-
1
-
-
0033519070
-
The fall and rise of sleeping sickness
-
Barrett MP. 1999. The fall and rise of sleeping sickness. Lancet 353:1113-1114.
-
(1999)
Lancet
, vol.353
, pp. 1113-1114
-
-
Barrett, M.P.1
-
3
-
-
78751534394
-
Trypanocidal drugs: Mechanisms, resistance and new targets
-
doi: 10.1017/S1462399409001252
-
Wilkinson SR, Kelly JM. 2009. Trypanocidal drugs: mechanisms, resistance and new targets. Expert Rev. Mol. Med. 11:e31. doi: 10.1017/S1462399409001252.
-
(2009)
Expert Rev. Mol. Med.
, vol.11
-
-
Wilkinson, S.R.1
Kelly, J.M.2
-
4
-
-
0034852287
-
Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy
-
Matovu E, Geiser F, Schneider V, Mäser P, Enyaru JC, Kaminsky R, Gallati S, Seebeck T. 2001. Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy. Mol. Biochem. Parasitol. 117:73- 81.
-
(2001)
Mol. Biochem. Parasitol.
, vol.117
, pp. 73-81
-
-
Matovu, E.1
Geiser, F.2
Schneider, V.3
Mäser, P.4
Enyaru, J.C.5
Kaminsky, R.6
Gallati, S.7
Seebeck, T.8
-
5
-
-
0034777039
-
The phenomenon of treatment failures in Human African trypanosomiasis
-
Brun R, Schumacher R, Schmid C, Kunz C, Burri C. 2001. The phenomenon of treatment failures in Human African trypanosomiasis. Trop. Med. Int. Health 6:906 -914.
-
(2001)
Trop. Med. Int. Health
, vol.6
, pp. 906-914
-
-
Brun, R.1
Schumacher, R.2
Schmid, C.3
Kunz, C.4
Burri, C.5
-
6
-
-
84925020947
-
The chemotherapeutic properties of 5-nitro-2-furaldehyde semicarbazone (Furacin)
-
Dodd MC. 1946. The chemotherapeutic properties of 5-nitro-2-furaldehyde semicarbazone (Furacin). J. Pharmacol. Exp. Ther. 86:311-323.
-
(1946)
J. Pharmacol. Exp. Ther.
, vol.86
, pp. 311-323
-
-
Dodd, M.C.1
-
7
-
-
2142680242
-
Nitrofurazone therapy of Trypanosoma gambiense sleeping sickness in man
-
Evens F, Niemegeers K, Packchanian A. 1957. Nitrofurazone therapy of Trypanosoma gambiense sleeping sickness in man. Am. J. Trop. Med. Hyg. 6:665- 678.
-
(1957)
Am. J. Trop. Med. Hyg.
, vol.6
, pp. 665-678
-
-
Evens, F.1
Niemegeers, K.2
Packchanian, A.3
-
8
-
-
77953082075
-
Chemotherapy of African sleeping sickness. I. Chemotherapy of experimental Trypanosoma gambiense infection in mice (Mus musculus) with nitrofurazone
-
Packchanian A. 1955. Chemotherapy of African sleeping sickness. I. Chemotherapy of experimental Trypanosoma gambiense infection in mice (Mus musculus) with nitrofurazone. Am. J. Trop. Med. Hyg. 4:705-711.
-
(1955)
Am. J. Trop. Med. Hyg.
, vol.4
, pp. 705-711
-
-
Packchanian, A.1
-
10
-
-
36349037267
-
An overview of Chagas disease treatment
-
Jannin J, Villa L. 2007. An overview of Chagas disease treatment. Mem. Inst. Oswaldo Cruz 102(Suppl 1):95-97.
