-
4
-
-
0033526595
-
-
N. J. White F. Nosten S. Looareesuwan W. M. Watkins K. Marsh R. W. Snow G. Kokwaro J. Ouma T. T. Hien M. E. Molyneux T. E. Taylor C. I. Newbold T. K. Ruebush M. Danis B. M. Greenwood R. M. Anderson P. Olliaro Lancet 1999 353 1965
-
(1999)
Lancet
, vol.353
, pp. 1965
-
-
White, N.J.1
Nosten, F.2
Looareesuwan, S.3
Watkins, W.M.4
Marsh, K.5
Snow, R.W.6
Kokwaro, G.7
Ouma, J.8
Hien, T.T.9
Molyneux, M.E.10
Taylor, T.E.11
Newbold, C.I.12
Ruebush, T.K.13
Danis, M.14
Greenwood, B.M.15
Anderson, R.M.16
Olliaro, P.17
-
11
-
-
33745975677
-
-
R. K. Haynes B. Fugmann J. Stetter K. Rieckmann H.-D. Heilmann H.-W. Chan M.-K. Cheung W.-L. Lam H.-N. Wong S. L. Croft L. Vivas L. Rattray L. Stewart W. Peters B. L. Robinson M. D. Edstein B. Kotecka D. E Kyle B. Beckermann M. Gerisch M. Radtke G. Schmuck W. Steinke U. Wollborn K. Schmeer A. Römer Angew. Chem., Int. Ed. 2006 45 2082
-
(2006)
Angew. Chem., Int. Ed.
, vol.45
, pp. 2082
-
-
Haynes, R.K.1
Fugmann, B.2
Stetter, J.3
Rieckmann, K.4
Heilmann, H.-D.5
Chan, H.-W.6
Cheung, M.-K.7
Lam, W.-L.8
Wong, H.-N.9
Croft, S.L.10
Vivas, L.11
Rattray, L.12
Stewart, L.13
Peters, W.14
Robinson, B.L.15
Edstein, M.D.16
Kotecka, B.17
Kyle, D.E.18
Beckermann, B.19
Gerisch, M.20
Radtke, M.21
Schmuck, G.22
Steinke, W.23
Wollborn, U.24
Schmeer, K.25
Römer, A.26
more..
-
13
-
-
11144357467
-
-
O. Dechy-Cabaret F. Benoit-Vical C. Loup A. Robert H. Gornitzka A. Bonhoure H. Vial J. Magnaval J. Séguéla B. Meunier Chem.-Eur. J. 2004 10 1625
-
(2004)
Chem.-Eur. J.
, vol.10
, pp. 1625
-
-
Dechy-Cabaret, O.1
Benoit-Vical, F.2
Loup, C.3
Robert, A.4
Gornitzka, H.5
Bonhoure, A.6
Vial, H.7
Magnaval, J.8
Séguéla, J.9
Meunier, B.10
-
14
-
-
56249098367
-
-
F. Coslédan L. Fraisse A. Pellet F. Guillou B. Mordmüller P. G. Kremsner A. Moreno D. Mazier J. P. Maffrand B. Meunier Proc. Natl. Acad. Sci. U. S. A. 2008 105 17579
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 17579
-
-
Coslédan, F.1
Fraisse, L.2
Pellet, A.3
Guillou, F.4
Mordmüller, B.5
Kremsner, P.G.6
Moreno, A.7
Mazier, D.8
Maffrand, J.P.9
Meunier, B.10
-
15
-
-
4344630762
-
-
J. L. Vennerstrom S. Arbe-Barnes R. Brun S. A. Charman F. C. K. Chiu J. Chollet Y. Dong A. Dorn D. Hunziker H. Matile K. McIntosh M. Padmanilayam J. Santo Tomas C. Scheurer B. Scorneaux Y. Tang H. Urwyler S. Wittlin W. N. Charman Nature 2004 430 900
-
(2004)
Nature
, vol.430
, pp. 900
-
-
Vennerstrom, J.L.1
Arbe-Barnes, S.2
Brun, R.3
Charman, S.A.4
Chiu, F.C.K.5
Chollet, J.6
Dong, Y.7
Dorn, A.8
Hunziker, D.9
Matile, H.10
McIntosh, K.11
Padmanilayam, M.12
Santo Tomas, J.13
Scheurer, C.14
Scorneaux, B.15
Tang, Y.16
Urwyler, H.17
Wittlin, S.18
Charman, W.N.19
-
16
-
-
36148961564
-
-
X. Wang Y. Dong S. Wittlin D. Creek J. Chollet S. A. Charman J. Santo Tomas C. Scheurer C. Snyder J. L. Vennerstrom J. Med. Chem. 2007 50 5840
-
(2007)
