Membrane-type matrix metalloproteinases (MT-MMPs): Expression and function during glioma invasion

Journal of Neuro-Oncology

Volumn 53, Issue 2, 2001, Pages 187-202

  Fillmore, Helen L ^a   VanMeter, Timothy E ^a   Broaddus, William C ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Extracellular matrix (ECM); Invasion; MMP 2; Motility; MT MMP; Proteolysis; Regulation; Signaling

Indexed keywords

GELATINASE A; MATRIX METALLOPROTEINASE; SCLEROPROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

BINDING KINETICS; BRAIN CANCER; BRAIN TISSUE; CANCER INFILTRATION; CANCER INVASION; CELL FUNCTION; CELL MOTILITY; CYTOPLASM; DIAGNOSTIC PROCEDURE; DISEASE ASSOCIATION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; GENE INSERTION SEQUENCE; GLIOMA; HUMAN; MALIGNANT TRANSFORMATION; MOLECULAR DYNAMICS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS REGULATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TREATMENT PLANNING;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; BRAIN; BRAIN NEOPLASMS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; DOGS; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME PRECURSORS; GLIOBLASTOMA; GLIOMA; HEPATOCYTE GROWTH FACTOR; HUMANS; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 0034765232     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012213604731     Document Type: Review

References (91)

