β-Catenin-independent Wnt pathways: Signals, core proteins, and effectors

Methods in Molecular Biology

Volumn 468, Issue , 2008, Pages 131-144

  James, Richard G ^a   Conrad, William H ^a   Moon, Randall T ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Wnt; Wnt Ca; Wnt PCP

Indexed keywords

BETA CATENIN; CALCIUM; DISHEVELLED PROTEINS; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; FRIZZLED PROTEIN; PHOSPHOPROTEIN; PRICKLE PROTEIN, DROSOPHILA; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL; ARTICLE; DROSOPHILA MELANOGASTER; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BETA CATENIN; CALCIUM; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FRIZZLED RECEPTORS; PHOSPHOPROTEINS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 58749106826     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-249-6_10     Document Type: Article

References (81)

1. Moon, R.T., A.D. Kohn, G.V. De Ferrari, and A. Kaykas. (2004) WNT and betacatenin signalling: diseases and therapies. Nat Rev Genet. 5, 691-701.
2. Seifert, J.R. and M. Mlodzik. (2007) Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility. Nat Rev Genet. 8,126-138.
3. Wu, J., T.J. Klein, and M. Mlodzik. (2004) Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity. PLoS Biol. 2, El58.
4. Amonlirdviman, K., N.A. Khare, D. R Tree, W.S. Chen, J.D. Axelrod, and C.J. Tomlin. (2005) Mathematical modeling of planar cell polarity to understand domineering nonautonomy. Science. 307, 423-426.
5. Yang, C.H., J.D. Axelrod, and M.A. Simon. (2002) Regulation of Frizzled by fat-like Cadherins during planar polarity signaling in the Drosophila compound eye. Cell. 108, 675-688.
6. Axelrod, J.D. (2001) Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. Genes Dev. 15, 1182-1187.
7. Das, G., A. Jenny, T.J. Klein, S. Eaton, and M. Mlodzik. (2004) Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes. Development. 131, 4467-4476.
8. Strutt, D.I. (2001) Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing. Mol Cell. 7, 367-375.
9. Bastock, R., H. Strutt, and D. Strutt. (2003) Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning. Development. 130, 3007-3014.
10. Tree, D.R., J.M. Shulman, R. Rousset, M.P. Scott, D. Gubb, and J.D. Axelrod. (2002) Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Cell. 109, 371-381.
11. Jenny, A., J. Reynolds-Kenneally, G. Das, M. Burnett, and M. Mlodzik. (2005) Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding. Nat Cell Biol. 7, 691-697.
12. Usui, T., Y. Shima, Y. Shimada, S. Hirano, R.W. Burgess, T.L. Schwarz, et al. (1999) Flamingo, a seven-pass transmembrane Cadherin, regulates planar cell polarity under the control of Frizzled. Cell. 98, 585-595.
13. Adler, P.N., J. Charlton, K.H. Jones, and J. Liu. (1994) The cold-sensitive period for frizzled in the development of wing hair polarity ends prior to the start of hair morphogenesis. Mech Dev. 46, 101-107.
14. Eaton, S., R. Wepf, and K. Simons. (1996) Roles for Racl and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila. J Cell Biol. 135, 1277-1289.
15. Fanto, M., U. Weber, D.I. Strutt, and M. Mlodzik. (2000) Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. Curr Biol. 10, 979-988.
16. Schwarz-Romond, T., C. Asbrand, J. Bakkers, M. Kuhl, H.J. Schaeffer, J. Huelsken, et al. (2002) The ankyrin repeat protein Diversin recruits Casein lcinase Iepsilon to the betacatenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev. 16, 2073-2084.
17. Park, M. and R.T. Moon. (2002) The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nat Cell Biol. 4, 20-25.
18. Wallingford, J.B., B.A. Rowning, K.M. Vogeli, U. Rothbacher, S.E. Fraser, and R.M.Harland. (2000) Dishevelled controls cell polarity during Xenopus gastrulation. Nature. 405, 81-85.
19. Wang, J., N.S. Hamblet, S. Mark, M.E. Dickinson, B.C. Brinkman, N. Segil, et al. (2006) Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development. 133, 1767-1778.
20. Formstone, C.J. and I. Mason. (2005) Combinatorial activity of Flamingo proteins directs convergence and extension within the early zebrafish embryo via the planar cell polarity pathway. Dev Biol. 282, 320-335.
21. Takeuchi, M., J. Nakabayashi, T. Sakaguchi, T.S. Yamamoto, H. Takahashi, H. Takeda, et al. (2003) The prickle-related gene in vertebrates is essential for gastrulation cell movements. Curr Biol. 13, 674-679.
22. Veeman, M.T., D.C. Slusarski, A. Kaykas, S.H. Louie, and R.T. Moon. (2003) Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol. 13, 680-685.
