Deletion of the last five C-terminal amino acid residues of connexin43 leads to lethal ventricular arrhythmias in mice without affecting coupling via gap junction channels

Basic Research in Cardiology

Volumn 108, Issue 3, 2013, Pages

  Lübkemeier, Indra ^a   Requardt, Robert Pascal ^b   Lin, Xianming ^c   Sasse, Philipp ^a   Andrié, René ^a   Schrickel, Jan Wilko ^a   Chkourko, Halina ^c   Bukauskas, Feliksas F ^d   Kim, Jung Sun ^e   Frank, Marina ^a   Malan, Daniela ^a   Zhang, Jiong ^a   Wirth, Angela ^f   Dobrowolski, Radoslaw ^g   Mohler, Peter J ^h   Offermanns, Stefan ^f   Fleischmann, Bernd K ^a   Delmar, Mario ^c   Willecke, Klaus ^a  

^a UNIVERSITY OF BONN   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e Sungkyunkwan University School of Medicine   (South Korea)

^f MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^g RUTGERS UNIVERSITY   (United States)

^h OHIO STATE UNIVERSITY   (United States)

Author keywords

Connexin43; Intercalated disc; Zonula occludens protein 1

Indexed keywords

AMINO ACID; CONNEXIN 43; ION CHANNEL; NAV1.5 PROTEIN; PROTEIN; PROTEIN ZO1; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL COMMUNICATION; CELL ISOLATION; CONTROLLED STUDY; EMBRYO; EXCITATION CONTRACTION COUPLING; GAP JUNCTION; GENE DELETION; GENE MUTATION; HEART MUSCLE; HEART MUSCLE CELL; HEART VENTRICLE ARRHYTHMIA; HOMOZYGOSITY; LETHALITY; MOUSE; MOUSE STRAIN; NEWBORN; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PROTEIN DEPLETION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; SODIUM CURRENT;

EID: 84875663184     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-013-0348-y     Document Type: Article

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