 2001;34:1158-1163.
    • (2001) Hepatology , vol.34 , pp. 1158-1163
    • Crespo, J.1    Cayon, A.2    Fernandez-Gil, P.3    Hernandez-Guerra, M.4    Mayorga, M.5    Dominguez-Diez, A.6
  • 37
    • 3042824524 scopus 로고    scopus 로고
    • Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
    • Feldstein AE, Werneburg NW, Canbay A, Guicciardi ME, Bronk SF, Rydzewski R, et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004;40:185-194.
    • (2004) Hepatology , vol.40 , pp. 185-194
    • Feldstein, A.E.1    Werneburg, N.W.2    Canbay, A.3    Guicciardi, M.E.4    Bronk, S.F.5    Rydzewski, R.6
  • 38
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003;37:343-350.
    • (2003) Hepatology , vol.37 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3    Huang, J.4    Watkins, P.A.5    Moser, A.B.6
  • 40
    • 0037135523 scopus 로고    scopus 로고
    • Disruption of adiponectin causes insulin resistance and neointimal formation
    • Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, Matsui J, et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 2002;277:25863-25866.
    • (2002) J Biol Chem , vol.277 , pp. 25863-25866
    • Kubota, N.1    Terauchi, Y.2    Yamauchi, T.3    Kubota, T.4    Moroi, M.5    Matsui, J.6
  • 44
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003;112:91-100.
    • (2003) J Clin Invest , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 45
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995;83:1263-1271.
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3    Deng, N.4    Culpepper, J.5    Devos, R.6
  • 46
    • 0032489223 scopus 로고    scopus 로고
    • Transdifferentiation of rat hepatic stellate cells results in leptin expression
    • Potter JJ, Womack L, Mezey E, Anania FA. Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem Biophys Res Commun 1998;244:178-182.
    • (1998) Biochem Biophys Res Commun , vol.244 , pp. 178-182
    • Potter, J.J.1    Womack, L.2    Mezey, E.3    Anania, F.A.4
  • 47
    • 0034927064 scopus 로고    scopus 로고
    • Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals
    • Ikejima K, Honda H, Yoshikawa M, Hirose M, Kitamura T, Takei Y, et al. Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals. Hepatology 2001;34:288-297.
    • (2001) Hepatology , vol.34 , pp. 288-297
    • Ikejima, K.1    Honda, H.2    Yoshikawa, M.3    Hirose, M.4    Kitamura, T.5    Takei, Y.6
  • 48
    • 0036288668 scopus 로고    scopus 로고
    • Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver
    • Honda H, Ikejima K, Hirose M, Yoshikawa M, Lang T, Enomoto N, et al. Leptin is required for fibrogenic responses induced by thioacetamide in the murine liver. Hepatology 2002;36:12-21.
    • (2002) Hepatology , vol.36 , pp. 12-21
    • Honda, H.1    Ikejima, K.2    Hirose, M.3    Yoshikawa, M.4    Lang, T.5    Enomoto, N.6
  • 49
    • 0036022846 scopus 로고    scopus 로고
    • Leptin is essential for the hepatic fibrogenic response to chronic liver injury
    • Leclercq IA, Farrell GC, Schriemer R, Robertson GR. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J Hepatol 2002;37:206-213.
    • (2002) J Hepatol , vol.37 , pp. 206-213
    • Leclercq, I.A.1    Farrell, G.C.2    Schriemer, R.3    Robertson, G.R.4
  • 50
    • 0036234147 scopus 로고    scopus 로고
    • Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat
    • Ikejima K, Takei Y, Honda H, Hirose M, Yoshikawa M, Zhang YJ, et al. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 2002;122:1399-1410.
    • (2002) Gastroenterology , vol.122 , pp. 1399-1410
    • Ikejima, K.1    Takei, Y.2    Honda, H.3    Hirose, M.4    Yoshikawa, M.5    Zhang, Y.J.6
  • 51
    • 29144492714 scopus 로고    scopus 로고
    • The role of leptin in progression of non-alcoholic fatty liver disease
    • Ikejima K, Okumura K, Lang T, Honda H, Abe W, Yamashina S, et al. The role of leptin in progression of non-alcoholic fatty liver disease. Hepatol Res 2005;33:151-154.