J. Med. Chem.
, vol.50
, pp. 5840
-
-
Wang, X.1
Dong, Y.2
Wittlin, S.3
Creek, D.4
Chollet, J.5
Charman, S.A.6
Santo Tomas, J.7
Scheurer, C.8
Snyder, C.9
Vennerstrom, J.L.10
-
17
-
-
74849086595
-
-
Y. Dong S. Wittlin K. Sriraghavan J. Chollet S. A. Charman W. N. Charman C. Scheurer H. Urwyler J. Santo Tomas C. Snyder D. J. Creek J. Morizzi M. Koltun H. Matile X. Wang M. Padmanilayam Y. Tang A. Dorn R. Brun J. L. Vennerstrom J. Med. Chem. 2010 53 481
-
(2010)
J. Med. Chem.
, vol.53
, pp. 481
-
-
Dong, Y.1
Wittlin, S.2
Sriraghavan, K.3
Chollet, J.4
Charman, S.A.5
Charman, W.N.6
Scheurer, C.7
Urwyler, H.8
Santo Tomas, J.9
Snyder, C.10
Creek, D.J.11
Morizzi, J.12
Koltun, M.13
Matile, H.14
Wang, X.15
Padmanilayam, M.16
Tang, Y.17
Dorn, A.18
Brun, R.19
Vennerstrom, J.L.20
more..
-
18
-
-
33751564517
-
-
R. Amewu A. V. Stachulski S. A. Ward N. G. Berry P. G. Bray J. Davies G. Labat L. Vivas P. M. O'Neill Org. Biomol. Chem. 2006 4 4431
-
(2006)
Org. Biomol. Chem.
, vol.4
, pp. 4431
-
-
Amewu, R.1
Stachulski, A.V.2
Ward, S.A.3
Berry, N.G.4
Bray, P.G.5
Davies, J.6
Labat, G.7
Vivas, L.8
O'Neill, P.M.9
-
19
-
-
41849123835
-
-
G. L. Ellis R. Amewu S. Sabbani P. A. Stocks A. Shone D. Stanford P. Gibbons J. Davies L. Vivas S. Charnaud E. Bongard C. Hall K. Rimmer S. Lozanom M. Jesús D. Gargallo S. A. Ward P. M. O'Neill J. Med. Chem. 2008 51 2170
-
(2008)
J. Med. Chem.
, vol.51
, pp. 2170
-
-
Ellis, G.L.1
Amewu, R.2
Sabbani, S.3
Stocks, P.A.4
Shone, A.5
Stanford, D.6
Gibbons, P.7
Davies, J.8
Vivas, L.9
Charnaud, S.10
Bongard, E.11
Hall, C.12
Rimmer, K.13
Lozanom, S.14
Jesús, M.15
Gargallo, D.16
Ward, S.A.17
O'Neill, P.M.18
-
20
-
-
77955336999
-
-
Supporting Information of ref. 18a
-
P. M. O'Neill R. K. Amewu G. L. Nixon F. Bousejra ElGarah M. Mungthin J. Chadwick A. E. Shone L. Vivas H. Lander V. Barton S. Muangnoicharoen P. G. Bray J. Davies B. K. Park S. Wittlin R. Brun M. Preschel K. Zhang S. A. Ward Angew. Chem., Int. Ed. 2010 49 5693
-
(2010)
Angew. Chem., Int. Ed.