-
(2007)
Mem. Inst. Oswaldo Cruz
, vol.102
, Issue.SUPPL. 1
, pp. 95-97
-
-
Jannin, J.1
Villa, L.2
-
11
-
-
77954978118
-
NECT is next: Implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness
-
doi: 10.1371/journal.pntd.0000720
-
Yun O, Priotto G, Tong J, Flevaud L, Chappuis F. 2010. NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness. PLoS Negl. Trop. Dis. 4:e720. doi: 10.1371/journal.pntd. 0000720.
-
(2010)
PLoS Negl. Trop. Dis.
, vol.4
-
-
Yun, O.1
Priotto, G.2
Tong, J.3
Flevaud, L.4
Chappuis, F.5
-
12
-
-
33749571402
-
Antitumor activity of nifurtimox observed in a patient with neuroblastoma
-
Saulnier Sholler GL, Kalkunte S, Greenlaw C, McCarten K, Forman E. 2006. Antitumor activity of nifurtimox observed in a patient with neuroblastoma. J. Pediatr. Hematol. Oncol. 28:693- 695.
-
(2006)
J. Pediatr. Hematol. Oncol.
, vol.28
, pp. 693-695
-
-
Saulnier Sholler, G.L.1
Kalkunte, S.2
Greenlaw, C.3
McCarten, K.4
Forman, E.5
-
13
-
-
0018800960
-
Oxygensensitive and -insensitive nitroreduction by Escherichia coli and rat hepatic microsomes
-
Peterson FJ, Mason RP, Hovsepian J, Holtzman JL. 1979. Oxygensensitive and -insensitive nitroreduction by Escherichia coli and rat hepatic microsomes. J. Biol. Chem. 254:4009-4014.
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 4009-4014
-
-
Peterson, F.J.1
Mason, R.P.2
Hovsepian, J.3
Holtzman, J.L.4
-
14
-
-
0016722580
-
The mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates
-
Mason RP, Holtzman JL. 1975. The mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates. Biochemistry 14:1626 -1632.
-
(1975)
Biochemistry
, vol.14
, pp. 1626-1632
-
-
Mason, R.P.1
Holtzman, J.L.2
-
15
-
-
0016837387
-
The role of catalytic superoxide formation in the O2 inhibition of nitroreductase
-
Mason RP, Holtzman JL. 1975. The role of catalytic superoxide formation in the O2 inhibition of nitroreductase. Biochem. Biophys. Res. Commun. 67:1267-1274.
-
(1975)
Biochem. Biophys. Res. Commun.
, vol.67
, pp. 1267-1274
-
-
Mason, R.P.1
Holtzman, J.L.2
-
16
-
-
0019512136
-
Mechanism of nifurtimox toxicity in different forms of Trypanosoma cruzi
-
Docampo R, Moreno SN, Stoppani AO, Leon W, Cruz FS, Villalta F, Muniz RF. 1981. Mechanism of nifurtimox toxicity in different forms of Trypanosoma cruzi. Biochem. Pharmacol. 30:1947-1951.
-
(1981)
Biochem. Pharmacol.
, vol.30
, pp. 1947-1951
-
-
Docampo, R.1
Moreno, S.N.2
Stoppani, A.O.3
Leon, W.4
Cruz, F.S.5
Villalta, F.6
Muniz, R.F.7
-
17
-
-
0018682874
-
Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi
-
Docampo R, Stoppani AO. 1979. Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi. Arch. Biochem. Biophys. 197:317-321.
-
(1979)
Arch. Biochem. Biophys.
, vol.197
, pp. 317-321
-
-
Docampo, R.1
Stoppani, A.O.2
-
18
-
-
0023810590
-
"Subversive" substrates for the enzyme trypanothione disulfide reductase: Alternative approach to chemotherapy of Chagas disease
-
Henderson GB, Ulrich P, Fairlamb AH, Rosenberg I, Pereira M, Sela M, Cerami A. 1988. "Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease. Proc. Natl. Acad. Sci. U. S. A. 85:5374 -5378.
-
(1988)
Proc. Natl. Acad. Sci. U. S. A.
