Type 2 diabetes in South Asians: Similarities and differences with white Caucasian and other populations

Annals of the New York Academy of Sciences

Volumn 1281, Issue 1, 2013, Pages 51-63

  Gujral, Unjali P ^a   Pradeepa, R ^b   Weber, Mary Beth ^c   Narayan, K M Venkat ^a,c   Mohan, V ^b  

^a EMORY UNIVERSITY   (United States)

^b MADRAS DIABETES RESEARCH FOUNDATION   (India)

^c EMORY UNIVERSITY   (United States)

Author keywords

Ethnic comparison; Prevalence; South Asians; Type 2 diabetes mellitus

Indexed keywords

C REACTIVE PROTEIN;

ANTHROPOMETRY; ARTICLE; ASIAN; BANGLADESH; BHUTAN; CAUCASIAN; DIET; ENVIRONMENTAL FACTOR; ETHNIC DIFFERENCE; ETHNIC GROUP; GENETIC ASSOCIATION; HUMAN; IMMOBILIZATION; INDIA; LIFESTYLE; MALDIVES; NEPAL; NON INSULIN DEPENDENT DIABETES MELLITUS; POLLUTANT; RACE DIFFERENCE; SLEEP TIME; SMOKING; SRI LANKA;

EID: 84875685376     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06838.x     Document Type: Article

References (123)

