Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds

Biochemical Pharmacology

Volumn 80, Issue 6, 2010, Pages 941-946

  Wille, Timo ^a   Ekström, Fredrik ^b   Lee, Jong Cheol ^c,d   Pang, Yuan Ping ^c   Thiermann, Horst ^a   Worek, Franz ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^b SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

^c MAYO CLINIC   (United States)

^d Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Acetylcholinesterase; Kinetics; Organophosphorus compounds; Oxime; Reactivation; Structure activity relationship

Indexed keywords

CHOLINESTERASE INHIBITOR; CYCLOSARIN; ORGANOPHOSPHORUS COMPOUND; OXIME DERIVATIVE; PARAOXON; SARIN; TABUN; UNCLASSIFIED DRUG; VX COMPOUND;

ARTICLE; CALCULATION; DRUG INHIBITION; DRUG STRUCTURE; ENZYME INHIBITION; KINETICS; PRIORITY JOURNAL;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; HUMANS; KINETICS; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; PYRIDINIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77954762331     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.05.022     Document Type: Article

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