-
1
-
-
77951115122
-
International network of cancer genome projects
-
Hudson T.J., Anderson W., Artez A., et al. International network of cancer genome projects. Nature 2010, 464(7291):993-998.
-
(2010)
Nature
, vol.464
, Issue.7291
, pp. 993-998
-
-
Hudson, T.J.1
Anderson, W.2
Artez, A.3
-
2
-
-
77951094805
-
Big science: The cancer genome challenge
-
Ledford H. Big science: The cancer genome challenge. Nature 2010, 464(7291):972-974.
-
(2010)
Nature
, vol.464
, Issue.7291
, pp. 972-974
-
-
Ledford, H.1
-
3
-
-
33947393565
-
Mapping the cancer genome. Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies
-
Collins F.S., Barker A.D. Mapping the cancer genome. Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies. Sci Am 2007, 296(3):50-57.
-
(2007)
Sci Am
, vol.296
, Issue.3
, pp. 50-57
-
-
Collins, F.S.1
Barker, A.D.2
-
4
-
-
0033592733
-
Wellcome funds cancer database
-
Dickson D. Wellcome funds cancer database. Nature 1999, 401(6755):729.
-
(1999)
Nature
, vol.401
, Issue.6755
, pp. 729
-
-
Dickson, D.1
-
5
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
Mardis E.R., Ding L., Dooling D.J., et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009, 361(11):1058-1066.
-
(2009)
N Engl J Med
, vol.361
, Issue.11
, pp. 1058-1066
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
-
6
-
-
78650791604
-
Analysis of next-generation genomic data in cancer: accomplishments and challenges
-
Ding L., Wendl M.C., Koboldt D.C., Mardis E.R. Analysis of next-generation genomic data in cancer: accomplishments and challenges. Hum Mol Genet 2010, 19(R2):15.
-
(2010)
Hum Mol Genet
, vol.19
, Issue.R2
, pp. 15
-
-
Ding, L.1
Wendl, M.C.2
Koboldt, D.C.3
Mardis, E.R.4
-
7
-
-
77956838065
-
Advances in understanding cancer genomes through second-generation sequencing
-
Meyerson M., Gabriel S., Getz G. Advances in understanding cancer genomes through second-generation sequencing. Nat Rev Genet 2010, 11(10):685-696.
-
(2010)
Nat Rev Genet
, vol.11
, Issue.10
, pp. 685-696
-
-
Meyerson, M.1
Gabriel, S.2
Getz, G.3
-
8
-
-
77950341829
-
Targeted high throughput sequencing of a cancer-related exome subset by specific sequence capture with a fully automated microarray platform
-
Summerer D., Schracke N., Wu H., et al. Targeted high throughput sequencing of a cancer-related exome subset by specific sequence capture with a fully automated microarray platform. Genomics 2010, 95(4):241-246.
-
(2010)
Genomics
, vol.95
, Issue.4
, pp. 241-246
-
-
Summerer, D.1
Schracke, N.2
Wu, H.3
-
9
-
-
79958835059
-
Comprehensive next-generation cancer genome sequencing in the era of targeted therapy and personalized oncology
-
Cronin M., Ross J.S. Comprehensive next-generation cancer genome sequencing in the era of targeted therapy and personalized oncology. Biomark Med 2011, 5(3):293-305.
-
(2011)
Biomark Med
, vol.5
, Issue.3
, pp. 293-305
-
-
Cronin, M.1
Ross, J.S.2
-
11
-
-
0003076661
-
Hematopoietic Stem cells, Progenitor cells, and Cytokines
-
McGraw-Hill Medical, New York
-
Kaushansky K., Williams W.J. Hematopoietic Stem cells, Progenitor cells, and Cytokines. Williams Hematology 2010, 153-175. McGraw-Hill Medical, New York. 8th ed.
-
(2010)
Williams Hematology
, pp. 153-175
-
-
Kaushansky, K.1
Williams, W.J.2
-
12
-
-
67349203626
-
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
-
van Haaften G., Dalgliesh G.L., Davies H., et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet 2009, 41(5):521-523.
-
(2009)
Nat Genet
, vol.41
, Issue.5
, pp. 521-523
-
-
van Haaften, G.1
Dalgliesh, G.L.2
Davies, H.3
-
13
-
-
84857699307
-
Acquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic value
-
Pratcorona M., Abbas S., Sanders M.A., et al. Acquired mutations in ASXL1 in acute myeloid leukemia: prevalence and prognostic value. Haematologica 2011, 97(3):388-392.
-
(2011)
Haematologica
, vol.97
, Issue.3
, pp. 388-392
-
-
Pratcorona, M.1
Abbas, S.2
Sanders, M.A.3
-
14
-
-
77955087290
-
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
-
Nikoloski G., Langemeijer S.M.C., Kuiper R.P., et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat Genet 2010, 42(8):665-667.
