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Volumn 23, Issue 4, 2007, Pages 395-399

Biological therapies in inflammatory bowel disease: Top-down or bottom-up?

Author keywords

Anti tumour necrosis factor drugs; Inflammatory bowel disease; Top down therapy

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; CERTOLIZUMAB PEGOL; CORTICOSTEROID; FONTOLIZUMAB; INFLIXIMAB; MERCAPTOPURINE; METHOTREXATE; NATALIZUMAB; PLACEBO; PREDNISOLONE; SALAZOSULFAPYRIDINE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; VISILIZUMAB;

EID: 34249929951     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e32815b601b     Document Type: Review
Times cited : (52)

References (57)
  • 1
    • 33144459948 scopus 로고    scopus 로고
    • Travis SPL, Stange EF, Lémann M, et al. European evidence based consensus on the diagnosis and management of Crohn's disease: current management. Gut 2006; 55:i16-i35. Well balanced review and practical guidelines for treatment of Crohn's disease.
    • Travis SPL, Stange EF, Lémann M, et al. European evidence based consensus on the diagnosis and management of Crohn's disease: current management. Gut 2006; 55:i16-i35. Well balanced review and practical guidelines for treatment of Crohn's disease.
  • 2
    • 4344602852 scopus 로고    scopus 로고
    • Guidelines for the management of inflammatory bowel disease in adults
    • Carter MJ, Lobo AJ, Travis SPL. Guidelines for the management of inflammatory bowel disease in adults. Gut 2004; 53 (Suppl 5):1-16.
    • (2004) Gut , vol.53 , Issue.SUPPL. 5 , pp. 1-16
    • Carter, M.J.1    Lobo, A.J.2    Travis, S.P.L.3
  • 3
    • 33747013894 scopus 로고    scopus 로고
    • Guidelines for treatment with infliximab for Crohn's disease
    • Hommes DW, Oldenburg B, van Bodegraven AA, et al. Guidelines for treatment with infliximab for Crohn's disease. Neth J Med 2006; 64:219-229.
    • (2006) Neth J Med , vol.64 , pp. 219-229
    • Hommes, D.W.1    Oldenburg, B.2    van Bodegraven, A.A.3
  • 5
    • 20444479336 scopus 로고    scopus 로고
    • Infliximab as rescue therapy in severe to moderate severe ulcerative colitis: A randomized, placebo-controlled study
    • Jarnerot G, Hertervig E, Friis-Liby I, et al. Infliximab as rescue therapy in severe to moderate severe ulcerative colitis: a randomized, placebo-controlled study. Gastroenterology 2005; 128:1805-1811.
    • (2005) Gastroenterology , vol.128 , pp. 1805-1811
    • Jarnerot, G.1    Hertervig, E.2    Friis-Liby, I.3
  • 6
    • 0033022146 scopus 로고    scopus 로고
    • Clinical course and costs of care for Crohn's disease: Markov model analysis of a population-based cohort
    • Silverstein MD, Loftus EV, Sandborn WJ, et al. Clinical course and costs of care for Crohn's disease: Markov model analysis of a population-based cohort. Gastroenterology 1999; 117:49-57.
    • (1999) Gastroenterology , vol.117 , pp. 49-57
    • Silverstein, M.D.1    Loftus, E.V.2    Sandborn, W.J.3
  • 7
    • 0034903792 scopus 로고    scopus 로고
    • The natural history of corticosteroid therapy for inflammatory bowel disease: A population-based study
    • Faubion WA Jr, Loftus EV, Harmsen WS, et al. The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study. Gastroenterology 2001; 121:255-260.
    • (2001) Gastroenterology , vol.121 , pp. 255-260
    • Faubion Jr, W.A.1    Loftus, E.V.2    Harmsen, W.S.3
  • 8
    • 0345655293 scopus 로고    scopus 로고
    • Survival and cause-specific mortality in ulcerative colitis: Follow-up of a population-based cohort in Copenhagen County
    • Winther KV, Jess T, Langholz E, et al. Survival and cause-specific mortality in ulcerative colitis: follow-up of a population-based cohort in Copenhagen County. Gastroenterology 2003;125:1576-1582.
    • (2003) Gastroenterology , vol.125 , pp. 1576-1582
    • Winther, K.V.1    Jess, T.2    Langholz, E.3
  • 9
    • 0035188740 scopus 로고    scopus 로고
    • Behaviour of Crohn's disease according to the Vienna classification: Changing pattern over the course of disease
    • Louis E, Collard A, Oger AF, et al. Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of disease. Gut 2001; 49:777-782.
