Different functions of HIPK2 and CtBP2 in traumatic brain injury

Journal of Molecular Neuroscience

Volumn 49, Issue 2, 2013, Pages 395-408

  Zou, Feihui ^a   Xu, Jian ^a   Fu, Hongran ^a   Cao, Jianhua ^a   Mao, Hui ^a   Gong, Mingjie ^a   Cui, Gang ^a   Zhang, Yang ^a   Shi, Wei ^a   Chen, Jian ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Apoptosis; CtBP2; HIPK2; Proliferation; Rat; Traumatic brain injury

Indexed keywords

BINDING PROTEIN; C TERMINAL BINDING PROTEIN 2; CASPASE 3; CYCLINE; GLIAL FIBRILLARY ACIDIC PROTEIN; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; NERVE CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TRAUMATIC BRAIN INJURY; WESTERN BLOTTING;

ANIMALS; ANTIGENS, NUCLEAR; APOPTOSIS; ASTROCYTES; BRAIN INJURIES; CASPASE 3; CEREBRAL CORTEX; EYE PROTEINS; GLIAL FIBRILLARY ACIDIC PROTEIN; MALE; NERVE TISSUE PROTEINS; NEURONS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84875740067     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9906-2     Document Type: Article

References (57)

1. Al-Beiti MA, Lu X (2008) Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis. Aust N Z J Obstet Gynaecol 48:329-336 (Pubitemid 351798374)
2. Birts CN, Bergman LM, Blaydes JP (2011) CtBPs promote mitotic fidelity through their activities in the cell nucleus. Oncogene 30:1272-1280
3. Bitomsky N, Hofmann TG (2009) Apoptosis and autophagy: regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2. FEBS J 276:6074-6083
4. Boyd JM, Subramanian T, Schaeper U, La Regina M, Bayley S, Chinnadurai G (1993) A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. EMBO J 12:469-478 (Pubitemid 23073693)
5. Bredesen DE (1995) Neural apoptosis. Ann Neurol 38:839-851 (Pubitemid 26004066)
6. Calzado MA, Renner F, Roscic A, Schmitz ML (2007) HIPK2: a versatile switchboard regulating the transcription machinery and cell death. Cell Cycle 6:139-143 (Pubitemid 46232491)
7. Cernak I, Stoica B, Byrnes KR, Di Giovanni S, Faden AI (2005) Role of the cell cycle in the pathobiology of central nervous system trauma. Cell Cycle 4:1286-1293 (Pubitemid 41365402)
8. Chinnadurai G (2002) CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol Cell 9:213-224 (Pubitemid 34195548)
9. Chinnadurai G (2009) The transcriptional corepressor CtBP: a foe of multiple tumor suppressors. Cancer Res 69:731-734
10. Clark RS, Kochanek PM, Watkins SC, Chen M, Dixon CE, Seidberg NA, Melick J, Loeffert JE, Nathaniel PD, Jin KL, Graham SH (2000) Caspase-3 mediated neuronal death after traumatic brain injury in rats. J Neurochem 74:740-753 (Pubitemid 30053747)
11. D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, Gostissa M, Coen S, Marchetti A, Del Sal G, Piaggio G, Fanciulli M, Appella E, Soddu S (2002) Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 4:11-19 (Pubitemid 34071975)
12. Di Stefano V, Blandino G, Sacchi A, Soddu S, D'Orazi G (2004) HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function. Oncogene 23:5185-5192 (Pubitemid 38980351)
13. Engelhardt OG, Boutell C, Orr A, Ullrich E, Haller O, Everett RD (2003) The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML. Exp Cell Res 283:36-50 (Pubitemid 36259894)
14. Erhardt L (1996) Biochemical markers in acute myocardial infarction - the beginning of a new era? Eur Heart J 17:1781-1782 (Pubitemid 26413906)
15. Gaetz M (2004) The neurophysiology of brain injury. Clin Neurophysiol 115:4-18 (Pubitemid 38045590)
16. Hamada F, Bienz M (2004) The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF. Dev Cell 7:677-685 (Pubitemid 39462688)
