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Volumn 6, Issue 8, 2011, Pages 1357-1361

Antimalarial Mannoxanes: Hybrid Antimalarial Drugs with Outstanding Oral Activity Profiles and A Potential Dual Mechanism of Action

(15) Chadwick, James a Amewu, Richard K a Marti, Francesc a Garah, Fatima Bousejra El a Sharma, Raman a Berry, Neil G a Stocks, Paul A b Burrell Saward, Hollie c Wittlin, Sergio d,e Rottmann, Matthias d,e Brun, Reto d,e Taramelli, Donatella f Parapini, Silvia f Ward, Stephen A b O'Neill, Paul M a

a UNIVERSITY OF LIVERPOOL (United Kingdom)

b LIVERPOOL SCHOOL OF TROPICAL MEDICINE (United Kingdom)

c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE (United Kingdom)

d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE (Switzerland)

e UNIVERSITY OF BASEL (Switzerland)

f UNIVERSITY OF MILAN (Italy)

Author keywords

Antimalarial agents; Antiprotozoal agents; Hybrids; Peroxides; Tetraoxanes

Indexed keywords

ADAMANTYLIDENE MANNOXANE DERIVATIVE; AMODIAQUINE; ANTIMALARIAL AGENT; ARTEROLANE; ARTESUNATE; ENDOPEROXIDE; HEMATIN; MANNICH BASE; PEROXIDE; RKA 182; TETRAOXANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; BINDING AFFINITY; CONTROLLED STUDY; DIMERIZATION; DRUG BINDING; DRUG MECHANISM; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MALARIA; MANNICH REACTION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NOTE; PARASITEMIA; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

ADMINISTRATION, ORAL; AMODIAQUINE; ANIMALS; ANTIMALARIALS; HEMEPROTEINS; HEMIN; HUMANS; MALARIA; MANNICH BASES; MICE; MOLECULAR DYNAMICS SIMULATION; PEROXIDES; PHENOLS; PLASMODIUM FALCIPARUM; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAOXANES;

EID: 79960683200 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201100196 Document Type: Note

Times cited : (26)

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