    • (2001) Gut , vol.49 , pp. 777-782
    • Louis, E.1    Collard, A.2    Oger, A.F.3
  • 10
    • 4344614373 scopus 로고    scopus 로고
    • the BSG Clinical Trials Network. Outcome of inpatient management of severe ulcerative colitis: A BSG Clinical Network Survey [abstract]
    • Hawthorne AB, Travis SPL, the BSG Clinical Trials Network. Outcome of inpatient management of severe ulcerative colitis: a BSG Clinical Network Survey [abstract]. Gut 2002; 50:A16.
    • (2002) Gut , vol.50
    • Hawthorne, A.B.1    Travis, S.P.L.2
  • 11
    • 0026761751 scopus 로고
    • Colorectal cancer risk and mortality in patients with ulcerative colitis
    • Langholz E, Munkholm P, Davidsen M, et al. Colorectal cancer risk and mortality in patients with ulcerative colitis. Gastroenterology 1992; 103:1444-1451.
    • (1992) Gastroenterology , vol.103 , pp. 1444-1451
    • Langholz, E.1    Munkholm, P.2    Davidsen, M.3
  • 12
    • 4544381908 scopus 로고    scopus 로고
    • Systematic review: Has disease outcome in Crohn's disease changed during the last four decades?
    • Wolters FL, Russel MG, Stockbrugger RW. Systematic review: has disease outcome in Crohn's disease changed during the last four decades? Aliment Pharmacol Ther 2004; 20:483-496.
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 483-496
    • Wolters, F.L.1    Russel, M.G.2    Stockbrugger, R.W.3
  • 13
    • 0035087887 scopus 로고    scopus 로고
    • Smoking cessation and the course of Crohn's disease: An intervention study
    • Cosnes J, Beaugerie L, Carbonnel F, et al. Smoking cessation and the course of Crohn's disease: an intervention study. Gastroenterology 2001;120:1093-1099.
    • (2001) Gastroenterology , vol.120 , pp. 1093-1099
    • Cosnes, J.1    Beaugerie, L.2    Carbonnel, F.3
  • 14
    • 21344448621 scopus 로고    scopus 로고
    • Are patients with inflammatory bowel disease receiving optimal care?
    • Reddy SI, Friedman S, Telford JJ, et al. Are patients with inflammatory bowel disease receiving optimal care? Am J Gastroenterol 2005; 100:1357-1361.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1357-1361
    • Reddy, S.I.1    Friedman, S.2    Telford, J.J.3
  • 15
    • 3843109109 scopus 로고    scopus 로고
    • Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameter Committee
    • Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameter Committee. Am J Gastroenterol 2004; 99:1371-1385.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1371-1385
    • Kornbluth, A.1    Sachar, D.B.2
  • 16
    • 21344472474 scopus 로고    scopus 로고
    • Oral 5-aminosalicylic acid for maintenance of medically-induced remission in Crohn's disease
    • CD003715
    • Akobeng AK, Gardener E. Oral 5-aminosalicylic acid for maintenance of medically-induced remission in Crohn's disease. Cochrane Database Syst Rev 2005; (1):CD003715.
    • (2005) Cochrane Database Syst Rev , Issue.1
    • Akobeng, A.K.1    Gardener, E.2
  • 17
    • 34249947193 scopus 로고    scopus 로고
    • Steinhart AH, Ewe K, Griffiths AM, et al. Corticosteroids for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2003; (4):CD00031.
    • Steinhart AH, Ewe K, Griffiths AM, et al. Corticosteroids for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev 2003; (4):CD00031.
  • 18
    • 25644456838 scopus 로고    scopus 로고
    • Budesonide for maintenance of remission in patients with Crohn's disease in medically induced remission: A predetermined pooled analysis of four randomized, double-blind, placebocontrolled trials
    • Sandborn WJ, Lofberg R, Feagan BG, et al. Budesonide for maintenance of remission in patients with Crohn's disease in medically induced remission: a predetermined pooled analysis of four randomized, double-blind, placebocontrolled trials. Am J Gastroenterol 2005; 100:1780-1787.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1780-1787
    • Sandborn, W.J.1    Lofberg, R.2    Feagan, B.G.3
  • 19
    • 84921430975 scopus 로고    scopus 로고
    • Azathioprine for maintaining remission of Crohn's disease
    • CD000067
    • Pearson D, May GR, Fick G, et al. Azathioprine for maintaining remission of Crohn's disease. Cochrane Database Syst Rev 2000; (2):CD000067.