1. Whiting, D.R. et al. 2011. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes. Res. Clin. Pract. 94: 311-321.
2. Mohan, V. 2004. Why are Indians more prone to diabetes J. Assoc. Physicians India 52: 468-474.
3. International Diabetes Federation. 2011. IDF Diabetes Atlas, 5th ed. Brussels, Belgium: International Diabetes Federation, 2011.
4. Hwang, C.K. et al. 2012. Rural diabetes prevalence quintuples over twenty-five years in low-and middle-income countries: a systematic review and meta-analysis. Diabetes Res. Clin. Pract. 96: 271-285.
5. Anjana, R.M. et al. 2011. Prevalence of diabetes and prediabetes (impaired fasting glucose and/or impaired glucose tolerance) in urban and rural India: phase I results of the Indian Council of Medical Research-INdiaDIABetes (ICMR-INDIAB) study. Diabetologia 54: 3022-3027.
6. Gupta, L. et al. 2011. Prevalence of Diabetes in New York City, 2002-2008: comparing foreign-born South Asians and other Asians with U.S.-born whites, blacks, and Hispanics. Diab. Care 34: 1791-1793.
7. Oza-Frank, R. et al. 2009. Asian Americans: diabetes prevalence across U.S. and World Health Organization weight classifications. Diab. Care 1644-1646.
8. Misra, R. et al. 2010. Prevalence of diabetes, metabolic syndrome, and cardiovascular risk factors in US Asian Indians: results from a national study. J. Diab. Complicat. 24: 145-153.
9. Mather, H.M. & H. Keen. 1985. The Southall Diabetes Survey: prevalence of known diabetes in Asians and Europeans. Br. Med. J. (Clin. Res. Ed.) 291: 1081-1084.
10. Zimmet, P. et al. 1983. Prevalence of diabetes and impaired glucose tolerance in the biracial (Melanesian and Indian) population of Fiji: a rural-urban comparison. Am. J. Epidemiol. 118: 673-688.
11. Omar, M.A. et al. 1994. South African Indians show a high prevalence of NIDDM and bimodality in plasma glucose distribution patterns. Diab. Care 17: 70-73.
12. Seedat, Y.K. et al. 1994. Risk factors for coronary heart disease in the white community of Durban. South Afr. Med. J. 84: 257-262.
13. Jenum, A.K. et al. 2005. Ethnicity and sex are strong determinants of diabetes in an urban Western society: implications for prevention. Diabetologia 48: 435-439.
14. Lee, W.R. 2000. The changing demography of diabetes mellitus in Singapore. Diab. Res. Clin. Pract. 50 (Suppl 2): S35-S39.
15. Mohan, V. et al. 2008. Incidence of diabetes and pre-diabetes in a selected urban south Indian population (CUPS-19). J. Assoc. Physicians India 56: 152-157.
16. Geiss, L. et al. 2006. Changes in incidence of diabetes in U.S. adults, 1997-2003. Am. J. Prev. Med. 30: 371-377.
17. Bonora, E. et al. 2004. Population-based incidence rates and risk factors for type 2 diabetes in white individuals: the Bruneck study. Diabetes 53: 1782-1789.
18. Valdes, S. et al. 2007. Population-based incidence of type 2 diabetes in northern Spain: the Asturias Study. Diab. Care 30: 2258-2263.
19. Kasuga, M. 2006. Insulin resistance and pancreatic beta cell failure. J. Clin. Invest. 116: 1756-1760.
20. Kahn, S.E. et al. 2003. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 46: 3-19.
21. Saad, M.F. et al. 1991. A two-step model for development of non-insulin-dependent diabetes. Am. J. Med. 90: 229-235.
22. Cnop, M. et al. 2007. Progressive loss of beta-cell function leads to worsening glucose tolerance in first degree relatives of subjects with type 2 diabetes. Diabet. Care 30: 677-682.
23. Cali, A.M. et al. 2009. Primary defects in beta-cell function further exacerbated by worsening of insulin resistance mark the development of impaired glucose tolerance in obese adolescents. Diabet. Care 32: 456-461.
24. Motala, A.A. et al. 1994. Evidence for impaired pancreatic beta cell function in South African Indians with impaired glucose tolerance. Diab. Med. 11: 437-444.
25. Kahn, S.E. 2001. Clinical review 135: the importance of β-cell failure in the development and progression of type 2 diabetes. J. Clin. Endocrinol. Metabol. 86: 4047-4058.
26. Polonsky, K. et al. 1996. Seminars in Medicine of the Beth Israel Hospital, Boston: non-Insulin-Dependent Diabetes Mellitus-A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance. N. Engl. J. Med. 334: 777-783.
27. Torrens, J.I. et al. 2004. Ethnic differences in insulin sensitivity and beta-cell function in premenopausal or early perimenopausal women without diabetes: the Study of Women's Health Across the Nation (SWAN). Diab. Care 27: 354-361.
28. Bi, Y. et al. 2012. Association of β-cell function and insulin sensitivity with fasting and 2-h plasma glucose in a large Chinese population. Diab. Obesity Metabol. 14: 174-180.
29. Abdul-Ghani, M.A., et al. 2007. The relative contributions of insulin resistance and beta cell failure to the transition from normal to impaired glucose tolerance varies in different ethnic groups. Diab. Met. Syn. Res. Rev. 1: 105-112.