, vol.49
, pp. 5693
-
-
O'Neill, P.M.1
Amewu, R.K.2
Nixon, G.L.3
Bousejra Elgarah, F.4
Mungthin, M.5
Chadwick, J.6
Shone, A.E.7
Vivas, L.8
Lander, H.9
Barton, V.10
Muangnoicharoen, S.11
Bray, P.G.12
Davies, J.13
Park, B.K.14
Wittlin, S.15
Brun, R.16
Preschel, M.17
Zhang, K.18
Ward, S.A.19
-
36
-
-
56249098367
-
-
F. Coslédan L. Fraisse A. Pellet F. Guillou B. Mordmüller P. G. Kremsner A. Moreno D. Mazier J.-P. Maffrand B. Meunier Proc. Natl. Acad. Sci. U. S. A. 2008 105 17579
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 17579
-
-
Coslédan, F.1
Fraisse, L.2
Pellet, A.3
Guillou, F.4
Mordmüller, B.5
Kremsner, P.G.6
Moreno, A.7
Mazier, D.8
Maffrand, J.-P.9
Meunier, B.10
-
37
-
-
77955336999
-
-
P. M. O'Neill R. K. Amewu G. L. Nixon F. Bousejra ElGarah M. Mungthin J. Chadwick A. E. Shone L. Vivas H. Lander V. Barton S. Muangnoicharoen P. G. Bray J. Davies B. K. Park S. Wittlin R. Brun M. Preschel K. Zhang S. A. Ward Angew. Chem., Int. Ed. 2010 49 5693
-
(2010)
Angew. Chem., Int. Ed.
, vol.49
, pp. 5693
-
-
O'Neill, P.M.1
Amewu, R.K.2
Nixon, G.L.3
Bousejra Elgarah, F.4
Mungthin, M.5
Chadwick, J.6
Shone, A.E.7
Vivas, L.8
Lander, H.9
Barton, V.10
Muangnoicharoen, S.11
Bray, P.G.12
Davies, J.13
Park, B.K.14
Wittlin, S.15
Brun, R.16
Preschel, M.17
Zhang, K.18
Ward, S.A.19
-
43
-
-
49649115285
-
-
W. Nosoongnoen J. Pratuangdejkul K. Sathirakul A. Jacob M. Conti S. Loric J.-M. Launay P. Manivet Phys. Chem. Chem. Phys. 2008 10 5083
-
(2008)
Phys. Chem. Chem. Phys.
, vol.10
, pp. 5083
-
-
Nosoongnoen, W.1
Pratuangdejkul, J.2
Sathirakul, K.3
Jacob, A.4
Conti, M.5
Loric, S.6
Launay, J.-M.7
Manivet, P.8
-
45
-
-
0028088750
-
-
For geometry optimizations, the following X-ray crystal structures from the CCDC were used: (i) artemisinin 1; 44 (ii) X-ray structure of 10-deoxo-13-carbaartemisinin 9a 6 was used for minimization of 6 and 7; (iii) X-ray structure of yingzhaosu 4 41 was used for minimization of 4 m (iv) X-ray of arteflene 5; 42 (v) X-ray structure of trioxanes 2; 11 X-ray structure of trioxaquines Cis-3 and Trans-3 11 for trioxanes Cis-3m and Trans-3m; (vi) trioxolane 8 45 for the fragment 8 m, and (vii) tetraoxane 9 16 for the fragment 9m
-
C. Jaquet H. R. Stohler J. Chollet W. Peters Trop. Med. Parasitol. 1994 45 266
-
(1994)
Trop. Med. Parasitol.