    • (2000) Cochrane Database Syst Rev , Issue.2
    • Pearson, D.1    May, G.R.2    Fick, G.3
  • 20
    • 0034214336 scopus 로고    scopus 로고
    • A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators
    • Feagan BG, Fedorak RN, Irvine EJ, et al. A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators. N Engl J Med 2000; 342:1627-1632.
    • (2000) N Engl J Med , vol.342 , pp. 1627-1632
    • Feagan, B.G.1    Fedorak, R.N.2    Irvine, E.J.3
  • 21
    • 10744224387 scopus 로고    scopus 로고
    • Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease
    • Rutgeerts P, Feagan BG, Lichtenstein GR, et al. Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease. Gastroenterology 2004; 126:402-413.
    • (2004) Gastroenterology , vol.126 , pp. 402-413
    • Rutgeerts, P.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 22
    • 0025219580 scopus 로고
    • Clinical, biological, and endoscopical picture of attacks of Crohn's disease: Evolution on prednisolone. Groupe d'etude therapeutique des affections inflammatoires digestives
    • Modigliani R, Mary JY, Simon JF, et al. Clinical, biological, and endoscopical picture of attacks of Crohn's disease: evolution on prednisolone. Groupe d'etude therapeutique des affections inflammatoires digestives. Gastroenterology 1990; 98:811-818.
    • (1990) Gastroenterology , vol.98 , pp. 811-818
    • Modigliani, R.1    Mary, J.Y.2    Simon, J.F.3
  • 23
    • 0032913394 scopus 로고    scopus 로고
    • Endoscopic and histological healing with infliximab antitumor necrosis factor antibodies in Crohn's disease: A European multicenter trial
    • D'Haens G, van Deventer S, van Hogezand R, et al. Endoscopic and histological healing with infliximab antitumor necrosis factor antibodies in Crohn's disease: a European multicenter trial. Gastroenterology 1999; 116:1029-1034.
    • (1999) Gastroenterology , vol.116 , pp. 1029-1034
    • D'Haens, G.1    van Deventer, S.2    van Hogezand, R.3
  • 24
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: The ACCENT I randomized trial
    • Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn's disease: the ACCENT I randomized trial. Lancet 2002; 359:1541-1549.
    • (2002) Lancet , vol.359 , pp. 1541-1549
    • Hanauer, S.B.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 25
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group
    • Targan SR, Hanauer SB, van Deventer SJ, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997; 337:1029-1035.
    • (1997) N Engl J Med , vol.337 , pp. 1029-1035
    • Targan, S.R.1    Hanauer, S.B.2    van Deventer, S.J.3
  • 26
    • 0033529049 scopus 로고    scopus 로고
    • Infliximab for the treatment of fistulas in patients with Crohn's disease
    • Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999; 340:1398-1405.
    • (1999) N Engl J Med , vol.340 , pp. 1398-1405
    • Present, D.H.1    Rutgeerts, P.2    Targan, S.3
  • 27
    • 28844473957 scopus 로고    scopus 로고
    • Infliximab for induction and maintenance therapy for ulcerative colitis
    • Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005; 353:2462-2476.
    • (2005) N Engl J Med , vol.353 , pp. 2462-2476
    • Rutgeerts, P.1    Sandborn, W.J.2    Feagan, B.G.3
  • 28
    • 33750105599 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha blocking agents for induction of remission in ulcerative colitis
    • CD005112
    • Lawson MM, Thomas AG, Akobeng AK. Tumour necrosis factor alpha blocking agents for induction of remission in ulcerative colitis. Cochrane Database Syst Rev 2006; (3):CD005112.
    • (2006) Cochrane Database Syst Rev , Issue.3
    • Lawson, M.M.1    Thomas, A.G.2    Akobeng, A.K.3
  • 29
    • 32044451548 scopus 로고    scopus 로고
    • Human antitumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-I trial
    • Well designed, large dose-finding study, showing the efficacy of adalimumab in inducing remission in Crohn's disease patients with active disease
    • Hanauer SB, Sandborn WJ, Rutgeerts P, et al. Human antitumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology 2006; 130:323-333. Well designed, large dose-finding study, showing the efficacy of adalimumab in inducing remission in Crohn's disease patients with active disease.
