Design and syntheses of diarylisoxazoles: Novel inhibitors of cyclooxygenase-2 (COX-2) with analgesic-antiinflammatory activity

Drug Development Research

Volumn 51, Issue 4, 2000, Pages 273-286

  Habeeb, Amgad G ^a   Praveen Rao, P N ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Analgesic antiinflammatory activity; Cyclooxygenase inhibition; Diarylisoxazoles; Molecular modeling

Indexed keywords

3,4 DIPHENYL 5 TRIFLUOROMETHYLISOXAZOLE DERIVATIVE; 4,5 DIPHENYL 3 METHYLSULFONAMIDOISOXAZOLE; 4,5 DIPHENYLISOXAZOLE DERIVATIVE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; ISOMERISM; MALE; MOLECULAR MODEL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0034463263     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.9     Document Type: Article

References (11)

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