30. Chiu, K.C. et al. 2000. Insulin sensitivity differs among ethnic groups with a compensatory response in beta-cell function. Diab. Care 23: 1353-1358.
31. Mohan, V. et al. 1986. Serum immunoreactive insulin responses to a glucose load in Asian Indian and European Type 2 (non-insulin dependent) diabetic patients and control subjects. Diabetologia 29: 235-237.
32. Sharp, P.S. et al. 1987. Insulin resistance in patients of Asian Indian and European origin with non-insulin dependent diabetes. Hormone Metabol. Res. 19: 84-85.
33. Raji, A. et al. 2001. Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. J. Clin. Endocrinol. Metabol. 86: 5366-5371.
34. Banerji, M.A. et al. 1999. Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men. J. Clin. Endocrinol. Metabol. 84: 137-144.
35. Indulekha, K. et al. 2011. Association of visceral and subcutaneous fat with glucose intolerance, insulin resistance, adipocytokines and inflammatory markers in Asian Indians (CURES-113). Clin. Biochem. 44: 281-287.
36. Sandeep, S. et al. 2010. Visceral & subcutaneous abdominal fat in relation to insulin resistance & metabolic syndrome in non-diabetic south Indians. Indian J. Med. Res. 131: 629-635.
37. Szuszkiewicz-Garcia, M. et al. 2012. Fat distribution and insulin resistance in young adult nonobese Asian Indian women. Metabol. Syndrome Related Disorders 10: 326-330.
38. Petersen, K.F et al. 2006. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc. Nat. Acad. Sci. USA 103: 18273-18277.
39. Hales, C.N. et al. 1991. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 303: 1019-1022.
40. Jaquet, D. et al. 2000. No evidence for a major beta-cell dysfunction in young adults born with intra-uterine growth retardation. Pediatric Diab. 1: 181-185.
41. Bavdekar, A. et al. 1999. Insulin resistance syndrome in 8-year-old Indian children: small at birth, big at 8 years, or both Diabetes 48: 2422-2429.
42. Pilgaard, K. et al. 2010. Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes. Diabetologia 53: 2526-2530.
43. Kooner, J.S. et al. 2011. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nature Genet. 43: 984-989.
44. Cho, Y.S. et al. 2012. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat. Genet. 44: 67-72.
45. Rees, S.D. et al. 2011. Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations. Diabetologia 54: 1368-1374.
46. Chauhan, G. et al. 2010. Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5, 164 Indians. Diabetes 59: 2068-2074.
47. Yajnik, C.S. et al. 2009. FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians. Diabetologia 52: 247-252.
48. Sanghera, D.K. et al. 2008. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med. Genet. 9: 59.
49. Ramya, K. et al. 2011. Genetic variations in the FTO gene are associated with type 2 diabetes and obesity in south Indians (CURES-79). Diab. Technol. Therap. 13: 33-42.
50. Frayling, T.M. et al. 2007. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
51. Chauhan, G. et al. 2011. Common variants of FTO and the risk of obesity and type 2 diabetes in Indians. J. Hum. Genet. 56: 720-726.
52. Wasim, H. et al. 2006. Relationship of serum adiponectin and resistin to glucose intolerance and fat topography in South-Asians. Cardiovasc. Diabetol. 5: 10.
53. Vimaleswaran, K.S. et al. 2005. Peroxisome proliferators-activated receptor-co-activator-1 (PGC-1) gene polymorphisms and their relationship to Type 2 diabetes in Asian Indians. (CURES-14). Diab. Med. 22: 1516-1521.
54. Qiao, Q. et al. 2003. Age- and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts. Diab. Care 26: 1770-1780.
55. Ramachandran, A. et al. 2001. High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey. Diabetologia 44: 1094-1101.
56. Center for Disease Control and Prevention. Diabetes Data & Trends. Available at http://www.cdc.gov/diabetes/statistics/incidence_national.htm. Accessed on June 1, 2012.
57. Chiu, M. et al. 2011. Deriving ethnic-specific BMI cutoff points for assessing diabetes risk. Diab. Care 34: 1741-1748.
58. Mohan, V. et al. 2007. Epidemiology of type 2 diabetes: Indian scenario. Indian J. Med. Res. 125: 217-230.
59. Chandalia, M. et al. 1999. Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men. J. Clin. Endocrinol. Metabol. 84: 2329-2335.
60. Rush, E.C. et al. 2009. Body size, body composition and fat distribution: comparative analysis of European, Maori, Pacific Island and Asian Indian adults. Br. J. Nutr. 102: 632-641.
61. Shaw, N.J. et al. 2007. Ethnic and gender differences in body fat in British school children as measured by DXA. Arch. Dis. Child 92: 872-875.
