Inhibitory effect of linoleic acid on transformation of IEC6 intestinal cells by in vitro azoxymethane treatment

International Journal of Cancer

Volumn 118, Issue 3, 2006, Pages 593-599

  Sasaki, Takamitsu ^a   Yoshida, Kazuhiro ^b   Shimura, Hideo ^c   Ichiba, Masayosi ^d   Sasahira, Tomonori ^a   Shimomoto, Takasumi ^a   Denda, Ayumi ^a   Kuniyasu, Hiroki ^a,e  

^a NARA MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d SAGA UNIVERSITY   (Japan)

^e NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Azoxymethane; Colon cancer; Linoleic acid; Peroxisome proliferator activated receptor; Transformation

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; AZOXYMETHANE; CARCINOGEN; CYCLOOXYGENASE 2; CYTOCHROME P450 2E1; DNA; LINOLEIC ACID; LIPOXYGENASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOROTHIOIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER PREVENTION; CELL GROWTH; COLON CARCINOGENESIS; COLORECTAL CANCER; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; ENZYME ASSAY; GENE EXPRESSION; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; AZOXYMETHANE; BCL-2-ASSOCIATED X PROTEIN; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; CYCLOOXYGENASE 2; CYTOCHROME P-450 CYP2E1; DNA DAMAGE; INTESTINAL MUCOSA; LIGANDS; LINOLEIC ACID; MICE; MICE, INBRED BALB C; NEOPLASMS, EXPERIMENTAL; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PHOSPHORYLATION; PPAR GAMMA; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 30444455740     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.21393     Document Type: Article

References (38)