, vol.85
, pp. 5374-5378
-
-
Henderson, G.B.1
Ulrich, P.2
Fairlamb, A.H.3
Rosenberg, I.4
Pereira, M.5
Sela, M.6
Cerami, A.7
-
19
-
-
0033105093
-
Enzymatic reduction studies of nitroheterocycles
-
Viodé C, Bettache N, Cenas N, Krauth-Siegel RL, Chauvière G, Bakalara N, Péri é J. 1999. Enzymatic reduction studies of nitroheterocycles. Biochem. Pharmacol. 57:549 -557.
-
(1999)
Biochem. Pharmacol.
, vol.57
, pp. 549-557
-
-
Viodé, C.1
Bettache, N.2
Cenas, N.3
Krauth-Siegel, R.L.4
Chauvière, G.5
Bakalara, N.6
Péri, E.J.7
-
20
-
-
0345035516
-
Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase
-
Blumenstiel K, Schöneck R, Yardley V, Croft SL, Krauth-Siegel RL. 1999. Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase. Biochem. Pharmacol. 58:1791-1799.
-
(1999)
Biochem. Pharmacol.
, vol.58
, pp. 1791-1799
-
-
Blumenstiel, K.1
Schöneck, R.2
Yardley, V.3
Croft, S.L.4
Krauth-Siegel, R.L.5
-
21
-
-
0019325482
-
Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi
-
Boveris A, Sies H, Martino EE, Docampo R, Turrens JF, Stoppani AO. 1980. Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi. Biochem. J. 188:643- 648.
-
(1980)
Biochem. J.
, vol.188
, pp. 643-648
-
-
Boveris, A.1
Sies, H.2
Martino, E.E.3
Docampo, R.4
Turrens, J.F.5
Stoppani, A.O.6
-
22
-
-
0032582844
-
Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole
-
Temperton NJ, Wilkinson SR, Meyer DJ, Kelly JM. 1998. Overexpression of superoxide dismutase in Trypanosoma cruzi results in increased sensitivity to the trypanocidal agents gentian violet and benznidazole. Mol. Biochem. Parasitol. 96:167-176.
-
(1998)
Mol. Biochem. Parasitol.
, vol.96
, pp. 167-176
-
-
Temperton, N.J.1
Wilkinson, S.R.2
Meyer, D.J.3
Kelly, J.M.4
-
23
-
-
33846600818
-
Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole
-
Prathalingham SR, Wilkinson SR, Horn D, Kelly JM. 2007. Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole. Antimicrob. Agents Chemother. 51:755-758.
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 755-758
-
-
Prathalingham, S.R.1
Wilkinson, S.R.2
Horn, D.3
Kelly, J.M.4
-
24
-
-
0027494350
-
Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress
-
Kelly JM, Taylor MC, Smith K, Hunter KJ, Fairlamb AH. 1993. Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity towards agents that are thought to induce oxidative stress. Eur. J. Biochem. 218:29 -37.
-
(1993)
Eur. J. Biochem.
, vol.218
, pp. 29-37
-
-
Kelly, J.M.1
Taylor, M.C.2
Smith, K.3
Hunter, K.J.4
Fairlamb, A.H.5
-
25
-
-
79953882988
-
Nifurtimox activation by trypanosomal type i nitroreductases generates cytotoxic nitrile metabolites
-
Hall BS, Bot C, Wilkinson SR. 2011. Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites. J. Biol. Chem. 286:13088 -13095.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 13088-13095
-
-
Hall, B.S.1
Bot, C.2
Wilkinson, S.R.3
-
26
-
-
59749086659
-
Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases)
-
Pal D, Banerjee S, Cui J, Schwartz A, Ghosh SK, Samuelson J. 2009. Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). Antimicrob. Agents Chemother. 53:458-464.
-
(2009)
Antimicrob. Agents Chemother.