-
(2010)
Nat Genet
, vol.42
, Issue.8
, pp. 665-667
-
-
Nikoloski, G.1
Langemeijer, S.M.C.2
Kuiper, R.P.3
-
15
-
-
75749124332
-
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
-
Morin R.D., Johnson N.A., Severson T.M., et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet 2010, 42(2):181-185.
-
(2010)
Nat Genet
, vol.42
, Issue.2
, pp. 181-185
-
-
Morin, R.D.1
Johnson, N.A.2
Severson, T.M.3
-
16
-
-
77955085750
-
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
-
Ernst T., Chase A.J., Score J., et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat Genet 2010, 42(8):722-726.
-
(2010)
Nat Genet
, vol.42
, Issue.8
, pp. 722-726
-
-
Ernst, T.1
Chase, A.J.2
Score, J.3
-
17
-
-
79960227474
-
Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
-
Abdel-Wahab O., Pardanani A., Patel J., et al. Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms. Leukemia 2011, 25(7):1200-1202.
-
(2011)
Leukemia
, vol.25
, Issue.7
, pp. 1200-1202
-
-
Abdel-Wahab, O.1
Pardanani, A.2
Patel, J.3
-
18
-
-
79953176952
-
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
-
Yan X.-J., Xu J., Gu Z.-H., et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet 2011, 43(4):309-315.
-
(2011)
Nat Genet
, vol.43
, Issue.4
, pp. 309-315
-
-
Yan, X.-J.1
Xu, J.2
Gu, Z.-H.3
-
19
-
-
77954089584
-
Array-based genomic resequencing of human leukemia
-
Yamashita Y., Yuan J., Suetake I., et al. Array-based genomic resequencing of human leukemia. Oncogene 2010, 29(25):3723-3731.
-
(2010)
Oncogene
, vol.29
, Issue.25
, pp. 3723-3731
-
-
Yamashita, Y.1
Yuan, J.2
Suetake, I.3
-
20
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
Ley T.J., Ding L., Walter M.J., et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med 2010, 363(25):2424-2433.
-
(2010)
N Engl J Med
, vol.363
, Issue.25
, pp. 2424-2433
-
-
Ley, T.J.1
Ding, L.2
Walter, M.J.3
-
21
-
-
66249137734
-
Mutation in TET2 in myeloid cancers
-
Delhommeau F., Dupont S., Valle V.D., et al. Mutation in TET2 in myeloid cancers. N Engl J Med 2009, 360(22):2289-2301.
-
(2009)
N Engl J Med
, vol.360
, Issue.22
, pp. 2289-2301
-
-
Delhommeau, F.1
Dupont, S.2
Valle, V.D.3
-
22
-
-
0033753779
-
The DNA methyltransferases of mammals
-
Bestor T.H. The DNA methyltransferases of mammals. Hum Mol Genet 2000, 9(16):2395-2402.
-
(2000)
Hum Mol Genet
, vol.9
, Issue.16
, pp. 2395-2402
-
-
Bestor, T.H.1
-
23
-
-
0033435205
-
The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
-
Hansen R.S., Wijmenga C., Luo P., et al. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc Natl Acad Sci U S A 1999, 96(25):14412-14417.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.25
, pp. 14412-14417
-
-
Hansen, R.S.1
Wijmenga, C.2
Luo, P.3
-
24
-
-
0033547330
-
Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
-
Xu G.L., Bestor T.H., Bourc'his D., et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 1999, 402(6758):187-191.
-
(1999)
Nature
, vol.402
, Issue.6758
, pp. 187-191
-
-
Xu, G.L.1
Bestor, T.H.2
Bourc'his, D.3
-
25
-
-
0019318994
-
DNA methylation and gene function
-
Razin A., Riggs A.D. DNA methylation and gene function. Science 1980, 210(4470):604-610.
-
(1980)
Science
, vol.210
, Issue.4470
, pp. 604-610
-
-
Razin, A.1
Riggs, A.D.2
-
26
-
-
77649267695
-
Dynamic changes in the human methylome during differentiation
-
Laurent L., Wong E., Li G., et al. Dynamic changes in the human methylome during differentiation. Genome Res 2010, 20(3):320-331.
-
(2010)
Genome Res
, vol.20
, Issue.3
, pp. 320-331
-
-
Laurent, L.1
Wong, E.2
Li, G.3
-
27
-
-
70450217879
-
Human DNA methylomes at base resolution show widespread epigenomic differences
-
Lister R., Pelizzola M., Dowen R.H., et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 2009, 462(7271):315-322.
