-
1
-
-
79958043675
-
-
National Cancer Institute. Bethesda, MD. Available at: Accessed January 18, 2011
-
Altekruse SF, Kosary CL, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2007, National Cancer Institute. Bethesda, MD. Available at: http://seer.cancer.gov/csr/1975-2007/. Accessed January 18, 2011.
-
SEER Cancer Statistics Review, 1975-2007
-
-
Altekruse, S.F.1
Kosary, C.L.2
Krapcho, M.3
-
3
-
-
78649486856
-
Intensive chemotherapy does not benefit most older patients (age 70 years or older) with acute myeloid leukemia
-
Kantarjian H, Ravandi F, O'Brien S, et al. Intensive chemotherapy does not benefit most older patients (age 70 years or older) with acute myeloid leukemia. Blood 2010;116:4422-4429.
-
(2010)
Blood
, vol.116
, pp. 4422-4429
-
-
Kantarjian, H.1
Ravandi, F.2
O'Brien, S.3
-
4
-
-
0031005627
-
Acute myeloid leukemia in the elderly: Assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy
-
A Southwest Oncology Group study
-
Leith CP, Kopecky KJ, Godwin J, et al. Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study. Blood 1997;89:3323-3329.
-
(1997)
Blood
, vol.89
, pp. 3323-3329
-
-
Leith, C.P.1
Kopecky, K.J.2
Godwin, J.3
-
5
-
-
78149294040
-
FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
-
Whitman SP, Maharry K, Radmacher MD, et al. FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. Blood 2010;116:3622-3626.
-
(2010)
Blood
, vol.116
, pp. 3622-3626
-
-
Whitman, S.P.1
Maharry, K.2
Radmacher, M.D.3
-
6
-
-
70349451999
-
High-dose daunorubicin in older patients with acute myeloid leukemia
-
Löwenberg B, Ossenkoppele GJ, van Putten W, et al. High-dose daunorubicin in older patients with acute myeloid leukemia. N Engl J Med 2009;361:1235-1248.
-
(2009)
N Engl J Med
, vol.361
, pp. 1235-1248
-
-
Löwenberg, B.1
Ossenkoppele, G.J.2
Van Putten, W.3
-
7
-
-
77649202987
-
Randomized study of intensified anthracycline doses for induction and recombinant interleukin-2 for maintenance in patients with acute myeloid leukemia age 50 to 70 years: Results of the ALFA-9801 study
-
Pautas C, Merabet F, Thomas X, et al. Randomized study of intensified anthracycline doses for induction and recombinant interleukin-2 for maintenance in patients with acute myeloid leukemia age 50 to 70 years: results of the ALFA-9801 study. J Clin Oncol 2010;28:808-814.
-
(2010)
J Clin Oncol
, vol.28
, pp. 808-814
-
-
Pautas, C.1
Merabet, F.2
Thomas, X.3
-
8
-
-
0028802425
-
Susceptibility of idarubicin, daunorubicin, and their C-13 alcohol metabolites to transport-mediated multidrug resistance
-
Ross DD, Doyle LA, Yang W, et al. Susceptibility of idarubicin, daunorubicin, and their C-13 alcohol metabolites to transport-mediated multidrug resistance. Biochem Pharmacol 1995;50:1673-1683.
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 1673-1683
-
-
Ross, D.D.1
Doyle, L.A.2
Yang, W.3
-
9
-
-
79952168974
-
Allogeneic hematopoietic stem cell transplantation (HCT) compared to chemotherapy only in acute myeloid leukemia (AML) patients 60 years and older: A Center for International Blood and Marrow Transplantation Research (CIBMTR)/Cancer and Leukemia Group B (CALGB) study
-
abstract Abstract 657
-
Farag SS, Maharry K, Perez W, et al. Allogeneic hematopoietic stem cell transplantation (HCT) compared to chemotherapy only in acute myeloid leukemia (AML) patients 60 years and older: A Center for International Blood and Marrow Transplantation Research (CIBMTR)/Cancer and Leukemia Group B (CALGB) study [abstract]. Blood 2009;114(Suppl):Abstract 657.
