Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites

Journal of Biological Chemistry

Volumn 286, Issue 15, 2011, Pages 13088-13095

  Hall, Belinda S ^a   Bot, Christopher ^a   Wilkinson, Shane R ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHAGAS DISEASE; CYTOCHROME P450 REDUCTASE; CYTOTOXIC; DRUG ACTION; ELEVATED LEVEL; EQUIVALENT CONCENTRATIONS; MAMMALIAN CELLS; NITROREDUCTASES; PARASITE-; PRODRUGS; REACTIVE OXYGEN; REDUCTIVE ACTIVATION; SYNTHASES; TARGET CELLS; TRYPANOSOMA BRUCEI;

CYANIDES; DISEASE CONTROL; ENZYMES; GROWTH KINETICS; MAMMALS; METABOLISM; OXYGEN;

METABOLITES;

NIFURTIMOX; NITROREDUCTASE;

ARTICLE; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME REPRESSION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CELL LINE; ENZYME ACTIVATION; HUMANS; NIFURTIMOX; NITRILES; NITROREDUCTASES; OXIDATION-REDUCTION; PROTOZOAN PROTEINS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EUKARYOTA; MAMMALIA; TRYPANOSOMA BRUCEI;

EID: 79953882988     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.230847     Document Type: Article

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