Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series

Journal of Medicinal Chemistry

Volumn 42, Issue 7, 1999, Pages 1161-1169

  Song, Yuntao ^a   Connor, David T ^a   Sercel, Anthony D ^a   Sorenson, Roderick J ^a   Doubleday, Robert ^a   Unangst, Paul C ^a   Roth, Bruce D ^a   Beylin, Vlad G ^a   Gilbertsen, Richard B ^a   Chan, Kam ^a   Schrier, Denis J ^a   Guglietta, Antonio ^a   Bornemeier, Dirk A ^a   Dyer, Richard D ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 THIADIAZOLE DERIVATIVE; 1,3,4 THIADIAZOLE DERIVATIVE; 2,6 DI TERT BUTYL 4 (5 ETHYLSULFANYL[1,3,4] THIADIAZOL 2 YL)PHENOL; 2,6 DI TERT BUTYL 4 (5 ETHYLTHIO 1,3,4 THIADIAZOL 2 YL)PHENOL; 2,6 DI TERT BUTYLPHENOL; CYCLOOXYGENASE 2 INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPARATIVE STUDY; DIGESTIVE SYSTEM ULCER; DOSE RESPONSE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; FOOT PAD; MALE; NONHUMAN; PROSTAGLANDIN SYNTHESIS INHIBITION; RAT; STOMACH MUCOSA; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD PLATELETS; CARRAGEENAN; CELL LINE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; EDEMA; GASTRIC MUCOSA; HUMANS; HYPERALGESIA; ISOENZYMES; MALE; MEMBRANE PROTEINS; MICE; PHENOLS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SHEEP; STOMACH ULCER; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 0033535606     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980570y     Document Type: Article

References (30)

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