Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 9, 2013, Pages 2551-2559

  Misra, Suniti ^a   Ghatak, Shibnath ^a   Patil, Neha ^b   Dandawate, Prasad ^b   Ambike, Vinita ^b   Adsule, Shreelekha ^b   Unni, Deepak ^c   Venkateswara Swamy, K ^c   Padhye, Subhash ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF PUNE   (India)

^c DR D Y PATIL BIOTECHNOLOGY AND BIOINFORMATICS INSTITUTE   (India)

Author keywords

CD44v6; Cell proliferation and drug resistance; Colon cancer; Cyclooxygenase; Dual COX LOX inhibitor; Hyaluronan; Lipoxygenase

Indexed keywords

1,4 BENZOQUINONE DERIVATIVE; 2,6 DI TERT BUTYL 4 BENZOQUINONE; ALPHA (3,5 DI TERT BUTYL 4 HYDROXYBENZYLIDENE) GAMMA BUTYROLACTONE; ARACHIDONATE 5 LIPOXYGENASE; CD44V6 ANTIGEN; CELECOXIB; CHEBULAGIC ACID; CI 987; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DARBUFELONE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ER 34122; HYALURONIC ACID; HYALURONIC ACID SYNTHETASE 2; HYDRAZIDE; LICOFELONE; LIPOXYGENASE INHIBITOR; N (3,5 DI TERT BUTYL 4 OXOCYCLOHEXA 2,5 DIENYLIDENE)BENZOHYDRAZIDE; N (3,5 DI TERT BUTYL 4 OXOCYCLOHEXA 2,5 DIENYLIDENE)ISONICOTINOHYDRAZIDE; N (3,5 DI TERT BUTYL 4 OXOCYCLOHEXA 2,5 DIENYLIDENE)NICOTINOHYDRAZIDE; S 2474; SYNTHETASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; COLON CANCER; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOLECULAR DOCKING; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANTIGENS, CD44; ANTINEOPLASTIC AGENTS; ARACHIDONATE 5-LIPOXYGENASE; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLOHEXANONES; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYALURONIC ACID; HYDRAZINES; LIPOXYGENASE INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876116149     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.02.033     Document Type: Article

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