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Volumn 6, Issue 2, 2007, Pages 139-143

HIPK2: A versatile switchboard regulating the transcription machinery and cell death

Author keywords

Apoptosis; Caspase; HIPK2; p53; Polycomb proteins; SUMO E3 ligase; SUMO 1; Ubc9

Indexed keywords

CISPLATIN; DOXORUBICIN; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; PROTEIN P53; PROTEIN SERINE THREONINE KINASE; WNT PROTEIN;

EID: 33846913249     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.2.3788     Document Type: Review
Times cited : (114)

References (35)
  • 1
    • 17644377920 scopus 로고    scopus 로고
    • Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability
    • Gresko E, Moller A, Roscic A, Schmitz ML. Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability. Biochem Biophys Res Commun 2005; 329:1293-9.
    • (2005) Biochem Biophys Res Commun , vol.329 , pp. 1293-1299
    • Gresko, E.1    Moller, A.2    Roscic, A.3    Schmitz, M.L.4
  • 2
    • 20444422945 scopus 로고    scopus 로고
    • Differential interactions of the homeodomain-interacting protein kinase 2 (HIPK2) by phosphorylation- dependent sumoylation
    • Sung KS, Go YY, Ahn JH, Kim YH, Kim Y, Choi CY. Differential interactions of the homeodomain-interacting protein kinase 2 (HIPK2) by phosphorylation- dependent sumoylation. FEBS Lett 2005; 579:3001-8.
    • (2005) FEBS Lett , vol.579 , pp. 3001-3008
    • Sung, K.S.1    Go, Y.Y.2    Ahn, J.H.3    Kim, Y.H.4    Kim, Y.5    Choi, C.Y.6
  • 3
    • 23844433285 scopus 로고    scopus 로고
    • Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification
    • Hofmann TG, Jaffray E, Stollberg N, Hay RT, Will H. Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification. J Biol Chem 2005; 280:29224-32.
    • (2005) J Biol Chem , vol.280 , pp. 29224-29232
    • Hofmann, T.G.1    Jaffray, E.2    Stollberg, N.3    Hay, R.T.4    Will, H.5
  • 4
    • 0345898928 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinases, a novel family of corepressors for homeodomain transcription factors
    • Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y. Homeodomain-interacting protein kinases, a novel family of corepressors for homeodomain transcription factors. J Biol Chem 1998; 273:25875-9.
    • (1998) J Biol Chem , vol.273 , pp. 25875-25879
    • Kim, Y.H.1    Choi, C.Y.2    Lee, S.J.3    Conti, M.A.4    Kim, Y.5
  • 5
    • 33645238760 scopus 로고    scopus 로고
    • Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals
    • Isono K, Nemoto K, Li Y, Takada Y, Suzuki R, Katsuki M, Nakagawara A, Koseki H. Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol Cell Biol 2006; 26:2758-71.
    • (2006) Mol Cell Biol , vol.26 , pp. 2758-2771
    • Isono, K.1    Nemoto, K.2    Li, Y.3    Takada, Y.4    Suzuki, R.5    Katsuki, M.6    Nakagawara, A.7    Koseki, H.8
  • 6
  • 11
    • 0000782017 scopus 로고    scopus 로고
    • The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription
    • Choi CY, Kim YH, Kwon HJ, Kim Y. The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription. J Biol Chem 1999; 274:33194-7.
    • (1999) J Biol Chem , vol.274 , pp. 33194-33197
    • Choi, C.Y.1    Kim, Y.H.2    Kwon, H.J.3    Kim, Y.4
  • 13
    • 0142258245 scopus 로고    scopus 로고
    • Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP
    • Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM, Goodman RH. Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell 2003; 115:177-86.
    • (2003) Cell , vol.115 , pp. 177-186
    • Zhang, Q.1    Yoshimatsu, Y.2    Hildebrand, J.3    Frisch, S.M.4    Goodman, R.H.5
  • 14
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • Sparmann A, van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 2006; 6:846-56.
    • (2006) Nat Rev Cancer , vol.6 , pp. 846-856
    • Sparmann, A.1    van Lohuizen, M.2
  • 15
    • 0037418829 scopus 로고    scopus 로고
    • The polycomb protein Pc2 is a SUMO E3
    • Kagey MH, Melhuish TA, Wotton D. The polycomb protein Pc2 is a SUMO E3. Cell 2003; 113:127-37.
    • (2003) Cell , vol.113 , pp. 127-137
    • Kagey, M.H.1    Melhuish, T.A.2    Wotton, D.3
  • 16
    • 24344445216 scopus 로고    scopus 로고
    • Something about SUMO inhibits transcription
    • Gill G. Something about SUMO inhibits transcription. Curr Opin Genet Dev 2005; 15:536-41.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 536-541