-
(2009)
Blood
, vol.114
, Issue.SUPPL.
-
-
Farag, S.S.1
Maharry, K.2
Perez, W.3
-
10
-
-
77954911871
-
Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome
-
Faderl S, Garcia-Manero G, Estrov Z, et al. Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome. J Clin Oncol 2010;28:2755-2760.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2755-2760
-
-
Faderl, S.1
Garcia-Manero, G.2
Estrov, Z.3
-
11
-
-
77449159668
-
Phase II study of clofarabine monotherapy in previously untreated older patients with acute myeloid leukemia and unfavorable prognostic factors
-
Kantarjian HM, Erba HP, Claxton D, et al. Phase II study of clofarabine monotherapy in previously untreated older patients with acute myeloid leukemia and unfavorable prognostic factors. J Clin Oncol 2010;28:549-555.
-
(2010)
J Clin Oncol
, vol.28
, pp. 549-555
-
-
Kantarjian, H.M.1
Erba, H.P.2
Claxton, D.3
-
12
-
-
77952491723
-
European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy
-
Burnett AK, Russell NH, Kell J, et al. European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy. J Clin Oncol 2010;28:2389-2395.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2389-2395
-
-
Burnett, A.K.1
Russell, N.H.2
Kell, J.3
-
13
-
-
33745586575
-
Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older
-
DOI 10.1182/blood-2005-08-3294
-
Faderl S, Verstovsek S, Cortes J, et al. Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older. Blood 2006;108:45-51. (Pubitemid 43990611)
-
(2006)
Blood
, vol.108
, Issue.1
, pp. 45-51
-
-
Faderl, S.1
Verstovsek, S.2
Cortes, J.3
Ravandi, F.4
Beran, M.5
Garcia-Manero, G.6
Ferrajoli, A.7
Estrov, Z.8
O'Brien, S.9
Koller, C.10
Giles, F.J.11
Wierda, W.12
Kwari, M.13
Kantarjian, H.M.14
-
14
-
-
52649154001
-
A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as frontline therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome
-
Faderl S, Ravandi F, Huang X, et al. A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as frontline therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome. Blood 2008;112:1638-1645.
-
(2008)
Blood
, vol.112
, pp. 1638-1645
-
-
Faderl, S.1
Ravandi, F.2
Huang, X.3
-
15
-
-
33748474416
-
Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: Studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
-
DOI 10.1200/JCO.2005.05.4346
-
Silverman LR, McKenzie DR, Peterson BL, et al. Further analysis of trials with azacytidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol 2006;24:3895-3903. (Pubitemid 46630737)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.24
, pp. 3895-3903
-
-
Silverman, L.R.1
McKenzie, D.R.2
Peterson, B.L.3
Holland, J.F.4
Backstrom, J.T.5
Beach, C.L.6
Larson, R.A.7
-
16
-
-
77449149373
-
Azacytidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
-
Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Azacytidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol 2010;28:562-569.
-
(2010)
J Clin Oncol
, vol.28
, pp. 562-569
-
-
Fenaux, P.1
Mufti, G.J.2
Hellstrom-Lindberg, E.3
-
17
-
-
61549137657
-
Continued low-dose decitabine (DAC) is an active first-line treatment in all cytogenetic subgroups of older AML patients: Results of the FR00331 multicenter phase II study
-
abstract. Abstract 300
-
Lubbert M, Ruter B, Claus R, et al. Continued low-dose decitabine (DAC) is an active first-line treatment in all cytogenetic subgroups of older AML patients: results of the FR00331 multicenter phase II study [abstract]. Blood 2007;110(Suppl):Abstract 300.
-
(2007)
Blood
, vol.110
, Issue.SUPPL.