    • (2006) Gastroenterology , vol.130 , pp. 323-333
    • Hanauer, S.B.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 30
    • 33846242958 scopus 로고    scopus 로고
    • Colombel JF, Sandborn WJ, Rutgeerts P, et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology 2007; 132:52-65. Study showing that adalimumab maintains remission in Crohn's disease patients responding to adalimumab induction therapy through 1 year.
    • Colombel JF, Sandborn WJ, Rutgeerts P, et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology 2007; 132:52-65. Study showing that adalimumab maintains remission in Crohn's disease patients responding to adalimumab induction therapy through 1 year.
  • 31
    • 24144483087 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease
    • Schreiber S, Rutgeerts P, Fedorak RN, et al. A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease. Gastroenterology 2005; 129:807-818.
    • (2005) Gastroenterology , vol.129 , pp. 807-818
    • Schreiber, S.1    Rutgeerts, P.2    Fedorak, R.N.3
  • 32
    • 33846079219 scopus 로고    scopus 로고
    • The comparative efficacy and safety of biologics for the treatment of rheumatoid arthritis: A systematic review and metaanalysis
    • Gartlehner G, Hansen RA, Jonas BL, et al. The comparative efficacy and safety of biologics for the treatment of rheumatoid arthritis: a systematic review and metaanalysis. J Rheumatol 2006; 33:2398-2408.
    • (2006) J Rheumatol , vol.33 , pp. 2398-2408
    • Gartlehner, G.1    Hansen, R.A.2    Jonas, B.L.3
  • 33
    • 33749038012 scopus 로고    scopus 로고
    • Current limitations of IBD treatment: Where do we go from here?
    • Targan SR. Current limitations of IBD treatment: where do we go from here? Ann N Y Acad Sci 2006; 1072:1-8.
    • (2006) Ann N Y Acad Sci , vol.1072 , pp. 1-8
    • Targan, S.R.1
  • 34
    • 27644441529 scopus 로고    scopus 로고
    • Natalizumab induction and maintenance therapy for Crohn's disease
    • Sandborn WJ, Colombel JR, Enns R, et al. Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med 2005; 353:1912-1925.
    • (2005) N Engl J Med , vol.353 , pp. 1912-1925
    • Sandborn, W.J.1    Colombel, J.R.2    Enns, R.3
  • 35
    • 8344284998 scopus 로고    scopus 로고
    • Antiinterleukin-12 antibody for active Crohn's disease
    • Mannon PJ, Fuss IJ, Mayer L, et al. Antiinterleukin-12 antibody for active Crohn's disease. N Engl J Med 2004; 351:2069-2079.
    • (2004) N Engl J Med , vol.351 , pp. 2069-2079
    • Mannon, P.J.1    Fuss, I.J.2    Mayer, L.3
  • 36
    • 11144358366 scopus 로고    scopus 로고
    • A pilot randomized trial of a human antiinterleukin 6 receptor monoclonal antibody in active Crohn's disease
    • Ito H, Takazoe M, Fukuda Y, et al. A pilot randomized trial of a human antiinterleukin 6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 2004; 126:989-996.
    • (2004) Gastroenterology , vol.126 , pp. 989-996
    • Ito, H.1    Takazoe, M.2    Fukuda, Y.3
  • 37
    • 29144506331 scopus 로고    scopus 로고
    • A phase I-II study: Multiple dose levels of visilizumab are well tolerated and produce rapid and sustained improvement in ulcerative colitis patients, refractory to treatment with iv steroids
    • Targan S, Salzberg BA, Mayer L, et al. A phase I-II study: multiple dose levels of visilizumab are well tolerated and produce rapid and sustained improvement in ulcerative colitis patients, refractory to treatment with iv steroids. Gastroenterology 2005; 128:A-75.
    • (2005) Gastroenterology , vol.128
    • Targan, S.1    Salzberg, B.A.2    Mayer, L.3
  • 38
    • 20444469332 scopus 로고    scopus 로고
    • Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin
    • Feagan BG, Greenberg GR, Wild G, et al. Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. N Engl J Med 2005; 352:2499-2507.
    • (2005) N Engl J Med , vol.352 , pp. 2499-2507
    • Feagan, B.G.1    Greenberg, G.R.2    Wild, G.3
  • 39
    • 0030751946 scopus 로고    scopus 로고
    • Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis
    • Boers M, Verhoeven AC, Markusse HM, et al. Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis. Lancet 1997; 350:309-318.