17. Hofmann TG, Moller A, Sirma H, Zentgraf H, Taya Y, Droge W, Will H, Schmitz ML (2002) Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol 4:1-10 (Pubitemid 34071974)
18. Hofmann TG, Stollberg N, Schmitz ML, Will H (2003) HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. Cancer Res 63:8271-8277 (Pubitemid 37549478)
19. Izutsu K, Kurokawa M, Imai Y, Maki K, Mitani K, Hirai H (2001) The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling. Blood 97:2815-2822
20. Katz DI, Alexander MP, Klein RB (1998) Recovery of arm function in patients with paresis after traumatic brain injury. Arch Phys Med Rehabil 79:488-493 (Pubitemid 28222157)
21. Kernie SG, Erwin TM, Parada LF (2001) Brain remodeling due to neuronal and astrocytic proliferation after controlled cortical injury in mice. J Neurosci Res 66:317-326 (Pubitemid 33027398)
22. Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y (1998) Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem 273:25875-25879 (Pubitemid 28475817)
23. Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK (2003) Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). Proc Natl Acad Sci U S A 100:5431-5436 (Pubitemid 36542722)
24. Königsmark BW, Murphy EA (1970) Neuronal populations in the human brain. Nature 228:1335-1336
25. Kovi RC, Paliwal S, Pande S, Grossman SR (2010) An ARF/CtBP2 complex regulates BH3-only gene expression and p53-independent apoptosis. Cell Death Differ 17:513-521
26. Lavra L, Rinaldo C, Ulivieri A, Luciani E, Fidanza P, Giacomelli L, Bellotti C, Ricci A, Trovato M, Soddu S, Bartolazzi A, Sciacchitano S (2011) The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas. PLoS One 6:e20665
27. Lee W, Swarup S, Chen J, Ishitani T, Verheyen EM (2009) Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of beta-catenin/Arm and stimulation of target gene expression. Development 136:241-251
28. Li X, Zhang R, Luo D, Park SJ, Wang Q, Kim Y, Min W (2005) Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. J Biol Chem 280:15061-15070 (Pubitemid 40562860)
29. Lin X, Liang YY, Sun B, Liang M, Shi Y, Brunicardi FC, Feng XH (2003) Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol Cell Biol 23:9081-9093 (Pubitemid 37499798)
30. Liu Y, Wang Y, Cheng C, Chen Y, Shi S, Qin J, Xiao F, Zhou D, Lu M, Lu Q, Shen A (2010) A relationship between p27(kip1) and Skp2 after adult brain injury: implications for glial proliferation. J Neurotrauma 27:361-371
31. Logan A, Frautschy SA, Gonzalez AM, Baird A (1992) A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury. J Neurosci 12:3828-3837
32. McDonald BC, Flashman LA, Saykin AJ (2002) Executive dysfunction following traumatic brain injury: neural substrates and treatment strategies. NeuroRehabilitation 17:333-344 (Pubitemid 41615954)
33. Meloni AR, Smith EJ, Nevins JR (1999) A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor. Proc Natl Acad Sci U S A 96:9574-9579 (Pubitemid 29398772)
34. Mirnezami AH, Campbell SJ, Darley M, Primrose JN, Johnson PW, Blaydes JP (2003) Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription. Curr Biol 13:1234-1239 (Pubitemid 36872947)
35. Moller A, Sirma H, Hofmann TG, Rueffer S, Klimczak E, Droge W, Will H, Schmitz ML (2003) PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. Cancer Res 63:4310-4314 (Pubitemid 36950995)
36. Morganti-Kossmann MC, Rancan M, Stahel PF, Kossmann T (2002) Inflammatory response in acute traumatic brain injury: a double-edged sword. Curr Opin Crit Care 8:101-105 (Pubitemid 36132681)
37. Morris GF, Mathews MB (1989) Regulation of proliferating cell nuclear antigen during the cell cycle. J Biol Chem 264:13856-13864 (Pubitemid 19198480)