    • (2005) Hepatol Res , vol.33 , pp. 151-154
    • Ikejima, K.1    Okumura, K.2    Lang, T.3    Honda, H.4    Abe, W.5    Yamashina, S.6
  • 52
    • 0036204924 scopus 로고    scopus 로고
    • Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice
    • Saxena NK, Ikeda K, Rockey DC, Friedman SL, Anania FA. Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology 2002;35:762-771.
    • (2002) Hepatology , vol.35 , pp. 762-771
    • Saxena, N.K.1    Ikeda, K.2    Rockey, D.C.3    Friedman, S.L.4    Anania, F.A.5
  • 53
    • 0038644530 scopus 로고    scopus 로고
    • Leptin induces increased alpha2(I) collagen gene expression in cultured rat hepatic stellate cells
    • Saxena NK, Saliba G, Floyd JJ, Anania FA. Leptin induces increased alpha2(I) collagen gene expression in cultured rat hepatic stellate cells. J Cell Biochem 2003;89:311-320.
    • (2003) J Cell Biochem , vol.89 , pp. 311-320
    • Saxena, N.K.1    Saliba, G.2    Floyd, J.J.3    Anania, F.A.4
  • 54
    • 30044443872 scopus 로고    scopus 로고
    • Leptin enhances alpha1(I) collagen gene expression in LX-2 human hepatic stellate cells through JAK-mediated H2O2-dependent MAPK pathways
    • Cao Q, Mak KM, Lieber CS. Leptin enhances alpha1(I) collagen gene expression in LX-2 human hepatic stellate cells through JAK-mediated H2O2-dependent MAPK pathways. J Cell Biochem 2006;97:188-197.
    • (2006) J Cell Biochem , vol.97 , pp. 188-197
    • Cao, Q.1    Mak, K.M.2    Lieber, C.S.3
  • 55
    • 1042289785 scopus 로고    scopus 로고
    • Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells: Respective roles of the JAK/STAT and JAK-mediated H2O2-dependant MAPK pathways
    • Cao Q, Mak KM, Ren C, Lieber CS. Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells: Respective roles of the JAK/STAT and JAK-mediated H2O2-dependant MAPK pathways. J Biol Chem 2004;279:4292-4304.
    • (2004) J Biol Chem , vol.279 , pp. 4292-4304
    • Cao, Q.1    Mak, K.M.2    Ren, C.3    Lieber, C.S.4
  • 56
    • 33751516706 scopus 로고    scopus 로고
    • Leptin increases tissue inhibitor of metalloproteinase I (TIMP-1) gene expression by a specificity protein 1/signal transducer and activator of transcription 3 mechanism
    • Lin S, Saxena NK, Ding X, Stein LL, Anania FA. Leptin increases tissue inhibitor of metalloproteinase I (TIMP-1) gene expression by a specificity protein 1/signal transducer and activator of transcription 3 mechanism. Mol Endocrinol 2006;20:3376-3388.
    • (2006) Mol Endocrinol , vol.20 , pp. 3376-3388
    • Lin, S.1    Saxena, N.K.2    Ding, X.3    Stein, L.L.4    Anania, F.A.5
  • 57
    • 34548162930 scopus 로고    scopus 로고
    • Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells
    • Cao Q, Mak KM, Lieber CS. Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells. J Hepatol 2007;46:124-133.
    • (2007) J Hepatol , vol.46 , pp. 124-133
    • Cao, Q.1    Mak, K.M.2    Lieber, C.S.3
  • 58
    • 32944478021 scopus 로고    scopus 로고
    • Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells
    • Aleffi S, Petrai I, Bertolani C, Parola M, Colombatto S, Novo E, et al. Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells. Hepatology 2005;42:1339-1348.
    • (2005) Hepatology , vol.42 , pp. 1339-1348
    • Aleffi, S.1    Petrai, I.2    Bertolani, C.3    Parola, M.4    Colombatto, S.5    Novo, E.6
  • 61
    • 12344305124 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and type 2 diabetes
    • Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science 2005;307:384-387.
    • (2005) Science , vol.307 , pp. 384-387
    • Lowell, B.B.1    Shulman, G.I.2
  • 63
    • 0036829816 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis C
    • Seeff LB. Natural history of chronic hepatitis C. Hepatology 2002;36:S35-46.