-
(2009)
Nature
, vol.462
, Issue.7271
, pp. 315-322
-
-
Lister, R.1
Pelizzola, M.2
Dowen, R.H.3
-
28
-
-
77956902023
-
Comprehensive methylome map of lineage commitment from haematopoietic progenitors
-
Ji H., Ehrlich L.I., Seita J., et al. Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature 2010, 467(7313):338-342.
-
(2010)
Nature
, vol.467
, Issue.7313
, pp. 338-342
-
-
Ji, H.1
Ehrlich, L.I.2
Seita, J.3
-
29
-
-
0036333103
-
Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice
-
Hata K., Okano M., Lei H., Li E. Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development 2002, 129(8):1983-1993.
-
(2002)
Development
, vol.129
, Issue.8
, pp. 1983-1993
-
-
Hata, K.1
Okano, M.2
Lei, H.3
Li, E.4
-
30
-
-
0033615717
-
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
-
Okano M., Bell D.W., Haber D.A., Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99(3):247-257.
-
(1999)
Cell
, vol.99
, Issue.3
, pp. 247-257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
31
-
-
38949212693
-
A novel CpG island set identifies tissue-specific methylation at developmental gene loci
-
Illingworth R., Kerr A., Desousa D., et al. A novel CpG island set identifies tissue-specific methylation at developmental gene loci. PLoS Biol 2008, 6(1):e22.
-
(2008)
PLoS Biol
, vol.6
, Issue.1
-
-
Illingworth, R.1
Kerr, A.2
Desousa, D.3
-
32
-
-
79952053850
-
Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation
-
Song J., Rechkoblit O., Bestor T.H., Patel D.J. Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science 2010, 331(6020):1036-1040.
-
(2010)
Science
, vol.331
, Issue.6020
, pp. 1036-1040
-
-
Song, J.1
Rechkoblit, O.2
Bestor, T.H.3
Patel, D.J.4
-
33
-
-
84856990498
-
Structure-based mechanistic insights into DNMT1-mediated maintenance DNA nmethylation
-
Song J., Teplova M., Ishibe-Murakami S., Patel D.J. Structure-based mechanistic insights into DNMT1-mediated maintenance DNA nmethylation. Science 2012, 335(6069):709-712.
-
(2012)
Science
, vol.335
, Issue.6069
, pp. 709-712
-
-
Song, J.1
Teplova, M.2
Ishibe-Murakami, S.3
Patel, D.J.4
-
34
-
-
70350654370
-
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
-
Broske A.M., Vockentanz L., Kharazi S., et al. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet 2009, 41(11):1207-1215.
-
(2009)
Nat Genet
, vol.41
, Issue.11
, pp. 1207-1215
-
-
Broske, A.M.1
Vockentanz, L.2
Kharazi, S.3
-
35
-
-
70349469788
-
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells
-
Trowbridge J.J., Snow J.W., Kim J., Orkin S.H. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell 2009, 5(4):442-449.
-
(2009)
Cell Stem Cell
, vol.5
, Issue.4
, pp. 442-449
-
-
Trowbridge, J.J.1
Snow, J.W.2
Kim, J.3
Orkin, S.H.4
-
36
-
-
31144449613
-
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2
-
Goll M.G., Kirpekar F., Maggert K.A., et al. Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science 2006, 311(5759):395-398.
-
(2006)
Science
, vol.311
, Issue.5759
, pp. 395-398
-
-
Goll, M.G.1
Kirpekar, F.2
Maggert, K.A.3
-
37
-
-
74049130225
-
Solving the Dnmt2 enigma
-
Schaefer M., Lyko F. Solving the Dnmt2 enigma. Chromosoma 2010, 119(1):35-40.
-
(2010)
Chromosoma
, vol.119
, Issue.1
, pp. 35-40
-
-
Schaefer, M.1
Lyko, F.2
-
38
-
-
77956193814
-
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation
-
Dhayalan A., Rajavelu A., Rathert P., et al. The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. J Biol Chem 2010, 285(34):26114-26120.
-
(2010)
J Biol Chem
, vol.285
, Issue.34
, pp. 26114-26120
-
-
Dhayalan, A.1
Rajavelu, A.2
Rathert, P.3
-
39
-
-
79959494918
-
Structural and histone binding ability characterizations of human PWWP domains
-
Kursula P., Wu H., Zeng H., et al. Structural and histone binding ability characterizations of human PWWP domains. PLoS ONE 2011, 6(6):e18919.
-
(2011)
PLoS ONE
, vol.6
, Issue.6
-
-
Kursula, P.1
Wu, H.2
Zeng, H.3
-
40
-
-
34548603504
-
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation
-
Jia D., Jurkowska R.Z., Zhang X., Jeltsch A., Cheng X. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature 2007, 449(7159):248-251.