38. Paliwal S, Pande S, Kovi RC, Sharpless NE, Bardeesy N, Grossman SR (2006) Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis. Mol Cell Biol 26:2360-2372 (Pubitemid 43346935)
39. Perel P, Arango M, Clayton T, Edwards P, Komolafe E, Poccock S, Roberts I, Shakur H, Steyerberg E, Yutthakasemsunt S (2008) Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients. BMJ 336:425-429 (Pubitemid 351310887)
40. Piek J, Chesnut RM, Marshall LF, van Berkum-Clark M, Klauber MR, Blunt BA, Eisenberg HM, Jane JA, Marmarou A, Foulkes MA (1992) Extracranial complications of severe head injury. J Neurosurg 77:901-907
41. Puca R, Nardinocchi L, Sacchi A, Rechavi G, Givol D, D'Orazi G (2009) HIPK2 modulates p53 activity towards pro-apoptotic transcription. Mol Cancer 8:85
42. Rinaldo C, Prodosmo A, Siepi F, Soddu S (2007) HIPK2: a multitalented partner for transcription factors in DNA damage response and development. Biochem Cell Biol 85:411-418 (Pubitemid 47518036)
43. Schaeper U, Boyd JM, Verma S, Uhlmann E, Subramanian T, Chinnadurai G (1995) Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc Natl Acad Sci U S A 92:10467-10471
44. Schirmer-Mikalsen K, Vik A, Gisvold SE, Skandsen T, Hynne H, Klepstad P (2007) Severe head injury: control of physiological variables, organ failure and complications in the intensive care unit. Acta Anaesthesiol Scand 51:1194-1201 (Pubitemid 47389677)
45. Subramanian T, La Regina M, Chinnadurai G (1989) Enhanced ras oncogene mediated cell transformation and tumorigenesis by adenovirus 2 mutants lacking the C-terminal region of E1a protein. Oncogene 4:415-420 (Pubitemid 19109754)
46. Sung KS, Go YY, Ahn JH, Kim YH, Kim Y, Choi CY (2005) Differential interactions of the homeodomain-interacting protein kinase 2 (HIPK2) by phosphorylation-dependent sumoylation. FEBS Lett 579:3001-3008 (Pubitemid 40797826)
47. Teasdale GM, Graham DI (1998) Craniocerebral trauma: protection and retrieval of the neuronal population after injury. Neurosurgery 43:723-737, discussion 737-728 (Pubitemid 28436305)
48. Turner J, Crossley M (2001) The CtBP family: enigmatic and enzymatic transcriptional co-repressors. Bioessays 23:683-690 (Pubitemid 32792512)
49. 2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor CtBP. J Biol Chem 281:34810-34815 (Pubitemid 46036520)
50. Wang Y, Debatin KM, Hug H (2001) HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels. BMC Mol Biol 2:8 (Pubitemid 38693006)
51. Wang Y, Marion Schneider E, Li X, Duttenhofer I, Debatin K, Hug H (2002) HIPK2 associates with RanBPM. Biochem Biophys Res Commun 297:148-153
52. Yu TS, Zhang G, Liebl DJ, Kernie SG (2008) Traumatic brain injury-induced hippocampal neurogenesis requires activation of early nestin-expressing progenitors. J Neurosci 28:12901-12912
53. Zhang L, Li J, Wang C, Ma Y, Huo K (2005a) A new human gene hNTKL-BP1 interacts with hPirh2. Biochem Biophys Res Commun 330:293-297 (Pubitemid 40394965)
54. Zhang Q, Nottke A, Goodman RH (2005b) Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis. Proc Natl Acad Sci U S A 102:2802-2807 (Pubitemid 40299873)
55. Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM, Goodman RH (2003) Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell 115:177-186 (Pubitemid 37329581)
56. Zhao LJ, Subramanian T, Zhou Y, Chinnadurai G (2006) Acetylation by p300 regulates nuclear localization and function of the transcriptional corepressor CtBP2. J Biol Chem 281:4183-4189 (Pubitemid 43847846)
57. Zygun DA, Kortbeek JB, Fick GH, Laupland KB, Doig CJ (2005) Non-neurologic organ dysfunction in severe traumatic brain injury. Crit Care Med 33:654-660 (Pubitemid 40365570)