메뉴 건너뛰기




Volumn 10, Issue 1, 2013, Pages

Phenotypic screens for compounds that target the cellular pathologies underlying Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; OXIDOPAMINE; ROTENONE; STROPHANTHIDIN;

EID: 84875724418     PISSN: None     EISSN: 17406749     Source Type: Journal    
DOI: 10.1016/j.ddtec.2012.02.003     Document Type: Review
Times cited : (26)

References (49)
  • 1
    • 0030882856 scopus 로고    scopus 로고
    • Alpha-synuclein in Lewy bodies
    • M.G. Spillantini Alpha-synuclein in Lewy bodies Nature 388 1997 839 840
    • (1997) Nature , vol.388 , pp. 839-840
    • Spillantini, M.G.1
  • 2
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • M.H. Polymeropoulos Mutation in the alpha-synuclein gene identified in families with Parkinson's disease Science 276 1997 2045 2047
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1
  • 3
    • 0242300619 scopus 로고    scopus 로고
    • Alpha-Synuclein locus triplication causes Parkinson's disease
    • A.B. Singleton Alpha-Synuclein locus triplication causes Parkinson's disease Science 302 2003 841
    • (2003) Science , vol.302 , pp. 841
    • Singleton, A.B.1
  • 4
    • 7244243876 scopus 로고    scopus 로고
    • Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation
    • W. Li Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation J. Neurosci. 24 2004 7400 7409
    • (2004) J. Neurosci. , vol.24 , pp. 7400-7409
    • Li, W.1
  • 5
    • 33751118534 scopus 로고    scopus 로고
    • Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?
    • Y. Chu, and J.H. Kordower Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease? Neurobiol. Dis. 25 2007 134 149
    • (2007) Neurobiol. Dis. , vol.25 , pp. 134-149
    • Chu, Y.1    Kordower, J.H.2
  • 6
    • 79960361814 scopus 로고    scopus 로고
    • Recent advances in the genetics of Parkinson's disease
    • I. Martin Recent advances in the genetics of Parkinson's disease Annu. Rev. Genomics Hum. Genet. 12 2011 301 325
    • (2011) Annu. Rev. Genomics Hum. Genet. , vol.12 , pp. 301-325
    • Martin, I.1
  • 7
    • 79952133911 scopus 로고    scopus 로고
    • Toxin-induced and genetic animal models of Parkinson's disease
    • S. Hisahara, and S. Shimohama Toxin-induced and genetic animal models of Parkinson's disease Parkinsons Dis. 2011 2010 951709
    • (2010) Parkinsons Dis. , vol.2011 , pp. 951709
    • Hisahara, S.1    Shimohama, S.2
  • 8
    • 77953666105 scopus 로고    scopus 로고
    • Genetic animal models of Parkinson's disease
    • T.M. Dawson Genetic animal models of Parkinson's disease Neuron 66 2010 646 661
    • (2010) Neuron , vol.66 , pp. 646-661
    • Dawson, T.M.1
  • 9
    • 79955622718 scopus 로고    scopus 로고
    • Priorities in Parkinson's disease research
    • W.G. Meissner Priorities in Parkinson's disease research Nat. Rev. Drug Discov. 10 2011 377 393
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 377-393
    • Meissner, W.G.1
  • 11
    • 34547599329 scopus 로고    scopus 로고
    • Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease
    • T.F. Outeiro Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease Science 317 2007 516 519
    • (2007) Science , vol.317 , pp. 516-519
    • Outeiro, T.F.1
  • 12
    • 34247603516 scopus 로고    scopus 로고
    • A cell-based model of alpha-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease
    • D.L. Zhao A cell-based model of alpha-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease Acta Pharmacol. Sin. 28 2007 616 626
    • (2007) Acta Pharmacol. Sin. , vol.28 , pp. 616-626
    • Zhao, D.L.1
  • 13
    • 4344569643 scopus 로고    scopus 로고
    • Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro
    • P.J. McLean Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro Biochem. Biophys. Res. Commun. 321 2004 665 669
    • (2004) Biochem. Biophys. Res. Commun. , vol.321 , pp. 665-669
    • McLean, P.J.1
  • 14
    • 77249101456 scopus 로고    scopus 로고
    • Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity
