Peroxisome proliterator-activated receptor-γ co-activator-1α (PGC-1α) gene polymorphisms and their relationship to Type 2 diabetes in Asian Indians

Diabetic Medicine

Volumn 22, Issue 11, 2005, Pages 1516-1521

  Vimaleswaran, K S ^a   Radha, V ^a   Ghosh, S ^b   Majumder, P P ^b   Deepa, R ^a   Babu, H N S ^c   Rao, M R S ^c,d   Mohan, V ^a  

^a MADRAS DIABETES RESEARCH FOUNDATION   (India)

^b INDIAN STATISTICAL INSTITUTE   (India)

^c INDIAN INSTITUTE OF SCIENCE   (India)

^d JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

Asian Indians; Genetics; Peroxisome proliferator activated receptor ; Peroxisome proliferator activated receptor co activator 1; Type 2 diabetes

Indexed keywords

GLYCINE; GLYCOSYLATED HEMOGLOBIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA CO ACTIVATOR 1ALPHA; SERINE; THREONINE; UNCLASSIFIED DRUG; HEAT SHOCK PROTEIN; PPARGC1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ALLELISM; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC RISK; GENOTYPE; GLUCOSE TOLERANCE; HAPLOTYPE; HUMAN; INDIAN; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PGC 1 GENE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; ADULT; ASIAN; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETICS; INDIA; MALE; MIDDLE AGED;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; DIABETES MELLITUS, TYPE 2; FEMALE; GENE FREQUENCY; HEAT-SHOCK PROTEINS; HUMANS; INDIA; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PPAR GAMMA; TRANSCRIPTION FACTORS;

EID: 24644464176     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2005.01709.x     Document Type: Article

References (33)