23. Kilian, B., H. Mansukoski, F.C. Barbosa, F. Ulrich, M. Tada, and C.P. Heisenberg. (2003) The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech Dev. 120, 467-476.
24. Heisenberg, C.P., M. Tada, G.J. Rauch, L. Saude, M.L. Concha, R Geisler, et al. (2000) Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature. 405, 76-81.
25. Carreira-Barbosa, F., M.L. Concha, M. Takeuchi, N. Ueno, S.W. Wilson, and M. Tada. (2003) Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development. 130, 4037-4046.
26. Moeller, H., A. Jenny, H.J. Schaeffer, T. Schwarz-Romond, M. Mlodzik, M. Hammerschmidt, et al. (2006) Diversin regulates heart formation and gastrulation movements in development. Proc Natl Acad Sci USA. 103, 15900-15905.
27. Axelrod, J.D., J.R Miller, J.M. Shulman, R.T. Moon, and N. Perrimon. (1998) Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev. 12, 2610-2622.
28. Boutros, M., J. Mihaly, T. Bouwmeester, and M. Mlodzik. (2000) Signaling specificity by Frizzled receptors in Drosophila. Science. 288, 1825-1828.
29. Yanagawa, S., F. van Leeuwen, A. Wodarz, J. Klingensmith, and R Nusse. (1995) The dishevelled protein is modified by wingless signaling in Drosophila. Genes Dev. 9, 1087-1097.
30. Gonzalez-Sancho, J.M., K.R Brennan, L.A. Castelo-Soccio, and A.M. Brown. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol. 24, 4757-4768.
31. Liu, T., A.J. DeCostanzo, X. Liu, H. Wang, S. Hallagan, R. T. Moon, et al. (2001) G. protein signaling from activated rat frizzled1 to the beta-catenin-Lef-Tcf pathway. Science. 292, 1718-1722.
32. Cong, F., L. Schweizer, and H. Varmus. (2004) Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Mol Cell Biol. 24, 2000-2011.
33. Peters, J.M., R.M. McKay, J.P. McKay, and J.M. Graff. (1999) Casein kinase I transduces Wnt signals. Nature. 401, 345-350.
34. Swiatek,W, I.C. Tsai, L. Klimowski, A. Pepler, J. Barnette, H.J. Yost, et al. (2004) Regulation of casein kinase I epsilon activity by Wnt signaling. J Biol Chem. 279, 13011-13017.
35. Klein, T.J., A. Jenny, A. Djiane, and M. Mlodzik. (2006) CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila. Curr Biol. 16, 1337-1343.
36. Strutt, H., MA. Price, and D. Strutt. (2006) Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila. Curr Biol. 16, 1329-1336.
37. Tao, Q., C. Yokota, H. Puck, M. Kofron, B. Birsoy, D. Yan, et al. (2005) Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell. 120, 857-871.
38. Lu, W., V. Yamamoto, B. Ortega, and D. Baltimore. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neu rite outgrowth. Cell. 119, 97-108.
39. Hikasa, H., M. Shibata, I. Hiratani, and M. Taira. (2002) The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling. Development. 129, 5227-5239.
40. Mikels, A.J. and R. Nusse. (2006) Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol. 4, el15.
41. Schambony, A. and D. Wedlich. (2007) Wnt5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. Dev Cell. 12, 779-792.
42. Keeble, T.R, M.M. Halford, C. Seaman, N. Kee, M. Macheda, R.B. Anderson, et al. (2006) The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. J Neurosci. 26, 5840-5848.
43. Yoshikawa, S., R.D. McKinnon, M. Kokel, and J.B. Thomas. (2003) Wnt-mediated axon guidance via the Drosophila Derailed receptor. Nature. 422, 583-588.
44. Lu, X., A.G. Borchers, C. Jolicoeur, H. Rayburn, J.C. Baker, and M. Tessier-Lavigne. (2004) PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature. 430, 93-98.
45. He, X., J.P. Saint-Jeannet, Y. Wang, J. Nathans, I. Dawid, and H. Varmus. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science. 275, 1652-1654.
46. Habas, R., Y. Kato, and X. He. (2001) Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daaml. Cell. 107, 843-854.
47. Price, M.H., D.M. Roberts, B.M. McCartney, E. Jezuit, and M. Peifer. (2006) Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle. J Cell Sci. 119, 403-415.
48. Harris, K.E. and S. K. Beckendorf. (2007) Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration. Development. 134, 2017-2025.
49. Wong, L.L. and P.N. Adler. (1993) Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells. J Cell Biol. 123, 209-221.
50. Gubb, D. and A. Garcia-Bellido. (1982) A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster. J Embryol Exp Morphol. 68, 37-57.
51. Hall, A. (1998) Rho GTPases and the actin cytoskeleton. Science. 279, 509-514.
52. Ridley, A.J. and A. Hall. (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 70, 389-399.