    • (2002) Hepatology , vol.36
    • Seeff, L.B.1
  • 65
    • 1542378867 scopus 로고    scopus 로고
    • Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: A randomized study of treatment duration and ribavirin dose
    • Hadziyannis SJ, Sette H, Jr., Morgan TR, Balan V, Diago M, Marcellin P, et al. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: A randomized study of treatment duration and ribavirin dose. Ann Intern Med 2004;140:346-355.
    • (2004) Ann Intern Med , vol.140 , pp. 346-355
    • Hadziyannis, S.J.1    Sette Jr., H.2    Morgan, T.R.3    Balan, V.4    Diago, M.5    Marcellin, P.6
  • 66
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
    • Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial. Lancet 2001;358:958-965.
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3    Rustgi, V.K.4    Shiffman, M.5    Reindollar, R.6
  • 67
    • 11144225924 scopus 로고    scopus 로고
    • Hepatitis C and nonalcoholic fatty liver disease
    • Ramesh S, Sanyal AJ. Hepatitis C and nonalcoholic fatty liver disease. Semin Liver Dis 2004;24:399-413.
    • (2004) Semin Liver Dis , vol.24 , pp. 399-413
    • Ramesh, S.1    Sanyal, A.J.2
  • 68
    • 0842300373 scopus 로고    scopus 로고
    • Steatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease
    • Lonardo A, Adinolfi LE, Loria P, Carulli N, Ruggiero G, Day CP. Steatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 2004;126:586-597.
    • (2004) Gastroenterology , vol.126 , pp. 586-597
    • Lonardo, A.1    Adinolfi, L.E.2    Loria, P.3    Carulli, N.4    Ruggiero, G.5    Day, C.P.6
  • 69
    • 0346874154 scopus 로고    scopus 로고
    • In overweight patients with chronic hepatitis C, circulating insulin is associated with hepatic fibrosis: Implications for therapy
    • Hickman IJ, Powell EE, Prins JB, Clouston AD, Ash S, Purdie DM, et al. In overweight patients with chronic hepatitis C, circulating insulin is associated with hepatic fibrosis: Implications for therapy. J Hepatol 2003;39:1042-1048.
    • (2003) J Hepatol , vol.39 , pp. 1042-1048
    • Hickman, I.J.1    Powell, E.E.2    Prins, J.B.3    Clouston, A.D.4    Ash, S.5    Purdie, D.M.6
  • 70
    • 0036727323 scopus 로고    scopus 로고
    • Steatosis in chronic hepatitis C: Relative contributions of obesity, diabetes mellitus, and alcohol
    • Monto A, Alonzo J, Watson JJ, Grunfeld C, Wright TL. Steatosis in chronic hepatitis C: Relative contributions of obesity, diabetes mellitus, and alcohol. Hepatology 2002;36:729-736.
    • (2002) Hepatology , vol.36 , pp. 729-736
    • Monto, A.1    Alonzo, J.2    Watson, J.J.3    Grunfeld, C.4    Wright, T.L.5
  • 71
    • 33644806684 scopus 로고    scopus 로고
    • Insulin resistance is associated with steatosis in nondiabetic patients with genotype 1 chronic hepatitis C
    • Camma C, Bruno S, Di Marco V, Di Bona D, Rumi M, Vinci M, et al. Insulin resistance is associated with steatosis in nondiabetic patients with genotype 1 chronic hepatitis C. Hepatology 2006;43:64-71.
    • (2006) Hepatology , vol.43 , pp. 64-71
    • Camma, C.1    Bruno, S.2    Di Marco, V.3    Di Bona, D.4    Rumi, M.5    Vinci, M.6
  • 73
  • 74
    • 10744227418 scopus 로고    scopus 로고
    • The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients
    • Patton HM, Patel K, Behling C, Bylund D, Blatt LM, Vallee M, et al. The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients. J Hepatol 2004;40:484-490.
    • (2004) J Hepatol , vol.40 , pp. 484-490
    • Patton, H.M.1    Patel, K.2    Behling, C.3    Bylund, D.4    Blatt, L.M.5    Vallee, M.6
  • 75
    • 0030859121 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces hepatic steatosis in transgenic mice
    • Moriya K, Yotsuyanagi H, Shintani Y, Fujie H, Ishibashi K, Matsuura Y, et al. Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J Gen Virol 1997;78(pt 7):1527-1531.