    • P. Putcha Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity J. Pharmacol. Exp. Ther. 332 2010 849 857
    • (2010) J. Pharmacol. Exp. Ther. , vol.332 , pp. 849-857
    • Putcha, P.1
  • 15
    • 44849125207 scopus 로고    scopus 로고
    • Formation of toxic oligomeric alpha-synuclein species in living cells
    • T.F. Outeiro Formation of toxic oligomeric alpha-synuclein species in living cells PLoS ONE 3 2008 e1867
    • (2008) PLoS ONE , vol.3 , pp. 1867
    • Outeiro, T.F.1
  • 16
    • 33645235438 scopus 로고    scopus 로고
    • Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington's and Parkinson's diseases
    • R.A. Bodner Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases Proc. Natl. Acad. Sci. U.S.A. 103 2006 4246 4251
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 4246-4251
    • Bodner, R.A.1
  • 17
    • 0036852712 scopus 로고    scopus 로고
    • Pharmacological prevention of Parkinson disease in Drosophila
    • P.K. Auluck, and N.M. Bonini Pharmacological prevention of Parkinson disease in Drosophila Nat. Med. 8 2002 1185 1186
    • (2002) Nat. Med. , vol.8 , pp. 1185-1186
    • Auluck, P.K.1    Bonini, N.M.2
  • 18
    • 0345189364 scopus 로고    scopus 로고
    • Yeast cells provide insight into alpha-synuclein biology and pathobiology
    • T.F. Outeiro, and S. Lindquist Yeast cells provide insight into alpha-synuclein biology and pathobiology Science 302 2003 1772 1775
    • (2003) Science , vol.302 , pp. 1772-1775
    • Outeiro, T.F.1    Lindquist, S.2
  • 19
    • 33847320669 scopus 로고    scopus 로고
    • The 5′-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element
    • A.L. Friedlich The 5′-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element Mol. Psychiatry 12 2007 222 223
    • (2007) Mol. Psychiatry , vol.12 , pp. 222-223
    • Friedlich, A.L.1
  • 20
    • 84871802347 scopus 로고    scopus 로고
    • Identification of a small molecule that selectively activates alpha-synuclein translational expression
    • Bethesda (MD): National Center for Biotechnology Information (US). (Updated 2011 Feb 15)
    • Ross NT, et al. (2011) Identification of a small molecule that selectively activates alpha-synuclein translational expression. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US). (Updated 2011 Feb 15)
    • (2011) Probe Reports from the NIH Molecular Libraries Program [Internet]
    • Ross, N.T.1
  • 21
    • 84871802347 scopus 로고    scopus 로고
    • Identification of a small molecule that selectively inhibits alpha-synuclein translational expression
    • Bethesda (MD): National Center for Biotechnology Information (US). (Updated 2011 Feb 15)
    • Ross NT, et al. (2011) Identification of a small molecule that selectively inhibits alpha-synuclein translational expression. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US). (Updated 2011 Feb 15)
    • (2011) Probe Reports from the NIH Molecular Libraries Program [Internet]
    • Ross, N.T.1
  • 22
    • 80051644911 scopus 로고    scopus 로고
    • The alpha-synuclein 5′-untranslated region targeted translation blockers: Anti-alpha synuclein efficacy of cardiac glycosides and Posiphen
    • J.T. Rogers The alpha-synuclein 5′-untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen J. Neural Transm. 118 2011 493 507
    • (2011) J. Neural Transm. , vol.118 , pp. 493-507
    • Rogers, J.T.1
  • 23
    • 77957240556 scopus 로고    scopus 로고
    • Development of a high-throughput screening assay for cytoprotective agents in rotenone-induced cell death
    • I.S. Yoon Development of a high-throughput screening assay for cytoprotective agents in rotenone-induced cell death Anal. Biochem. 407 2010 205 210
    • (2010) Anal. Biochem. , vol.407 , pp. 205-210
    • Yoon, I.S.1
  • 24
    • 0346158531 scopus 로고    scopus 로고
    • High content screening applied to large-scale cell biology
    • V.C. Abraham High content screening applied to large-scale cell biology Trends Biotechnol. 22 2004 15 22
    • (2004) Trends Biotechnol. , vol.22 , pp. 15-22
