G13-mediated signaling pathway is required for pressure overload-induced cardiac remodeling and heart failure

Circulation

Volumn 126, Issue 16, 2012, Pages 1972-1982

  Takefuji, Mikito ^a   Wirth, Angela ^b   Lukasova, Martina ^a   Takefuji, Seiko ^a   Boettger, Thomas ^a   Braun, Thomas ^a   Althoff, Till ^a   Offermanns, Stefan ^a   Wettschureck, Nina ^a  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

heart failure; hypertrophy, left ventricular; mice; signal transduction; ventricular remodeling

Indexed keywords

ANGIOTENSIN II; ENDOTHELIN 1; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; MYOCARDIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE INACTIVATION; HEART FAILURE; HEART HYPERTROPHY; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOMYOCARDIAL FIBROSIS; GENE EXPRESSION; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEART FAILURE; HYPERTROPHY, LEFT VENTRICULAR; MALE; MICE; MICE, MUTANT STRAINS; MUTAGENESIS; MYOCYTES, CARDIAC; RHOA GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; VENTRICULAR PRESSURE; VENTRICULAR REMODELING;

EID: 84867581721     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.109256     Document Type: Article

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