-
-
Lubbert, M.1
Ruter, B.2
Claus, R.3
-
18
-
-
77449149374
-
Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia
-
Cashen AF, Schiller GJ, O'Donnell MR, DiPersio JF. Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia. J Clin Oncol 2010;28:556-561.
-
(2010)
J Clin Oncol
, vol.28
, pp. 556-561
-
-
Cashen, A.F.1
Schiller, G.J.2
O'Donnell, M.R.3
DiPersio, J.F.4
-
19
-
-
77952140672
-
Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine
-
Blum W, Garzon R, Klisovic RB, et al. Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine. Proc Natl Acad Sci U S A 2010;107:7473-7478.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 7473-7478
-
-
Blum, W.1
Garzon, R.2
Klisovic, R.B.3
-
20
-
-
79951495012
-
A phase II study of high dose lenalidomide as initial therapy for older patients with acute myeloid leukemia
-
Fehniger TA, Uy GL, Trinkaus K, et al. A phase II study of high dose lenalidomide as initial therapy for older patients with acute myeloid leukemia. Blood 2011;117:1828-1833.
-
(2011)
Blood
, vol.117
, pp. 1828-1833
-
-
Fehniger, T.A.1
Uy, G.L.2
Trinkaus, K.3
-
21
-
-
60849098162
-
Single-agent lenalidomide induces complete remission of acute myeloid leukemia in patients with isolated trisomy 13
-
Fehniger TA, Byrd JC, Marcucci G, et al. Single-agent lenalidomide induces complete remission of acute myeloid leukemia in patients with isolated trisomy 13. Blood 2009;113:1002-1005.
-
(2009)
Blood
, vol.113
, pp. 1002-1005
-
-
Fehniger, T.A.1
Byrd, J.C.2
Marcucci, G.3
-
22
-
-
33847001315
-
A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia
-
DOI 10.1182/blood-2006-04-014357
-
Lancet JE, Gojo I, Gotlib J, et al. A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia. Blood 2007;109:1387-1394. (Pubitemid 46242109)
-
(2007)
Blood
, vol.109
, Issue.4
, pp. 1387-1394
-
-
Lancet, J.E.1
Gojo, I.2
Gotlib, J.3
Feldman, E.J.4
Greer, J.5
Liesveld, J.L.6
Bruzek, L.M.7
Morris, L.8
Park, Y.9
Adjei, A.A.10
Kaufmann, S.H.11
Garrett-Mayer, E.12
Greenberg, P.L.13
Wright, J.J.14
Karp, J.E.15
-
23
-
-
41949125894
-
A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia
-
Raponi M, Lancet JE, Fan H, et al. A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia. Blood 2008;111:2589-2596.
-
(2008)
Blood
, vol.111
, pp. 2589-2596
-
-
Raponi, M.1
Lancet, J.E.2
Fan, H.3
-
24
-
-
69849092737
-
A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older
-
Harousseau JL, Martinelli G, Jedrzejczak WW, et al. A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older. Blood 2009;114:1166-1173.
-
(2009)
Blood
, vol.114
, pp. 1166-1173
-
-
Harousseau, J.L.1
Martinelli, G.2
Jedrzejczak, W.W.3
-
25
-
-
66549129197
-
Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: A preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide
-
Karp JE, Flatten K, Feldman EJ, et al. Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide. Blood 2009;113:4841-4852.
-
(2009)
Blood
, vol.113
, pp. 4841-4852
-
-
Karp, J.E.1
Flatten, K.2
Feldman, E.J.3
-
26
-
-
74949124273
-
Phase I clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome
-
Kantarjian H, Garcia-Manero G, O'Brien S, et al. Phase I clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome. J Clin Oncol 2010;28:285-291.
-
(2010)
J Clin Oncol
, vol.28
, pp. 285-291
-
-
Kantarjian, H.1
Garcia-Manero, G.2
O'Brien, S.3
|