Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis

Toxicology

Volumn 265, Issue 3, 2009, Pages 108-114

  Artursson, Elisabet ^a   Akfur, Christine ^a   Hörnberg, Andreas ^a   Worek, Franz ^b   Ekström, Fredrik ^a  

^a SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^b BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

Acetylcholinesterase; HI 6; HL 7; K027; Mutagenesis; Reactivation kinetics; Tabun

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 [2,4 BIS(HYDROXYIMINOMETHYL)PYRIDINIO] 1' (4 CARBAMOYLPYRIDINIO)DIMETHYL ETHER DIIODIDE; 1 [[[4 (AMINOCARBONYL)PYRIDINO]METHOXY]METHYL] 2,4 BIS [(HYDROXYIMINO)METHYL]PYRIDINIUM DIMETHANESULFONATE; [1 (4 HYDROXYIMINOMETHYLPYRIDINIUM) 3 (4 CARBAMOYLPYRIDINIUM)PROPANE DIBROMIDE]; [[1 [(4 CARBAMOYLPYRIDIN 1 IUM 1 YL)METHOXYMETHYL]PYRIDIN 2 YLIDENE]METHYL]OXOAZANIUM DICHLORIDE MONOHYDRATE; ACETYLCHOLINESTERASE; ALANINE; ASPARAGINE; ASPARTIC ACID; GLUTAMIC ACID; K 027; MUTANT PROTEIN; OXIME DERIVATIVE; PHENYLALANINE; TABUN; TYROSINE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME REACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FOLDING; SITE DIRECTED MUTAGENESIS;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; CLONING, MOLECULAR; HUMANS; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; OXIMES; PHOSPHORIC ACID ESTERS; PYRIDINIUM COMPOUNDS; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS, DNA; TEMPLATES, GENETIC;

EID: 72049107837     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.09.002     Document Type: Article

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