, vol.53
, pp. 458-464
-
-
Pal, D.1
Banerjee, S.2
Cui, J.3
Schwartz, A.4
Ghosh, S.K.5
Samuelson, J.6
-
27
-
-
42449155428
-
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes
-
Wilkinson SR, Taylor MC, Horn D, Kelly JM, Cheeseman I. 2008. A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proc. Natl. Acad. Sci. U. S. A. 105:5022-5027.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 5022-5027
-
-
Wilkinson, S.R.1
Taylor, M.C.2
Horn, D.3
Kelly, J.M.4
Cheeseman, I.5
-
28
-
-
84455170162
-
Activation of benznidazole by trypano-somal type i nitroreductases results in glyoxal formation
-
Hall BS, Wilkinson SR. 2012. Activation of benznidazole by trypano-somal type I nitroreductases results in glyoxal formation. Antimicrob. Agents Chemother. 56:115-123.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 115-123
-
-
Hall, B.S.1
Wilkinson, S.R.2
-
29
-
-
78951491179
-
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6
-
Baker N, Alsford S, Horn D. 2011. Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6. Mol. Biochem. Parasitol. 176:55-57.
-
(2011)
Mol. Biochem. Parasitol.
, vol.176
, pp. 55-57
-
-
Baker, N.1
Alsford, S.2
Horn, D.3
-
30
-
-
84856955769
-
High-throughput decoding of antitrypanosomal drug efficacy and resistance
-
Alsford S, Eckert S, Baker N, Glover L, Sanchez-Flores A, Leung KF, Turner DJ, Field MC, Berriman M, Horn D. 2012. High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature 482: 232-236.
-
(2012)
Nature
, vol.482
, pp. 232-236
-
-
Alsford, S.1
Eckert, S.2
Baker, N.3
Glover, L.4
Sanchez-Flores, A.5
Leung, K.F.6
Turner, D.J.7
Field, M.C.8
Berriman, M.9
Horn, D.10
-
31
-
-
0013877705
-
The aerobic degradation of 1-(5-nitrofurfurylideneamino)-2- imidazolidinone (NF-246) by Escherichia coli
-
Gavin JJ, Ebetino FF, Freedman R, Waterbury WE. 1966. The aerobic degradation of 1-(5-nitrofurfurylideneamino)-2-imidazolidinone (NF-246) by Escherichia coli. Arch. Biochem. Biophys. 113:399-404.
-
(1966)
Arch. Biochem. Biophys.
, vol.113
, pp. 399-404
-
-
Gavin, J.J.1
Ebetino, F.F.2
Freedman, R.3
Waterbury, W.E.4
-
32
-
-
0037020868
-
A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi
-
Kubata BK, Kabututu Z, Nozaki T, Munday CJ, Fukuzumi S, Ohkubo K, Lazarus M, Maruyama T, Martin SK, Duszenko M, Urade Y. 2002. A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi. J. Exp. Med. 196:1241-1251.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1241-1251
-
-
Kubata, B.K.1
Kabututu, Z.2
Nozaki, T.3
Munday, C.J.4
Fukuzumi, S.5
Ohkubo, K.6
Lazarus, M.7
Maruyama, T.8
Martin, S.K.9
Duszenko, M.10
Urade, Y.11
-
33
-
-
73949135846
-
5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene
-
Gerpe A, Alvarez G, Benítez D, Boiani L, Quiroga M, Hernández P, Sortino M, Zacchino S, González M, Cerecetto H. 2009. 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene. Bioorg. Med. Chem. 17:7500 -7509.
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 7500-7509
-
-
Gerpe, A.1
Alvarez, G.2
Benítez, D.3
Boiani, L.4
Quiroga, M.5
Hernández, P.6
Sortino, M.7
Zacchino, S.8
González, M.9
Cerecetto, H.10
-
34
-
-
38049100672
-
Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action
-
Gerpe A, Odreman-Nuñez I, Draper P, Boiani L, Urbina JA, González M, Cerecetto H. 2008. Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action. Bioorg. Med. Chem. 16:569 -577.