-
(2007)
Nature
, vol.449
, Issue.7159
, pp. 248-251
-
-
Jia, D.1
Jurkowska, R.Z.2
Zhang, X.3
Jeltsch, A.4
Cheng, X.5
-
41
-
-
34547725157
-
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
-
Ooi S.K., Qiu C., Bernstein E., et al. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature 2007, 448(7154):714-717.
-
(2007)
Nature
, vol.448
, Issue.7154
, pp. 714-717
-
-
Ooi, S.K.1
Qiu, C.2
Bernstein, E.3
-
42
-
-
70449099301
-
Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain
-
Otani J., Nankumo T., Arita K., Inamoto S., Ariyoshi M., Shirakawa M. Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain. EMBO Rep 2009, 10(11):1235-1241.
-
(2009)
EMBO Rep
, vol.10
, Issue.11
, pp. 1235-1241
-
-
Otani, J.1
Nankumo, T.2
Arita, K.3
Inamoto, S.4
Ariyoshi, M.5
Shirakawa, M.6
-
43
-
-
77954659099
-
Relationship between nucleosome positioning and DNA methylation
-
Chodavarapu R.K., Feng S., Bernatavichute Y.V., et al. Relationship between nucleosome positioning and DNA methylation. Nature 2010, 466(7304):388-392.
-
(2010)
Nature
, vol.466
, Issue.7304
, pp. 388-392
-
-
Chodavarapu, R.K.1
Feng, S.2
Bernatavichute, Y.V.3
-
44
-
-
79960255863
-
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
-
Walter M.J., Ding L., Shen D., et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia 2011, 25(7):1153-1158.
-
(2011)
Leukemia
, vol.25
, Issue.7
, pp. 1153-1158
-
-
Walter, M.J.1
Ding, L.2
Shen, D.3
-
45
-
-
79960257531
-
DNMT3a mutations in high-risk myelodysplastic syndrome parallel those found in acute myeloid leukemia
-
Ewalt M., Galili N., Mumtaz M., et al. DNMT3a mutations in high-risk myelodysplastic syndrome parallel those found in acute myeloid leukemia. Blood Cancer J 2011, 1(e9):1-3.
-
(2011)
Blood Cancer J
, vol.1
, Issue.E9
, pp. 1-3
-
-
Ewalt, M.1
Galili, N.2
Mumtaz, M.3
-
46
-
-
40049094942
-
Mammalian DNA methyltransferases: a structural perspective
-
Cheng X., Blumenthal R.M. Mammalian DNA methyltransferases: a structural perspective. Structure 2008, 16(3):341-350.
-
(2008)
Structure
, vol.16
, Issue.3
, pp. 341-350
-
-
Cheng, X.1
Blumenthal, R.M.2
-
47
-
-
0035283201
-
Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
-
Mizuno S., Chijiwa T., Okamura T., et al. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood 2001, 97(5):1172-1179.
-
(2001)
Blood
, vol.97
, Issue.5
, pp. 1172-1179
-
-
Mizuno, S.1
Chijiwa, T.2
Okamura, T.3
-
48
-
-
0035667192
-
DNA methyltransferase 3B mutations linked to the ICF syndrome cause dysregulation of lymphogenesis genes
-
Ehrlich M., Buchanan K.L., Tsien F., et al. DNA methyltransferase 3B mutations linked to the ICF syndrome cause dysregulation of lymphogenesis genes. Hum Mol Genet 2001, 10(25):2917-2931.
-
(2001)
Hum Mol Genet
, vol.10
, Issue.25
, pp. 2917-2931
-
-
Ehrlich, M.1
Buchanan, K.L.2
Tsien, F.3
-
49
-
-
0035930660
-
Dnmt3L and the establishment of maternal genomic imprints
-
Bourc'his D., Xu G.L., Lin C.S., Bollman B., Bestor T.H. Dnmt3L and the establishment of maternal genomic imprints. Science 2001, 294(5551):2536-2539.
-
(2001)
Science
, vol.294
, Issue.5551
, pp. 2536-2539
-
-
Bourc'his, D.1
Xu, G.L.2
Lin, C.S.3
Bollman, B.4
Bestor, T.H.5
-
50
-
-
84878648347
-
Application of epigenome-modifying small molecules in induced pluripotent stem cells
-
Lu J., Kong X., Luo C., Li K. Application of epigenome-modifying small molecules in induced pluripotent stem cells. Med Res Rev 2012, 11(10):21265.
-
(2012)
Med Res Rev
, vol.11
, Issue.10
, pp. 21265
-
-
Lu, J.1
Kong, X.2
Luo, C.3
Li, K.4
-
51
-
-
38349100549
-
Epigenetic events in mammalian germ-cell development: reprogramming and beyond
-
Sasaki H., Matsui Y. Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat Rev Genet 2008, 2008(2):129-140.
