Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme

Journal of Molecular Biology

Volumn 425, Issue 6, 2013, Pages 1028-1038

  Ben David, Moshe ^a   Wieczorek, Grzegorz ^a   Elias, Mikael ^a   Silman, Israel ^a   Sussman, Joel L ^a   Tawfik, Dan S ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

catalytic calcium; catalytic promiscuity; conformational diversity; enzyme catalysis; metal catalysis

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1; CALCIUM; HISTIDINE; METAL ION;

ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HYDROLYSIS KINETICS; MOLECULAR DYNAMICS; MUTATION; PLASTICITY; PRIORITY JOURNAL; REACTION ANALYSIS; WILD TYPE;

EID: 84875443183     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.01.009     Document Type: Article

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