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Volumn 288, Issue 13, 2013, Pages 9428-9437

Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE SUBSTITUTION; C-TERMINAL DOMAINS; CASEIN KINASE; CATENIN SIGNALING; ELECTROPHORETIC MOBILITY SHIFT; MOBILITY SHIFT; NEURITE OUTGROWTH; WNT SIGNALING;

EID: 84875972585     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.448480     Document Type: Article
Times cited : (54)

References (54)
  • 1
    • 0027954477 scopus 로고
    • The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal
    • Klingensmith, J., Nusse, R., and Perrimon, N. (1994) The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev. 8, 118-130
    • (1994) Genes Dev , vol.8 , pp. 118-130
    • Klingensmith, J.1    Nusse, R.2    Perrimon, N.3
  • 2
    • 0027944513 scopus 로고
    • Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled
    • Sussman, D. J., Klingensmith, J., Salinas, P., Adams, P. S., Nusse, R., and Perrimon, N. (1994) Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. Dev. Biol. 166, 73-86
    • (1994) Dev. Biol. , vol.166 , pp. 73-86
    • Sussman, D.J.1    Klingensmith, J.2    Salinas, P.3    Adams, P.S.4    Nusse, R.5    Perrimon, N.6
  • 3
    • 77951888466 scopus 로고    scopus 로고
    • Dishevelled. The hub of Wnt signaling
    • Gao, C., and Chen, Y. G. (2010) Dishevelled. The hub of Wnt signaling. Cell Signal. 22, 717-727
    • (2010) Cell Signal , vol.22 , pp. 717-727
    • Gao, C.1    Chen, Y.G.2
  • 4
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • Klaus, A., and Birchmeier, W. (2008) Wnt signalling and its impact on development and cancer. Nat. Rev. Cancer 8, 387-398
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 5
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling in development and disease
    • Clevers, H. (2006) Wnt/β-catenin signaling in development and disease. Cell 127, 469-480
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 6
    • 0041695485 scopus 로고    scopus 로고
    • A second canon. Functions and mechanisms of β-catenin-independent Wnt signaling
    • Veeman, M. T., Axelrod, J. D., and Moon, R. T. (2003) A second canon. Functions and mechanisms of β-catenin-independent Wnt signaling. Dev. Cell 5, 367-377
    • (2003) Dev. Cell , vol.5 , pp. 367-377
    • Veeman, M.T.1    Axelrod, J.D.2    Moon, R.T.3
  • 7
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling. Components, mechanisms, and diseases
    • MacDonald, B. T., Tamai, K., and He, X. (2009) Wnt/β-catenin signaling. Components, mechanisms, and diseases. Dev. Cell 17, 9-26
    • (2009) Dev. Cell , vol.17 , pp. 9-26
    • Macdonald, B.T.1    Tamai, K.2    He, X.3
  • 10
    • 41149156857 scopus 로고    scopus 로고
    • Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinasedependent mechanism
    • Endo, Y., Beauchamp, E., Woods, D., Taylor, W. G., Toretsky, J. A., Uren, A., and Rubin, J. S. (2008) Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinasedependent mechanism. Mol. Cell. Biol. 28, 2368-2379
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 2368-2379
    • Endo, Y.1    Beauchamp, E.2    Woods, D.3    Taylor, W.G.4    Toretsky, J.A.5    Uren, A.6    Rubin, J.S.7
  • 11
    • 0035966322 scopus 로고    scopus 로고
    • Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1
    • Habas, R., Kato, Y., and He, X. (2001) Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell 107, 843-854
    • (2001) Cell , vol.107 , pp. 843-854
