Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration

Cell Death and Disease

Volumn 4, Issue 3, 2013, Pages

  Choudhury, S ^a   Bhootada, Y ^a   Gorbatyuk, O ^b   Gorbatyuk, M ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Apoptosis; Caspase 7; HT17M RHO; Retinal degeneration; UPR

Indexed keywords

CASPASE 7; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN P30; PROTEIN P90; RHODOPSIN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CONTROLLED STUDY; DISEASE SEVERITY; ELECTRORETINOGRAM; ENZYME ACTIVATION; HISTOPATHOLOGY; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PHOTORECEPTOR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RETINA DEGENERATION; RETINA INJURY; RETINITIS PIGMENTOSA; RNA ANALYSIS; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; TISSUE PRESERVATION; UNFOLDED PROTEIN RESPONSE; ANIMAL; CHEMISTRY; GENE EXPRESSION; GENETICS; LIGHT; METABOLISM; PATHOPHYSIOLOGY; RADIATION EXPOSURE; RETINA; RNA INTERFERENCE; TRANSGENIC MOUSE;

MUS;

ANIMALS; APOPTOSIS; CASPASE 7; GENE EXPRESSION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIGHT; MICE; MICE, TRANSGENIC; POLY(ADP-RIBOSE) POLYMERASES; RETINA; RETINAL DEGENERATION; RETINITIS PIGMENTOSA; RHODOPSIN; RNA INTERFERENCE; RNA, SMALL INTERFERING; TNF RECEPTOR-ASSOCIATED FACTOR 2; TOR SERINE-THREONINE KINASES; UNFOLDED PROTEIN RESPONSE;

MLCS; MLOWN;

EID: 84875893851     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.34     Document Type: Article

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