Cubic phase gels as drug delivery systems

Advanced Drug Delivery Reviews

Volumn 47, Issue 2-3, 2001, Pages 229-250

  Shah, Jaymin C ^a,b   Sadhale, Yogesh ^a   Chilukuri, Dakshina Murthy ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Amphiphilic; Biomembrane; Crystal structure; Drug delivery; Glyceryl monooleate; Lipids; Liquid crystals; Phase behavior; Protein stability; Release; X ray diffraction

Indexed keywords

BIODEGRADATION; CRYSTALLIZATION; ENZYME KINETICS; GELS; PROTEINS; SPECTROSCOPY;

DRUG DELIVERY SYSTEMS;

LIPIDS;

AMPHIPHILIC LIPID; AMPHOPHILE; CEFAZOLIN; CEFUROXIME; HUMAN INSULIN; ILETIN I; INSULIN; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; CONTROLLED DRUG RELEASE; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; GLUCOSE BLOOD LEVEL; LIPID BILAYER; MEMBRANE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STABILITY; REVIEW;

EID: 0035946622     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(01)00108-9     Document Type: Article

References (62)

1. Polymorphism of lipids. A novel cubic phase - A cage-like network of rods with enclosed spherical micelles
2. Structural relationships between lamellar, cubic and hexagonal phases in monoglyceride-water systems. Possibility of cubic structures in biological systems
3. Polymorphic phase behaviour of dilinoleoylphosphatidylethanolamine and palmitoyloleoylphosphatidylcholine mixtures. Structural changes between hexagonal, cubic and bilayer phases
4. Cubic phases as delivery systems for peptide drugs
5. Cubic lipid-water phases: Structures and biomembrane aspects
6. The curvature elastic-energy function of the lipid-water cubic mesophase
7. Geometrical aspects of the frustration in the cubic phases of lyotropic liquid crystals
8. Encapsulation of hemoglobin in a bicontinuous cubic phase lipid
9. Polymorphism, mesomorphism, and metastability of monoelaidin in excess water
10. Temperature- and pressure-dependent phase behavior of monoacylglycerides monoolein and monoelaidin
11. New phases induced by sucrose in saturated phosphatidylethanolamines: An expanded lamellar gel phase and a cubic phase
12. Accelerated formation of cubic phases in phosphatidylethanolamine dispersions
13. Hydrophobic molecules in lecithin-water systems. I. Formation of reversed hexagonal phases at high and low water contents
14. Spin label ESR and 31P-NMR studies of the cubic and inverted hexagonal phases of dimyristoylphosphatidylcholine/myristic acid (1:2, mol/mol)mixtures
15. Lipid and water diffusion in bicontinuous cubic phases measured by NMR
16. Cubic phases in hydrated 1:1 and 1:2 dipalmitoylphosphatidylcholine-dipalmitoylglycerol mixtures
17. Low amounts of PEG-lipid induce cubic phase in phosphatidylethanolamine dispersions
18. Phase behavior in the system pine needle oil monoglycerides-poloxamer 407-water at 20°C
19. Synthesis of palladium metal nanoparticles in the bicontinuous cubic phase of glycerol monooleate
20. Crystallographic analysis of freeze-fracture electron micrographs: Application to the structure determination of cubic lipid-water phases
21. Effects of distearoylphosphatidylglycerol and lysozyme on the structure of the monoolein-water cubic phase: X-ray diffraction and Raman scattering studies
22. Bicontinuous cubic phase: A model for investigating the effects on a lipid bilayer due to a foreign substance
23. Relationship between three-dimensional arrays of 'lipidic particles' and bicontinuous cubic lipid phases
24. A cubic protein-monoolein-water phase
25. Cubic lipid-water phase dispersed into submicron particles
26. Assessing the functionality of a membrane protein in a three-dimensional crystal
27. Characterization of the effects of drug addition on the structure of glyceryl monoolein/water gel systems using low frequency dielectric spectroscopy
28. Fourier-transform infrared spectroscopy study of dioleoylphosphatidylcholine and monooleoylglycerol in lamellar and cubic liquid crystals
29. A study of polar lipid drug carrier systems undergoing a thermoreversible lamellar-to-cubic phase transition
30. Synchrotron X-ray investigation of the structure of colloidal dispersions of liquid crystalline monoolein-water phases
31. Investigations of bicontinuous cubic liquid crystalline phases
32. Lipid phase transitions in membranes involving intrinsic periodic curvature
33. Detergent-free membrane protein crystallization
34. Protein, lipid and water organization in bacteriorhodopsin crystals: A molecular view of the purple membrane at 1.9 Å resolution
35. Increased activation of protein kinase C with cubic phase lipid compared with liposomes
36. Cubic phases for studies of drug partition into lipid bilayers
37. Injectable, self-assembling, enzymatic bioreactor for enzyme replacement therapy
38. Cubic phases as drug delivery systems
39. A cubic-phase delivery system composed of glyceryl monooleate and water for sustained release of water-soluble drugs
40. In vitro release of some antimuscarinic drugs from monoolein/water lyotropic liquid crystalline gels
41. Formulation of a drug delivery system based on a mixture of monoglycerides and triglycerides for use in the treatment of peiodontal disease
42. Comparative analysis of tetracycline-containing dental gels: Poloxamer- and monoglyceride-based formulations
43. Influence of a charged phospholipid on the release pattern of timolol maleate from cubic liquid crystalline phases
44. Swelling of and drug release from monoglyceride-based drug delivery systems
45. Release of drugs from monoglyceride-water liquid crystalline phases
46. Glyceryl monooleate cubic phase gel as chemical stability enhancer of cefazolin and cefuroxime
47. Stabilization of insulin against agitation-induced aggregation by the GMO cubic phase gel
48. Biological activity of insulin in GMO gels and the effect of agitation
49. Diffusional models useful in biopharmaceutics: Drug release rate processes
50. A cubic-phase oral drug delivery system for controlled release of AG337
51. Bioadhesive drug delivery systems. I. Characterisation of mucoadhesive properties of systems based on glyceryl mono-oleate and glyceryl monolinoleate
52. Phase behavior of the lidocaine-monoolein-water system
53. Mechanism of drug release from glyceryl monooleate cubic phase gel using bupivacaine as a model drug
54. Biodegradable polyanhydride devices of cefazolin sodium, bupivacaine, and taxol for site-specific drug delivery: Preparation, and kinetics and mechanism of in vitro release
55. Development of an implantable, biodegradable, controlled drug delivery system for local antibiotic therapy
56. Kinetics and mechanism of release from glyceryl monostearate based implants for the site-specific delivery of cefazolin
57. Efficacy and pharmacokinetics of site-specific cefazolin delivery using biodegradable implants in the prevention of post-operative wound infections
58. Effect of water mobility on drug hydrolysis rates in gelatin gels
59. Low viscosity monoglyceride-based drug delivery systems transforming into a highly viscous cubic phase
60. Drug compatibility with the sponge phases formed in monoolein, water, and propylene glycol or poly(ethylene glycol)
61. pH dependent solubility and dissolution of bupivacaine and its relevance to the formulation of a controlled release system
62. Binding of drugs to monoglyceride-based drug delivery systems