    • Habas, R.1    Kato, Y.2    He, X.3
  • 12
    • 2442680430 scopus 로고    scopus 로고
    • Wnt proteins induce dishevelled phosphorylation via an LRP5/6-independent mechanism, irrespective of their ability to stabilize β-catenin
    • González-Sancho, J. M., Brennan, K. R., Castelo-Soccio, L. A., and Brown, A. M. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6-independent mechanism, irrespective of their ability to stabilize β-catenin. Mol. Cell. Biol. 24, 4757-4768
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 4757-4768
    • González-Sancho, J.M.1    Brennan, K.R.2    Castelo-Soccio, L.A.3    Brown, A.M.4
  • 13
    • 33846396811 scopus 로고    scopus 로고
    • Frizzled/PCP signalling. A conserved mechanism regulating cell polarity and directed motility
    • Seifert, J. R., and Mlodzik, M. (2007) Frizzled/PCP signalling. A conserved mechanism regulating cell polarity and directed motility. Nat. Rev. Genet. 8, 126-138
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 126-138
    • Seifert, J.R.1    Mlodzik, M.2
  • 16
    • 38949187882 scopus 로고    scopus 로고
    • Tumor formation due to abnormalities in the β-catenin-independent pathway of Wnt signaling
    • Kikuchi, A., and Yamamoto, H. (2008) Tumor formation due to abnormalities in the β-catenin-independent pathway of Wnt signaling. Cancer Sci. 99, 202-208
    • (2008) Cancer Sci , vol.99 , pp. 202-208
    • Kikuchi, A.1    Yamamoto, H.2
  • 17
    • 67650594771 scopus 로고    scopus 로고
    • The opposing roles of Wnt-5a in cancer
    • McDonald, S. L., and Silver, A. (2009) The opposing roles of Wnt-5a in cancer. Br. J. Cancer 101, 209-214
    • (2009) Br. J. Cancer , vol.101 , pp. 209-214
    • McDonald, S.L.1    Silver, A.2
  • 18
    • 77953539908 scopus 로고    scopus 로고
    • Cell/ tissue-tropic functions of Wnt5a signaling in normal and cancer cells
    • Nishita, M., Enomoto, M., Yamagata, K., and Minami, Y. (2010) Cell/ tissue-tropic functions of Wnt5a signaling in normal and cancer cells. Trends Cell Biol. 20, 346-354
    • (2010) Trends Cell Biol , vol.20 , pp. 346-354
    • Nishita, M.1    Enomoto, M.2    Yamagata, K.3    Minami, Y.4
  • 19
    • 58749106826 scopus 로고    scopus 로고
    • β-Catenin-independent Wnt pathways. Signals, core proteins, and effectors
    • James, R. G., Conrad, W. H., and Moon, R. T. (2008) β-Catenin- independent Wnt pathways. Signals, core proteins, and effectors. Methods Mol. Biol. 468, 131-144
    • (2008) Methods Mol. Biol. , vol.468 , pp. 131-144
    • James, R.G.1    Conrad, W.H.2    Moon, R.T.3
  • 21
    • 80054777961 scopus 로고    scopus 로고
    • New insights into the mechanism of Wnt signaling pathway activation
    • Kikuchi, A., Yamamoto, H., Sato, A., and Matsumoto, S. (2011) New insights into the mechanism of Wnt signaling pathway activation. Int. Rev. Cell Mol. Biol. 291, 21-71
    • (2011) Int. Rev. Cell Mol. Biol. , vol.291 , pp. 21-71
    • Kikuchi, A.1    Yamamoto, H.2    Sato, A.3    Matsumoto, S.4
  • 22
    • 37349025355 scopus 로고    scopus 로고
    • SnapShot. Noncanonical Wnt signaling pathways
    • Semenov, M. V., Habas, R., Macdonald, B. T., and He, X. (2007) SnapShot. Noncanonical Wnt signaling pathways. Cell 131, 1378
    • (2007) Cell , vol.131 , pp. 1378
    • Semenov, M.V.1    Habas, R.2    Macdonald, B.T.3    He, X.4
  • 23
    • 0037229938 scopus 로고    scopus 로고
    • Runnin' with the Dvl. Proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction
    • Wharton, K. A., Jr. (2003) Runnin' with the Dvl. Proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev. Biol. 253, 1-17
    • (2003) Dev. Biol. , vol.253 , pp. 1-17
    • Wharton Jr., K.A.1
  • 24
    • 29244462476 scopus 로고    scopus 로고
    • The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles
    • Schwarz-Romond, T., Merrifield, C., Nichols, B. J., and Bienz, M. (2005) The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles. J. Cell Sci. 118, 5269-5277
    • (2005) J. Cell Sci. , vol.118 , pp. 5269-5277
    • Schwarz-Romond, T.1    Merrifield, C.2    Nichols, B.J.3    Bienz, M.4
  • 25
    • 34547750005 scopus 로고    scopus 로고
    • Dynamic recruitment of axin by Dishevelled protein assemblies
    • Schwarz-Romond, T., Metcalfe, C., and Bienz, M. (2007) Dynamic recruitment of axin by Dishevelled protein assemblies. J. Cell Sci. 120, 2402-2412
    • (2007) J. Cell Sci. , vol.120 , pp. 2402-2412
    • Schwarz-Romond, T.1    Metcalfe, C.2    Bienz, M.3
  • 27
    • 34250827150 scopus 로고    scopus 로고
    • Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
    • Bilic, J., Huang, Y. L., Davidson, G., Zimmermann, T., Cruciat, C. M., Bienz, M., and Niehrs, C. (2007) Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 316, 1619-1622
    • (2007) Science , vol.316 , pp. 1619-1622
    • Bilic, J.1    Huang, Y.L.2    Davidson, G.3    Zimmermann, T.4    Cruciat, C.M.5    Bienz, M.6    Niehrs, C.7
  • 29
    • 0033597886 scopus 로고    scopus 로고
    • Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway
    • Lee, J. S., Ishimoto, A., and Yanagawa, S. (1999) Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. J. Biol. Chem. 274, 21464-21470
    • (1999) J. Biol. Chem. , vol.274 , pp. 21464-21470
    • Lee, J.S.1    Ishimoto, A.2    Yanagawa, S.3
  • 30
    • 33947312488 scopus 로고    scopus 로고
    • Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism
    • Bryja, V., Schulte, G., Rawal, N., Grahn, A., and Arenas, E. (2007) Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J. Cell Sci. 120, 586-595
    • (2007) J. Cell Sci. , vol.120 , pp. 586-595
    • Bryja, V.1    Schulte, G.2    Rawal, N.3    Grahn, A.4    Arenas, E.5
  • 31
    • 23444459214 scopus 로고
    • Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells
    • van Leeuwen, F., Samos, C. H., and Nusse, R. (1994) Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells. Nature 368, 342-344
    • (1994) Nature , vol.368 , pp. 342-344
    • Van Leeuwen, F.1    Samos, C.H.2    Nusse, R.3
  • 32
    • 0035802116 scopus 로고    scopus 로고
    • Physiological regulation of β′-catenin stability by Tcf3 and CK1ε
    • Lee, E., Salic, A., and Kirschner, M. W. (2001) Physiological regulation of β′-catenin stability by Tcf3 and CK1ε. J. Cell Biol. 154, 983-993
    • (2001) J. Cell Biol. , vol.154 , pp. 983-993
    • Lee, E.1    Salic, A.2    Kirschner, M.W.3
  • 33
    • 15244360639 scopus 로고    scopus 로고
    • Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation
    • Schulte, G., Bryja, V., Rawal, N., Castelo-Branco, G., Sousa, K. M., and Arenas, E. (2005) Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation. J. Neurochem. 92, 1550-1553
    • (2005) J. Neurochem. , vol.92 , pp. 1550-1553
    • Schulte, G.1    Bryja, V.2    Rawal, N.3    Castelo-Branco, G.4    Sousa, K.M.5    Arenas, E.6
  • 34
    • 33846235822 scopus 로고    scopus 로고
    • Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate β-catenin
    • Bryja, V., Schulte, G., and Arenas, E. (2007) Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate β-catenin. Cell Signal. 19, 610-616
    • (2007) Cell Signal , vol.19 , pp. 610-616
    • Bryja, V.1    Schulte, G.2    Arenas, E.3
  • 35
    • 80755139617 scopus 로고    scopus 로고
    • Functional dissection of phosphorylation of Disheveled in Drosophila
    • Yanfeng, W. A., Berhane, H., Mola, M., Singh, J., Jenny, A., and Mlodzik, M. (2011) Functional dissection of phosphorylation of Disheveled in Drosophila. Dev. Biol. 360, 132-142
    • (2011) Dev. Biol. , vol.360 , pp. 132-142
    • Yanfeng, W.A.1    Berhane, H.2    Mola, M.3    Singh, J.4    Jenny, A.5    Mlodzik, M.6
  • 36
    • 33749380033 scopus 로고    scopus 로고
    • Site-specific casein kinase 1ε-dependent phosphorylation of Dishevelled modulates β-catenin signaling
    • Klimowski, L. K., Garcia, B. A., Shabanowitz, J., Hunt, D. F., and Virshup, D. M. (2006) Site-specific casein kinase 1ε-dependent phosphorylation of Dishevelled modulates β-catenin signaling. FEBS J. 273, 4594-4602
    • (2006) FEBS J , vol.273 , pp. 4594-4602
    • Klimowski, L.K.1    Garcia, B.A.2    Shabanowitz, J.3    Hunt, D.F.4    Virshup, D.M.5
  • 37
    • 33746615950 scopus 로고    scopus 로고
    • PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin- Darby canine kidney cells
    • Elbert, M., Cohen, D., and Müsch, A. (2006) PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin- Darby canine kidney cells. Mol. Biol. Cell 17, 3345-3355
    • (2006) Mol. Biol. Cell , vol.17 , pp. 3345-3355
    • Elbert, M.1    Cohen, D.2    Müsch, A.3
  • 38
    • 77958462847 scopus 로고    scopus 로고
    • Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1
    • Kikuchi, K., Niikura, Y., Kitagawa, K., and Kikuchi, A. (2010) Dishevelled, a Wnt signalling component, is involved in mitotic progression in cooperation with Plk1. EMBO J. 29, 3470-3483
    • (2010) EMBO J , vol.29 , pp. 3470-3483
    • Kikuchi, K.1    Niikura, Y.2    Kitagawa, K.3    Kikuchi, A.4
  • 40
    • 13844294211 scopus 로고    scopus 로고
    • The casein kinase 1 family. Participation in multiple cellular processes in eukaryotes
    • Knippschild, U., Gocht, A., Wolff, S., Huber, N., Löhler, J., and Stöter, M. (2005) The casein kinase 1 family. Participation in multiple cellular processes in eukaryotes. Cell Signal. 17, 675-689
    • (2005) Cell Signal , vol.17 , pp. 675-689
    • Knippschild, U.1    Gocht, A.2    Wolff, S.3    Huber, N.4    Löhler, J.5    Stöter, M.6
  • 41
    • 0037155691 scopus 로고    scopus 로고
    • Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism
    • Liu, C., Li, Y., Semenov, M., Han, C., Baeg, G. H., Tan, Y., Zhang, Z., Lin, X., and He, X. (2002) Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108, 837-847
    • (2002) Cell , vol.108 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3    Han, C.4    Baeg, G.H.5    Tan, Y.6    Zhang, Z.7    Lin, X.8    He, X.9
  • 42
  • 43
    • 79955506828 scopus 로고    scopus 로고
    • Casein kinase 1δ functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth
    • Greer, Y. E., and Rubin, J. S. (2011) Casein kinase 1δ functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth. J. Cell Biol. 192, 993-1004
    • (2011) J. Cell Biol. , vol.192 , pp. 993-1004
    • Greer, Y.E.1    Rubin, J.S.2
  • 45
    • 3042848976 scopus 로고    scopus 로고
    • Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize β-catenin independently of Frizzled proteins
    • Brennan, K., Gonzalez-Sancho, J. M., Castelo-Soccio, L. A., Howe, L. R., and Brown, A. M. (2004) Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize β-catenin independently of Frizzled proteins. Oncogene 23, 4873-4884
    • (2004) Oncogene , vol.23 , pp. 4873-4884
    • Brennan, K.1    Gonzalez-Sancho, J.M.2    Castelo-Soccio, L.A.3    Howe, L.R.4    Brown, A.M.5
  • 47
    • 84855416391 scopus 로고    scopus 로고
    • Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells
    • Baljinnyam, B., Klauzinska, M., Saffo, S., Callahan, R., and Rubin, J. S. (2012) Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells. PLoS One 7, e29455
    • (2012) PLoS One , vol.7
    • Baljinnyam, B.1    Klauzinska, M.2    Saffo, S.3    Callahan, R.4    Rubin, J.S.5
  • 48
    • 0028989112 scopus 로고
    • The dishevelled protein is modified by wingless signaling in Drosophila
    • Yanagawa, S., van Leeuwen, F., Wodarz, A., Klingensmith, J., and Nusse, R. (1995) The dishevelled protein is modified by wingless signaling in Drosophila. Genes Dev. 9, 1087-1097
    • (1995) Genes Dev , vol.9 , pp. 1087-1097
    • Yanagawa, S.1    Van Leeuwen, F.2    Wodarz, A.3    Klingensmith, J.4    Nusse, R.5
  • 49
    • 0030265570 scopus 로고    scopus 로고
    • Afrizzled homolog functions in a vertebrate Wnt signaling pathway
    • Yang-Snyder, J., Miller, J. R., Brown, J. D., Lai, C. J., and Moon, R. T. (1996) Afrizzled homolog functions in a vertebrate Wnt signaling pathway. Curr. Biol. 6, 1302-1306
    • (1996) Curr. Biol. , vol.6 , pp. 1302-1306
    • Yang-Snyder, J.1    Miller, J.R.2    Brown, J.D.3    Lai, C.J.4    Moon, R.T.5
  • 50
    • 0037126331 scopus 로고    scopus 로고
    • The DIX domain targets dishevelled to actin stress fibres and vesicular membranes
    • Capelluto, D. G., Kutateladze, T. G., Habas, R., Finkielstein, C. V., He, X., and Overduin, M. (2002) The DIX domain targets dishevelled to actin stress fibres and vesicular membranes. Nature 419, 726-729
    • (2002) Nature , vol.419 , pp. 726-729
    • Capelluto, D.G.1    Kutateladze, T.G.2    Habas, R.3    Finkielstein, C.V.4    He, X.5    Overduin, M.6
  • 51
    • 0031172433 scopus 로고    scopus 로고
    • Human dishevelled genes constitute a DHR-containing multigene family
    • Semënov, M. V., and Snyder, M. (1997) Human dishevelled genes constitute a DHR-containing multigene family. Genomics 42, 302-310
    • (1997) Genomics , vol.42 , pp. 302-310
    • Semënov, M.V.1    Snyder, M.2
  • 52
    • 0033598401 scopus 로고    scopus 로고
    • Casein kinase i transduces Wnt signals
    • Peters, J. M., McKay, R. M., McKay, J. P., and Graff, J. M. (1999) Casein kinase I transduces Wnt signals. Nature 401, 345-350
    • (1999) Nature , vol.401 , pp. 345-350
    • Peters, J.M.1    McKay, R.M.2    McKay, J.P.3    Graff, J.M.4
  • 54
    • 84875968695 scopus 로고    scopus 로고
    • Atypical protein kinaseC is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated Dishevelled 2
    • Greer, Y. E., Fields, A. P., Brown, A. M., and Rubin, J. S. (2013) Atypical protein kinaseC is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated Dishevelled 2. J. Biol. Chem. 288, 9438-9446
    • (2013) J. Biol. Chem. , vol.288 , pp. 9438-9446
    • Greer, Y.E.1    Fields, A.P.2    Brown, A.M.3    Rubin, J.S.4


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