53. Ridley, A.J., H.F. Paterson, C.L. Johnston, D. Diekmann, and A. Hall. (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 70, 401-410.
54. Boutros, M., N. Paricio, D.I. Strutt, and M. Mlodzik. (1998) Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell. 94, 109-118.
55. Zhu, S., L. Liu, V. Korzh, Z. Gong, and B.C. Low. (2006) RhoAacts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling. Cell Signal. 18, 359-372.
56. Tahinci, E. and K. Symes. (2003) Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation. Dev Biol. 259, 318-335.
57. Marlow, F., J. Topczewski, D. Sepich, and L. Solnka-Krezel. (2002) Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements. Curr Biol. 12, 876-884.
58. Winter, C.G., B.Wang, A.Ballew, A.Royou, R. Karess, J.D. Axelrod, et al. (2001) Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell. 105, 81-91.
59. Kim, G.H. and J.K. Han. (2005) JNK and ROKalpha function in the noncanonical Wnt/RhoA signaling pathway to regulate Xenopus convergent extension movements. Dev Dyn. 232, 958-968.
60. Strutt, D.I., U. Weber, and M. Mlodzik. (1997) The role of RhoA in tissue polarity and Frizzled signalling. Nature. 387, 292-295.
61. Yamanaka, H., T. Moriguchi, N. Masuyama, M. Kusakabe, H. Hanafusa, R. Takada, et al. (2002) JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBORep. 3, 69-75.
62. Kohn, A.D. and R.T. Moon. (2005) Wnt and calcium signaling: beta-catenin-independent pathways. Cell Calcium. 38, 439-146.
63. Slusarski, D.C. and F. Pelegri. (2007) Calcium signaling in vertebrate embryonic patterning and morphogenesis. Dev Biol. 307, 1-13.
64. Webb, S.E. and A.L. Miller. (2003) Calcium signalling during embryonic development. Nat Rev Mol Cell Biol. 4, 539-551.
65. Dejmek, J., A. Safholm, C. Kamp Nielsen, T. Andersson, and K. Leandersson. (2006) Wnt-5a/Ca2+-induced NFAT activity is counteracted byWnt-5a/Yes-Cdc42-casein kinase 1 alpha signaling in human mammary epithelial cells. Mol Cell Biol. 26, 6024-6036.
66. Ma, L. and H.Y. Wang. (2006) Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway. J Biol Chem. 281, 30990-31001.
67. Reinhard, E., H. Yokoe, K.R. Niebling, N.L. Allbritton, M.A. Kuhn, and T. Meyer. (1995) Localized calcium signals in early zebrafish development. Dev Biol. 170, 50-61.
68. Slusarski, D.C.,V.G. Corees, and R.T. Moon. (1997) Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature. 390, 410-113.
69. Slusarski, D.C., J. Yang-Snyder, W.B. Busa, and R.T. Moon. (1997) Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A. Dev Biol. 182, 114-120.
70. Gilland, E., A.L. Miller, E. Karplus, R. Baker, and S.E. Webb. (1999) Imaging of multicellular large-scale rhythmic calcium waves during zebrafish gastrulation. Proc Natl Acad Sci USA. 96, 157-161.
71. Wallingford, J.B., A.J. Ewald, R.M. Harland, and S.E. Fraser. (2001) Calcium signaling during convergent extension in Xenopus. Curr Biol. 11, 652-661.
72. Westfall, T.A., R. Brimeyer, J. Twedt, J. Gladon, A. Olberding, M. Furutani-Seiki, et al. (2003) Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J. Cell Biol. 162, 889-898.
73. Kuhl, M., L.C. Sheldahl, C.C. Malbon, and RT. Moon. (2000) Ca(2+)/calmodulindependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J Biol Chem. 275, 12701-12711.
74. Sheldahl, L.C., D.C. Slusarski, P. Pandur, J.R. Miller, M. Kuhl, and R.T. Moon. (2003) Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. J Cell Biol. 161, 769-777.
75. Sheldahl, L.C., M. Park, C.C. Malbon, and R. T. Moon. (1999) Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr Biol. 9, 695-698.
76. Saneyoshi, T., S. Kume, Y. Amasaki, and K. Mikoshiba. (2002) The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature. 417, 295-299.
77. Westfall, T.A., B. Hjertos, and D.C. Slusarski. (2003) Requirement for intracellular calcium modulation in zebrafish dorsal-ventral patterning. Dev Biol. 259, 380-391.
78. Gwak, J., M. Cho, S.J. Gong, J. Won, D.E. Kim, E.Y. Kim, et al. (2006) Protein-kinase-C-mediated beta-catenin phosphorylation negatively regulates the Wnt/beta-catenin pathway. J Cell Sci. 119, 4702-4709.
79. Ishitani, T., S. Kishida, J. Hyodo-Miura, N. Ueno, J. Yasuda, M. Waterman, et al. (2003) The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 23, 131-139.
80. Ishitani, T., J. Ninomiya-Tsuji, and K. Matsumoto. (2003) Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. Mol Cell Biol. 23, 1379-1389.
81. Ishitani, T., J. Ninomiya-Tsuji, S. Nagai, M. Nishita, M. Meneghini, N. Barker, et al. (1999) The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature. 399, 798-802.