    • (1997) J Gen Virol , vol.78 , Issue.PART 7 , pp. 1527-1531
    • Moriya, K.1    Yotsuyanagi, H.2    Shintani, Y.3    Fujie, H.4    Ishibashi, K.5    Matsuura, Y.6
  • 76
    • 1542287381 scopus 로고    scopus 로고
    • Hepatitis C virus infection and diabetes: Direct involvement of the virus in the development of insulin resistance
    • Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, Tsukamoto K, Kimura S, et al. Hepatitis C virus infection and diabetes: Direct involvement of the virus in the development of insulin resistance. Gastroenterology 2004;126:840-848.
    • (2004) Gastroenterology , vol.126 , pp. 840-848
    • Shintani, Y.1    Fujie, H.2    Miyoshi, H.3    Tsutsumi, T.4    Tsukamoto, K.5    Kimura, S.6
  • 77
    • 0043037223 scopus 로고    scopus 로고
    • High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C
    • Bressler BL, Guindi M, Tomlinson G, Heathcote J. High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C. Hepatology 2003;38:639-644.
    • (2003) Hepatology , vol.38 , pp. 639-644
    • Bressler, B.L.1    Guindi, M.2    Tomlinson, G.3    Heathcote, J.4
  • 78
    • 33745560465 scopus 로고    scopus 로고
    • Impact of obesity on treatment of chronic hepatitis C
    • Charlton MR, Pockros PJ, Harrison SA. Impact of obesity on treatment of chronic hepatitis C. Hepatology 2006;43:1177-1186.
    • (2006) Hepatology , vol.43 , pp. 1177-1186
    • Charlton, M.R.1    Pockros, P.J.2    Harrison, S.A.3
  • 79
    • 0038122773 scopus 로고    scopus 로고
    • Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C
    • Poynard T, Ratziu V, McHutchison J, Manns M, Goodman Z, Zeuzem S, et al. Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C. Hepatology 2003;38:75-85.
    • (2003) Hepatology , vol.38 , pp. 75-85
    • Poynard, T.1    Ratziu, V.2    McHutchison, J.3    Manns, M.4    Goodman, Z.5    Zeuzem, S.6
  • 80
    • 0141682739 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndrome
    • Sanyal AJ, Contos MJ, Sterling RK, Luketic VA, Shiffman ML, Stravitz RT, et al. Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndrome. Am J Gastroenterol 2003;98:2064-2071.
    • (2003) Am J Gastroenterol , vol.98 , pp. 2064-2071
    • Sanyal, A.J.1    Contos, M.J.2    Sterling, R.K.3    Luketic, V.A.4    Shiffman, M.L.5    Stravitz, R.T.6
  • 84
    • 22744435914 scopus 로고    scopus 로고
    • Insulin resistance plays a significant role in liver fibrosis in chronic hepatitis C and in the response to antiviral therapy
    • D'souza R, Sabin CA, Foster GR. Insulin resistance plays a significant role in liver fibrosis in chronic hepatitis C and in the response to antiviral therapy. Am J Gastroenterol 2005;100:1509-1515.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1509-1515
    • D'souza, R.1    Sabin, C.A.2    Foster, G.R.3
  • 85
    • 33645932317 scopus 로고    scopus 로고
    • Hepatic steatosis is a predictor of poor response to interferon alpha-2b and ribavirin combination therapy in Japanese patients with chronic hepatitis C
    • Yaginuma R, Ikejima K, Okumura K, Kon K, Suzuki S, Takei Y, et al. Hepatic steatosis is a predictor of poor response to interferon alpha-2b and ribavirin combination therapy in Japanese patients with chronic hepatitis C. Hepatol Res 2006;35:19-25.
    • (2006) Hepatol Res , vol.35 , pp. 19-25
    • Yaginuma, R.1    Ikejima, K.2    Okumura, K.3    Kon, K.4    Suzuki, S.5    Takei, Y.6
  • 86
    • 33645968108 scopus 로고    scopus 로고
    • Effects of fatty liver and related factors on the efficacy of combination antiviral therapy in patients with chronic hepatitis C
    • Jian Wu Y, Shu Chen L, Gui Qiang W. Effects of fatty liver and related factors on the efficacy of combination antiviral therapy in patients with chronic hepatitis C. Liver Int 2006;26:166-172.