-
(2008)
Nat Rev Genet
, vol.2008
, Issue.2
, pp. 129-140
-
-
Sasaki, H.1
Matsui, Y.2
-
52
-
-
79960098405
-
Differential recruitment of methyl CpG-binding domain factors and DNA methyltransferases by the orphan receptor germ cell nuclear factor initiates the repression and silencing of Oct4
-
Gu P., Xu X., Le Menuet D., Chung A.C., Cooney A.J. Differential recruitment of methyl CpG-binding domain factors and DNA methyltransferases by the orphan receptor germ cell nuclear factor initiates the repression and silencing of Oct4. Stem Cells 2011, 29(7):1041-1051.
-
(2011)
Stem Cells
, vol.29
, Issue.7
, pp. 1041-1051
-
-
Gu, P.1
Xu, X.2
Le Menuet, D.3
Chung, A.C.4
Cooney, A.J.5
-
53
-
-
79956318370
-
De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state
-
Pawlak M., Jaenisch R. De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state. Genes Dev 2011, 25(10):1035-1040.
-
(2011)
Genes Dev
, vol.25
, Issue.10
, pp. 1035-1040
-
-
Pawlak, M.1
Jaenisch, R.2
-
54
-
-
77957824513
-
DNA methylation is dispensable for the growth and survival of the extraembryonic lineages
-
Sakaue M., Ohta H., Kumaki Y., et al. DNA methylation is dispensable for the growth and survival of the extraembryonic lineages. Curr Biol 2010, 20(16):1452-1457.
-
(2010)
Curr Biol
, vol.20
, Issue.16
, pp. 1452-1457
-
-
Sakaue, M.1
Ohta, H.2
Kumaki, Y.3
-
55
-
-
84555207349
-
Dnmt3a is essential for hematopoietic stem cell differentiation
-
Challen G.A., Sun D., Jeong M., et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet 2011, 44(1):23-31.
-
(2011)
Nat Genet
, vol.44
, Issue.1
, pp. 23-31
-
-
Challen, G.A.1
Sun, D.2
Jeong, M.3
-
56
-
-
36749023976
-
HOXB4's road map to stem cell expansion
-
Schiedlmeier B., Santos A.C., Ribeiro A., et al. HOXB4's road map to stem cell expansion. Proc Natl Acad Sci U S A 2007, 104(43):16952-16957.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.43
, pp. 16952-16957
-
-
Schiedlmeier, B.1
Santos, A.C.2
Ribeiro, A.3
-
57
-
-
81555228423
-
Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia
-
Shen Y., Zhu Y.M., Fan X., et al. Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood 2011, 118(20):5593-5603.
-
(2011)
Blood
, vol.118
, Issue.20
, pp. 5593-5603
-
-
Shen, Y.1
Zhu, Y.M.2
Fan, X.3
-
58
-
-
84863176405
-
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains
-
Trowbridge J.J., Sinha A.U., Zhu N., Li M., Armstrong S.A., Orkin S.H. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev 2012, 26(4):344-349.
-
(2012)
Genes Dev
, vol.26
, Issue.4
, pp. 344-349
-
-
Trowbridge, J.J.1
Sinha, A.U.2
Zhu, N.3
Li, M.4
Armstrong, S.A.5
Orkin, S.H.6
-
59
-
-
84855410220
-
Concise review: multidimensional regulation of the hematopoietic stem cell state
-
Oh I.H., Humphries R.K. Concise review: multidimensional regulation of the hematopoietic stem cell state. Stem Cells 2012, 30(1):82-88.
-
(2012)
Stem Cells
, vol.30
, Issue.1
, pp. 82-88
-
-
Oh, I.H.1
Humphries, R.K.2
-
60
-
-
33748421236
-
Leukemia stem cells
-
Luo L., Han Z. Leukemia stem cells. Int J Hematol 2006, 84(2):123-127.
-
(2006)
Int J Hematol
, vol.84
, Issue.2
, pp. 123-127
-
-
Luo, L.1
Han, Z.2
-
61
-
-
0141483064
-
Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
-
Passegue E., Jamieson C.H., Ailles L.E., Weissman I.L. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?. Proc Natl Acad Sci U S A 2003, 100(Suppl 1):11842-11849.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.SUPPL 1
, pp. 11842-11849
-
-
Passegue, E.1
Jamieson, C.H.2
Ailles, L.E.3
Weissman, I.L.4
-
62
-
-
0029001154
-
Suppression of intestinal neoplasia by DNA hypomethylation
-
Laird P.W., Jackson-Grusby L., Fazeli A., et al. Suppression of intestinal neoplasia by DNA hypomethylation. Cell 1995, 81(2):197-205.