    • (1997) Lancet , vol.350 , pp. 309-318
    • Boers, M.1    Verhoeven, A.C.2    Markusse, H.M.3
  • 40
    • 0034735827 scopus 로고    scopus 로고
    • A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis
    • Bathon JM, Martin RW, Fleischmann RM, et al. A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N Eng J Med 2000; 343:1586-1593.
    • (2000) N Eng J Med , vol.343 , pp. 1586-1593
    • Bathon, J.M.1    Martin, R.W.2    Fleischmann, R.M.3
  • 41
    • 9144264155 scopus 로고    scopus 로고
    • Infliximab in active early rheumatoid arthritis
    • Breedveld FC, Emery P, Keystone E, et al. Infliximab in active early rheumatoid arthritis. Ann Rheum Dis 2004; 63:149-155.
    • (2004) Ann Rheum Dis , vol.63 , pp. 149-155
    • Breedveld, F.C.1    Emery, P.2    Keystone, E.3
  • 42
    • 8444239359 scopus 로고    scopus 로고
    • Combination of infliximab and methotrexate therapy for early active rheumatoid arthritis: A randomized, controlled trial
    • St Clair EW, van der Heijde DM, Smolen JS, et al. Combination of infliximab and methotrexate therapy for early active rheumatoid arthritis: a randomized, controlled trial. Arthritis Rheum 2004; 50:3423-3443.
    • (2004) Arthritis Rheum , vol.50 , pp. 3423-3443
    • St Clair, E.W.1    van der Heijde, D.M.2    Smolen, J.S.3
  • 43
    • 27744514865 scopus 로고    scopus 로고
    • Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial
    • Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Allaart CF, et al. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial. Arthritis Rheum 2005; 52:3381-3390.
    • (2005) Arthritis Rheum , vol.52 , pp. 3381-3390
    • Goekoop-Ruiterman, Y.P.1    de Vries-Bouwstra, J.K.2    Allaart, C.F.3
  • 44
    • 33748460486 scopus 로고    scopus 로고
    • Azathioprine maintains first remission in newly diagnosed pediatric Crohn's disease
    • Jaspers GJ, Verkade HJ, Escher JC, et al. Azathioprine maintains first remission in newly diagnosed pediatric Crohn's disease. Inflamm Bowel Dis 2006; 12:831-836.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 831-836
    • Jaspers, G.J.1    Verkade, H.J.2    Escher, J.C.3
  • 45
    • 0042329252 scopus 로고    scopus 로고
    • Response to infliximab is related to disease duration in paediatric Crohn's disease
    • Lionetti P, Bronzini F, Salvestrini C, et al. Response to infliximab is related to disease duration in paediatric Crohn's disease. Aliment Pharmacol Ther 2003; 18:425-431.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 425-431
    • Lionetti, P.1    Bronzini, F.2    Salvestrini, C.3
  • 46
    • 0033770169 scopus 로고    scopus 로고
    • A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease
    • Markowitz J, Grancher K, Kohn N, et al. A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease. Gastroenterology 2000; 119:895-902.
    • (2000) Gastroenterology , vol.119 , pp. 895-902
    • Markowitz, J.1    Grancher, K.2    Kohn, N.3
  • 47
    • 29444445452 scopus 로고    scopus 로고
    • Management of recent onset Crohn's disease: A controlled randomized trialcomparing step-up and top-down therapy
    • Hommes DW, Baert F, van Assche G, et al. Management of recent onset Crohn's disease: a controlled randomized trialcomparing step-up and top-down therapy. Gastroenterology 2005; 128 (Suppl 2):A577.
    • (2005) Gastroenterology , vol.128 , Issue.SUPPL. 2
    • Hommes, D.W.1    Baert, F.2    van Assche, G.3
  • 48
    • 33646147141 scopus 로고    scopus 로고
    • Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry
    • Since no long-term randomized studies have been published, this registry provides the best available data on the side effects of infliximab in Crohn's disease patients in the long run
    • Lichtenstein GR, Feagan BG, Cohen RD, et al. Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry. Clin Gastroenterol Hepatol 2006; 4:621-630. Since no long-term randomized studies have been published, this registry provides the best available data on the side effects of infliximab in Crohn's disease patients in the long run.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 621-630
    • Lichtenstein, G.R.1    Feagan, B.G.2    Cohen, R.D.3
  • 49
    • 0037148920 scopus 로고    scopus 로고
    • Tuberculosis and treatment with infliximab
    • Myers A, Clark J, Foster H. Tuberculosis and treatment with infliximab. N Engl J Med 2002; 346:623-626.