1. Shike M, Nawer SJ, Greenwald PH, Bloch A, Hill MJ, Swaroop SV. Primary prevention of colorectal cancer. The WHO Collaborating Centre for the Prevention of Colorectal Cancer. Bull World Health Organ 1990;68:377-85.
2. Miller AB, Howe GR, Jain M, Craib KJ, Harrison L. Food items and food groups as risk factors in a case-control study of diet and colo-rectal cancer. Int J Cancer 1983;32:155-61.
3. Giovannucci E, Willett WC. Dietary factors and risk of colon cancer. Ann Med 1994;26:443-52.
4. Herschman HR, Xie W, Reddy S. Inflammation, reproduction, cancer and all that....The regulation and role of the inducible prostaglandin synthase. Bioessays 1995;17:103l-7.
5. Gupta RA, Dubois RN. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nature Rev Cancer 2001;1:11-21.
6. Singh J, Hamid R, Reddy BS. Dietary fat and colon cancer: modulation of cyclooxygenase-2 by types and amount of dietary fat during the postinitiation stage of colon carcinogenesis. Cancer Res 1997;57:3465-70.
7. Chang WC, Chapkin RS, Lupton JR. Predictive value of proliferation, differentiation and apoptosis as intermediate markers for colon tumorigenesis. Carcinogenesis 1997;18:721-30.
8. Reddy BS, Burill C, Rigotty J. Effect of diets high in ω-3 and ω-6 fatty acids on initiation and postinitiation stages of colon carcinogenesis. Cancer Res 1991;51:487-91.
9. Zhou S, Wang G, Chen B, Wang P. Effect of dietary fatty acids on tumorigenesis of colon cancer induced by methyl nitrosourea in rats. J Environ Pathol Toxicol Oncol 2000;19:81-6.
10. Rao CV, Hirose Y, Indranie C, Reddy BS. Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids. Cancer Res 2001;61:1927-33.
11. Morotomi M, Sakaitani Y, Satou M, Takahashi T, Takagi A, Onoue M. Effects of a high-fat diet on azoxymethane-induced aberrant crypt foci and fecal biochemistry and microbial activity in rats. Nutr Cancer 1997;27:84-91.
12. Takahashi M, Wakabayashi K. Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci 2004;95:475-80.
13. Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR-y. Cell 1998;93:229-40.
14. Belury MA. Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. J Nutr 2002;132:2995-8.
15. Miller A. Stanton C, Devery R. Cis 9,trans 11- and trans 10,cis 12-conjugated linoleic acid isomers induce apoptosis in cultured SW480 cells. Anticancer Res 2002;22:3879-87.
16. Osawa E, Nakajima A, Wada K, Ishimine S, Fujisawa N, Kawamori T, Matsuhashi N, Kadowaki T, Ochiai M, Sekihara H, Nakagama H. Peroxisome proliferator-activated receptor γ ligands suppress colon carcinogenesis induced by azoxymethane in mice. Gastroenterology 2003;124:361-7.
17. Funk CD. The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice. Biochim Biophys Acta 1996;1304:65-84.
18. Steele VE, Holmes CA, Hawk ET, Kopelovich L, Lubet RA, Crowell JA, Sigman CC, Kelloff GJ. Potential use of lipoxygenase inhibitors for cancer chemoprevention. Expert Opin Investig Drugs 2000;9:2121-38.
19. Yang WL, Frucht H. Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells. Carcinogenesis 2001;22:1379-83.
20. Desreumaux P, Dubuquoy L, Nutten S, Peuchmaur M, Englaro W, Schoonjans K, Derijard B, Desvergne B, Wahli W, Chambon P, Leibowitz MD, Colombel JF, Auwerx J. Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor γ (PPAR-γ) heterodimer. A basis for new therapeutic strategies. J Exp Med 2001;193:827-38.
21. Schild RL, Schaiff WT, Carlson MG, Cronbach EJ, Nelson DM, Sadovsky Y. The activity of PPARγ in primary human trophoblasts is enhanced by oxidized lipids. J Clin Endocrinol Metab 2002;87:1105-10.
22. Chen GG, Xu H, Lee JF, Subramaniam M, Leung KL, Wang SH, Chan UP, Speisberg TC. 15-Hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor γ-dependent pathway. Int J Cancer 2003;107:837-43.
23. Quaroni A, Isselbacher KJ, Ruoslahti E. Fibronectin synthesis by epithelial crypt cells of rat small intestine. Proc Natl Acad Sci USA 1978;75:5548-52.
24. Conteas CN, Majumdar AP. The effects of gastrin, epidermal growth factor, and somatostatin on DNA synthesis in a small intestinal crypt cell line (IEC-6). Proc Soc Exp Biol Med 1987;184:307-11.
25. Nesterova M, Cho-Chung YS. Killing the messenger: antisense DNA and siRNA. Curr Drug Targets 2004;5:683-9.
26. Guengerich FP, Wang P, Davidson NK. Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Biochemistry 1982;21:1698-1706.
27. Zhuge J, Luo Y, Yu YN. Heterologous expression of human cytochrome P450 2E1 in HepG2 cell line. World J Gastroenterol 2003;9:2732-6.
28. Kip1 in a human gastric carcinoma cell line. Cell Growth Differ 1997;8:47-52.
29. Li Q, Cheon YP, Kannan A, Shanker S, Bagchi IC, Bagchi MK. A novel pathway involving progesterone receptor. 12/15-lipoxygenase-derived eicosanoids, and peroxisome proliferator-activated receptor γ regulates implantation in mice. J Biol Chem 2004;279:11570-81.
30. Osawa E, Nakajima A, Wada K, Ishimine S, Fujisawa N, Kawamori T, Matsuhashi N. Kadowaki T, Ochiai M, Sekihara H, Nakagama H. Peroxisome proliferator-activated receptor γ ligands suppress colon carcinogenesis induced by azoxymethane in mice. Gastroenterology 2003;124:361-7.
31. Tanaka T, Kohno H, Yoshitani S, Takashima S, Okumura A, Murakami A, Hosokawa M. Ligands for peroxisome proliferator-activated receptors α and γ inhibit chemically induced colitis and formation of aberrant crypt foci in rats. Cancer Res 2001;61:2424-8.
32. Kohno H, Yoshitani S, Takashima S, Okumura A, Hosokawa M, Yamaguchi N, Tanaka T. Troglitazone, a ligand for peroxisome proliferator-activated receptor γ, inhibits chemically-induced aberrant crypt foci in rats. Jpn J Cancer Res 2001;92:396-403.
33. Chen A, Xu J. Activation of PPARγ by curcumin inhibits Moser cell growth and mediates the suppression of the gene expression of cyclinD1 and EGFR. Am J Physiol Gastrointest Liver Physiol 2004;14:14.
34. Liu JJ, Huang RW, Lin DJ, Peng J, Wu XY, Lin Q, Pan XL, Song YQ, Zhang MH, Hou M, Chen F. Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor-γ ligands induces apoptosis on human myeloid leukemia cells in vitro. Ann Oncol 2005;10:10.
35. Hsi LC, Wilson L, Nixon J, Eling TE. 15-Lipoxygenase-1 metabolites down-regulate peroxisome proliferator-activated receptor γ via the MAPK signaling pathway. J Biol Chem 2001;276:34545-52.
36. Sohn OS, Ishizaki H, Yang CS, Fiala ES. Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1. Carcinogenesis 1991;12:127-31.
37. Feinberg A, Zedeck MS. Production of a highly reactive alkylating agent from the organospecific carcinogen methylazoxymethanol by alcohol dehydrogenase. Cancer Res 1980;40:4446-50.
38. Sohn OS, Fiala ES, Requeijo SP, Weisburger JH, Gonzalez FJ. Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol. Cancer Res 2001;61:8435-40.