1. Matrix metalloproteinases and their biological function in human gliomas
2. Control of matrix metalloproteinase activity in cancer
3. The role of proteolytic enzymes in brain tumor infiltration
4. Secretion of matrix metalloproteinase-2 (72 kDa gelatinase/type IV collagenase = gelatinase A) by malignant human glioma cell lines: Implications for the growth and cellular invasion of the extracellular matrix
5. Effect of synthetic matrix-metalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro
6. Matrix metalloproteinase-2 activation modulates glioma cell migration
7. Cell-extracellular matrix interaction in glioma invasion
8. Expression and tissue localization of membrane-type 1, 2, and 3 metallo-proteinases in human astrocytic tumors
9. Glioma invasion in vitro: Regulation by matrix metalloproteinase-2 and protein kinase C
10. Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro
11. Matrix metallo-proteinases and tissue inhibitors of metalloproteinases in human gliomas
12. Production of collagenase and inhibitor (TIMP) by intracranial tumors and dura in vitro
13. Mechanisms of glioma invasion: Role of matrix-metalloproteinases
14. Host TIMP-1 expression confers resistance to experimental brain metastasis of a fibrosarcoma cell line
15. Reduced angiogenesis and tumor progression in gelatinase A deficient mice
16. Heterogeneous regional expression patterns of matrix metalloproteinases in human malignant gliomas
17. Matrix metalloproteinases
18. Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases
19. Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase
20. Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP
21. A matrix metalloproteinase expressed on the surface of invasive tumour cells
22. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas
23. cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment
24. Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family
25. Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA
26. Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma
27. Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: Isolation of complementary DNA clones for human and mouse MT4-MMP transcripts
28. Identification and characterisation of human MT5-MMP, a new membrane-bound activator of progelatinase A over-expressed in brain tumors
29. Leukolysin/MMP25/MT6-MMP: A novel matrix metalloproteinase specifically expressed in the leukocyte lineage
30. Human MT6-matrix metalloproteinase: Identification, progelatinase A activation, and expression in brain tumors
31. A transcriptional map of the FMF region
32. Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2
33. Membrane type matrix metalloproteinase activates pro-gelatinase A without furin cleavage of the N-terminal domain
34. The propeptide domain of membrane type 1-matrix metalloproteinase acts as an intramolecular chaperone when expressed in trans with the mature sequence in COS1 cells
35. Furin-independent pathway of membrane type 1-matrix metalloproteinase activation in rabbit dermal fibroblasts
36. Extracellular matrix-degrading proteinases in the nervous system
37. Membrane-type matrix metalloproteinases 1 and 2 (MT1-MMP and MT2-MMP) exhibit a broad spectrum proteolytic capacity comparable to many matrix metalloproteinases
38. Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases
39. Human membrane type-2 matrix metalloproteinase is defective in cell-associated activation of progelatinase A
40. Transmembrane/cytoplasmic domain-mediated membrane type-1 matrix metalloproteinase docking to invadopodia is required for cell invasion
41. The cytoplasmic carboxy-terminal amino acid determines the subcellular localization of proTGF-(alpha) and membrane type matrix metalloproteinase (MT1-MMP)
42. Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain
43. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
44. Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
45. Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins
46. Three-dimensional type I collagen lattices induce coordinate expression of matrix metalloproteinases MT1-MMP and MMP-2 in microvascular endothelial cells
47. Mechanisms for pro matrix metalloproteinase activation
48. Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in as complex with tissue inhibitor of metalloproteinase 2
49. Domain interactions in the gelatinase A. TIMP-2. MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activation
50. Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type-1 matrix metalloproteinase 1 (MT1-MMP)
51. Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of proMMP-2
52. TIMP-2 is required for efficient activation of proMMP-2 in vivo
53. Binding of active (57kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and proMMP-2 activation
54. Membrane type 1 matrix metalloproteinase-associated degradation of tissue ihibitor of metalloproteinase 2 in human tumor cell lines
55. Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity
56. Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules
57. Glioma invasion in the central nervous system
58. Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate proMMP2
59. Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3
60. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3
61. TNF-α stimulates activation of proMMP2 in human skin through NF-κB mediated induction of MT1-MMP
62. Regulation of membrane-type matrix metalloproteinae-1 expression by growth factors and phorbol 12-myristate 13-acetate
63. Gelatinase A activation is regulated by the organization of the polymerized actin cytoskeleton
64. Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene
65. Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix metalloproteinases and activated gelatinase A in co-cultures with brain-derived fibroblasts
66. Regulation of matrix metalloproteinase-2 (MMP-2) by hepatocyte growth factor/scatter factor (HGF/SF) in human glioma cells: HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane type-1 MMP
67. Protein kinase C activation by phorbol ester increases in vitro invasion through regulation of matrix metalloproteinases/tissue inhibitors of metalloproteinases system in D54 human glioblastoma cells
68. Activated isoforms of MMP-2 are induced in U87 human glioma cells in response to beta-amyloid peptide
69. Extracellular matrix degradation by metalloproteinases and central nervous system diseases
70. Matrix metalloproteinases: Effectors of development and normal physiology
71. Membrane-type metalloproteinases in tumor invasion
72. Matrix metalloproteinases in human gliomas: Activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression
73. Overview of matrix metalloproteinase expression in cultured cells
74. Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cells
75. Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors
76. Expression of adhesion factors and degrading proteins in primary and secondary glioblastomas and their precursor tumors
77. Comparative analysis of matrix metalloproteinases by immunocytochemistry, immunohistochemistry, immunohistochemistry and zymography in human primary brain tumours
78. Gelatinase-A (MMP-2), gelatinase-B (MMP-9), and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas
79. Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matter
80. Hydroxamate-type matrix metallooproteinase inhibitor batimastat promotes liver metastases
81. Cell adhesion: Old and new questions
82. Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity
83. Matrix metallo-proteinases and diseases of the CNS
84. Elevated expression of membrane type 1 metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system
85. Expression of the membrane-type 3 matrix metalloproteinase (MT3-MMP) in human brain tissues
86. Developmental regulation of membrane type-5 matrix metalloproteinase (MT5-MMP) expression in the rat nervous system
87. Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase
88. Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively
89. Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24
90. Expression of TIMP-1, TIMP-2, 72- and 92-kDa type IV collagenase transcripts in human astrocytoma cell lines: Correlation with invasiveness
91. Proteolysis and cell migration: Creating a path?