Self-assembling modified β-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: Focus on huntington's disease

Molecular Pharmaceutics

Volumn 10, Issue 2, 2013, Pages 640-649

  Godinho, Bruno M D C ^a   Ogier, Julien R ^b   Darcy, Raphael ^b   O'Driscoll, Caitriona M ^a   Cryan, John F ^a,c  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

gene therapy; neurodegenerative disease; nonviral vectors; RNAi CNS delivery; rotarod

Indexed keywords

BETA CYCLODEXTRIN; HUNTINGTIN; LIPOFECTAMINE; NANOPARTICLE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CEREBROSPINAL FLUID; CONTROLLED STUDY; CORPUS STRIATUM; DRUG CYTOTOXICITY; DRUG STABILITY; FEMALE; FIBROBLAST; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IN VITRO STUDY; IN VIVO STUDY; MALE; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; REPEAT PROCEDURE; RNA INTERFERENCE;

ANIMALS; BETA-CYCLODEXTRINS; CELLS, CULTURED; GENETIC THERAPY; GENETIC VECTORS; HUMANS; HUNTINGTON DISEASE; MICE; NANOPARTICLES; NEURODEGENERATIVE DISEASES; RATS; RNA, SMALL INTERFERING;

EID: 84873331696     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp3003946     Document Type: Article

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