-
(1995)
Cell
, vol.81
, Issue.2
, pp. 197-205
-
-
Laird, P.W.1
Jackson-Grusby, L.2
Fazeli, A.3
-
63
-
-
0036814971
-
Molecular genetics of human leukemias: new insights into therapy
-
Gilliland D.G. Molecular genetics of human leukemias: new insights into therapy. Semin Hematol 2002, 39(4 Suppl 3):6-11.
-
(2002)
Semin Hematol
, vol.39
, Issue.4 SUPPL 3
, pp. 6-11
-
-
Gilliland, D.G.1
-
64
-
-
34147181120
-
Mutant transcription factors and tyrosine kinases as therapeutic targets for leukemias: from acute promyelocytic leukemia to chronic myeloid leukemia and beyond
-
Hu J., Zhou G.B., Wang Z.Y., Chen S.J., Chen Z. Mutant transcription factors and tyrosine kinases as therapeutic targets for leukemias: from acute promyelocytic leukemia to chronic myeloid leukemia and beyond. Adv Cancer Res 2007, 98:191-220.
-
(2007)
Adv Cancer Res
, vol.98
, pp. 191-220
-
-
Hu, J.1
Zhou, G.B.2
Wang, Z.Y.3
Chen, S.J.4
Chen, Z.5
-
65
-
-
70349256226
-
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
-
Vardiman J.W., Thiele J., Arber D.A., et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009, 114(5):937-951.
-
(2009)
Blood
, vol.114
, Issue.5
, pp. 937-951
-
-
Vardiman, J.W.1
Thiele, J.2
Arber, D.A.3
-
66
-
-
84856694362
-
Low frequency of DNMT3A mutations in pediatric AML, and the identification of the OCI-AML3 cell line as an in vitro model
-
Hollink I.H.I.M., Feng Q., Danen-van Oorschot A.A., et al. Low frequency of DNMT3A mutations in pediatric AML, and the identification of the OCI-AML3 cell line as an in vitro model. Leukemia 2011, 26(2):371-373.
-
(2011)
Leukemia
, vol.26
, Issue.2
, pp. 371-373
-
-
Hollink, I.H.I.M.1
Feng, Q.2
Danen-van Oorschot, A.A.3
-
67
-
-
80053135096
-
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
-
Jankowska A.M., Makishima H., Tiu R.V., et al. Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood 2011, 118(14):3932-3941.
-
(2011)
Blood
, vol.118
, Issue.14
, pp. 3932-3941
-
-
Jankowska, A.M.1
Makishima, H.2
Tiu, R.V.3
-
68
-
-
84855718050
-
TET2 and DNMT3A mutations in human T-cell lymphoma
-
Couronné L., Bastard C., Bernard O.A. TET2 and DNMT3A mutations in human T-cell lymphoma. N Engl J Med 2012, 366(1):95-96.
-
(2012)
N Engl J Med
, vol.366
, Issue.1
, pp. 95-96
-
-
Couronné, L.1
Bastard, C.2
Bernard, O.A.3
-
69
-
-
79960248721
-
DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms
-
Abdel-Wahab O., Pardanani A., Rampal R., Lasho T.L., Levine R.L., Tefferi A. DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms. Leukemia 2011, 25(7):1219-1220.
-
(2011)
Leukemia
, vol.25
, Issue.7
, pp. 1219-1220
-
-
Abdel-Wahab, O.1
Pardanani, A.2
Rampal, R.3
Lasho, T.L.4
Levine, R.L.5
Tefferi, A.6
-
70
-
-
79960210747
-
DNMT3A mutations in myeloproliferative neoplasms
-
Stegelmann F., Bullinger L., Schlenk R.F., et al. DNMT3A mutations in myeloproliferative neoplasms. Leukemia 2011, 25(7):1217-1219.
-
(2011)
Leukemia
, vol.25
, Issue.7
, pp. 1217-1219
-
-
Stegelmann, F.1
Bullinger, L.2
Schlenk, R.F.3
-
71
-
-
84862776906
-
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
-
Ding L., Ley T.J., Larson D.E., et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature 2012, 481(7382):506-510.
-
(2012)
Nature
, vol.481
, Issue.7382
, pp. 506-510
-
-
Ding, L.1
Ley, T.J.2
Larson, D.E.3
-
72
-
-
35348849015
-
Hox genes in hematopoiesis and leukemogenesis
-
Argiropoulos B., Humphries R.K. Hox genes in hematopoiesis and leukemogenesis. Oncogene 2007, 26(47):6766-6776.
-
(2007)
Oncogene
, vol.26
, Issue.47
, pp. 6766-6776
-
-
Argiropoulos, B.1
Humphries, R.K.2
-
73
-
-
80055007688
-
Acute myeloid leukemia with mutated nucleophosmin (NPM1): any hope for a targeted therapy?
