Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 4, 2008, Pages 1291-1296

  Creek, Darren J ^a   Charman, William N ^a   Chiu, Francis C K ^a   Prankerd, Richard J ^a   Dong, Yuxiang ^b   Vennerstrom, Jonathan L ^b   Charman, Susan A ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; HEME; HEMIN;

ALKYLATION; ANTIMALARIAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL REACTION; CORRELATION ANALYSIS; DEGRADATION; DRUG MECHANISM; DRUG POTENCY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RISK FACTOR;

ALKYLATION; ANIMALS; ANTIMALARIALS; ARTEMISININS; HEME; HUMANS; KINETICS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 42049102584     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01033-07     Document Type: Article

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