    • Abraham, V.C.1
  • 25
    • 38349160161 scopus 로고    scopus 로고
    • The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis
    • A.D. Gitler The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis Proc. Natl. Acad. Sci. U.S.A. 105 2008 145 150
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 145-150
    • Gitler, A.D.1
  • 26
    • 33746533924 scopus 로고    scopus 로고
    • Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
    • A.A. Cooper Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models Science 313 2006 324 328
    • (2006) Science , vol.313 , pp. 324-328
    • Cooper, A.A.1
  • 27
    • 61349147706 scopus 로고    scopus 로고
    • Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
    • A.D. Gitler Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity Nat. Genet. 41 2009 308 315
    • (2009) Nat. Genet. , vol.41 , pp. 308-315
    • Gitler, A.D.1
  • 28
    • 77949438990 scopus 로고    scopus 로고
    • Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models
    • L.J. Su Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models Dis. Model Mech. 3 2010 194 208
    • (2010) Dis. Model Mech. , vol.3 , pp. 194-208
    • Su, L.J.1
  • 29
    • 47649093352 scopus 로고    scopus 로고
    • An integrated platform of genomic assays reveals small-molecule bioactivities
    • S. Hoon An integrated platform of genomic assays reveals small-molecule bioactivities Nat. Chem. Biol. 4 2008 498 506
    • (2008) Nat. Chem. Biol. , vol.4 , pp. 498-506
    • Hoon, S.1
  • 30
    • 31644443193 scopus 로고    scopus 로고
    • A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential
    • G. Griffioen A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential Biochim. Biophys. Acta 1762 2006 312 318
    • (2006) Biochim. Biophys. Acta , vol.1762 , pp. 312-318
    • Griffioen, G.1
  • 31
    • 0033598747 scopus 로고    scopus 로고
    • Production of cyclic peptides and proteins in vivo
    • C.P. Scott Production of cyclic peptides and proteins in vivo Proc. Natl. Acad. Sci. U.S.A. 96 1999 13638 13643
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 13638-13643
    • Scott, C.P.1
  • 32
    • 69249124948 scopus 로고    scopus 로고
    • Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models
    • J.A. Kritzer Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models Nat. Chem. Biol. 5 2009 655 663
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 655-663
    • Kritzer, J.A.1
  • 33
    • 34248994604 scopus 로고    scopus 로고
    • Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
    • S. Sarkar Small molecules enhance autophagy and reduce toxicity in Huntington's disease models Nat. Chem. Biol. 3 2007 331 338
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 331-338
    • Sarkar, S.1
  • 34
    • 9344247454 scopus 로고    scopus 로고
    • Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips
    • J. Huang Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips Proc. Natl. Acad. Sci. U.S.A. 101 2004 16594 16599
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 16594-16599
    • Huang, J.1
  • 35
    • 75749136948 scopus 로고    scopus 로고
    • Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease
    • D.W. Neef Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease PLoS Biol. 8 2010 e1000291
    • (2010) PLoS Biol. , vol.8 , pp. 1000291
    • Neef, D.W.1
  • 36
    • 0036468432 scopus 로고    scopus 로고
    • Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
    • P.K. Auluck Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease Science 295 2002 865 868
    • (2002) Science , vol.295 , pp. 865-868
    • Auluck, P.K.1
  • 37
    • 61349114190 scopus 로고    scopus 로고
    • Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity
    • E. Yeger-Lotem Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity Nat. Genet. 41 2009 316 323
    • (2009) Nat. Genet. , vol.41 , pp. 316-323
    • Yeger-Lotem, E.1
  • 38
    • 84856707768 scopus 로고    scopus 로고