1. Pratley RE, Thompson DB, Prochazka M, Baier L, Mott D, Ravussin E et al. An aurosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. J Clin Invest 1998; 101: 757-764.
2. Allayee H, de Bruin TW, Michelle Dominguez K, Cheng LS, Ipp E, Cantor RM et al. Genome scan for blood pressure in Dutch dyslipidemic families reveals linkage to a locus on chromosome 4p. Hypertension 2001; 38: 773-738.
3. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 2003; 100: 8466-8471.
4. Chandalia M, Abate N, Garg A, Stray-Gundersen J, Grundy SM. Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men. J Clin Endocrinol Metab 1999; 84: 2329-2335.
5. Ramachandran A, Snehalatha C, Viswanathan V, Viswanathan M, Haffner SM. Risk of noninsulin-dependent diabetes mellitus conferred by obesity and central adiposity in different ethnic groups, a comparative analysis between Asian Indians, Mexican Americans and Whites. Diabetes Res Clin Pract 1997; 36: 121-125.
6. Joshi SR. Metabolic syndrome-emerging clusters of the Indian phenotype. J Assoc Physicians India 2003; 51: 445-446.
7. McKeigue PM, Pierpoint T, Ferrie JE, Marmot MG. Relationship of glucose intolerance and hyperinsulinaemia to body fat pattern in south Asians and Europeans. Diabetologia 1992; 35: 785-791.
8. Abate N, Chandalia M. The impact of ethnicity on type 2 diabetes. J Diabetes Complications 2003; 17: 39-58.
9. Zimmet P, Taylor R, Ram P, King H, Sloman G, Raper LR et al. Prevalence of diabetes and impaired glucose tolerance in the biracial (Melanesien and Indian) population of Fiji: a rural-urban comparison. Am J Epidemiol 1983; 118: 673-688.
10. Mckeigue PM, Miller GJ, Marmot MG. Coronary artery disease in South Asian Overseas: a review. J Clin Epidemiol 1989; 41: 597-598.
11. Mckeigue PM. Coronary heart disease in Indians, Pakistanis and Bangladeshis: aetiology and possibilities for prevention. Br Heart J 1992; 67: 341-342.
12. Mohan V, Sharp PS, Aber VR, Mather HM, Kohner EM. Family histories of Asian Indian and Europeans non-insulin-dependent diabetic patients. Pract Diabetes 1986; 3: 254-256.
13. Viswanathan M, Mohan V, Snehalatha C, Ramachandran A. High prevalence of type 2 (non-insulin-dependent) diabetes among the offspring of conjugal type 2 diabetic parents in India. Diabetologia 1985; 28: 907-910.
14. Mohan V, Ramachandran A, Snehalatha C, Mohan R, Bharani G, Viswanathan M. High prevalence of maturity-onset diabetes of the young (MODY) among Indians. Diabetes Care 1985; 8: 371-374.
15. Sharp PS, Mohan V, Levy JC, Mather HM, Kohner EM. Insulin resistance in patients of Asian Indian and European origin with non-insulin dependent diabetes. Horm Metab Res 1987; 19: 84-85.
16. Mohan V, Sharp PS, Cloke HR, Burrin JM, Schumer B, Kohner EM. Serum immunoreactive insulin responses to a glucose load in Asian Indian and European Type 2 (non-insulin-dependent) diabetic patients and control subjects. Diabetologia 1986; 29: 235-237.
17. Simmons D, Powell MJ. Metabolic and clinical characteristics of south Asians and Europeans in Coventry. Diabet Med 1993; 10: 751-758.
18. Misra A, Vikram NK. Insulin resistance syndrome [metabolic syndrome] and Asian Indians. Curr Sci 2002; 83: 1483-1496.
19. Kumar R, Thompson EB. Transactivation functions of the N-terminal domains of nuclear hormone receptors: protein folding and coactivator interactions. Mol Endocrinol 2003; 17: 1-10.
20. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998; 92: 829-839.
21. Hara K, Tobe K, Okada T, Kadowaki H, Akanuma Y, Ito C. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. Diabetologia 2002; 45: 740-743.
22. Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K et al. Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. Diabetologia 2001; 44: 2220-2225.
23. Esterbauer H, Oberkofler H, Linnemayr V, Iglseder B, Hedegger M, Wolfsgruber P et al. Peroxisome proliferator-activated receptor-gamma coactivator-1 gene locus: associations with obesity indices in middle-aged women. Diabetes 2002; 51: 1281-1286.
24. Oberkofler H, Holzl B, Esterbauer H, Xie M, Iglseder B, Krempler F et al. Peroxisome proliferator-activated receptor-γ coactivator-1 gene locus: associations with hypertension in middle-aged men. Hypertension 2003; 41: 368-372.
25. Deepa M, Pradeepa R, Rema M, Anjama M, Deepa R, Shanthirani S et al. The Chennai Urban Rural Epidemiology Study (CURES)-Study design and methodology (urban component) (CURES-1). J Assoc Physicians India 2003; 51: 863-870.
26. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DE, Turner RC. Homeostasis model assessment, insulin resistance and β cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
27. Maniatis T, Fritsch EF, Sambrook J. Molecular (Zoning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory 1982: 149-151.
28. McLachlan GJ, Krishnan T. The EM Algorithm and Extensions: Wiley Series in Probability and Statistics. New York: John Wiley and Sons 1997.
29. Oberkofler H, Linnemayr V, Weitgasser R, Klein K, Xie M, Iglseder B et al. Complex haplotypes of the PGC-1α gene are associated with carbohydrate metabolism and type 2 diabetes. Diabetes 2004; 53: 1385-1393.
30. Elavell DM, Torra IP, Jamshidi Y, Evans D, Diamond JR, Elkeles RS et al. Variation in the PPARα gene is associated with altered function in vitro and plasma lipid concentrations in type 2 diabetic subjects. Diabetologia 2000; 43: 673-680.
31. Lacquemant C, Chikri M, Boutin P, Samson C, Froguel P. No association between the G482S polymorphism of the proliferator-activated receptor-γ coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians. Diabetologia 2002; 45: 602-603.
32. Basu A, Mukherjee N, Roy S, Sengupta S, Banerjee S, Chakraborty M et al. Ethnic India: a genomic view, with special reference to peopling and structure. Genome Res 2003; 13: 2277-2290.
33. Devlin B, Roeder K, Wasserman L. Genomic control, a new approach to genetic-based association studies. Theor Popul Biol 2001; 60: 155-166.