Enzymatically degradable temperature-sensitive polypeptide as a new in-situ gelling biomaterial

Journal of Controlled Release

Volumn 137, Issue 1, 2009, Pages 25-30

  Jeong, Yuri ^a   Joo, Min Kyung ^a   Bahk, Kyung Hyun ^a   Choi, Yun Young ^a   Kim, Ho Tae ^b   Kim, Won Ki ^c   Jeong Lee, Hwa ^a   Sohn, Youn Soo ^a   Jeong, Byeongmoon ^a  

^a Ewha Womans University   (South Korea)

^b Kumoh National Institute of Technology   (South Korea)

^c Korea University   (South Korea)

Author keywords

Enzymatic degradability; Hydrogel; Polymer; Polypeptide; Sol gel transition

Indexed keywords

AQUEOUS SOLUTIONS; CATHEPSIN B; CELL THERAPY; CONFORMATIONAL CHANGE; ELASTASE; ENZYMATIC DEGRADABILITY; FEASIBILITY STUDIES; HYPOGLYCEMIC EFFECT; IN-SITU-GELLING; IN-VITRO; MAMMALIAN TISSUES; MICELLAR AGGREGATION; PHENYL-ALANINE; PHOSPHATE-BUFFERED SALINES; PROTEOLYTIC ENZYME; RANDOM COIL; SINGLE SHOTS; SOL-GEL TRANSITION; SOL-TO-GEL TRANSITION; TEMPERATURE INCREASE; TEMPERATURE-SENSITIVE;

AMINES; BIOLOGICAL MATERIALS; DRUG DELIVERY; ETHYLENE; ETHYLENE GLYCOL; GELS; HYDROGELS; PLANNING; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYMERS; RATS; RESOURCE ALLOCATION; SOL-GEL PROCESS; SOL-GELS; SOLS; SOLUTIONS; TISSUE ENGINEERING;

GELATION;

BIOMATERIAL; CATHEPSIN B; DIPEPTIDYL PEPTIDASE I; ELASTASE; INSULIN; MACROGOL; PHOSPHATE BUFFERED SALINE; POLY(ALANINE CO PHENYLALANINE); POLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; BETA SHEET; CONFORMATIONAL TRANSITION; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DELIVERY SYSTEM; ENZYMATIC DEGRADATION; HYPOGLYCEMIA; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; STEM CELL TRANSPLANTATION; TEMPERATURE DEPENDENCE; TISSUE ENGINEERING;

ANIMALS; BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FEASIBILITY STUDIES; GELS; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; MICELLES; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PEPTIDES; PHASE TRANSITION; POLYETHYLENE GLYCOLS; POLYMERS; PROTEIN CONFORMATION; RATS; SOLUTIONS; SUBCUTANEOUS FAT; TEMPERATURE; TIME FACTORS; WATER;

EID: 67349139118     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.03.008     Document Type: Article

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