62. Krishnaveni, G.V. et al. 2005. Truncal adiposity is present at birth and in early childhood in South Indian children. Indian Pediatr. 42: 527-538.
63. Yajnik, C.S. et al. 2003. Neonatal anthropometry: the thin-fat Indian baby. The Pune Maternal Nutrition Study. Int. J. Obes. Relat. Metabol. Disord. 27: 173-180.
64. Chan, J. et al. 2009. Diabetes in Asia: epidemiology, Risk Factors, and Pathophysiology. JAMA 301: 2129-2140.
65. Ramachandran, P. 2010. Nutrition and child survival in India. Indian. J. Pediatr. 77: 301-305.
66. Ramakrishnan, U. 2004. Nutrition and low birth weight: from research to practice. Am. J. Clin. Nutr. 79: 17-21.
67. Sachdev, H.S. et al. 2005. Anthropometric indicators of body composition in young adults: relation to size at birth and serial measurements of body mass index in childhood in the New Delhi birth cohort. Am. J. Clin. Nutr. 82: 456-466.
68. Bhargava, S.K. et al. 2004. Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. New England J. Med. 350: 865-875.
69. Levy-Marchal, C. & D. Jaquet. 2004. Long-term metabolic consequences of being born small for gestational age. Pediatric Diab. 5: 147-153.
70. Veena, S.R. et al. 2012. Newborn size and body composition as predictors of insulin resistance and diabetes in the parents: Parthenon Birth Cohort Study, Mysore, India. Diab. Care 35: 1884-1890.
71. Maritim, A.C. et al. 2003. Diabetes, oxidative stress, and antioxidants: a review. J. Biochem. Mol. Toxicol. 17: 24-38.
72. Evans, J.L. et al. 2003. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction Diabetes 52: 1-8.
73. Pou, K.M. et al. 2007. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation 116: 1234-1241.
74. Indulekha, K. et al. 2011. Association of visceral and subcutaneous fat with glucose intolerance, insulin resistance, adipocytokines and inflammatory markers in Asian Indians (CURES-113). Clin. Biochem. 44: 281-287.
75. Mohan, V. et al. 2005. Association of C-reactive protein with body fat, diabetes and coronary artery disease in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-6). Diab. Med. 22: 863-870.
76. Pradhan, A.D. et al. 2001. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286: 327-334.
77. Abate, N. et al. 2004. Adipose tissue metabolites and insulin resistance in nondiabetic Asian Indian men. J. Clin. Endocrinol. Metabol. 89: 2750-2755.
78. Forouhi, N.G. et al. 2001. Relation of C-reactive protein to body fat distribution and features of the metabolic syndrome in Europeans and South Asians. Int. J. Obes. Relat. Metabol. Disord. 25: 1327-1331.
79. Chambers, J.C. et al. 2001. C-reactive protein, insulin resistance, central obesity, and coronary heart disease risk in Indian Asians from the United Kingdom compared with European whites. Circulation 104: 145-150.
80. Chandalia, M. et al. 2003. Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States. J. Clin. Endocrinol. Metabol. 88: 3773-3776.
81. Shetty, P.S. 2002. Nutrition transition in India. Public Health Nutr. 5: 175-182.
82. Helmrich, S.P. et al. 1991. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. New England J. Med. 325: 147-152.
83. Laaksonen, D.E. et al. 2005. Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study. Diabetes 54: 158-165.
84. Mohan, V. et al. 2005. Association of physical inactivity with components of metabolic syndrome and coronary artery disease-the Chennai Urban Population Study (CUPS no. 15). Diabet. Med. 22: 1206-1211.
85. Williams, E.D. et al. 2011. Assessment of physical activity levels in South Asians in the UK: findings from the Health Survey for England. J. Epidemiol. Commun. Health 65: 517-521.
86. Lip, G.Y. et al. 1996. Ethnic differences in public health awareness, health perceptions and physical exercise: implications for heart disease prevention. Ethn. Health 1: 47-53.
87. Fischbacher, C.M. et al. 2004. How physically active are South Asians in the United Kingdom? A literature review. J. Public Health (Oxf.) 26: 250-258.
88. Hayes, L. et al. 2002. Patterns of physical activity and relationship with risk markers for cardiovascular disease and diabetes in Indian, Pakistani, Bangladeshi and European adults in a UK population. J. Public Health Med. 24: 170-178.
89. Hu, F.B. et al. 2001. Diet and risk of Type II diabetes: the role of types of fat and carbohydrate. Diabetologia 44: 805-817.
90. Mohan, V. et al. 2009. Dietary carbohydrates, glycemic load, food groups and newly detected type 2 diabetes among urban Asian Indian population in Chennai, India (Chennai Urban Rural Epidemiology Study 59). Br. J. Nutr. 102: 1498-1506.
91. Misra, A. et al. 2009. South Asian diets and insulin resistance. Br. J. Nutr. 101: 465-473.
92. Burden, M.L. et al. 1994. A comparison of the glycemic and insulinaemic effects of an Asian and a European meal. Pract. Diab. Int. 11: 208-211.
