Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases)

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 2, 2009, Pages 458-464

  Pal, Dibyarupa ^a   Banerjee, Sulagna ^b   Cui, Jike ^b   Schwartz, Aaron ^b   Ghosh, Sudip K ^a   Samuelson, John ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

^b BOSTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; METRONIDAZOLE; NITROIMIDAZOLE OXIDOREDUCTASE; NITROREDUCTASE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; CONTROLLED STUDY; ENTAMOEBA HISTOLYTICA; ENZYME ACTIVATION; GENE EXPRESSION; GENE OVEREXPRESSION; GIARDIA LAMBLIA; HELICOBACTER PYLORI; NONHUMAN; NONSENSE MUTATION; PRIORITY JOURNAL; TRICHOMONAS VAGINALIS;

AMEBICIDES; AMINO ACID SEQUENCE; ANIMALS; ANTIPROTOZOAL AGENTS; ANTITRICHOMONAL AGENTS; BACTEROIDES; BIOTRANSFORMATION; CODON, NONSENSE; DRUG RESISTANCE, BACTERIAL; ENTAMOEBA; GIARDIA; HELICOBACTER; METRONIDAZOLE; MOLECULAR SEQUENCE DATA; NITROREDUCTASES; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRICHOMONAS;

EID: 59749086659     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00909-08     Document Type: Article

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