Biorelevant media to simulate fluids in the ascending colon of humans and their usefulness in predicting intracolonic drug solubility

Pharmaceutical Research

Volumn 27, Issue 10, 2010, Pages 2187-2196

  Vertzoni, Maria ^a   Diakidou, Amalia ^a   Chatzilias, Manos ^a   Söderlind, Erik ^b   Abrahamsson, Bertil ^b   Dressman, Jennifer B ^c   Reppas, Christos ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b ASTRAZENECA R AND D   (Sweden)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

ascending colon; drug solubility; FaSSCoF; FeSSCoF; simulated colonic fluids

Indexed keywords

BILE ACID; DANAZOL; FELODIPINE; KETOCONAZOLE; PALMITIC ACID; PHOSPHATIDYLCHOLINE;

ADULT; ARTICLE; ASCENDING COLON; CONTROLLED STUDY; DIET RESTRICTION; DRUG SOLUBILITY; HUMAN; INTESTINE FLUID; NORMAL HUMAN; PH; POSTPRANDIAL STATE; PREDICTION; PRIORITY JOURNAL; STOMACH JUICE;

ADULT; BIOLOGICAL AVAILABILITY; BODY FLUIDS; BUFFERS; COLON, ASCENDING; CROSS-OVER STUDIES; DANAZOL; FASTING; FELODIPINE; GASTROINTESTINAL CONTENTS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; KETOCONAZOLE; MODELS, BIOLOGICAL; OSMOLAR CONCENTRATION; PREDICTIVE VALUE OF TESTS; SOLUBILITY;

EID: 77957366049     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0223-6     Document Type: Article

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