93. Raj, S. et al. 1999. Dietary habits of Asian Indians in relation to length of residence in the United States. J. Am. Diet. Assoc. 99: 1106-1108.
94. Kulkarni, K. 2004. Food, culture, and diabetes in the United States. Clin. Diab. 22: 190-192.
95. Wandel, M. et al. 2008. Changes in food habits after migration among South Asians settled in Oslo: the effect of demographic, socio-economic and integration factors. Appetite 50: 376-385.
96. Garduno-Diaz, S.D. & S. Khokhar. 2012. Prevalence, risk factors and complications associated with type 2 diabetes in migrant South Asians. Diab. Metabol. Res. Rev. 28: 6-24.
97. Isharwal, S. et al. 2009. Diet & insulin resistance: a review & Asian Indian perspective. Indian J. Med. Res. 129: 485-499.
98. Donin, A.S. et al. 2010. Nutritional composition of the diets of South Asian, black African-Caribbean and white European children in the United Kingdom: the Child Heart and Health Study in England (CHASE). Br. J. Nutr. 104: 276-285.
99. Shah, T. et al. 2005. Prevalence of metabolic syndrome risk factors among young adult Asian Indians. Jimmigr. Health 7: 117-126.
100. Rimm, E.B. et al. 1995. Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men. BMJ 310: 555-559.
101. Rimm, E.B. et al. 1993. Cigarette smoking and the risk of diabetes in women. Am. J. Public Health 83: 211-214.
102. Frati, A.C. et al. 1996. Acute effect of cigarette smoking on glucose tolerance and other cardiovascular risk factors. Diab. Care 19: 112-118.
103. Persson, P.G. et al. 2000. Cigarette smoking, oral moist snuff use and glucose intolerance. J. Intern. Med. 248: 103-110.
104. Baris, E. et al. 2000. Research priorities for tobacco control in developing countries: a regional approach to a global consultative process. Tob. Control. 9: 217-223.
105. Rani, M. et al. 2003. Tobacco use in India: prevalence and predictors of smoking and chewing in a national cross sectional household survey. Tob. Control. 12: e4.
106. Gupta, P.C. & C.S. Ray. 2003. Smokeless tobacco and health in India and South Asia. Respirology 8: 419-431.
107. Govino, G. 2002. Epidemiology of tobacco use in the United States. Oncogene 21: 7326-7340.
108. Spiegel, K. et al. 2004. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann. Int. Med. 141: 846-850.
109. Beihl, D.A. et al. 2009. Sleep duration as a risk factor for incident type 2 diabetes in a multiethnic cohort. Ann. Epidemiol. 19: 351-357.
110. Nilsson, P.M. et al. 2004. Incidence of diabetes in middle-aged men is related to sleep disturbances. Diab. Care 27: 2464-2469.
111. Roopa, M. et al. 2010. Prevalence of sleep abnormalities and their association with metabolic syndrome among Asian Indians: Chennai Urban Rural Epidemiology Study (CURES-67). J. Diab. Sci. Technol. 4: 1524-1531.
112. Bhushan, B. et al. 2010. Obstructive sleep apnea is independently associated with the metabolic syndrome in obese Asian Indians in northern India. Metabol. Syndrome Related Disord. 8: 431-435.
113. Barone, M.T. & L. Menna-Barreto. 2011. Diabetes and sleep: a complex cause-and-effect relationship. Diab. Res. Clin. Pract. 91: 129-137.
114. Carpenter, D.O. 2008. Environmental contaminants as risk factors for developing diabetes. Rev. Environ. Health 23: 59-74.
115. Lee, D.H. et al. 2006. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002. Diab. Care 29: 1638-1644.
116. Monirith, I. et al. 2003. Asia-Pacific mussel watch: monitoring contamination of persistent organochlorine compounds in coastal waters of Asian countries. Mar. Pollut. Bull. 46: 281-300.
117. Minh, N.H. et al. 2006. Contamination by persistent organic pollutants in dumping sites of Asian developing countries: implication of emerging pollution sources. Arch. Environ. Contaminat. Toxicol. 50: 474-481.
118. Weber, M.B. et al. 2010. Lifestyle interventions and the prevention and treatment of Type 2 diabetes. Am. J. Lifestyle Med. 4: 468-480.
119. Narayan, K.M. & D.F. Williamson. 2010. Prevention of type 2 diabetes: risk status, clinic, and community. J. Gen. Internal Med. 25: 154-157.
120. deVegt, F. et al. 2001. Relation of impaired fasting and postload glucose with incident type 2diabetes in a Dutch population: the Hoorn study. JAMA 285: 2109-2113.
121. Knowler, W.C. et al. 2002. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346: 393-403.
122. Lindstrom, J. et al. 2003. The Finnish Diabetes Prevention Study (DPS): lifestyle intervention and 3-year results on diet and physical activity. Diab. Care 20: 537-544.
123. Weber, M.B. et al. 2012. A model of translational research for diabetes prevention in low and middle-income countries: The Diabetes Community Lifestyle Improvement Program (D-CLIP) trial. Primary Care Diab. 6: 3-9.