    • Gill, G.1
  • 18
    • 0141916811 scopus 로고    scopus 로고
    • Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses
    • Gentile M, Latonen L, Laiho M. Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses. Nucleic Acids Res 2003; 31:4779-90.
    • (2003) Nucleic Acids Res , vol.31 , pp. 4779-4790
    • Gentile, M.1    Latonen, L.2    Laiho, M.3
  • 20
    • 0345734277 scopus 로고    scopus 로고
    • HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells
    • Hofmann TG, Stollberg N, Schmitz ML, Will H. HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. Cancer Res 2003; 63:8271-7.
    • (2003) Cancer Res , vol.63 , pp. 8271-8277
    • Hofmann, T.G.1    Stollberg, N.2    Schmitz, M.L.3    Will, H.4
  • 21
    • 0037200042 scopus 로고    scopus 로고
    • Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo
    • Kim EJ, Park JS, Um SJ. Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo. J Biol Chem 2002; 277:32020-8.
    • (2002) J Biol Chem , vol.277 , pp. 32020-32028
    • Kim, E.J.1    Park, J.S.2    Um, S.J.3
  • 23
    • 0345830383 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis
    • Di Stefano V, Rinaldo C, Sacchi A, Soddu S, D'Orazi G. Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis. Exp Cell Res 2004; 293:311-20.
    • (2004) Exp Cell Res , vol.293 , pp. 311-320
    • Di Stefano, V.1    Rinaldo, C.2    Sacchi, A.3    Soddu, S.4    D'Orazi, G.5
  • 24
    • 1642512435 scopus 로고    scopus 로고
    • Role of PML and the PML-nuclear body in the control of programmed cell death
    • Bernardi R, Pandolfi PP. Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene 2003; 22:9048-57.
    • (2003) Oncogene , vol.22 , pp. 9048-9057
    • Bernardi, R.1    Pandolfi, P.P.2
  • 25
    • 2442678753 scopus 로고    scopus 로고
    • PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains
    • Moller A, Sirma H, Hofmann TG, Rueffer S, Klimczak E, Droge W, Will H, Schmitz ML. PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. Cancer Res 2003; 63:4310-4.
    • (2003) Cancer Res , vol.63 , pp. 4310-4314
    • Moller, A.1    Sirma, H.2    Hofmann, T.G.3    Rueffer, S.4    Klimczak, E.5    Droge, W.6    Will, H.7    Schmitz, M.L.8
  • 27
    • 3142682521 scopus 로고    scopus 로고
    • HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function
    • Di Stefano V, Blandino G, Sacchi A, Soddu S, D'Orazi G. HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function. Oncogene 2004; 23:5185-92.
    • (2004) Oncogene , vol.23 , pp. 5185-5192
    • Di Stefano, V.1    Blandino, G.2    Sacchi, A.3    Soddu, S.4    D'Orazi, G.5
  • 29
    • 22544433198 scopus 로고    scopus 로고
    • Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified
    • Mayo LD, Seo YR, Jackson MW, Smith ML, Rivera Guzman J, Korgaonkar CK, Donner DB. Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. J Biol Chem 2005; 280:25953-9.
    • (2005) J Biol Chem , vol.280 , pp. 25953-25959
    • Mayo, L.D.1    Seo, Y.R.2    Jackson, M.W.3    Smith, M.L.4    Rivera Guzman, J.5    Korgaonkar, C.K.6    Donner, D.B.7
  • 30
    • 0037047157 scopus 로고    scopus 로고
    • Apoptotic threshold is lowered by p53 transactivation of caspase-6
    • MacLachlan TK, El-Deiry WS. Apoptotic threshold is lowered by p53 transactivation of caspase-6. Proc Natl Acad Sci USA 2002; 99:9492-7.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 9492-9497
    • MacLachlan, T.K.1    El-Deiry, W.S.2
  • 31
    • 4444344019 scopus 로고    scopus 로고
    • Caspase 10 levels are increased following DNA damage in a p53-dependent manner
    • Rikhof B, Corn PG, El-Deiry WS. Caspase 10 levels are increased following DNA damage in a p53-dependent manner. Cancer Biol Ther 2003; 2:707-12.
    • (2003) Cancer Biol Ther , vol.2 , pp. 707-712
    • Rikhof, B.1    Corn, P.G.2    El-Deiry, W.S.3
  • 33
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • Harris SL, Levine AJ. The p53 pathway: Positive and negative feedback loops. Oncogene 2005; 24:2899-908.
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 35
    • 11244305618 scopus 로고    scopus 로고
    • WNT signalling and haematopoiesis: AWNT-WNT situation
    • Staal FJ, Clevers HC. WNT signalling and haematopoiesis: AWNT-WNT situation. Nat Rev Immunol 2005; 5:21-30.
    • (2005) Nat Rev Immunol , vol.5 , pp. 21-30
    • Staal, F.J.1    Clevers, H.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.