Low frequency of DNMT3A mutations in pediatric AML, and the identification of the OCI-AML3 cell line as an in vitro model

Leukemia

Volumn 26, Issue 2, 2012, Pages 371-373

  Hollink, I H I M ^a   Feng, Q ^b   Danen Van Oorschot, A A ^a   Arentsen Peters, S T C J M ^a   Verboon, L J ^a   Zhang, P ^b   De Haas, V ^c   Reinhardt, D ^d   Creutzig, U ^e   Trka, J ^f   Pieters, R ^a   Van Den Heuvel Eibrink, M M ^a   Wang, J ^b   Zwaan, C M ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b BGI SHENZHEN   (China)

^c Dutch Childhood Oncology Group DCOG   (Netherlands)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^f CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CD135 ANTIGEN; DNA METHYLTRANSFERASE 3A; HISTONE H3; METHYLTRANSFERASE;

ACUTE GRANULOCYTIC LEUKEMIA; BINDING AFFINITY; CYTOGENETICS; ENZYME ACTIVITY; EXOME; EXON; GENE DELETION; GENE DUPLICATION; GENE FREQUENCY; GENE IDENTIFICATION; GENE INSERTION; GENE LOCATION; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; HETEROZYGOTE; HUMAN; IN VITRO STUDY; LETTER; LEUKEMIA CELL LINE; MISSENSE MUTATION; MONOCYTIC LEUKEMIA; MYELOMONOCYTIC LEUKEMIA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 84856694362     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.210     Document Type: Letter

References (9)

1. Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 2008; 456: 66-72.
2. Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009; 361: 1058-1066.
3. Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med 2010; 363: 2424-2433.
4. Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet 2011; 43: 309-315.
5. Ho PA, Kutny MA, Alonzo TA, Gerbing RB, Joaquin J, Raimondi SC et al. Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: a report from the Children's Oncology Group. Pediatr Blood Cancer 2011; 57: 204-209.
6. Quentmeier H, Martelli MP, Dirks WG, Bolli N, Liso A, Macleod RA et al. Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin. Leukemia 2005; 19: 1760-1767. (Pubitemid 41486153)
7. Hollink IH, Zwaan CM, Zimmermann M, Arentsen-Peters TC, Pieters R, Cloos J et al. Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML. Leukemia 2009; 23: 262-270.
8. Thiede C, Creutzig E, Reinhardt D, Ehninger G, Creutzig U. Different types of NPM1 mutations in children and adults: evidence for an effect of patient age on the prevalence of the TCTG-tandem duplication in NPM1-exon 12. Leukemia 2007; 21: 366-367. (Pubitemid 46158137)
9. Damm F, Thol F, Hollink I, Zimmermann M, Reinhardt K, van den Heuvel-Eibrink MM et al. Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups Leukemia 2011; e-pub ahead of print 7 June 2011.