Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation

Oncogene

Volumn 30, Issue 2, 2011, Pages 201-211

  Park, H D ^a,b   Lee, Y ^a,c   Oh, Y K ^b   Jung, J G ^c   Park, Y W ^c   Myung, K ^d   Kim, K H ^c   Koh, S S ^c   Lim, D S ^a  

^a National Creative Research Initiative Center   (South Korea)

^b LG Chemical Ltd   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

CXCR4; ERK; NF B; PAUF; TLR; TPL2

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; LECTIN; MIGRATION INHIBITION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PANCREATIC ADENOCARCINOMA UPREGULATED FACTOR; PROTEIN TPL2; RANTES; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE ACTIVATION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ADENOCARCINOMA; ANIMALS; CHEMOKINE CCL5; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEK293 CELLS; HUMANS; I-KAPPA B KINASE; INTRAMOLECULAR OXIDOREDUCTASES; LECTINS; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MAP KINASE KINASE KINASES; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; RECEPTORS, CXCR4; SUBSTRATE SPECIFICITY; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

MAMMALIA;

EID: 78651407343     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.401     Document Type: Article

References (34)

1. Adachi H, Takano K, Morikawa M, Kanaya S, Yoshimura M, Mori Y et al. (2003). Application of a two-liquid system to sitting-drop vapour-diffusion protein crystallization. Acta Crystallogr D Biol Crystallogr 59: 194-196.
2. Akira S, Takeda K. (2004). Toll-like receptor signalling. Nat Rev Immunol 4: 499-511.
3. Azenshtein E, Luboshits G, Shina S, Neumark E, Shahbazian D, Weil M et al. (2002). The CC chemokine RANTES in breast carcinoma progression: regulation of expression and potential mechanisms of promalignant activity. Cancer Res 62: 1093-1102.
4. Bach JP, Rinn B, Meyer B, Dodel R, Bacher M. (2008). Role of MIF in inflammation and tumorigenesis. Oncology 75: 127-133.
5. Banerjee A, Gugasyan R, McMahon M, Gerondakis S. (2006). Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. Proc Natl Acad Sci USA 103: 3274-3279.
6. Barre A, Bourne Y, Van Damme EJ, Peumans WJ, Rouge P. (2001). Mannose-binding plant lectins: different structural scaffolds for a common sugar-recognition process. Biochimie 83: 645-651.
7. Bourne Y, Zamboni V, Barre A, Peumans WJ, Van Damme EJ, Rouge P. (1999). Helianthus tuberosus lectin reveals a widespread scaffold for mannose-binding lectins. Structure 7: 1473-1482.
8. Chen R, Alvero AB, Silasi DA, Steffensen KD, Mor G. (2008). Cancers take their Toll- the function and regulation of Toll-like receptors in cancer cells. Oncogene 27: 225-233.
9. Cho J, Melnick M, Solidakis GP, Tsichlis PN. (2005). Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals. J Biol Chem 280: 20442-20448.
10. Folkman J. (1990). What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4-6.
11. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ et al. (2004). IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118: 285-296.
12. Hajishengallis G, Wang M, Liang S, Triantafilou M, Triantafilou K. (2008). Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function. Proc Natl Acad Sci USA 105: 13532-13537.
13. Huang B, Zhao J, Li H, He KL, Chen Y, Chen SH et al. (2005). Tolllike receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res 65: 5009-5014.
14. Huang B, Zhao J, Shen S, Li H, He KL, Shen GX et al. (2007). Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Res 67: 4346-4352.
15. Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E et al. (2004). Cancer statistics, 2004. CA Cancer J Clin 54: 8-29.
16. Jeyaprakash AA, Katiyar S, Swaminathan CP, Sekar K, Surolia A, Vijayan M. (2003). Structural basis of the carbohydrate specificities of jacalin: an X-ray and modeling study. J Mol Biol 332: 217-228.
17. Jeyaprakash AA, Srivastav A, Surolia A, Vijayan M. (2004). Structural basis for the carbohydrate specificities of artocarpin: variation in the length of a loop as a strategy for generating ligand specificity. J Mol Biol 338: 757-770.
18. Jouault T, El Abed-El Behi M, Martinez-Esparza M, Breuilh L, Trinel PA, Chamaillard M et al. (2006). Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling. J Immunol 177: 4679-4687.
19. Ju G, Labriola-Tompkins E, Campen CA, Benjamin WR, Karas J, Plocinski J et al. (1991). Conversion of the interleukin 1 receptor antagonist into an agonist by site-specific mutagenesis. Proc Natl Acad Sci USA 88: 2658-2662.
20. Kelly MG, Alvero AB, Chen R, Silasi DA, Abrahams VM, Chan S et al. (2006). TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer. Cancer Res 66: 3859-3868.
21. Kim SA, Lee Y, Jung DE, Park KH, Park JY, Gang J et al. (2009). Pancreatic adenocarcinoma up-regulated factor (PAUF), a novel up-regulated secretory protein in pancreatic ductal adenocarcinoma. Cancer Sci 100: 828-836.
22. Lee Y, Kim SJ, Park HD, Park EH, Huang SM, Jeon SB et al. (2010). PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression. Oncogene 29: 56-67.
23. Li Y, Komai-Koma M, Gilchrist DS, Hsu DK, Liu FT, Springall T et al. (2008). Galectin-3 is a negative regulator of lipopolysacchar-ide-mediated inflammation. J Immunol 181: 2781-2789.
24. Li YM, Pan Y, Wei Y, Cheng X, Zhou BP, Tan M et al. (2004). Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell 6: 459-469.
25. Liu FT, Rabinovich GA. (2005). Galectins as modulators of tumour progression. Nat Rev Cancer 5: 29-41.
26. Miettinen M, Veckman V, Latvala S, Sareneva T, Matikainen S, Julkunen I. (2008). Live Lactobacillus rhamnosus and Streptococcus pyogenes differentially regulate Toll-like receptor (TLR) gene expression in human primary macrophages. J Leukoc Biol 84: 1092-1100.
27. Morse RJ, Yamamoto T, Stroud RM. (2001). Structure of Cry2Aa suggests an unexpected receptor binding epitope. Structure 9: 409-417.
28. Nishihira J, Ishibashi T, Fukushima T, Sun B, Sato Y, Todo S. (2003). Macrophage migration inhibitory factor (MIF): its potential role in tumor growth and tumor-associated angiogenesis. Ann NY Acad Sci 995: 171-182.
29. Raman D, Baugher PJ, Thu YM, Richmond A. (2007). Role of chemokines in tumor growth. Cancer Lett 256: 137-165.
30. Raz A, Lotan R. (1987). Endogenous galactoside-binding lectins: a new class of functional tumor cell surface molecules related to metastasis. Cancer Metastasis Rev 6: 433-452.
31. Shimizu T, Vassylyev DG, Kido S, Doi Y, Morikawa K. (1994). Crystal structure of vitelline membrane outer layer protein I (VMO-I): a folding motif with homologous Greek key structures related by an internal three-fold symmetry. EMBO J 13: 1003-1010.
32. Singh S, Sadanandam A, Singh RK. (2007). Chemokines in tumor angiogenesis and metastasis. Cancer Metastasis Rev 26: 453-467.
33. Strieter RM, Burdick MD, Mestas J, Gomperts B, Keane MP, Belperio JA. (2006). Cancer CXC chemokine networks and tumour angiogenesis. Eur J Cancer 42: 768-778.
34. Triantafilou M, Lepper PM, Briault CD, Ahmed MA, Dmochowski JM, Schumann C et al. (2008). Chemokine receptor 4 (CXCR4) is part of the lipopolysaccharide 'sensing apparatus'. Eur J Immunol 38: 192-203.