Characterization and evaluation of β-glucan formulations as injectable implants for protein and peptide delivery

Drug Development and Industrial Pharmacy

Volumn 38, Issue 11, 2012, Pages 1337-1343

  Jacobs, Simone ^a   Bunt, Craig R ^b   Wu, Zimei ^c   Lehr, Claus Michael ^a,d   Rupenthal, Ilva D ^c  

^a SAARLAND UNIVERSITY   (Germany)

^b LINCOLN UNIVERSITY   (New Zealand)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d SAARLAND UNIVERSITY   (Germany)

Author keywords

In situ gel formation; Natural polymer; PEG; Two phase systems

Indexed keywords

BETA GLUCAN; DEXTRAN 40; MACROGOL 20000;

AREA UNDER THE CURVE; ARTICLE; BIODEGRADABLE IMPLANT; DISPERSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; GEL; GELATION; HARDNESS; IN VITRO STUDY; SUSTAINED DRUG RELEASE; TEMPERATURE DEPENDENCE; VISCOMETRY;

BETA-GLUCANS; BIOCOMPATIBLE MATERIALS; DEXTRANS; DRUG CARRIERS; DRUG IMPLANTS; EXCIPIENTS; FLUORESCEIN; GELS; HARDNESS; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; PEPTIDES; PHASE TRANSITION; POLYETHYLENE GLYCOLS; PROTEINS; RHEOLOGY; SOLUBILITY; SPECTROMETRY, FLUORESCENCE; VISCOSITY;

EID: 84858406056     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2011.650646     Document Type: Article

References (26)

1. Cui W, Wood PJ. 2000. Relationships between structural features, molecular weight and rheological properties of cereal [β]-d-glucans. In: Katsuyoshi N (ed.), Hydrocolloids, Amsterdam: Elsevier Science, 159-168.
2. Rahar S, Swami G, Nagpal N, Nagpal MA, Singh GS. (2011). Preparation, characterization, and biological properties of ß-glucans. J Adv Pharm Technol Res, 2:94-103.
3. Kanke M, Koda K, Koda Y, Katayama H. (1992). Application of curdlan to controlled drug delivery. I. The preparation and evaluation of theophylline-containing curdlan tablets. Pharm Res, 9:414-418.
4. Karinaga R, Koumoto K, Mizu M, Anada T, Shinkai S, Sakurai K. (2005). PEG-appended β-(1->3)-d-glucan schizophyllan to delive antisense-oligonucleotides with avoiding lysosomal degradation. Biomaterials, 26:4866-4873.
5. Cleland JL, Daugherty A, Mrsny R. (2001). Emerging protein delivery methods. Curr Opin Biotechnol, 12:212-219.
6. Shaji J, Patole V. (2008). Protein and Peptide drug delivery: oral approaches. Indian J Pharm Sci, 70:269-277.
7. Cho KY, Lee S, Park JK. (2007). In situ micro-sized gel-forming injectable implant using biodegradable amphiphilic graft copolymer. Macromol Biosci, 7:784-788.
8. Hatef A, Amsden B. (2002). Biodegradable injectable in situ forming drug delivery systems. J Control Release, 80:9-28.
9. Dunn R. (2003). Application of the Atrigel® implant drug delivery technology for patient-friendly, cost-efective product development. Drug Dev Del, 3:6.
10. Shively ML, Coonts BA, Renner WD, Southard JL, Bennett AT. (1995). Physico-chemical characterization of a polymeric injectable implant delivery system. J Control Release, 33:237-243.
11. Rathmell JP, Lake T, Ramundo MB. (2006). Infectious risks of chronic pain treatments: injection therapy, surgical implants, and intradiscal techniques. Reg Anesth Pain Med, 31:346-352.
12. Gupta D, Tator CH, Shoichet MS. (2006). Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord. Biomaterials, 27:2370-2379.
13. Jordan O, Doelker E, Rüfenacht DA. (2005). Biomaterials used in injectable implants (liquid embolics) for percutaneous flling of vascular spaces. Cardiovasc Intervent Radiol, 28:561-569.
14. Van Tomme SR, Storm G, Hennink WE. (2008). In situ gelling hydrogels for pharmaceutical and biomedical applications. Int J Pharm, 355:1-18.
15. Stenekes RJ, Franssen O, van Bommel EM, Crommelin DJ, Hennink WE. (1999). The use of aqueous PEG/dextran phase separation for the preparation of dextran microspheres. Int J Pharm, 183:29-32.
16. Silva ME, Franco TT (2000). Liquid-liquid extraction of biomolecules in downstream processing-A review paper. Braz J Chem Eng, 17:1-17.
17. Jones DS, Woolfson AD, Brown AF. (1997). Textural analysis and fow rheometry of novel, bioadhesive antimicrobial oral gels. Pharm Res, 14:450-457.
18. Jones DS, Woolfson AD, Djokic J. (1996). Texture profle analysis of bioadhesive polymeric semisolids: Mechanical characterization and investigation of interactions between formulation comp onents. J Appl Polym Sci, 61:2229-2234.
19. HIGUCHI T. (1961). Rate of release of medicaments from ointment bases containing drugs in suspension. J Pharm Sci, 50:874-875.
20. Hixson AW, Crowell JH. (1931). Dependence of reaction velocity upon surface and agitation (I) theoretical consideration. Ind Eng Chem, 23:923-931.
21. Shoaib MH, Tazeen J, Merchant HA, Yousuf RI. (2006). Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. Pak J Pharm Sci, 19:119-124.
22. Trimawithana TR, Young S, Alany RG. (2011). Efect of cations on the microstructure and in-vitro drug release of K-and i-carrageenan liquid and semi-solid aqueous dispersions. J Pharm Pharmacol, 63:11-18.
23. Alger MSM. 1989. Polymer science dictionary. First Edition ed.: Chapman & Hall.
24. Jones DS. (1999). Dynamic mechanical analysis of polymeric systems of pharmaceutical and biomedical signifcance. Int J Pharm, 179:167-178.
25. Böhm N, Kulicke WM (1999). Rheological studies of barley (1->3) (1->4)-[(B]-glucan in concentrated solution: investigation of the viscoelastic fow behaviour in the sol-state. Carbohydr Res, 315:293-301.
26. Hassinen C, Köhler K, Veide A. (1994). Polyethylene glycol-potassium phosphate aqueous two-phase systems. Insertion of short peptide units into a protein and its efects on partitioning. J Chromatogr A, 668:121-128.