The DIX domain targets dishevelled to actin stress fibres and vesicular membranes

Nature

Volumn 419, Issue 6908, 2002, Pages 726-729

  Capelluto, Daniel G S ^a   Kutateladze, Tatiana G ^a   Habas, Raymond ^a,b,c   Finkielstein, Carla V ^a   He, Xi ^b   Overduin, Michael ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS; TUMORS;

MUTATIONS;

BIOLOGICAL MEMBRANES;

ACTIN; BETA CATENIN; PHOSPHOLIPID;

CANCER; MUTATION;

ARTICLE; CELL DIVISION; CELL PROLIFERATION; CELL STRUCTURE; COLORECTAL CANCER; CYTOSKELETON; EMBRYO; GASTRULATION; MEMBRANE VESICLE; MUTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; STRESS FIBER;

ACTINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; ANIMALS; CHO CELLS; CRICETINAE; CYTOPLASMIC VESICLES; EMBRYO, NONMAMMALIAN; HUMANS; INTRACELLULAR MEMBRANES; MICE; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEINS; REPRESSOR PROTEINS; SEQUENCE DELETION; STRESS FIBERS; XENOPUS LAEVIS;

EUKARYOTA;

EID: 0037126331     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01056     Document Type: Article

References (30)

1. Peifer, M. & Polakis, P. Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science 287, 1606-1609 (2000).
2. Moon, R. T. & Kimelman, D. From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus. BioEssays 20, 536-545 (1998).
3. Habas, R., Kato, Y. & He, X. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell 107, 843-854 (2001).
4. Tada, M. & Smith, J. C. Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development 127, 2227-2238 (2000).
5. Wallingford, J. B. et al. Dishevelled controls cell polarity during Xenopus gastrulation. Nature 405, 81-85 (2000).
6. Gho, M. & Schweisguth, F. Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila. Nature 393, 178-181 (1998).
7. Cadigan, K. M. & Nusse, R. Wnt signaling: a common theme in animal development. Genes Dev. 11, 3286-3305 (1997).
8. Torres, M. A. & Nelson, W. J. Colocalization and redistribution of dishevelled and actin during Wnt-induced mesenchymal morphogenesis. J. Cell Biol. 149, 1433-1442 (2000).
9. Pantaloni, D., Le Clainche, C. & Carlier, M. F. Mechanism of actin-based motility. Science 292, 1502-1506 (2001).
10. Yanagawa, S., van Leeuwen, E, Wodarz, A., Klingensmith, J. & Nusse, R. The dishevelled protein is modified by wingless signaling in Drosophila. Genes Dev. 9, 1087-1097 (1995).
11. Krylova, O., Messenger, M. J. & Salinas, P. C. Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3β. J. Cell Biol. 151, 83-94 (2000).
12. Morfini, G., Szebenyi, G., Elluru, R., Ratner, N. & Brady, S. T. Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility. EMBO J. 21, 281-293 (2002).
13. Adamson, P., Paterson, H. F. & Hall, A. Intracellular localization of the P21rho proteins. J. Cell Biol. 119, 617-627 (1992).
14. Smalley, M. J. et al. Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription. EMBO J. 18, 2823-2835 (1999).
15. Miller, J. R. et al. Establishment of the dorsal-ventral axis in Xenopus embryos coincides with the dorsal enrichment of dishevelled that is dependent on cortical rotation. J. Cell Biol. 146, 427-437 (1999).
16. Sun, T. Q. et al. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nature Cell Biol. 3, 628-636 (2001).
17. Kishida, S. et al. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate β-catenin stability. Mol. Cell. BioL 19, 4414-4422 (1999).
18. Li, L. et al. Axin and Frat 1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J. 18, 4233-4240 (1999).
19. Henry, G. D. & Sykes, B. D. Methods to study membrane protein structure in solution. Methods Enzymol. 239, 515-535 (1994).
20. Yarmola, E. G., Edison, A. S., Lenox, R. H. & Bubb, M. R. Actin filament cross-linking by MARCKS: characterization of two actin-binding sites within the phosphorylation site domain. J. Biol. Chem. 276, 22351-22358 (2001).
21. Vancompernolle, K., Vandekerckhove, J., Bubb, M. R. & Korn, E. D. The interfaces of actin and Acanthamoeba actobindin. Identification of a new actin-binding motif. J. Biol. Chem. 266, 15427-15431 (1991).
22. Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T. & Perrimon, N. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev. 12, 2610-2622 (1998).
23. Rothbacher, U. et al. Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J. 19, 1010-1022 (2000).
24. Fagotto, F. et al. Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization. J. Cell Biol. 145, 741-756 (1999).
25. Axelrod, J. D. Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. Genes Dev. 15, 1182-1187 (2001).
26. Peters, J. M., McKay, R. M., McKay, J. P. & Graff, J. M. Casein kinase 1 transduces Wnt signals. Nature 401, 345-350 (1999).
27. Seeling, J. M. et al. Regulation of β-catenin signaling by the B56 subunit of protein phosphatase 2A. Science 283, 2089-2091 (1999).
28. Dahmen, R. P. et al. Deletions of axin1, a component of the wnt/wingless pathway, in sporadic medulloblastomas. Cancer Res. 61, 7039-7043 (2001).
29. Anderson, C. W., Baum, P. R. & Gestaland, R. F. Processing of adenovirus 2-induced proteins. J. Virol. 12, 241-252 (1973).
30. Kato, Y., Shi, Y. & He, X. Neuralization of the Xenopus embryo by inhibition of p300/CREB-binding protein function. J. Neurosci. 19, 9364-9373 (1999).