Functional TNFα gene silencing mediated by polyethyleneimine/TNFα siRNA nanocomplexes in inflamed colon

Biomaterials

Volumn 32, Issue 4, 2011, Pages 1218-1228

  Laroui, Hamed ^a   Theiss, Arianne L ^a   Yan, Yutao ^a   Dalmasso, Guillaume ^a   Nguyen, Hang T T ^a   Sitaraman, Shanthi V ^a   Merlin, Didier ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Macrophages; Mice colon; Poly (lactic acid) nanoparticle; Polyethyleimine complex; Small interfering RNA; Transfection

Indexed keywords

MICE COLON; POLY(LACTIC ACID); POLYETHYLEIMINE COMPLEX; SMALL INTERFERING RNA; TRANSFECTION;

BIODEGRADATION; BODY FLUIDS; COMPLEXATION; CYTOTOXICITY; GENETIC ENGINEERING; LACTIC ACID; MACROPHAGES; NANOPARTICLES; POLYETHYLENES; ZETA POTENTIAL;

RNA;

ALGINIC ACID; CHITOSAN; LIPOFECTAMINE; NANOCOMPOSITE; POLYETHYLENEIMINE; POLYLACTIDE; POLYVINYL ALCOHOL; RIBONUCLEASE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TUMOR NECROSIS FACTOR ALPHA PLUS SMALL INTERFERING RNA NANOCOMPLEX; UNCLASSIFIED DRUG;

ALKALINITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIODEGRADABILITY; COLON CROHN DISEASE; CONTROLLED STUDY; GENE SILENCING; IN VIVO STUDY; LOW DRUG DOSE; MOUSE; NANOENCAPSULATION; NANOPHARMACEUTICS; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TOXICITY TESTING; ULCERATIVE COLITIS; ZETA POTENTIAL;

ANIMALS; COLON; GENE SILENCING; HUMANS; INFLAMMATORY BOWEL DISEASES; MACROPHAGES; MATERIALS TESTING; MICE; NANOPARTICLES; POLYETHYLENEIMINE; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 78649445973     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.09.062     Document Type: Article

References (26)

1. Holtmann M.H., Neurath M.F. Anti-TNF strategies in stenosing and fistulizing Crohn's disease. Int J Colorectal Dis 2005, 20(1):1-8.
2. de Vries A., Hazlewood L., Fitch P.M., Seckl J.R., Foster P., Howie S.E. High-fat feeding redirects cytokine responses and decreases allergic airway eosinophilia. Clin Exp Allergy 2009, 39(5):731-739.
3. D'Haens G. Anti-TNF therapy for Crohn's disease. Curr Pharm Des 2003, 9(4):289-294.
4. Toub N., Bertrand J.R., Tamaddon A., Elhamess H., Hillaireau H., Maksimenko A., et al. Efficacy of siRNA nanocapsules targeted against the EWS-Fli1 oncogene in Ewing sarcoma. Pharm Res 2006, 23(5):892-900.
5. Lieberman J., Song E., Lee S.K., Shankar P. Interfering with disease: opportunities and roadblocks to harnessing RNA interference. Trends Mol Med 2003, 9(9):397-403.
6. Meade B.R., Dowdy S.F. Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides. Adv Drug Deliv Rev 2007, 59(2-3):134-140.
7. Schiffelers R.M., Ansari A., Xu J., Zhou Q., Tang Q., Storm G., et al. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res 2004, 32(19):e149.
8. Raper S.E. Gene therapy: the good, the bad, and the ugly. Surgery 2005, 137(5):487-492.
9. Farokhzad O.C., Jon S., Khademhosseini A., Tran T.N., Lavan D.A., Langer R. Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res 2004, 64(21):7668-7672.
10. Gunther M., Wagner E., Ogris M. Specific targets in tumor tissue for the delivery of therapeutic genes. Curr Med Chem Anticancer Agents 2005, 5(2):157-171.
11. Hood J.D., Bednarski M., Frausto R., Guccione S., Reisfeld R.A., Xiang R., et al. Tumor regression by targeted gene delivery to the neovasculature. Science 2002, 296(5577):2404-2407.
12. Kim B., Tang Q., Biswas P.S., Xu J., Schiffelers R.M., Xie F.Y., et al. Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. Am J Pathol 2004, 165(6):2177-2185.
13. Pardridge W.M. Intravenous, non-viral RNAi gene therapy of brain cancer. Expert Opin Biol Ther 2004, 4(7):1103-1113.
14. Fattal E., Vauthier C., Aynie I., Nakada Y., Lambert G., Malvy C., et al. Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of oligonucleotides. J Control Release 1998, 53(1-3):137-143.
15. Lamprecht A., Schafer U., Lehr C.M. Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa. Pharm Res 2001, 18(6):788-793.
16. Laroui H., Dalmasso G., Nguyen H.T., Yan Y., Sitaraman S.V., Merlin D. Drug-loaded nanoparticles targeted to the colon with polysaccharide hydrogel reduce colitis in a mouse model. Gastroenterology 2010, 138(3):843-853. e1-2.
17. Zambaux M.F., Bonneaux F., Gref R., Maincent P., Dellacherie E., Alonso M.J., et al. Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method. J Control Release 1998, 50(1-3):31-40.
18. Ngamwongsatit P., Banada P.P., Panbangred W., Bhunia A.K. WST-1-based cell cytotoxicity assay as a substitute for MTT-based assay for rapid detection of toxigenic Bacillus species using CHO cell line. J Microbiol Methods 2008, 73(3):211-215.
19. Siegmund B., Lehr H.A., Fantuzzi G., Dinarello C.A. IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation. Proc Natl Acad Sci U S A 2001, 98(23):13249-13254.
20. Liberman E.A., Topaly V.P., Tsofina L.M., Jasaitis A.A., Skulachev V.P. Mechanism of coupling of oxidative phosphorylation and the membrane potential of mitochondria. Nature 1969, 222(5198):1076-1078.
21. Ketterer B., Neumcke B., Laeuger P. Transport mechanism of hydrophobic ions across through lipid bilayers. J Memb Biol 1971, 5:225-245.
22. Yamanaka Y.J., Leong K.W. Engineering strategies to enhance nanoparticle-mediated oral delivery. J Biomater Sci Polym Ed 2008, 19(12):1549-1570.
23. Del Cacho E., Gallego M., Lopez-Bernard F., Sanchez-Acedo C., Lillehoj H.S. Isolation of chicken follicular dendritic cells. J Immunol Methods 2008, 334(1-2):59-69.
24. Shankar S.P., Babensee J.E. Comparative characterization of cultures of primary human macrophages or dendritic cells relevant to biomaterial studies. J Biomed Mater Res A 2010, 92(2):791-800.
25. Maruyama K., Iwasaki F., Takizawa T., Yanagie H., Niidome T., Yamada E., et al. Novel receptor-mediated gene delivery system comprising plasmid/protamine/sugar-containing polyanion ternary complex. Biomaterials 2004, 25(16):3267-3273.
26. Akinc A., Thomas M., Klibanov A.M., Langer R. Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med 2005, 7(5):657-663.