    • (2006) Liver Int , vol.26 , pp. 166-172
    • Jian Wu, Y.1    Shu Chen, L.2    Gui Qiang, W.3
  • 87
    • 33749589381 scopus 로고    scopus 로고
    • Impact of liver steatosis on the antiviral response in the hepatitis C virus-associated chronic hepatitis
    • Soresi M, Tripi S, Franco V, Giannitrapani L, Alessandri A, Rappa F, et al. Impact of liver steatosis on the antiviral response in the hepatitis C virus-associated chronic hepatitis. Liver Int 2006;26:1119-1125.
    • (2006) Liver Int , vol.26 , pp. 1119-1125
    • Soresi, M.1    Tripi, S.2    Franco, V.3    Giannitrapani, L.4    Alessandri, A.5    Rappa, F.6
  • 88
    • 0030052322 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C
    • Larrea E, Garcia N, Qian C, Civeira MP, Prieto J. Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C. Hepatology 1996;23:210-217.
    • (1996) Hepatology , vol.23 , pp. 210-217
    • Larrea, E.1    Garcia, N.2    Qian, C.3    Civeira, M.P.4    Prieto, J.5
  • 89
    • 33745580391 scopus 로고    scopus 로고
    • Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway
    • Di Bona D, Cippitelli M, Fionda C, Camma C, Licata A, Santoni A, et al. Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway. J Hepatol 2006;45:271-279.
    • (2006) J Hepatol , vol.45 , pp. 271-279
    • Di Bona, D.1    Cippitelli, M.2    Fionda, C.3    Camma, C.4    Licata, A.5    Santoni, A.6
  • 90
    • 13844294333 scopus 로고    scopus 로고
    • Etanercept as an adjuvant to interferon and ribavirin in treatment-naive patients with chronic hepatitis C virus infection: A phase 2 randomized, double-blind, placebo-controlled study
    • Zein NN. Etanercept as an adjuvant to interferon and ribavirin in treatment-naive patients with chronic hepatitis C virus infection: A phase 2 randomized, double-blind, placebo-controlled study. J Hepatol 2005;42:315-322.
    • (2005) J Hepatol , vol.42 , pp. 315-322
    • Zein, N.N.1
  • 91
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
    • Angulo P, Keach JC, Batts KP, Lindor KD. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 1999;30:1356-1362.
    • (1999) Hepatology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Keach, J.C.2    Batts, K.P.3    Lindor, K.D.4
  • 92
    • 0034950652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    • Dixon JB, Bhathal PS, O'Brien PE. Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001;121:91-100.
    • (2001) Gastroenterology , vol.121 , pp. 91-100
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 93
    • 4344628555 scopus 로고    scopus 로고
    • The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
    • viii
    • McCullough AJ. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 2004;8:521-33, viii.
    • (2004) Clin Liver Dis , vol.8 , pp. 521-533
    • McCullough, A.J.1
  • 95
    • 0842321807 scopus 로고    scopus 로고
    • Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma
    • El-Serag HB, Tran T, Everhart JE. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology 2004;126:460-468.
    • (2004) Gastroenterology , vol.126 , pp. 460-468
    • El-Serag, H.B.1    Tran, T.2    Everhart, J.E.3
  • 96
    • 15544382574 scopus 로고    scopus 로고
    • Diabetes increases the risk of hepatocellular carcinoma in the United States: A population based case control study
    • Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB. Diabetes increases the risk of hepatocellular carcinoma in the United States: A population based case control study. Gut 2005;54:533-539.
    • (2005) Gut , vol.54 , pp. 533-539
    • Davila, J.A.1    Morgan, R.O.2    Shaib, Y.3    McGlynn, K.A.4    El-Serag, H.B.5
  • 97
    • 0037714524 scopus 로고    scopus 로고
    • Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection
    • Ohata K, Hamasaki K, Toriyama K, Matsumoto K, Saeki A, Yanagi K, et al. Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Cancer (Phila) 2003;97:3036-3043.