    • Different 8-hydroxyquinolines protect models of TDP-43 protein, alpha-synuclein, and polyglutamine proteotoxicity through distinct mechanisms
    • D.F. Tardiff Different 8-hydroxyquinolines protect models of TDP-43 protein, alpha-synuclein, and polyglutamine proteotoxicity through distinct mechanisms J. Biol. Chem. 287 2012 4107 4120
    • (2012) J. Biol. Chem. , vol.287 , pp. 4107-4120
    • Tardiff, D.F.1
  • 39
    • 77951558389 scopus 로고    scopus 로고
    • C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease
    • A.J. Harrington C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease Dev. Dyn. 239 2010 1282 1295
    • (2010) Dev. Dyn. , vol.239 , pp. 1282-1295
    • Harrington, A.J.1
  • 40
    • 34248380418 scopus 로고    scopus 로고
    • Identification of neuroprotective compounds of caenorhabditis elegans dopaminergic neurons against 6-OHDA
    • M. Marvanova, and C.D. Nichols Identification of neuroprotective compounds of caenorhabditis elegans dopaminergic neurons against 6-OHDA J. Mol. Neurosci. 31 2007 127 137
    • (2007) J. Mol. Neurosci. , vol.31 , pp. 127-137
    • Marvanova, M.1    Nichols, C.D.2
  • 41
    • 9244251118 scopus 로고    scopus 로고
    • Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings
    • E. Braungart Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings Neurodegen. Dis. 1 2004 175 183
    • (2004) Neurodegen. Dis. , vol.1 , pp. 175-183
    • Braungart, E.1
  • 42
    • 78649840854 scopus 로고    scopus 로고
    • Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration
    • C. Samara Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration Proc. Natl. Acad. Sci. U.S.A. 107 2010 18342 18347
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 18342-18347
    • Samara, C.1
  • 43
    • 66449115032 scopus 로고    scopus 로고
    • A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
    • D. Paquet A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation J. Clin. Invest. 119 2009 1382 1395
    • (2009) J. Clin. Invest. , vol.119 , pp. 1382-1395
    • Paquet, D.1
  • 44
    • 77449155155 scopus 로고    scopus 로고
    • Swimming into the future of drug discovery: In vivo chemical screens in zebrafish
    • T.V. Bowman, and L.I. Zon Swimming into the future of drug discovery: in vivo chemical screens in zebrafish ACS Chem. Biol. 5 2010 159 161
    • (2010) ACS Chem. Biol. , vol.5 , pp. 159-161
    • Bowman, T.V.1    Zon, L.I.2
  • 45
    • 79960833952 scopus 로고    scopus 로고
    • Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
    • F. Soldner Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations Cell 146 2011 318 331
    • (2011) Cell , vol.146 , pp. 318-331
    • Soldner, F.1
  • 46
    • 61349100729 scopus 로고    scopus 로고
    • Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors
    • F. Soldner Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors Cell 136 2009 964 977
    • (2009) Cell , vol.136 , pp. 964-977
    • Soldner, F.1
  • 47
    • 79952172335 scopus 로고    scopus 로고
    • LRRK2 mutant iPSC-derived da neurons demonstrate increased susceptibility to oxidative stress
    • H.N. Nguyen LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress Cell Stem Cell 8 2011 267 280
    • (2011) Cell Stem Cell , vol.8 , pp. 267-280
    • Nguyen, H.N.1
  • 48
    • 80052419902 scopus 로고    scopus 로고
    • Parkinson's disease induced pluripotent stem cells with triplication of the alpha-synuclein locus
    • M.J. Devine Parkinson's disease induced pluripotent stem cells with triplication of the alpha-synuclein locus Nat. Commun. 2 2011 440
    • (2011) Nat. Commun. , vol.2 , pp. 440
    • Devine, M.J.1
  • 49
    • 79959786193 scopus 로고    scopus 로고
    • How to revive breakthrough innovation in the pharmaceutical industry
    • 89cm16
    • B.H. Munos, and W.W. Chin How to revive breakthrough innovation in the pharmaceutical industry Sci. Transl. Med. 3 2011 89cm16
    • (2011) Sci. Transl. Med. , vol.3
    • Munos, B.H.1    Chin, W.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.