    • (2002) N Engl J Med , vol.346 , pp. 623-626
    • Myers, A.1    Clark, J.2    Foster, H.3
  • 50
    • 0036822552 scopus 로고    scopus 로고
    • Life-threatening histoplasmosis complicating immunotherapy with tumor necrosis factor alpha antagonists infliximab and etanercept
    • Lee JH, Slifman NR, Gershon SK, et al. Life-threatening histoplasmosis complicating immunotherapy with tumor necrosis factor alpha antagonists infliximab and etanercept. Arthritis Rheum 2002; 46:2565-2570.
    • (2002) Arthritis Rheum , vol.46 , pp. 2565-2570
    • Lee, J.H.1    Slifman, N.R.2    Gershon, S.K.3
  • 51
    • 33846592386 scopus 로고    scopus 로고
    • Mackey AC, Green L, Liang LC, et al. Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2007; 44:265-267. Report of the occurrence of aggressive T-cell lymphomas in young Crohn's disease patients exposed to infliximab. Although rare, this kind of potentially fatal complication should be taken into account when prescribing anti-TNF compounds to young Crohn's disease patients.
    • Mackey AC, Green L, Liang LC, et al. Hepatosplenic T cell lymphoma associated with infliximab use in young patients treated for inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2007; 44:265-267. Report of the occurrence of aggressive T-cell lymphomas in young Crohn's disease patients exposed to infliximab. Although rare, this kind of potentially fatal complication should be taken into account when prescribing anti-TNF compounds to young Crohn's disease patients.
  • 52
    • 30944442404 scopus 로고    scopus 로고
    • Infliximab and newly diagnosed neoplasia in Crohn's disease: A multicentre matched pair study
    • Biancone L, Orlando A, Kohn A, et al. Infliximab and newly diagnosed neoplasia in Crohn's disease: a multicentre matched pair study. Gut 2006; 55:228-233.
    • (2006) Gut , vol.55 , pp. 228-233
    • Biancone, L.1    Orlando, A.2    Kohn, A.3
  • 53
    • 22644446331 scopus 로고    scopus 로고
    • Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine
    • Kandiel A, Fraser AG, Korelitz BI, et al. Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine. Gut 2005; 54:1121-1125.
    • (2005) Gut , vol.54 , pp. 1121-1125
    • Kandiel, A.1    Fraser, A.G.2    Korelitz, B.I.3
  • 54
    • 0028823950 scopus 로고
    • Identifying patients with high risk of relapse in quiescent Crohn's disease. The GETAID group
    • Sahmoud T, Hoctin-Boes G, Modigliani R, et al. Identifying patients with high risk of relapse in quiescent Crohn's disease. The GETAID group. Gut 1995; 37:811-818.
    • (1995) Gut , vol.37 , pp. 811-818
    • Sahmoud, T.1    Hoctin-Boes, G.2    Modigliani, R.3
  • 55
    • 0023033107 scopus 로고
    • A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease
    • Brignola C, Campieri M, Bazzocchi G, et al. A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease. Gastroenterology 1986; 8:1490-1494.
    • (1986) Gastroenterology , vol.8 , pp. 1490-1494
    • Brignola, C.1    Campieri, M.2    Bazzocchi, G.3
  • 56
    • 33746136945 scopus 로고    scopus 로고
    • Wolters FL, Russel MG, Sijbrandij J, et al. Phenotype at diagnosis predicts recurrence rates in Crohn's disease. Gut 2006; 55:1124-1130. In this study, parameters predicting disease recurrence were identified in a unique large European cohort of Crohn's disease patients followed for 10 years.
    • Wolters FL, Russel MG, Sijbrandij J, et al. Phenotype at diagnosis predicts recurrence rates in Crohn's disease. Gut 2006; 55:1124-1130. In this study, parameters predicting disease recurrence were identified in a unique large European cohort of Crohn's disease patients followed for 10 years.
  • 57
    • 33845463326 scopus 로고    scopus 로고
    • Pit patterns in rectal mucosa assessed by magnifying colonoscope are predictive of relapse in patients with quiescent ulcerative colitis
    • Nishio Y, Ando T, Maeda O, et al. Pit patterns in rectal mucosa assessed by magnifying colonoscope are predictive of relapse in patients with quiescent ulcerative colitis. Gut 2006; 55:1768-1773.
    • (2006) Gut , vol.55 , pp. 1768-1773
    • Nishio, Y.1    Ando, T.2    Maeda, O.3


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