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 569-577
-
-
Gerpe, A.1
Odreman-Nuñez, I.2
Draper, P.3
Boiani, L.4
Urbina, J.A.5
González, M.6
Cerecetto, H.7
-
35
-
-
11144355789
-
Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti-Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design
-
Aguirre G, Cabrera E, Cerecetto H, Di Maio R, Gonzalez M, Seoane G, Duffaut A, Denicola A, Gil MJ, Martinez-Merino V. 2004. Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti-Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design. Eur. J. Med. Chem. 39:421- 431.
-
(2004)
Eur. J. Med. Chem.
, vol.39
, pp. 421-431
-
-
Aguirre, G.1
Cabrera, E.2
Cerecetto, H.3
Di Maio, R.4
Gonzalez, M.5
Seoane, G.6
Duffaut, A.7
Denicola, A.8
Gil, M.J.9
Martinez-Merino, V.10
-
36
-
-
4444312101
-
In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones
-
Aguirre G, Boiani L, Cerecetto H, Fernandez M, Gonzalez M, Denicola A, Otero L, Gambino D, Rigol C, Olea-Azar C, Faundez M. 2004. In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones. Bioorg. Med. Chem. 12:4885- 4893.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, pp. 4885-4893
-
-
Aguirre, G.1
Boiani, L.2
Cerecetto, H.3
Fernandez, M.4
Gonzalez, M.5
Denicola, A.6
Otero, L.7
Gambino, D.8
Rigol, C.9
Olea-Azar, C.10
Faundez, M.11
-
37
-
-
0024948840
-
Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers
-
Hirumi H, Hirumi K. 1989. Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J. Parasitol. 75:985-989.
-
(1989)
J. Parasitol.
, vol.75
, pp. 985-989
-
-
Hirumi, H.1
Hirumi, K.2
-
38
-
-
27644517022
-
Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects
-
Alsford S, Kawahara T, Glover L, Horn D. 2005. Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects. Mol. Biochem. Parasitol. 144:142-148.
-
(2005)
Mol. Biochem. Parasitol.
, vol.144
, pp. 142-148
-
-
Alsford, S.1
Kawahara, T.2
Glover, L.3
Horn, D.4
-
39
-
-
43949098939
-
Multiple NADPH-cytochrome P450 reductases from Trypanosoma cruzi suggested role on drug resistance
-
Portal P, Villamil SF, Alonso GD, De Vas MG, Flawia MM, Torres HN, Paveto C. 2008. Multiple NADPH-cytochrome P450 reductases from Trypanosoma cruzi suggested role on drug resistance. Mol. Biochem. Parasitol. 160:42-51.
-
(2008)
Mol. Biochem. Parasitol.
, vol.160
, pp. 42-51
-
-
Portal, P.1
Villamil, S.F.2
Alonso, G.D.3
De Vas, M.G.4
Flawia, M.M.5
Torres, H.N.6
Paveto, C.7
-
40
-
-
77957016594
-
Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis
-
Jones DC, Hallyburton I, Stojanovski L, Read KD, Frearson JA, Fairlamb AH. 2010. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem. Pharmacol. 80:1478 -1486.
-
(2010)
Biochem. Pharmacol.
, vol.80
, pp. 1478-1486
-
-
Jones, D.C.1
Hallyburton, I.2
Stojanovski, L.3
Read, K.D.4
Frearson, J.A.5
Fairlamb, A.H.6
-
41
-
-
77149159732
-
Exploiting the drugactivating properties of a novel trypanosomal nitroreductase
-
Hall BS, Wu X, Hu L, Wilkinson SR. 2010. Exploiting the drugactivating properties of a novel trypanosomal nitroreductase. Antimicrob. Agents Chemother. 54:1193-1199.