    • (2003) Cancer (Phila) , vol.97 , pp. 3036-3043
    • Ohata, K.1    Hamasaki, K.2    Toriyama, K.3    Matsumoto, K.4    Saeki, A.5    Yanagi, K.6
  • 98
    • 85047694402 scopus 로고    scopus 로고
    • Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    • Horie Y, Suzuki A, Kataoka E, Sasaki T, Hamada K, Sasaki J, et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004;113:1774-1783.
    • (2004) J Clin Invest , vol.113 , pp. 1774-1783
    • Horie, Y.1    Suzuki, A.2    Kataoka, E.3    Sasaki, T.4    Hamada, K.5    Sasaki, J.6
  • 99
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943-1947.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3    Podsypanina, K.4    Bose, S.5    Wang, S.I.6
  • 101
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis: An inflammatory disease
    • Ross R. Atherosclerosis: An inflammatory disease. N Engl J Med 1999;340:115-126.
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 103
    • 0033613545 scopus 로고    scopus 로고
    • Novel modulator for endothelial adhesion molecules: Adipocyte-derived plasma protein adiponectin
    • Ouchi N, Kihara S, Arita Y, Maeda K, Kuriyama H, Okamoto Y, et al. Novel modulator for endothelial adhesion molecules: Adipocyte-derived plasma protein adiponectin. Circulation 1999;100:2473-2476.
    • (1999) Circulation , vol.100 , pp. 2473-2476
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3    Maeda, K.4    Kuriyama, H.5    Okamoto, Y.6
  • 104
    • 0036139677 scopus 로고    scopus 로고
    • Adiponectin, metabolic risk factors, and car diovascular events among patients with end-stage renal disease
    • Zoccali C, Mallamaci F, Tripepi G, Benedetto FA, Cutrupi S, Parlongo S, et al. Adiponectin, metabolic risk factors, and car diovascular events among patients with end-stage renal disease. J Am Soc Nephrol 2002;13:134-141.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 134-141
    • Zoccali, C.1    Mallamaci, F.2    Tripepi, G.3    Benedetto, F.A.4    Cutrupi, S.5    Parlongo, S.6
  • 105
    • 0037180472 scopus 로고    scopus 로고
    • Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice
    • Okamoto Y, Kihara S, Ouchi N, Nishida M, Arita Y, Kumada M, et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 2002;106:2767-2770.
    • (2002) Circulation , vol.106 , pp. 2767-2770
    • Okamoto, Y.1    Kihara, S.2    Ouchi, N.3    Nishida, M.4    Arita, Y.5    Kumada, M.6
  • 106
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): A randomised controlled trial
    • Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): A randomised controlled trial. Lancet 2005;366:1279-1289.
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.3    Erdmann, E.4    Massi-Benedetti, M.5    Moules, I.K.6
  • 107
    • 3042628302 scopus 로고    scopus 로고
    • Fatty liver, hypertension, and the metabolic syndrome
    • Diehl AM. Fatty liver, hypertension, and the metabolic syndrome. Gut 2004;53:923-924.
    • (2004) Gut , vol.53 , pp. 923-924
    • Diehl, A.M.1
  • 108
    • 33645963121 scopus 로고    scopus 로고
    • Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
    • Sanyal AJ, Banas C, Sargeant C, Luketic VA, Sterling RK, Stravitz RT, et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology 2006;43:682-689.
    • (2006) Hepatology , vol.43 , pp. 682-689
    • Sanyal, A.J.1    Banas, C.2    Sargeant, C.3    Luketic, V.A.4    Sterling, R.K.5    Stravitz, R.T.6
  • 109
    • 3042521502 scopus 로고    scopus 로고
    • Increased prevalence of fatty liver in arterial hypertensive patients with normal liver enzymes: Role of insulin resistance
    • Donati G, Stagni B, Piscaglia F, Venturoli N, Morselli-Labate AM, Rasciti L, et al. Increased prevalence of fatty liver in arterial hypertensive patients with normal liver enzymes: Role of insulin resistance. Gut 2004;53:1020-1023.
    • (2004) Gut , vol.53 , pp. 1020-1023
    • Donati, G.1    Stagni, B.2    Piscaglia, F.3    Venturoli, N.4    Morselli-Labate, A.M.5    Rasciti, L.6
  • 110
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 2006;355:2297-2307.
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3    Darland, C.4    Finch, J.5    Hardies, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.