, vol.45
, pp. 266
-
-
Jaquet, C.1
Stohler, H.R.2
Chollet, J.3
Peters, W.4
-
49
-
-
11244282931
-
-
Gaussian, Inc., Wallingford CT
-
Gaussian 03, Revision D.01, M. J. Frisch, G. W. Trucks, H. B. Schlegel, G. E. Scuseria, M. A. Robb, J. R. Cheeseman, J. A. Montgomery, Jr., T. Vreven, K. N. Kudin, J. C. Burant, J. M. Millam, S. S. Iyengar, J. Tomasi, V. Barone, B. Mennucci, M. Cossi, G. Scalmani, N. Rega, G. A. Petersson, H. Nakatsuji, M. Hada, M. Ehara, K. Toyota, R. Fukuda, J. Hasegawa, M. Ishida, T. Nakajima, Y. Honda, O. Kitao, H. Nakai, M. Klene, X. Li, J. E. Knox, H. P. Hratchian, J. B. Cross, V. Bakken, C. Adamo, J. Jaramillo, R. Gomperts, R. E. Stratmann, O. Yazyev, A. J. Austin, R. Cammi, C. Pomelli, J. W. Ochterski, P. Y. Ayala, K. Morokuma, G. A. Voth, P. Salvador, J. J. Dannenberg, V. G. Zakrzewski, S. Dapprich, A. D. Daniels, M. C. Strain, O. Farkas, D. K. Malick, A. D. Rabuck, K. Raghavachari, J. B. Foresman, J. V. Ortiz, Q. Cui, A. G. Baboul, S. Clifford, J. Cioslowski, B. B. Stefanov, G. Liu, A. Liashenko, P. Piskorz, I. Komaromi, R. L. Martin, D. J. Fox, T. Keith, M. A. Al-Laham, C. Y. Peng, A. Nanayakkara, M. Challacombe, P. M. W. Gill, B. Johnson, W. Chen, M. W. Wong, C. Gonzalez, and J. A. Pople, Gaussian, Inc., Wallingford CT, 2004
-
(2004)
Gaussian 03, Revision D.01
-
-
Frisch, M.J.1
Trucks, G.W.2
Schlegel, H.B.3
Scuseria, G.E.4
Robb, M.A.5
Cheeseman, J.R.6
Montgomery, Jr.J.A.7
Vreven, T.8
Kudin, K.N.9
Burant, J.C.10
Millam, J.M.11
Iyengar, S.S.12
Tomasi, J.13
Barone, V.14
Mennucci, B.15
Cossi, M.16
Scalmani, G.17
Rega, N.18
Petersson, G.A.19
Nakatsuji, H.20
Hada, M.21
Ehara, M.22
Toyota, K.23
Fukuda, R.24
Hasegawa, J.25
Ishida, M.26
Nakajima, T.27
Honda, Y.28
Kitao, O.29
Nakai, H.30
Klene, M.31
Li, X.32
Knox, J.E.33
Hratchian, H.P.34
Cross, J.B.35
Bakken, V.36
Adamo, C.37
Jaramillo, J.38
Gomperts, R.39
Stratmann, R.E.40
Yazyev, O.41
Austin, A.J.42
Cammi, R.43
Pomelli, C.44
Ochterski, J.W.45
Ayala, P.Y.46
Morokuma, K.47
Voth, G.A.48
Salvador, P.49
Dannenberg, J.J.50
Zakrzewski, V.G.51
Dapprich, S.52
Daniels, A.D.53
Strain, M.C.54
Farkas, O.55
Malick, D.K.56
Rabuck, A.D.57
Raghavachari, K.58
Foresman, J.B.59
Ortiz, J.V.60
Cui, Q.61
Baboul, A.G.62
Clifford, S.63
Cioslowski, J.64
Stefanov, B.B.65
Liu, G.66
Liashenko, A.67
Piskorz, P.68
Komaromi, I.69
Martin, R.L.70
Fox, D.J.71
Keith, T.72
Al-Laham, M.A.73
Peng, C.Y.74
Nanayakkara, A.75
Challacombe, M.76
Gill, P.M.W.77
Johnson, B.78
Chen, W.79
Wong, M.W.80
Gonzalez, C.81
Pople, J.A.82
more..
-
53
-
-
84873055189
-
-
Wiley, New York, 76 and references therein
-
W. J. Hehre, L. Radom, P.v.R. Schleyer, J. A. Pople, Ab Initio Molecular Orbital Theory, Wiley, New York, 1986, p. 76 and references therein
-
(1986)
Ab Initio Molecular Orbital Theory
-
-
Hehre, W.J.1
Radom, L.2
Schleyer, V.P.R.3
Pople, J.A.4
|