-
Falini B., Gionfriddo I., Cecchetti F., Ballanti S., Pettirossi V., Martelli M.P. Acute myeloid leukemia with mutated nucleophosmin (NPM1): any hope for a targeted therapy?. Blood Rev 2011, 25(6):247-254.
-
(2011)
Blood Rev
, vol.25
, Issue.6
, pp. 247-254
-
-
Falini, B.1
Gionfriddo, I.2
Cecchetti, F.3
Ballanti, S.4
Pettirossi, V.5
Martelli, M.P.6
-
74
-
-
79251556241
-
Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?
-
Falini B., Martelli M.P., Bolli N., et al. Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?. Blood 2011, 117(4):1109-1120.
-
(2011)
Blood
, vol.117
, Issue.4
, pp. 1109-1120
-
-
Falini, B.1
Martelli, M.P.2
Bolli, N.3
-
75
-
-
33745534443
-
Nucleophosmin and cancer
-
Grisendi S., Mecucci C., Falini B., Pandolfi P.P. Nucleophosmin and cancer. Nat Rev Cancer 2006, 6(7):493-505.
-
(2006)
Nat Rev Cancer
, vol.6
, Issue.7
, pp. 493-505
-
-
Grisendi, S.1
Mecucci, C.2
Falini, B.3
Pandolfi, P.P.4
-
76
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
Patel J.P., Gonen M., Figueroa M.E., et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012, 366(12):1079-1089.
-
(2012)
N Engl J Med
, vol.366
, Issue.12
, pp. 1079-1089
-
-
Patel, J.P.1
Gonen, M.2
Figueroa, M.E.3
-
77
-
-
34547799171
-
DNA methyltransferases as targets for cancer therapy
-
Ghoshal K., Bai S. DNA methyltransferases as targets for cancer therapy. Drugs Today 2007, 43(6):395-422.
-
(2007)
Drugs Today
, vol.43
, Issue.6
, pp. 395-422
-
-
Ghoshal, K.1
Bai, S.2
-
78
-
-
79960891281
-
DNA methylation as a pathogenic event and as a therapeutic target in AML
-
Schoofs T., Muller-Tidow C. DNA methylation as a pathogenic event and as a therapeutic target in AML. Cancer Treat Rev 2011, 37(1):25.
-
(2011)
Cancer Treat Rev
, vol.37
, Issue.1
, pp. 25
-
-
Schoofs, T.1
Muller-Tidow, C.2
-
79
-
-
79953138219
-
Hypomethylating agents for urologic cancers
-
Alva A.S., Hahn N.M., Aparicio A.M., Singal R., Yellapragada S., Sonpavde G. Hypomethylating agents for urologic cancers. Future Oncol 2011, 7(3):447-463.
-
(2011)
Future Oncol
, vol.7
, Issue.3
, pp. 447-463
-
-
Alva, A.S.1
Hahn, N.M.2
Aparicio, A.M.3
Singal, R.4
Yellapragada, S.5
Sonpavde, G.6
-
80
-
-
84856720426
-
CpG methylation patterns and decitabine treatment response in acute myeloid leukemia cells and normal hematopoietic precursors
-
Negrotto S., Ng K.P., Jankowska A.M., et al. CpG methylation patterns and decitabine treatment response in acute myeloid leukemia cells and normal hematopoietic precursors. Leukemia 2012, 26(2):244-254.
-
(2012)
Leukemia
, vol.26
, Issue.2
, pp. 244-254
-
-
Negrotto, S.1
Ng, K.P.2
Jankowska, A.M.3
-
81
-
-
80053545678
-
Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy
-
Fathi A.T., Abdel-Wahab O. Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy. Adv Hematol 2012, 2012:469592.
-
(2012)
Adv Hematol
, vol.2012
, pp. 469592
-
-
Fathi, A.T.1
Abdel-Wahab, O.2
-
82
-
-
82955169581
-
Epigenetic-based therapies in cancer: progress to date
-
Song S.H., Han S.W., Bang Y.J. Epigenetic-based therapies in cancer: progress to date. Drugs 2011, 71(18):2391-2403.
-
(2011)
Drugs
, vol.71
, Issue.18
, pp. 2391-2403
-
-
Song, S.H.1
Han, S.W.2
Bang, Y.J.3
-
83
-
-
84857999119
-
Azacitidine for treatment of imminent relapse in MDS or AML patients after allogeneic HSCT: results of the RELAZA trial
-
Platzbecker U., Wermke M., Radke J., et al. Azacitidine for treatment of imminent relapse in MDS or AML patients after allogeneic HSCT: results of the RELAZA trial. Leukemia 2012, 26(3):381-389.