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 1193-1199
-
-
Hall, B.S.1
Wu, X.2
Hu, L.3
Wilkinson, S.R.4
-
42
-
-
77957374117
-
Trypanocidal activity of aziridinyl nitrobenzamide prodrugs
-
Bot C, Hall BS, Bashir N, Taylor MC, Helsby NA, Wilkinson SR. 2010. Trypanocidal activity of aziridinyl nitrobenzamide prodrugs. Antimicrob. Agents Chemother. 54:4246-4252.
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 4246-4252
-
-
Bot, C.1
Hall, B.S.2
Bashir, N.3
Taylor, M.C.4
Helsby, N.A.5
Wilkinson, S.R.6
-
43
-
-
0021027459
-
Mutagenicity of nitrofuran derivatives
-
review
-
McCalla DR. 1983. Mutagenicity of nitrofuran derivatives: review. Environ. Mutagen. 5:745-765.
-
(1983)
Environ. Mutagen.
, vol.5
, pp. 745-765
-
-
McCalla, D.R.1
-
44
-
-
78650682602
-
Fexinidazole - A new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness
-
doi: 10.1371/journal.pntd.0000923
-
Torreele E, Bourdin Trunz B, Tweats D, Kaiser M, Brun R, Mazue G, Bray MA, Pecoul B. 2010. Fexinidazole - a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl. Trop. Dis. 4:e923. doi: 10.1371/journal.pntd.0000923.
-
(2010)
PLoS Negl. Trop. Dis.
, vol.4
-
-
Torreele, E.1
Bourdin Trunz, B.2
Tweats, D.3
Kaiser, M.4
Brun, R.5
Mazue, G.6
Bray, M.A.7
Pecoul, B.8
-
45
-
-
0033758773
-
The adaptative mechanisms of Trypanosoma brucei for sterol homeostasis in its different life-cycle environments
-
Coppens I, Courtoy PJ. 2000. The adaptative mechanisms of Trypanosoma brucei for sterol homeostasis in its different life-cycle environments. Annu. Rev. Microbiol. 54:129 -156.
-
(2000)
Annu. Rev. Microbiol.
, vol.54
, pp. 129-156
-
-
Coppens, I.1
Courtoy, P.J.2
-
46
-
-
77953760001
-
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis
-
Sokolova AY, Wyllie S, Patterson S, Oza SL, Read KD, Fairlamb AH. 2010. Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis. Antimicrob. Agents Chemother. 54: 2893-2900.
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 2893-2900
-
-
Sokolova, A.Y.1
Wyllie, S.2
Patterson, S.3
Oza, S.L.4
Read, K.D.5
Fairlamb, A.H.6
-
47
-
-
0023355592
-
Generation of radical anions of nitrofurantoin, misonidazole, and metronidazole by ascorbate
-
Rao DN, Harman L, Motten A, Schreiber J, Mason RP. 1987. Generation of radical anions of nitrofurantoin, misonidazole, and metronidazole by ascorbate. Arch. Biochem. Biophys. 255:419-427.
-
(1987)
Arch. Biochem. Biophys.
, vol.255
, pp. 419-427
-
-
Rao, D.N.1
Harman, L.2
Motten, A.3
Schreiber, J.4
Mason, R.P.5
-
48
-
-
0023274989
-
Generation of nitro radical anions of some 5-nitrofurans, 2- and 5-nitroimidazoles by norepinephrine, dopamine, and serotonin. A possible mechanism for neurotoxicity caused by nitroheterocyclic drugs
-
Rao DN, Mason RP. 1987. Generation of nitro radical anions of some 5-nitrofurans, 2- and 5-nitroimidazoles by norepinephrine, dopamine, and serotonin. A possible mechanism for neurotoxicity caused by nitroheterocyclic drugs. J. Biol. Chem. 262:11731-11736.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 11731-11736
-
-
Rao, D.N.1
Mason, R.P.2
|