-
(2012)
Leukemia
, vol.26
, Issue.3
, pp. 381-389
-
-
Platzbecker, U.1
Wermke, M.2
Radke, J.3
-
84
-
-
77957878987
-
Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine
-
Champion C., Guianvarc'h D., Senamaud-Beaufort C., et al. Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine. PLoS One 2010, 5(8).
-
(2010)
PLoS One
, vol.5
, Issue.8
-
-
Champion, C.1
Guianvarc'h, D.2
Senamaud-Beaufort, C.3
-
85
-
-
84863130872
-
DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer
-
Chen M., Shabashvili D., Nawab A., et al. DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer. Mol Cancer Ther 2012, 11(2):370-382.
-
(2012)
Mol Cancer Ther
, vol.11
, Issue.2
, pp. 370-382
-
-
Chen, M.1
Shabashvili, D.2
Nawab, A.3
-
86
-
-
33846260563
-
Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice
-
Beumer J.H., Eiseman J.L., Parise R.A., et al. Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice. Clin Cancer Res 2006, 12(24):7483-7491.
-
(2006)
Clin Cancer Res
, vol.12
, Issue.24
, pp. 7483-7491
-
-
Beumer, J.H.1
Eiseman, J.L.2
Parise, R.A.3
-
87
-
-
0038392721
-
Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme
-
Reither S., Li F., Gowher H., Jeltsch A. Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme. J Mol Biol 2003, 329(4):675-684.
-
(2003)
J Mol Biol
, vol.329
, Issue.4
, pp. 675-684
-
-
Reither, S.1
Li, F.2
Gowher, H.3
Jeltsch, A.4
-
88
-
-
22144461094
-
Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy
-
Gowher H., Jeltsch A. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther 2004, 3(11):1062-1068.
-
(2004)
Cancer Biol Ther
, vol.3
, Issue.11
, pp. 1062-1068
-
-
Gowher, H.1
Jeltsch, A.2
-
89
-
-
79959820766
-
An overview of epigenetics and chemoprevention
-
Huang Y.W., Kuo C.T., Stoner K., Huang T.H., Wang L.S. An overview of epigenetics and chemoprevention. FEBS Lett 2011, 585(13):2129-2136.
-
(2011)
FEBS Lett
, vol.585
, Issue.13
, pp. 2129-2136
-
-
Huang, Y.W.1
Kuo, C.T.2
Stoner, K.3
Huang, T.H.4
Wang, L.S.5
-
90
-
-
27144509196
-
DNA methyltransferase inhibitors and the development of epigenetic cancer therapies
-
Lyko F., Brown R. DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Cancer Inst 2005, 97(20):1498-1506.
-
(2005)
J Natl Cancer Inst
, vol.97
, Issue.20
, pp. 1498-1506
-
-
Lyko, F.1
Brown, R.2
-
91
-
-
79952710830
-
Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas
-
Stathis A., Hotte S.J., Chen E.X., et al. Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas. Clin Cancer Res 2011, 17(6):1582-1590.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.6
, pp. 1582-1590
-
-
Stathis, A.1
Hotte, S.J.2
Chen, E.X.3
-
92
-
-
79952642498
-
Novel agents for the treatment of acute myeloid leukemia in the older patient
-
Baer M.R., Gojo I. Novel agents for the treatment of acute myeloid leukemia in the older patient. J Natl Compr Canc Netw 2011, 9(3):331-335.
-
(2011)
J Natl Compr Canc Netw
, vol.9
, Issue.3
, pp. 331-335
-
-
Baer, M.R.1
Gojo, I.2
-
93
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones P.A., Baylin S.B. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002, 3(6):415-428.
-
(2002)
Nat Rev Genet
, vol.3
, Issue.6
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
94
-
-
70149101696
-
Analysis of the Ten-Eleven Translocation 2 (TET2) gene in familial myeloproliferative neoplasms
-
Saint-Martin C., Leroy G., Delhommeau F., et al. Analysis of the Ten-Eleven Translocation 2 (TET2) gene in familial myeloproliferative neoplasms. Blood 2009, 114(8):1628-1632.
-
(2009)
Blood
, vol.114
, Issue.8
, pp. 1628-1632
-
-
Saint-Martin, C.1
Leroy, G.2
Delhommeau, F.3
-
95
-
-
67649876132
-
Acquired mutations in TET2 are common in myelodysplastic syndromes
-
Langemeijer S.M.C., Kuiper R.P., Berends M., et al. Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat Genet 2009, 41(7):838-842.
-
(2009)
Nat Genet
, vol.41
, Issue.7
, pp. 838-842
-
-
Langemeijer, S.M.C.1
Kuiper, R.P.2
Berends, M.3
|